Implantation Profiles Research Articles

Unveiling the safety landscape: A comprehensive review of the toxicological profile of facial aesthetic implants and biomaterials

Exploring diverse biomaterials and implants in the ear, nose, and throat by understanding adverse effects and post-usage events. Literature was obtained from Scopus, PubMed, Google Scholar, and Web of Science. A comprehensive analysis was conducted on original research studies, case reports, and case series spanning from December 2010 to May 2022. Our analysis underscores that the effectiveness of cochlear implants (CIs) relies on factors such as biocompatibility, anti-inflammatory measures, and fibrosis reduction. Although silicone is employed in otologic applications, allergic reactions leading to CI extrusion are rare. In the context of partial ossicular replacement prostheses or total ossicular replacement prostheses, polyethylene grafts (Teflon) are utilized, and Nitinol-pistons are employed in stapedotomy, with adverse consequences encompassing graft extrusion and residual perforation. Chronic sphenoid sinusitis is linked to the use of Medpor porous polyethylene implants in sellar reconstruction during skull-based surgeries. Injectable collagen preparations in vocal cord paralysis lead to submucosal deposits and resultant dysphonia. Montgomery T-tubes are employed for subglottic stenosis but are associated with granulation tissue formation. Metallic tracheostomy tubes give rise to secondary foreign bodies, and double-lumen tracheostomy tubes are prone to biofilm formation. Despite numerous research studies, there remains a necessity for the refinement of implant designs to mitigate complications and enhance the overall quality of life for patients.

Towards in vitro – In vivo correlation models for in situ forming drug implants

In vitro-In vivo correlation (IVIVC) is a main focus of the pharmaceutical industry, academia and the regulatory sectors, as this is an effective modelling tool to predict drug product in vivo performance based on in vitro release data and serve as a surrogate for bioequivalence studies, significantly reducing the need for clinical studies. Till now, IVIVCs have not been successfully developed for in situ forming implants due to the significantly different in vitro and in vivo drug release profiles that are typically achieved for these dosage forms. This is not unexpected considering the unique complexity of the drug release mechanisms of these products. Using risperidone in situ forming implants as a model, the current work focuses on: 1) identification of critical attributes of in vitro release testing methods that may contribute to differences in in vitro and in vivo drug release from in situ forming implants; and 2) optimization of the in vitro release method, with the aim of developing Level A IVIVCs for risperidone implants. Dissolution methods based on a novel Teflon shape controlling adapter along with a water non-dissolvable glass fiber membrane (GF/F) instead of a water dissolvable PVA film (named as GF/F-Teflon adapter and PVA-Teflon adapter, respectively), and an in-house fabricated Glass slide adapter were used to investigate the impact of: the surface-to-volume ratio, water uptake ratio, phase separation rate (measured by NMP release in 24 h post injection in vitro or in vivo), and mechanical pressure on the drug release patterns. The surface-to-volume ratio and water uptake were shown to be more critical in vitro release testing method attributes compared to the phase separation rate and mechanical pressure. The Glass slide adapter-based dissolution method, which allowed for the formation of depots with bio-mimicking surface-to-volume ratios and sufficient water uptake, has the ability to generate bio-relevant degradation profiles as well as in vitro release profiles for risperidone implants. For the first time, a Level A IVIVC (rabbit model) has been successfully developed for in situ forming implants. Release data for implant formulations with slightly different PLGA molecular weights (MWs) were used to develop the IVIVC. The predictability of the model passed external validation using the reference listed drug (RLD), Perseris®. IVIVC could not be developed when formulations with different PLGA molar ratios of lactic acid to glycolic acid (L/G) were included. The present work provides a comprehensive understanding of the impact of the testing method attributes on drug release from in situ forming implants, which is a valuable practice for level A IVIVC development.

Optimisation of Negative Fixed Charge Based Edge Termination for Vertical GaN Schottky Devices.

This study focuses on the impact of negative fixed charge, achieved through fluorine (F) implantation, on breakdown voltage (BV) enhancement in vertical GaN Schottky diodes. Several device and implant-related parameters are examined using Synopsys Sentaurus TCAD simulations in order to determine the optimum fixed negative charge concentration required to achieve the highest BV. The simulated structure consisted of a Schottky diode with a box consisting of negative fixed charges to achieve the edge termination of the Schottky device. An empirical equation is proposed to determine the optimum fixed charge concentration for the highest BV based on depth. The simulation also considered implantation profiles derived from SIMS data from an actual device implanted with multi-energy and multi-dose F. It is demonstrated that the BV has a similar dependence on the key parameters like in the box profile. In summary, this work provides valuable insights into optimizing edge termination techniques using negative fixed charge for improved BV in vertical GaN power devices.

