Health Risk Implications Research Articles

The end of convergence in developmental patterns of frequent marijuana use from ages 18 to 30: An analysis of cohort change from 1976–2016

BackgroundThis study examines the extent to which the developmental pattern of frequent marijuana use prevalence from ages 18 to 30 (overall and by gender) has varied across historical time (cohort groups) using data from a national sample of US young adults. MethodsSelf-reported data on frequent marijuana use (use on 20+ occasions in the past 30 days) from modal ages 18 to 30 were obtained from 58,059 individuals from 29 sequential cohorts (graduating high school classes of 1976–2004) participating in the Monitoring the Future study. Time-varying effect modeling was used to model cohort group differences in developmental patterns of frequent use overall and by gender. ResultsDevelopmental patterns of frequent marijuana use prevalence varied meaningfully across cohort groups. Frequent use at age 18 differed significantly across cohort groups as expected based on national data. Among earlier cohort groups (reaching age 30 during 1987–2008), developmental patterns converged by age 30 to relatively low frequent marijuana use prevalence. In contrast, among cohort groups reaching age 30 during 2008–2016, frequent marijuana use at age 30 was significantly higher than all previous cohort groups. Observed cohort differences did not vary significantly by gender. ConclusionsCross-cohort convergence in developmental patterns of frequent marijuana use prevalence by age 30 was not observed among recent cohort groups, among whom age 30 frequent marijuana use prevalence was at the highest levels observed since the study began. Higher frequent marijuana use prevalence in late young adulthood has meaningful health risk and service provision implications.

Variations in polyphenol and heavy metal contents of wild-harvested and cultivated seaweed bulk biomass: Health risk assessment and implication for food applications

Seaweeds are increasingly used in European cuisines due to their nutritional value. Many algal constituents, such as polyphenols, are important antioxidants and thus considered beneficial to humans. However, many seaweed species can accumulate heavy metals and exhibit potential health risks upon ingestion. We investigated temporal and spatial variations in polyphenol and heavy metal (As, Cd, Hg, Pb) concentrations of three edible seaweed species. The brown algae Saccharina latissima and Alaria esculenta, and the red alga Palmaria palmata were sourced from natural populations and aquaculture in the NE Atlantic and processed as bulk biomass mimicking industrial scales. The mean polyphenol content was species-specific (Alaria > Saccharina > Palmaria), and highest in winter (for Alaria and Saccharina) and spring (for Palmaria); inter-annual and spatial variations were marginal. Heavy metal concentrations varied between species and depended on collection site, but seasonal variations were minimal. Our data suggest that all three species are good sources of antioxidants, and the heavy metal concentrations are below the upper limits set by the French recommendation and the EU Commission Regulation on contaminants in foodstuffs. A health risk assessment indicated that consumption of these seaweed species poses a low risk for humans with regard to heavy metals. However, an EU-wide regulation on maximal concentration of heavy metals in seaweeds should be established.

Distribution of Chemical Species in the Water-Soil-Plant (Carya illinoiensis) System near a Mineralization Area in Chihuahua, Mexico-Health Risk Implications.

The aim of this study was to quantify major and trace elements in the water, soil, and plants (Carya illionensis) in an agricultural area; and to determine the health risks associated with the walnuts ingestion by calculating the risk quotient. Samples of water, soil, tree leaves, and walnuts were collected; in total, 135 samples were analyzed. Physicochemical parameters were obtained in irrigation water and soil samples. Elemental measurements were performed in an ICP, -OES and -MS. In addition, the distribution coefficient (soil–water), transfer factor (soil–plant), and hazard quotient were evaluated. In the irrigation water, As, Cr, and Pb, showed concentrations above the maximum allowable limits. Likewise, high concentrations of As, Cr, Pb, and Sb were found in tree leave samples, indicating a possible tendency of hyperaccumulation of those elements. Furthermore, Cr concentrations in walnuts were high by far than the reference value (FAO/WHO). A possible competition between chemical congeners were detected from transfer factors. Although, Sb concentrations in walnuts were also high, and no legislation for it in fruits exists. The hazard risk quotient for Sb did indicate a potential health risk. Finally, it is important to consider that the health risk increases when exposure through consumption takes place over a prolonged period of time, even in low concentrations.

