In the realm of high-performance motor drive systems, achieving stable and optimal motor operation is crucial, particularly in environments characterized by disturbances. The implementation of model predictive control (MPC) represents a strategic methodology. However, conventional predictive controllers frequently encounter challenges due to uncertainties regarding the motor's internal parameters and external load characteristics, subsequently impacting the effectiveness of the control algorithm. This paper proposes a new robust predictive control combined with an artificial neural network (RMPC-ANN) approach applied to a permanent magnet synchronous motor (PMSM) to tackle challenges posed by external perturbations and parameter variations. The development of the proposed robust predictive controller involves optimizing a novel finite horizon cost function based on Taylor series expansion, which incorporates dual integral action into the control law. Crucially, this approach eliminates the necessity for measuring and observing external perturbations and parameter uncertainties. Additionally, for attaining high-precision speed control, the speed loop regulation relies on a multi-layer feedforward ANN algorithm. A comprehensive comparison was conducted using MATLAB/SIMULINK, assessing performance across diverse operating conditions. To further substantiate the numerical simulation results, a hardware-in-the-loop (HIL) configuration is implemented on the OPAL-RT platform, demonstrating the robustness and efficiency of the proposed control strategy.