Effects of ion implantation with arsenic and boron in germanium-tin layers

Ion implantation is widely used in the complementary metal–oxide–semiconductor process, which stimulates to study its role for doping control in rapidly emerging group IV Ge1−xSnx materials. We tested the impact of As and B implantation and of subsequent rapid thermal annealing (RTA) on the damage formation and healing of the Ge1−xSnx lattice. Ion implantation was done at 30, 40, and 150 keV and with various doses. The implantation profiles were confirmed using secondary ion mass spectrometry. X-ray diffraction in combination with Raman and photoluminescence spectroscopies indicated notable crystal damage with the increase of the implantation dose and energy. Significant damage recovery was confirmed after RTA treatment at 300 °C and to a larger extent at 400 °C for a Ge1−xSnx sample with Sn content less than 11%. A GeSn NP diode was fabricated after ion implantation. The device showed rectifying current-voltage characteristics with maximum responsivity and detectivity of 1.29 × 10−3 A/W and 3.0 × 106 cm (Hz)1/2/W at 77 K, respectively.

Aesthetic Potential and Safety Profile with Nanotextured Breast Implants With 1,000 Cases of Breast Augmentation as Evaluation of Single-Center Experience.

Nanotextured implants, an innovation in implant technology, are designed to enhance tissue interaction, reduce inflammation, and mitigate complications compared to traditional implants. The aim of the study was to evaluate the aesthetic potential and safety profile of nanotextured breast implants in breast augmentation from a single-surgeon experience. This prospective cohort study included 1,000 patients who underwent breast augmentation with nanotextured implants. Aesthetic outcomes were assessed using direct measurements and BCCT.core software, focusing on breast projection, symmetry, and upper pole fullness. Patient satisfaction was measured through BREAST-Q and overall satisfaction surveys. Safety profiles were evaluated based on the incidence of complications such as infection, hematoma, capsular contracture, and implant rupture. Statistical analyses were conducted to assess the outcomes. The study found significant improvements in aesthetic outcomes, with 92.8% of cases achieving substantial aesthetic enhancements. Patient satisfaction was high, with 96.4% reporting enhanced self-esteem and contentment. The safety profile was favorable, with a low incidence of complications (0.7% requiring revision surgery) and no major complications reported. Long-term follow-up data indicated sustained aesthetic outcomes and a stable safety profile. Insights into the synergistic relationship between nanotextured implants are defined by a significantly wider range of aesthetic options. The findings of this study underscore the positive impact of nanotextured breast implants on enhancing the aesthetic potential of breast augmentation. and contributing to a low incidence of complications.

Assessment of Effectiveness and Side Effects of Subdermal Implant among User Women

Abstract Background: Implanon is a progestin-only implantable contraceptive; it offers promise, long-term, with a high-efficacy contraceptive. It is one of the most effective reversible contraceptives and is of the same effectiveness to sterilization. Objective: To assess the adverse effect profile and effectiveness of subdermal implants. Materials and Methods: A prospective study involved 48 women attending for insertion of the subdermal implant on days 2–5 of their cycle. The implant was inserted subdermally under the effect of local xylocaine of the nondominant arm. Results: The commonest side effect was weight gain constituted 62.5%. At the same time, amenorrhea was reported in 31.3%. Pain at the site of insertion constitutes 14.6%. While bleeding occurred in one case, which responded to local pressure. The commonest cause of discontinuation was weight gain constituted 12.5%. Followed by disturbances in the menstrual cycle. Discontinuation rate 41.7% (20 out of 48 cases). Conclusion: Implanon is an effective long-term contraception with few adverse effects.

Comparison of Mg-based liquid metal ion sources for scalable focused-ion-implantation doping of GaN

We compare the suitability of various magnesium-based liquid metal alloy ion sources (LMAISs) for scalable focused-ion-beam (FIB) implantation doping of GaN. We consider GaMg, MgSO4●7H2O, MgZn, AlMg, and AuMgSi alloys. Although issues of oxidation (GaMg), decomposition (MgSO4●7H2O), and excessive vapor pressure (MgZn and AlMg) were encountered, the AuMgSi alloy LMAIS operating in a Wien-filtered FIB column emits all Mg isotopes in singly and doubly charged ionization states. We discuss the operating conditions to achieve <20 nm spot size Mg FIB implantation and present Mg depth profile data from time-of-flight secondary ion mass spectrometry. We also provide insight into implantation damage and recovery based on cathodoluminescence spectroscopy before and after rapid thermal processing. Prospects for incorporating the Mg LMAIS into high-power electronic device fabrication are also discussed.