Assessing the reliability of FTIR spectroscopy measurements and validity of bioelectrical impedance analysis as a surrogate measure of body composition among children and adolescents aged 8\u201319\xa0years attending schools in Kampala, Uganda

BackgroundAccurate measurement of body composition in children and adolescents is important as the quantities of fat and fat-free mass have implications for health risk. The objectives of the present study were: to determine the reliability of Fourier Transform Infrared spectroscopy (FTIR) measurements and; compare the Fat Mass (FM), Fat Free Mass (FFM) and body fat percentage (%BF) values determined by bioelectrical impedance analysis (BIA) to those determined by deuterium dilution method (DDM) to identify correlations and agreement between the two methods.MethodsA cross-sectional study was conducted among 203 children and adolescents aged 8–19 years attending schools in Kampala city, Uganda. Pearson product-moment correlation at 5% significance level was considered for assessing correlations. Bland Altman analysis was used to examine the agreement between of FTIR measurements and between estimates by DDM and BIA.. Reliability of measurements was determined by Cronbach’s alpha.ResultsThere was good agreement between the in vivo D2O saliva enrichment measurements at 3 and 4 h among the studied age groups based on Bland-Altman plots. Cronbach’s alpha revealed that measurements of D2O saliva enrichment had very good reliability. For children and young adolescents, DDM and BIA gave similar estimates of FFM, FM, and %BF. Among older adolescents, BIA significantly over-estimated FFM and significantly under-estimated FM and %BF compared to estimates by DDM. The correlation between FFM, FM and %BF estimates by DDM and BIA was high and significant among young and older adolescents and for FFM among children.ConclusionsReliability of the FTIR spectroscopy measurements was very good among the studied population. BIA is suitable for assessing body composition among children (8–9 years) and young adolescents (10–14 years) but not among older adolescents (15–19 years) in Uganda. The body composition measurements of older adolescents determined by DDM can be predicted using those provided by BIA using population-specific regression equations.

Geologic and anthropogenic sources of contamination in settled dust of a historic mining port city in northern Chile: health risk implications.

Chile is the leading producer of copper worldwide and its richest mineral deposits are found in the Antofagasta Region of northern Chile. Mining activities have significantly increased income and employment in the region; however, there has been little assessment of the resulting environmental impacts to residents. The port of Antofagasta, located 1,430 km north of Santiago, the capital of Chile, functioned as mineral stockpile until 1998 and has served as a copper concentrate stockpile since 2014. Samples were collected in 2014 and 2016 that show elevated concentrations of As, Cu, Pb, and Zn in street dust and in residents’ blood (Pb) and urine (As) samples. To interpret and analyze the spatial variability and likely sources of contamination, existent data of basement rocks and soil geochemistry in the city as well as public-domain airborne dust were studied. Additionally, a bioaccessibility assay of airborne dust was conducted and the chemical daily intake and hazard index were calculated to provide a preliminary health risk assessment in the vicinity of the port. The main conclusions indicate that the concentrations of Ba, Co, Cr, Mn, Ni, and V recorded from Antofagasta dust likely originate from intrusive, volcanic, metamorphic rocks, dikes, or soil within the city. However, the elevated concentrations of As, Cd, Cu, Mo, Pb, and Zn do not originate from these geologic outcrops, and are thus considered anthropogenic contaminants. The average concentrations of As, Cu, and Zn are possibly the highest in recorded street dust worldwide at 239, 10,821, and 11,869 mg kg−1, respectively. Furthermore, the contaminants As, Pb, and Cu exhibit the highest bioaccessibilities and preliminary health risk indices show that As and Cu contribute to elevated health risks in exposed children and adults chronically exposed to dust in Antofagasta, whereas Pb is considered harmful at any concentration. Therefore, an increased environmental awareness and greater protective measures are necessary in Antofagasta and possibly other similar mining port cities in developing countries.

