Researchers have been paying attention to the utilization of nanofluid since they have disclosed their potentiality as a magnificent working fluid in thermal energy systems. Also, metal-oxide nanoparticles are among the most widely used nanomaterials due to their distinct characteristics such as limited size and high density. Holding such interesting characteristics of oxide-nanoparticles in mind, this research considers heat and mass transport attributes of γ-oxide nanoparticles in chemically reacted kerosene based nanofluid over a vertical cone in the presence of heat generation/absorption. An implicit finite difference method is implemented to obtain the numerical solutions of a constructed mathematical model with the aid of MATLAB software. The effects of numerous parameters on the associated distributions are examined, and their results are illustrated graphically. It is culminated that the velocity and temperature of nanofluid are increased in the presence of heat generation. The thermal conductivity of GO/kerosene is 0.633%, 0.443%, 0.126%, and 0.063% greater than CuO/kerosene, Al2O3/kerosene, TiO2/kerosene, and Fe3O4/kerosene, respectively, at 3% Vol. concentration of nanoparticles. To confirm the authenticity of current research, the acquired results are contrasted with the results of earlier published articles under certain conditions, and an outstanding coexistence is attained.