Important Outcomes Research Articles

Safety of fluconazole in kidney transplant recipients for prevention of coccidioidomycosis.

Coccidioides is an endemic fungus that causes infections ranging from mild respiratory illness to life-threatening disease, and immunocompromised hosts such as solid organ transplant recipients are at higher risk for disseminated infection and mortality. Our center administers fluconazole prophylaxis to kidney transplant recipients residing in geographic areas with higher incidences of coccidioidomycosis. However, because drug-drug interactions occur between triazoles and immunosuppressants used in transplant medicine, we undertook a study to ascertain whether fluconazole prophylaxis was associated with any important safety outcomes in kidney transplant recipients. This retrospective study evaluated patients who had undergone kidney transplantation between 2016 and 2019. Data on patient demographics, transplant-related clinical information, use of fluconazole prophylaxis (200 mg daily for 6-12 months post-transplant), and patient outcomes were obtained. The primary outcome was mean estimated glomerular filtration rate (eGFR) at 12 months, comparing those who received fluconazole prophylaxis to those who did not. Secondary outcomes included mean eGFR at 3 months, 6 months, and 9 months post-transplant, patient survival, biopsy-proven graft rejection, graft loss, or a new requirement for post-transplant dialysis, all within 12 months post-transplant. The mean eGFR at 12 months was similar between both groups, with 66.4 ml/min/1.73 m² in the fluconazole prophylaxis group vs. 64.3 ml/min/1.73 m² in the non-fluconazole prophylaxis group (P=0.55). Secondary outcomes were similar across both groups. Multivariable linear regression found no significant association between fluconazole use and graft function. Fluconazole prophylaxis for prevention of coccidioidomycosis was not associated with adverse graft outcomes in kidney transplant recipients.

Conspiracy Mentality: How it Relates to Populism, Relative Deprivation, Mistrust of Expertise and Voting Behaviour.

Studies utilised OSL regression and structural equation modelling. The overall regression was statistically significant. It was found that dimensions of populist attitudes (anti-elitism, sovereignty), relative deprivation and mistrust of expertise were significant predictors of conspiracy mentality. In line with the second research aim, the fitness of models was confirmed and results suggest mistrust of expertise is also a significant predictor of far-right voting. The contribution of the paper lies in connecting conspiracy mentality with not only attitudes but also with important behaviour outcome - voting behaviour. We propose future research should experimentally examine whether the reduction of some of the identified predictors could possibly lower levels of conspiracy mentality and whether this reduction translates into voting behaviour.

Improving University Second-year Students’ Problem-Solving Skills in Computer Science Course (Digital Logic course) through Engineering Design Process in Inner Mongolia

Many researchers regarded that problem solving skill is one of the most important learning outcomes to help students adapt to the learning and working environment (Xiao et al, 2019). Through reading a large number of articles and experimental research, this study finds that currently the development of and research on problem-solving skill in university students who are major in computer science in digital logic course in Inner Mongolia is limited, especially in the context of STEM education. STEM education is currently widely valued in the K12 stage, but the STEM literacy of college students also needs to be paid attention to. There is an important need for developing university students’ problem-solving skill systematically and effectively, revealing the importance of this research. In the research field, process of engineering design was designed to developing students’ problem-solving skill. In order to have an in-depth understanding of the research questions, mixed methods were adopted. Students were divided into 2 groups: Experimental Group and the Control Group. The participants were 1 teacher and 140 students at university second-year at a university in Inner Mongolia. To collect reliable and valid data, standardized test of problem-solving skill, teacher interview form was designed. Independent T-test was used to analyze the quantitative data.

Predicting soldier retention from army spouse characteristics and attitudes: Soldiering on with spouse support

ABSTRACT The U.S. Army has a vested interest in retaining the skilled personnel necessary to achieve its mission and strategic goals. A wealth of research has investigated the retention process and what influences service member decisions to stay in the military. While families are an important influence on soldier retention decisions, research on the mechanism by which this happens is lacking. This report explores the relationship between spouse attitudes and perceptions, resource use, and soldier retention almost two years later, using a proposed theoretical model. Our results generally support our model, with the important change that resource use and unmet needs and stress were not directly associated with specific attitudes toward staying in the military as we had expected. Instead, the association was accounted for by relationship with general attitudes toward the military. Spouses whose needs were unmet after seeking help from available resources experienced greater stress, and spouse unmet needs and reports of greater stress were associated with worse general attitudes toward the military; worse general attitudes toward the military were associated with less inclination to stay a military family; which in turn predicted soldier turnover almost two years later. As the research in this report shows, providing benefits to military spouses is also associated with a tangible and important outcome for the military: improved service member retention.