Organochlorines in urban soils from Central India: probabilistic health hazard and risk implications to human population.

This study presents distribution of organochlorines (OCs) including HCH, DDT and PCBs in urban soils, and their environmental and human health risk. Forty-eight soil samples were extracted using ultrasonication, cleaned with modified silica gel chromatography and analyzed by GC-ECD. The observed concentrations of ∑HCH, ∑DDT and ∑PCBs in soils ranged between < 0.01-2.54, 1.30-27.41 and < 0.01-62.8µgkg-1, respectively, which were lower than the recommended soil quality guidelines. Human health risk was estimated following recommended guidelines. Lifetime average daily dose (LADD), non-cancer risk or hazard quotient (HQ) and incremental lifetime cancer risk (ILCR) for humans due to individual and total OCs were estimated and presented. Estimated LADD were lower than acceptable daily intake and reference dose. Human health risk estimates were lower than safe limit of non-cancer risk (HQ < 1.0) and the acceptable distribution range of ILCR (10-6-10-4). Therefore, this study concluded that present levels of OCs (HCH, DDT and PCBs) in studied soils were low, and subsequently posed low health risk to human population in the study area.

High-resolution sampling and analysis of ambient particulate matter in the Pearl River Delta region of southern China: source apportionment and health risk implications

Abstract. Hazardous air pollutants, such as trace elements in particulate matter (PM), are known or highly suspected to cause detrimental effects on human health. To understand the sources and associated risks of PM to human health, hourly time-integrated major trace elements in size-segregated coarse (PM2.5–10) and fine (PM2.5) particulate matter were collected at the industrial city of Foshan in the Pearl River Delta region, China. Receptor modeling of the data set by positive matrix factorization (PMF) was used to identify six sources contributing to PM2.5 and PM10 concentrations at the site. Dominant sources included industrial coal combustion, secondary inorganic aerosol, motor vehicles and construction dust along with two intermittent sources (biomass combustion and marine aerosol). The biomass combustion source was found to be a significant contributor to peak PM2.5 episodes along with motor vehicles and industrial coal combustion. Conditional probability function (CPF) analysis was applied to estimate the source locations using the PMF-resolved source contribution coupled with the surface wind direction data. Health exposure risk of hazardous trace elements (Pb, As, Si, Cr, Mn and Ni) and source-specific values were estimated. The total hazard quotient (HQ) of PM2.5 was 2.09, higher than the acceptable limit (HQ = 1). The total carcinogenic risk (CR) was 3.37 × 10−3 for PM2.5, which was 3 times higher than the least stringent limit (1.0 × 10−4). Among the selected trace elements, As and Pb posed the highest non-carcinogenic and carcinogenic risks to human health, respectively. In addition, our results show that the industrial coal combustion source is the dominant non-carcinogenic and carcinogenic risk contributor, highlighting the need for stringent control of this source. This study provides new insight for policy makers to prioritize sources in air quality management and health risk reduction.

Elemental Concentrations in Roadside Dust Along Two National Highways in Northern Vietnam and the Health-Risk Implication.

There is a need to assess the risk of exposure to metals via roadside dust in Vietnam where many people live along the road/highways and are constantly exposed to roadside dust. In this study, we collected dust samples at 55 locations along two major Highways in north-east Vietnam, which passed through different land use areas. Samples were sieved into three different particle sizes and analyzed for concentrations of eight metals using a X-ray fluorescence instrument. The concentrations and environmental indices (EF, I geo) of metals were used to evaluate the degree of pollution in the samples. Among different land uses, industrial areas could be highly polluted with heavy metals in roadside dust, followed by commerce and power plants. Additionally, the traffic density probably played an important role; higher concentrations were observed in samples from Highway No. 5 where traffic is several times higher than Highway No. 18. According to the risk assessment, Cr poses the highest noncarcinogenic risk even though the health hazard index values of assessed heavy metals in this study were within the acceptable range. Our assessment also found that the risk of exposure to heavy metals through roadside dust is much higher for children than for adults.

