In this work, a novel Hermite-type mesh-free model for incompressible viscous fluid flows is proposed, as a way, to overcome the numerical difficulties experienced by solving under weak or strong formulation the pure stream-function Navier–Stokes equation. In this model a dimensionless virtual domain is utilized, in order to make an accurate dimensionless shape-functions of the recently developed Hermite-type collocation Weighted Least Square approximation, by using dimensionless scale parameters. Then, a Jacobian transformation matrix is built to express the shape-functions spatial derivatives from the virtual to the considered domain. The resolution of the obtained nonlinear algebraic system is performed by the High Order Continuation Method. Numerical tests were investigated on incompressible viscous isothermal fluid flows in lid-driven cavity, backward-facing step, sudden expansions and around various obstacle shapes. They show the advantages of the proposed model compared to the reference Hermite-type collocation models used for pure stream-function equation and the weak Galerkin procedures as Finite Element Method and Element Free Galerkin method, in term of computation accuracy, number of degree of freedom, implementation simplicity and computation time. The numerical and experimental results of literature confirm the validity and capability of the proposed dimensionless model to simulate fluid flows in a expended-lengths inflow–outflow geometry and around obstacles of circular, inclined elliptical and Joukowski airfoil shapes.