Outcomes of Women Undergoing Noncardiac Surgery in Veterans Affairs Compared With Non–Veterans Affairs Care Settings

Recent legislation facilitates veterans' ability to receive non-Veterans Affairs (VA) surgical care. Although veterans are predominantly male, the number of women receiving care within the VA has nearly doubled to 10% over the past decade and recent data comparing the surgical care of women in VA and non-VA care settings are lacking. To compare postoperative outcomes among women treated in VA hospitals vs private-sector hospitals. This coarsened exact-matched cohort study across 9 noncardiac specialties in the Veterans Affairs Surgical Quality Improvement Program (VASQIP) and American College of Surgeons National Surgical Quality Improvement Program (NSQIP) took place from January 1, 2016, to December 31, 2019. Multivariable Poisson models with robust standard errors were used to evaluate the association between VA vs private-sector care settings and 30-day mortality. Hospitals participating in American College of Surgeons NSQIP and VASQIP were included. Data analysis was performed in January 2023. Participants included female patients 18 years old or older. Surgical care in VA or private-sector hospitals. Postoperative 30-day mortality and failure to rescue (FTR). Among 1 913 033 procedures analyzed, patients in VASQIP were younger (VASQIP: mean age, 49.8 [SD, 13.0] years; NSQIP: mean age, 55.9 [SD, 16.9] years; P < .001) and although most patients in both groups identified as White, there were significantly more Black women in VASQIP compared with NSQIP (29.6% vs 12.7%; P < .001). The mean risk analysis index score was lower in VASQIP (13.9 [SD, 6.4]) compared with NSQIP (16.3 [SD, 7.8]) (P < .001 for both). Patients in the VA were more likely to have a preoperative acute serious condition (2.4% vs 1.8%: P < .001), but cases in NSQIP were more frequently emergent (6.9% vs 2.6%; P < .001). The 30-day mortality, complications, and FTR were 0.2%, 3.2%, and 0.1% in VASQIP (n = 36 762 procedures) as compared with 0.8%, 5.0%, and 0.5% in NSQIP (n = 1 876 271 procedures), respectively (all P < .001). Among 1 763 540 matched women (n = 36 478 procedures in VASQIP; n = 1 727 062 procedures in NSQIP), these rates were 0.3%, 3.7%, and 0.2% in NSQIP and 0.1%, 3.4%, and 0.1% in VASQIP (all P < .01). Relative to private-sector care, VA surgical care was associated with a lower risk of death (adjusted risk ratio [aRR], 0.41; 95% CI, 0.23-0.76). This finding was robust among women undergoing gynecologic surgery, inpatient surgery, and low-physiologic stress procedures. VA surgical care was also associated with lower risk of FTR (aRR, 0.41; 95% CI, 0.18-0.92) for frail or Black women and inpatient and low-physiologic stress procedures. Although women comprise the minority of veterans receiving care within the VA, in this study, VA surgical care for women was associated with half the risk of postoperative death and FTR. The VA appears better equipped to meet the unique surgical needs and risk profiles of veterans, regardless of sex and health policy decisions, including funding, should reflect these important outcome differences.

Evaluation of the Embrittlement in Reactor Pressure-Vessel Steels Using a Hybrid Nondestructive Electromagnetic Testing and Evaluation Approach.