Obesity and the burden of health risks among the elderly in Ghana: A population study.

BackgroundThe causes and health risks associated with obesity in young people have been extensively documented, but elderly obesity is less well understood, especially in sub-Saharan Africa. This study examines the relationship between obesity and the risk of chronic diseases, cognitive impairment, and functional disability among the elderly in Ghana. It highlights the social and cultural dimensions of elderly obesity and discusses the implications of related health risks using a socio-ecological model.MethodologyWe used data from wave 1 of the Ghana Study on Global Ageing and Adult Health (SAGE) survey-2007/8, with a restricted sample of 2,091 for those 65 years and older. Using random effects multinomial, ordered, and binary logit models, we examined the relationship between obesity and the risk of stage 1 and stage 2 hypertension, arthritis, difficulties with recall and learning new tasks, and deficiencies with activities of daily living and instrumental activities of daily living.FindingsElderly Ghanaians who were overweight and obese had a higher risk of stage 1 and stage 2 hypertension, and were more likely to be diagnosed with arthritis and report severe deficiencies with instrumental activities of daily living. Those who were underweight were 1.71 times more likely to report severe difficulties with activities of daily living. A sub analysis using waist circumference as a measure of body fat showed elderly females with abdominal adiposity were relatively more likely to have stage 2 hypertension.ConclusionsThese findings call for urgent policy initiatives geared towards reducing obesity among working adults given the potentially detrimental consequences in late adulthood. Future research should explore the gendered pathways leading to health disadvantages among Ghanaian women in late adulthood.

Evidence on the Validity of a Comprehensive Health Risk Index and Implications for Ambulatory Care and Population Health Management.

A novel, comprehensive health risk index for adults has been validated and is now ready for use to improve the health of individuals and populations. This health risk index provides an estimate of the avoidable risk of death for adults 30 years or older. It includes 12 evidence-based clinical and behavioral risk factors and was validated on discrimination and calibration using the NHANES (National Health and Nutrition Examination Survey) and Framingham Heart Study cohorts. The results from both cohorts were consistent and similar. Discrimination was good, and calibration was acceptable but tended to overpredict mortality risk for females in the higher-risk deciles.

Health Risk Implications of Terrestrial Gamma Radiation Dose Rate in Central Jakarta, Indonesia: Short Communications

Terrestrial gamma radiation dose (TGRD) rate measurement has been conducted around downtown region of Central Jakarta Indonesia. The real time count data was taken 1 m above the ground in eight sub district locations by using a portable gamma Surveymeter of Exploranium GR-135 Plus Model. The reading position was detemined using Garmin GPSMAP 62s. The average value of TGRD rate of (47.76 ± 18.24) nSv h-1 ranged from 6.40 nSv h-1 to 120.90 nSv-1, it is higher than Indonesia. The annual effective dose rate of 0.058 mSv. Its contributes to fatal cancer risk of about 3.22 x 10-5 per year for each individual in Central Jakarta. For the subdistrict TGRD rate value was variated, however all the result is not high enough to cause for alarm.

A Market Basket Survey of Horticultural Fruits for Arsenic and Trace Metal Contamination in Southeast Nigeria and Potential Health Risk Implications

A Market Basket Survey of Horticultural Fruits for Arsenic and Trace Metal Contamination in Southeast Nigeria and Potential Health Risk Implications

A Market Basket Survey of Horticultural Fruits for Arsenic and Trace Metal Contamination in Southeast Nigeria and Potential Health Risk Implications.

Background.Elevated arsenic and trace metal contamination of the terrestrial food chain represents one of the most significant environmental risk exposures for human populations in developing countries. Metalloid and metal contamination in horticultural crop produce such as fruit is a public health concern in Nigeria. Local fruits are cheap sources of vitamins and minerals for the resident population and pose an important dietary threat of metal(loid) toxicity through consumption.Objectives.Market basket investigation of five locally grown (guava, pineapple, orange, and pawpaw) and imported (apple) fruits was conducted to measure the total concentrations of arsenic (As), mercury (Hg), copper (Cu), and lead (Pb) present in these fruits from southeastern Nigeria (Awka, Anambra).Methods.Fruits were analyzed for As and the three metals using atomic absorption spectrophotometry. Moisture content of fruits was determined and used to transform metal concentrations in dry weight to wet weight and compared to Codex food grade standards and assorted (sub)tropical fruits, edible and inedible peels.Results.The mean ± standard deviation of elemental concentrations in dry weight ranged from 20.0±0.71–96.84±0.00 μg g−1 for As, 0.02±0.02 – 0.89±0.33 μg g−1 for Hg, 0.11±0.01 - 0.18±0.40 μg g−1 for Cu, and <0.001 – 0.03±0.05 μg g−1 for Pb. The As concentrations (wet weight) in fruits were ~32–166 orders of magnitude higher than Codex Alimentarius Commission (Codex) maximum As food grade levels. Guava and apple methyl Hg concentrations were ~6–~1 orders of magnitude higher than Codex maximum levels, while the content of Cu and Pb in fruits were within acceptable standard limits.Conclusions.The significant concentrations of As and Hg in the examined fruits indicate a potential public health threat. Efforts are needed to initiate and sustain continued monitoring of trace elements in fruits and food sold to consumers due to variation in contaminating sources to ensure food safety. Although a great deal of information exists on Hg toxicity, research on metalloids such as As remains limited in Nigeria and no reliable guidelines exist. Further research is recommended to determine the ecotoxicity of As in Nigeria.

Abstract 4252: New molecular evidence associating exposure to aristolochic acid with urothelial cancers in South Korean patients: Implications for global public health risk linked to carcinogenic herbal medicines

Abstract Aristolochic acid (AA) is a potent nephrotoxin and carcinogen (IARC Group 1) associated with urothelial, hepatobiliary, and renal carcinomas. Exposure to AA from dietary intake of traditional herbal medicines containing Aristolochia species poses a global health hazard, yet also an opportunity for disease prevention. Molecular epidemiology studies employing sensitive and specific biomarkers for screening of populations at risk are thus warranted. Genome-scale studies established a characteristic mutational signature of AA. Exploiting its unique features (predominant A&amp;gt;T transversions), alongside the knowledge of key affected cancer genes, we devised a cost-effective targeted resequencing (TRseq) method to detect AA etiology in upper tract urothelial carcinoma (UTUC) samples from South Korean patients. Aristolochia species (e.g., A. contorta, Bunge) are included in the Korean traditional pharmacopoeia although the local occurrence of AA-associated cancers remains unexplored. DNA from archived, paired kidney and UTUC samples of 16 Korean patients was used for adduct and TRseq analyses. Thirty-one cancer genes, previously found recurrently mutated in AA-induced UTUCs from Asia and Europe, were selectively captured using SeqCap EZ enrichment kit (Nimblegen Roche) and sequenced using Illumina MiSeq. Sets of UTUCs from Croatia (harboring AA signature) and from US patients (unlikely to be exposed) were included as respective positive and negative controls. Somatic variants were called against the patient-matched non-tumor DNA, using two distinct variant calling strategies. Three out of 16 kidney cortex samples tested positive for aristolactam-dA (AL-dA) adducts, indicative of past exposure to AA. One UTUC sample with A&amp;gt;T-mutated TP53 harbored 32 A&amp;gt;T mutations across the 31-gene panel, and another 8 cases, 3 of which were adduct-positive, harbored lower counts of A&amp;gt;T mutations (up to 3 per gene panel per sample). The allelic frequencies of the considered A&amp;gt;T mutations ranged between 10-83%. The positive control samples exhibited a strong A&amp;gt;T signal while the US samples were all A&amp;gt;T-negative, as expected. We propose that the TRseq approach can detect AA-driven mutagenesis in UTUC tumors, providing a sensitive complement to the AL-dA adduct analysis, at low per-sample cost. Importantly, the presence of adducts and AA signature mutations in South Korean UTUC cases highlights a previously uncharacterized population at risk. The future use of TRseq, either alone or in combination with adduct analysis, can address exposure to AA in extended UTUC case series, thereby assisting in the design of preventive measures against this global public health hazard. Funding: IARC; SW is Recipient of research support from the Drs. Martin &amp; Dorothy Spatz Charitable Foundation; Henry and Marsha Laufer grant to KGD, VSS, APG. Citation Format: Shuhan Wang, Daeeun Choi, Jaesung Lim, Kathleen G. Dickman, Magali Olivier, Stephanie Villar, Viktoriya S. Sidorenko, Maude Ardin, Byeong H. Yun, Robert J. Turesky, Minho Shong, Jiri Zavadil, Arthur P. Grollman. New molecular evidence associating exposure to aristolochic acid with urothelial cancers in South Korean patients: Implications for global public health risk linked to carcinogenic herbal medicines [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4252. doi:10.1158/1538-7445.AM2017-4252