The nondestructive determination of the neutron-irradiation-induced embrittlement of nuclear reactor pressure-vessel steel is a very important and recent problem. Within the scope of the so-called NOMAD project funded by the Euratom research and training program, novel nondestructive electromagnetic testing and evaluation (NDE) methods were applied to the inspection of irradiated reactor pressure-vessel steel. In this review, the most important results of this project are summarized. Different methods were used and compared with each other. The measurement results were compared with the destructively determined ductile-to-brittle transition temperature (DBTT) values. Three magnetic methods, 3MA (micromagnetic, multiparameter, microstructure and stress analysis), MAT (magnetic adaptive testing), and Barkhausen noise technique (MBN), were found to be the most promising techniques. The results of these methods were in good agreement with each other. A good correlation was found between the magnetic parameters and the DBTT values. The basic idea of the NOMAD project is to use a multi-method/multi-parameter approach and to focus on the synergies that allow us to recognize the side effects, therefore suppressing them at the same time. Different types of machine-learning (ML) algorithms were tested in a competitive manner, and their performances were evaluated. The important outcome of the ML technique is that not only one but several different ML techniques could reach the required precision and reliability, i.e., keeping the DBTT prediction error lower than a ±25 °C threshold, which was previously not possible for any of the NDE methods as single entities. A calibration/training procedure was carried out on the merged outcome of the testing methods with excellent results to predict the transition temperature, yield strength, and mechanical hardness for all investigated materials. Our results, achieved within the NOMAD project, can be useful for the future potential introduction of this (and, in general, any) nondestructive evolution method.

Beyond NICE: Updated Systematic Review on the Current Evidence of Using Puberty Blocking Pharmacological Agents and Cross-Sex-Hormones in Minors with Gender Dysphoria

Beyond NICE: Updated Systematic Review on the Current Evidence of Using Puberty Blocking Pharmacological Agents and Cross-Sex-Hormones in Minors with Gender Dysphoria Abstract: Objective: The suppression of physiological puberty using puberty-blocking pharmacological agents (PB) and prescribing cross-sex hormones (CSH) to minors with gender dysphoria (GD) is a current matter of discussion, and in some cases, PB and CSH are used in clinical practice for this particular population. Two systematic reviews (one on PB, one on CSH treatment) by the British National Institute for Clinical Excellence (NICE) from 2020 indicated no clear clinical benefit of such treatments regarding critical outcome variables. In particular, these two systematic NICE reviews on the use of PB and CSH in minors with GD detected no clear improvements of GD symptoms. Moreover, the overall scientific quality of the available evidence, as discussed within the above-mentioned two NICE reviews, was classified as "very low certainty" regarding modified GRADE criteria. Method: The present systematic review presents an updated literature search on this particular topic (use of PB and CSH in minors with GD) following NICE principles and PICO criteria for all relevant new original research studies published since the release of the two above-mentioned NICE reviews (updated literature search period was July 2020-August 2023). Results: The newly conducted literature search revealed no newly published original studies targeting NICE-defined critical and important outcomes and the related use of PB in minors with GD following PICO criteria. For CSH treatment, we found two new studies that met PICO criteria, but these particular two studies had low participant numbers, yielded no significant additional clear evidence for specific and clearly beneficial effects of CSH in minors with GD, and could be classified as "low certainty" tfollowing modified GRADE criteria. Conclusions: The currently available studies on the use of PB and CSH in minors with GD have significant conceptual and methodological flaws. The available evidence on the use of PB and CSH in minors with GD is very limited and based on only a few studies with small numbers, and these studies have problematic methodology and quality. There also is a lack of adequate and meaningful long-term studies. Current evidence doesn't suggest that GD symptoms and mental health significantly improve when PB or CSH are used in minors with GD. Psychotherapeutic interventions to address and reduce the experienced burden can become relevant in children and adolescents with GD. If the decision to use PB and/or CSH is made on an individual case-by-case basis and after a complete and thorough mental health assessment, potential treatment of possibly co-occurring mental health problems as well as after a thoroughly conducted and carefully executed individual risk-benefit evaluation, doing so as part of clinical studies or research projects, as currently done in England, can be of value in terms of generation of new research data. The electronic supplement (ESM) 1 is an adapted and abreviated English version of this work.

Impact of Frailty on Healthcare Outcomes after Cardioembolic Ischaemic Stroke Due to Atrial Fibrillation.