Assessing the impact of adjusting for maturity in weight status classification in a cross-sectional sample of UK children

ObjectivesTo compare the weight categorisation of a cohort of UK children using standard procedures (ie, comparing body mass index (BMI) centiles to age-matched UK reference data) versus an approach adjusted...

Occurrence, distribution and sources of bisphenol analogues in a shallow Chinese freshwater lake (Taihu Lake): Implications for ecological and human health risk

Since the production and use of BPA were regulated in China around 2008, several bisphenol analogues were widely used to substitute BPA in the manufacture of polycarbonates, epoxy resins, and plastics. However, there is limited understanding of the spatial distribution, potential sources and risk assessment for those bisphenol analogues. In this study, seven bisphenol analogues were investigated in water and sediment samples from Taihu Lake, China. Compared to the same lake in 2013 (range: 5.4–87ng/L for waters and 0.37–8.3ng/g dw for sediments), the samples from Taihu Lake contained comparatively higher BPs (2.0×102–9.5×102ng/L and 23–4.3×102ng/gdw) in 2016, indicating that the BPs levels in Taihu Lake have aggravated recently. In waters, BPAF has become the predominant congener in Taihu Lake, suggesting that BPAF was the most widely used substitute of BPA, recently. In sediments, BPA was the most abundant compound. Moderate or strong correlations between some individual BPs indicated that those BPs may have the common sources and/or similar environmental behavior. The strongly positive correlation between ∑BPs and TOC content indicated that TOC content was one of the major factors controlled the distribution of ∑BPs in the sediment. The risk assessment at the sampling sites showed no high eco-toxicity or estrogenic risk in Taihu Lake.

Ebola on Instagram and Twitter: How health organizations address the health crisis in their social media engagement

Although social media have been used by public relations practitioners as a key vehicle for crisis communication, little is known about how these platforms were utilized by public health organizations in infectious disease outbreak situations and how this may have shaped the publics’ responses to the outbreak on and off social media. Taking the approach of strategic health risk communication, this study examined Ebola-related social media posts by three major health organizations, Centers for Disease Control and Prevention (CDC), World Health Organization (WHO), Médecins Sans Frontières (MSF, also known as Doctors without Borders), on Twitter and Instagram, focusing on the types of communication that were used during the outbreak, the content and context of these communications, and the responses they elicited from the publics. While both platforms were utilized by all three health organizations, the results suggest that Instagram may be a particularly useful platform for establishing meaningful, interactive communication with the publics in times of global health crises, as evidenced by significantly greater levels of engagement on the part of health organizations and the publics. Furthermore, our findings indicate that social media messaging may be most effective when it is used by health organizations that are familiar with and to the publics, and when it is based on the strategic use of risk communication principles such as solution-based messaging, incorporation of visual imagery, and acknowledgement of public fears and concerns. We discuss the results in the context of strategic health risk communication guidelines and implications for public relations practice.

Molecular detection of tick-borne pathogens Borrelia afzelii, Borrelia miyamotoi and Anaplasma phagocytophilum in Eurasian red squirrels (Sciurus vulgaris)

Eurasian red squirrels (Sciurus vulgaris) are common hosts of ixodid ticks and could thus carry tick-borne disease agents. The relative contribution of the red squirrel, a medium-sized rodent species, to the transmission dynamics of tick-borne pathogens in Europe yet remains unclear. We analysed spleen and liver samples from 45 dead squirrels collected in Flanders, Belgium, during tick activity season and detected the presence of Borrelia burgdorferi s.l. in the spleen of two squirrels (4.4%). One of the sequences could be identified as Borrelia afzelii. Borrelia miyamotoi was detected in the spleen of three squirrels (6.7%) and Anaplasma phagocytophilum in four spleen samples (8.9%). Both A. phagocytophilum ecotype I and II were found. We could not detect the presence of “Candidatus Neoehrlichia mikurensis” or tick-borne encephalitis virus in any of the squirrels. Our results suggest that Eurasian red squirrels can host B. afzelii, as already proposed by previous studies, but we could not confirm the previous established association between squirrels and B. burgdorferi sensu stricto. Our results demonstrate the epidemiological importance of the red squirrel, particularly in (sub)urban areas, since they can harbour a similar community of tick-borne pathogens as do mice and voles and can act as hosts for A. phagocytophilum ecotype I, which has important implications for human health risk.

Significance of Cooking Oil to Bioaccessibility of Dichlorodiphenyltrichloroethanes (DDTs) and Polybrominated Diphenyl Ethers (PBDEs) in Raw and Cooked Fish: Implications for Human Health Risk

The present study examined the bioacessibility of DDTs and PBDEs in cooked fish (yellow grouper; Epinephelus awoara) with and without heating using the colon extended physiologically based extraction test. The bioaccessibility of DDTs and PBDEs increased from 60 and 26% in raw fish to 83 and 63%, respectively, after the addition of oil to raw fish. However, they decreased from 83 to 66% and from 63 to 40%, respectively, when oil-added fish were cooked. Human health risk assessment based on bioaccessible concentrations of DDTs and PBDEs in fish showed that the maximum allowable daily fish consumption rates decreased from 25, 59, and 86 g day-1 to 22, 53, and 77 g day-1 for children, youths, and adults, respectively, after fish were cooked with oil. These findings indicated that the significance of cooking oil to the bioaccessibility of DDTs and PBDEs in food should be considered in assessments of human health risk.

Cadmium in edible plants from Silesia, Poland, and its implications for health risk in populations

The health risk associated with cadmium exposure through consumption of edible plants cultivated in different parts of the Silesia administration area inhabitants has been estimated. The impact of the arable soils acidity on the BCF (bioconcentration factor) has been also analyzed. The concentration of cadmium in arable soils and in 118 samples of vegetables - carrots, beets, potato, celery (tuber), parsley (root) were determined. The cadmium content in examined soil samples were in the range from >0.5–68.5mgkg−1 d.w. The most contaminated samples, above the maximum permissible concentration, originated from the central part of the region. The highest BCF value in case of parsley roots and carrots has been shown (0.941 and 0.828 respectively). Significant correlation between soil pH and BCF in examined edible plants has been demonstrated. In the exposure scenario, which assumes the consumption of the most contaminated vegetables from Silesia administration area, the value of the hazard quotient (HQ) for Cd was 2.56. On the contaminated arable soils from the central part of Silesia administration area the non-edible plants should be cultivated. In case of acidic and slightly acidic pH-range of arable soils, some methods of metals immobilization in soil are recommended e.g. liming.