Stroke due to atrial fibrillation (AF) is more common in older adults. Frailty is associated with AF. As little is known about the impact of frailty on cardioembolic stroke, we examined its association with important healthcare outcomes including mortality and functional outcome in stroke with AF. Data were collected from patients presenting consecutively to a regional university hospital to assess pre-admission frailty using the Clinical Frailty Scale (CFS) and function with the Modified Rankin Scale (mRS). Stroke severity was assessed on the National Institute of Health Stroke Scale (NIHSS). In total, 113 patients presenting between August 2014 and July 2016 were identified with cardioembolic stroke, median age 80 years; 60% were male. Their median NIHSS score was 6. The median pre-admission CFS score was 3; 26.5% scored ≥5/9, indicating frailty. The median pre-admission mRS scores increased significantly from 1 to 3 at discharge (p < 0.001). Frailty was associated with worse mRS scores at discharge, odds ratio 1.5, (p = 0.03). While no patients with frailty were suitable to avail of early supported discharge, 10% of those without frailty were (p = 0.02). There was no significant difference in 30-day mortality. Frailty is prevalent among patients with cardioembolic stroke due to AF and was associated with poorer functional outcomes. Although the numbers were small, these data suggest that brief frailty assessments are useful to risk-stratify patients with acute cardioembolic stroke. Frailty status on admission with stroke due to AF can help identify those more likely to have poorer outcomes, to benefit from intervention, to require prolonged rehabilitation, and to avail of ESD.

Multiple primary carcinoma in post renal transplant immunocompromised patient-a case report

Introduction: Cancer is an important outcome after kidney transplantation because of immunosuppression and it is the second leading cause of death. The excess risk of cancer after transplantation is approximately two to three times higher than the age- and sex-matched general population, driven largely by viral- and immune-related cancers. Case presentation: 68 yr old male with single transplanted kidney and no tobacco habit presented with multiple primary malignancy over 8 yr period from carcinoma soft palate, carcinoma rectum and Hepatocellular carcinoma. Diagnosis: Patient underwent Radiation alone for softplate carcinoma, Surgery followed by chemo radiation for carcinoma rectum and Hepatocellular carcinoma. Patient on follow up PET CT and MRI have no active disease Conclusion: Carcinoma incidence is inevitable for renal transplant patient. With multimodality approach of surgery, Radiation and chemotherapy patient having a better quality of life

Bridge the gap caused by public health crises: medical humanization and communication skills build a psychological bond that satisfies patients

BackgroundPatient satisfaction is an important outcome domain of patient-centered care. Medical humanization follows the patient-centered principle and provides a more holistic view to treat patients. The COVID-19 pandemic posed significant barriers to maintaining medical humanization. However, empirical study on the relationship between medical humanization and patient satisfaction is clearly absent.ObjectivesWe examined the mediation effects of communication on the relationship between medical humanization and patient satisfaction when faced with a huge public health crisis like the COVID-19 pandemic, and the moderation effect of medical institutional trust on the mediation models.MethodsA cross-sectional survey study was performed. A final sample size of 1445 patients was surveyed on medical humanization, communication, patient satisfaction and medical institutional trust.ResultsAll correlations were significantly positive across the main variables (r = 0.35–0.67, p < 0.001 for all) except for medical institutional trust, which was negatively correlated with the medical humanization (r=-0.14, p < 0.001). Moderated mediation analysis showed that the indirect effect of medical humanization on patient satisfaction through communication was significant (b = 0.22, 95% CI: 0.18 ~ 0.25). Medical institutional trust significantly moderated the effect of medical humanization on patient satisfaction (b=-0.09, p < 0.001) and the effect of medical humanization on communication (b= -0.14, p < 0.001).ConclusionMedical humanization positively influence patient satisfaction, communication mediated the association between medical humanization and patient satisfaction, and medical institutional trust negatively moderated the effects of medical humanization on patient satisfaction and communication. These findings suggest that humanistic communication contributes to patient satisfaction in the face of a huge public health crisis, and patients’ evaluation of satisfaction is also regulated by rational cognition.

Melting and heat generating influences on radiative flow of two-phase magneto-Williamson nanofluid via stretchable surface with slippage velocity and activation energy

Melting heat and solutal transference in a magnetohydrodynamic flowing of Williamson nanofluid have been described, with the mathematical model guided by Arrhenius activation energy, chemically reactive species, and convective boundary restrictions. By implementing suitable similarity conversions, the regulating equations of partial differential equations (PDEs) (formed by continuity, impetus, energy, and concentricity components) are condensed to an arrangement of ordinary differential equations (ODEs). These commonalities are in nonlinear form, which includes the fluid’s velocity, heat, and concentration changes. Finally, the standard Keller box approach is used to solve this ODEs system computationally (KBM). Under the influence of regulating parameters, the computational results are tallied and displayed in suitable diagrams. The friction force factor, local Nusselt, and Sherwood values are tabulated. Furthermore, the velocity, energy, and concentration contours are plotted versus fluid thickness. The attributes of Williamson nanofluid flowing, melting heat transfer, and mass transference are debated in depth toward the end of this study. Among the most important outcomes that have been reached is that the rate of heat and solutal transport heightened between 52.5 and 55.2% by detraction of the magnetic field, Weissenberg number, and Brownian motion. We also found that there is an inverse relationship between the mass transmission and heat generating factor.

Correlating pipe dimensions and success of local heat treatment: Developing nomograms to deduce heat treatment parameters

Local post-weld heat treatment (PWHT) is the only option for heat treating field welded joints. Quite often, the success of local PWHT in alleviating the residual stress and tempering the material within the soak band (SB) is dependent on the ability to achieve the required heat treatment temperature and maintain through-thickness temperature gradient (TTG) within the specified limits at the end of heating cycle, whence soaking begins. Field observations reveal the inadequacy of AWS D 10.10 specified parameters viz. rate of heating (ROH), heat band (HB) and insulation band width in not achieving the required TTG for certain pipe dimensions. Although prior works have attempted to address this issue by widening the HB, the capacity of the heating equipment often pose a limitation. In such cases, reducing ROH is a plausible alternative. With, no such prior studies seen in literature, an exhaustive finite-element analysis simulating the local PWHT on 81, SA106GrC pipe samples (diameter and thickness varied in 9 levels each) was performed, thrice. First as per AWS recommendations, second by halving the code deduced ROH and third by doubling the code deduced HB. The trend of important outcomes (TTG, power source rating and energy consumption) with great significance to the heat treatment industry were also compared and analysed. Two nomograms were developed to serve as a ready reckoner for field heat treater in not only assessing the adequacy of heat treatment parameters but also with possible alternatives in achieving the desired TTG using field-available power source.

Fostering Executive-Function Skills and Promoting Far Transfer to Real-World Outcomes: The Importance of Life Skills and Civic Science

Executive-function (EF) skills are a set of attention-regulation skills that provide a neurocognitive foundation for adapting to changing circumstances across the life span; EF skills measured in childhood are associated with important real-world outcomes (e.g., school and job success). Although training can improve EF skills, the benefits of training frequently fail to transfer to these outcomes. We argue that EF skills are associated with outcomes such as school success only to the extent that they first contribute to intermediate-level EF-based life skills that are more directly instrumental in achieving key outcomes. These intentional intermediate-level skills are configurations of specific EF skills and non-EF skills that are used when reasoning and solving problems in a variety of domains. We further argue that an effective way to bridge the gap between specific EF skills and real-world outcomes is by training these EF-based life skills that people need to function effectively in society. We propose that this can best be achieved using a civic-scientific approach, engaging citizens (e.g., children, youth, parents, teachers) in the design process from the beginning so that interventions are responsive to perceived needs and address perceived obstacles to success and sustainability.

COVID-19 VACCINE UPTAKE AMONG OPULENT VS SLUMS OF URBAN SETTING IN KARACHI, PAKISTAN

Background: COVID-19 vaccine effectiveness and acceptability are critical for a number of important outcomes, including symptomatic COVID-19, severe illnesses, and COVID-19-related mortality. Aim: To assess the immunization status regarding age, gender, and living standards and the reason for non-compliance to the Covid-19 vaccine among people of urban opulent and slums areas of a single city, i.e., Karachi, Pakistan. Method: This cross-sectional study was conducted from December 2022 to January 2023 in Karachi, Pakistan. Data were collected through social media websites, including WhatsApp and Facebook, telephonic interviews from opulent urban areas, and direct contact during the visit to primary health care clinics in urban slum areas. STATA software was used for data analysis. Result: Of 1265 respondents from slums and opulent areas, 15.8% were non-vaccinated slums, whereas 14.16% belonged to opulent areas needing vaccination with adjusted OR 95% is 0.74(0.41-0.95). Of 1265 respondents, 825(65%) were females, and 440 (34.7%) were male. The vaccine compliance among females was 49%, and 32% among male respondents with adjusted OR 95% 1.84(1.12-3.03). Only 6% of the slums area were vaccinated with the required shots of vaccine (2 doses and one booster) compared to opulent areas, i.e., 20%. Conclusion: Our research at the population level adds to the knowledge we now have from patient data and demonstrates how aggregated data from fully functioning epidemic surveillance and monitoring may provide information about the possible effects of extended COVID on national and international public health.

A balanced treatment of perceived organizational politics: A review of the positive influences

&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The purpose of this paper is to review literature in the area of perceived organizational politics (POPs) and to present a model that explains the positive role of the phenomenon in the work place. This involves understanding how POPs has evolved from playing a much-publicized destructive role to an emerging constructive one. &lt;strong&gt;Design/methodology/approach:&lt;/strong&gt; An integrative review method was used to review articles on POPs published over the last 13 years (2010–2022). The primary sources of information were several databases, such as ISI Web of Science, Google Scholar, and Scopus. Specific search terms were considered to find relevant articles, leading to 7803 articles (3894 hits on Scopus, 1723 hits on Google Scholar and 2186 hits on Web of Science). These studies were further examined for their relevance to this study, and 103 articles were identified. The application of an exclusion criteria funneled them to 66 studies. The articles, employing quantitative, mixed, and qualitative approaches were coded. The themes were subsequently determined. &lt;strong&gt;Findings:&lt;/strong&gt; The review notes that the POPs literature emphasis is shifting from a negative and dysfunctional approach to one where positive organizational outcomes are possible. The review concludes that POPs has functional consequences too. The phenomenon could illuminate favorable workplace outcomes if viewed as an enhancer rather than a hindrance. POPs should be viewed as a phenomenon that for all purposes is essentially neutral. It is individuals who label the otherwise neutral construct as negative (negative POPs) or as positive (positive POPs). &lt;strong&gt;Practical implications:&lt;/strong&gt; The paper reveals how antecedents help organizational members label politics as positive. Perceived organizational politics is largely a neutral construct until the perceiver decides to label it otherwise. Positive perception of politics is significant in predicting important employee outcomes such as motivation, employee satisfaction, and job performance. Management needs to invest in antecedents and moderators, needed to help employees label the construct as positive rather than negative. &lt;strong&gt;Originality/value&lt;/strong&gt;: The study is an original review of the positive POPs literature to identify the significant antecedents, moderators, and work outcomes, vital to organizational success.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;

Mobile health (m-health) smartphone interventions for adolescents and adults with overweight or obesity.

Mobile health (m-health) smartphone interventions for adolescents and adults with overweight or obesity.

Policy implementation and outcome evaluation: establishing a framework and expanding capacity for advocacy organizations to assess the impact of their work in public policy

Advocacy organizations can play a crucial role in evaluating whether legislation or regulation has had its intended effect by supporting robust public policy implementation and outcome evaluation. The American Heart Association, working with expert advisors, has developed a framework for effective evaluation that can be used by advocacy organizations, in partnership with researchers, public health agencies, funders, and policy makers to assess the health and equity impact of legislation and regulation over time. Advocacy organizations can use parts of this framework to evaluate the impact of policies relevant to their own advocacy and public policy efforts and inform policy development and guide their organizational resource allocation. Ultimately, working in partnership, advocacy organizations can help bring capacity, commitment and funding to this important implementation and outcome evaluation work that informs impactful public policy for equitable population health and well-being.

A New Scale for Rating Oral Health-Related Quality of Life in Denture Wearers.

When carrying out prosthetic rehabilitation of edentulous and partially edentulous patients, great attention is paid to the personal attitude of the patients, their satisfaction with oral health and psychosocial interaction due to tooth loss, as well as the treatment of the resulting disorders. This attention has led to the development of various instruments for examining the quality of life related to oral health. The aim of this study was to develop and validate a reliable instrument in the Serbian language suitable for measuring oral health-related quality of life in patients who have been rehabilitated with complete or partial dentures. Мaterials and Methods: The study was unicentric and cross-sectional, and assessed the reliability and validity of a newly developed instrument for measuring the oral health-related quality of life in denture wearers (OHRQoL-DW). It was conducted on a sample of 200 adults from Serbia, wearers of various types of dentures, with a mean age 66.9 ± 10.3 years and male/female ratio of 86/114 (43%/57%). The definitive version of the OHRQoL-DW scale with 28 items showed very good reliability, with Cronbach's alpha = 0.938. Good temporal stability of the questionnaire was demonstrated, and satisfactory results were obtained for divergent and convergent validity tests. Exploratory factorial analysis revealed four domains of oral health-related quality of life in denture wearers: physical, psychosocial, environmental and aesthetic. The OHRQoL-DW scale is a reliable and valid generic instrument for measuring the oral health-related quality of life in patients wearing dentures, which is one of the most important outcomes of oral health in prosthetic treatment.

Relation among hypertriglyceridaemia, cardiometabolic disease, and hereditary factors-design and rationale of the Stockholm hyperTRIglyceridaemia REGister study.

Hypertriglyceridaemia (hTG) is associated with atherosclerotic cardiovascular disease, pancreatitis, and non-alcoholic fatty liver disease (NAFLD) in large population-based studies. The understanding of the impact of hereditary hTG and cardiometabolic disease status on the development of hTG and its associated cardiometabolic outcomes is more limited. We aimed to establish a multigenerational cohort to enable studies of the relationship between hTG, cardiometabolic disease and hereditary factors. The population-based observational Stockholm hyperTRIglyceridaemia REGister (STRIREG) study includes 1 460 184 index individuals who have measured plasma triglycerides in the clinical routine in Region Stockholm, Sweden, between 1 January 2000 and 31 December 2021. The laboratory measurements also included basic haematology, blood lipid panel, liver function tests, and HbA1c. Using the Swedish Multi-Generation register, 2 147 635 parents and siblings to the indexes were identified to form the complete study cohort. Laboratory data from participants were combined with data from several national registers that provided information on the cause of death, medical diagnoses, dispensed medicines, and socioeconomic factors including country of birth, education level, and marital status. The multi-generational longitudinal STRIREG cohort provides a unique opportunity to investigate different aspects of hTG as well as heredity for other metabolic diseases. Important outcome measures include mortality, cardiovascular mortality, major cardiovascular events, development of incident diabetes, and NAFLD. The STRIREG study will provide a deeper understanding of the impact of hereditary factors and associated cardiometabolic complications.

Towards a core outcome set for dysarthria after stroke: What should we measure?

To identify and agree on what outcome domains should be measured in research and clinical practice when working with stroke survivors who have dysarthria. Delphi process, two rounds of an online survey followed by two online consensus meetings. UK and Australia. Stroke survivors with experience of dysarthria, speech and language therapists/pathologists working in stroke and communication researchers. Initial list of outcome domains generated from existing literature and with our patient and public involvement group to develop the survey. Participants completed two rounds of this survey to rate importance. Outcomes were identified as 'in', 'unclear' or 'out' from the second survey. All participants were invited to two consensus meetings to discuss these results followed by voting to identify critically important outcome domains for a future Core Outcome Set. All outcomes were voted on in the consensus meetings and included if 70% of meeting participants voted 'yes' for critically important. In total, 148 surveys were fully completed, and 28 participants attended the consensus meetings. A core outcome set for dysarthria after stroke should include four outcome domains: (a) intelligibility of speech, (b) ability to participate in conversations, (c) living well with dysarthria, (d) skills and knowledge of communication partners (where relevant). We describe the consensus of 'what' speech outcomes after stroke are valued by all stakeholders including those with lived experience. We share these findings to encourage the measurement of these domains in clinical practice and research and for future research to identify 'how' best to measure these outcomes.