Affordable and reliable three-dimensional printing: a prospective study of seven distal radius fractures

Purpose: Three-dimensional (3D) printing is now widely available, and its potential applications to surgery are limitless. However, 3D printing is presently performed at only a few large institutions. We developed a 3D printing workflow using an affordable 3D printer and open-source 3D printing software. We tested whether this combination could produce a model that reliably reflects real bone. Methods: We performed a prospective study with a target sample size of seven. Patients with distal radius fractures were enrolled from October 2021 to February 2022. The 3D-printed models of the fractures were produced using open-source software (3D Slicer [Surgical Planning Laboratory, Harvard Medical School] and Cura [Ultimaker]) and a $600 printer. The anterior-to-posterior (AP) and radial-to-ulnar (RU) widths of the fracture sites were measured on computed tomography (CT) images, in 3D printed models, and in real bones (during surgery). Surgery was simulated using the 3D models; the locations and profiles of implants were compared to those placed during real surgery, which was performed without simulation data.Results: The fracture AP and RU widths did not differ significantly among the CT, 3D model, and real bone measurements. Interclass correlation coefficients indicated that the measurements were reliable (0.943 [p<0.001] and 0.917 [p<0.001], respectively). When the implant profiles of the simulations and surgical procedures were compared, only the most distal (radial) screws were significantly longer in the simulations (p=0.016). The plate location also differed significantly (p=0.043). Conclusions: Our 3D printing workflow is affordable yet produces reliable bone models.

Correlated characterization of 20Ne-implanted targets using nuclear reaction analysis, Rutherford backscattering spectrometry, and ion transport modeling

We present the preparation and characterization of a large sample of implanted noble gas targets for use in precision nuclear astrophysics measurements with intense proton beams. Tantalum and titanium backings were prepared using wet-acid etching, outgassed via resistive heating, and implanted with 20Ne+ beams from differing ion sources. These experimental targets were investigated using both nuclear reaction analysis techniques on the 1169-keV resonance in 20Ne(p, γ)21Na and Rutherford backscattering spectrometry analysis with 2-MeV α-particle beams. Results from these analyses reveal small target-to-target variations in stoichiometry, while exhibiting excellent agreement independent of ion-beam analysis method. We also present a self-consistent validation of the nuclear reaction analysis results using ion transport simulations in TRIM-2013 that rely on input parameters from SIMNRA scattering-yield fits to Rutherford backscattering spectra. In addition to a complete description of the implantation profile, this analysis method provides an alternate solution for characterizing a large sample of implanted targets when no suitable resonances are available for nuclear reaction analysis.

Corticosteroid implants for chronic non-infectious uveitis.

Corticosteroid implants for chronic non-infectious uveitis.

Low energy ion-solid interactions: a quantitative experimental verification of binary collision approximation simulations

Ultra-low energy ion implantation has become an attractive method for doping of two-dimensional materials and ultra-thin films. The new dynamic Monte Carlo program IMINTDYN based on the binary collision approximation allows a reliable prediction of low energy implantation profiles and target compositional changes, as well as efficient simulation of high energy light ion scattering. To demonstrate the quality of these predictions and simulations, we present a model case experiment where we implanted W ions into tetrahedral amorphous carbon with low (10 keV) and ultra-low (20 eV) ion energies and analyzed the W implantation profiles with high resolution Rutherford backscattering spectrometry (HR-RBS). This experiment is compared with a complete simulation of all aspects of ion-solid-interactions of the experiment using the new IMINTDYN program. A unique novel simulation option, also relevant for implantation into 2D materials, is the inclusion of the vacancy as target species with dynamic vacancy generation and annihilation. Whereas simulations neglecting vacancy formation cannot reproduce the measured implantation profiles, we find excellent agreement between simulated and measured HR-RBS spectra. We also demonstrate the important role of simultaneous weak collisions in the binary collision approximation at low projectile energies.

O-288 Implantation, ultrastructure and metabolic profiling of embryos from PGT-M and PGT-A Cycles

Abstract Study question Can metabolic profiling predict embryos at risk of single gene defects and chromosomal abnormalities and how are these reflected in their ultrustructure? Summary answer Different metabolic profiles are observed between embryos with chromosomal abnormalities and monogenic disorders and normal embryos, linked to altered mitochondrial and other organelles’ structure/function What is known already Down’s syndrome embryos and Monosomy 21 embryos have previously been shown to have differential expression of metabolites compared to normal embryos, but limited studies, have investigated in detail the metabolic profiling of embryos with other abnormalities or those with monogenic disorders in comparison to chromosomally normal embryos or their reflection in their ultrustructure. Study design, size, duration 520 embryos were biopsied on day5 for PGT-A (n = 178-47 cycles) or on day3 for PGT-A (n = 178-33 cycles) and PGT-M (n = 164-24 cycles). Following transfer of normal embryos, spare embryos, rejected for transfer following day5 or day3 biopsy were processed for TEM (n = 60 day3 biopsied, n = 60 day5 biopsied/vitrified), 60 unbiopsied/vitrified embryos from egg donation cycles used as control. Culture media were collected from the embryos and analysed by hydrophilic interaction liquid chromatography tandem mass spectrometry (HILIC-MS/MS). Participants/materials, setting, methods PGT-A and PGT-M were performed in 2 IVF Units. Metabolic profiling was conducted in a Forensic Toxicology Laboratory by HILIC-MS/MS (100 metabolites). Ultrastructure analysis by TEM was carried out in an Academic Hospital and Histology/Embryology Laboratory following embryo fixation in 3% glutaraldehyde, 1% osmium tetroxide, washes in PBS and staining with 1% aqueous uranyl acetate. Main results and the role of chance The implantation rates (+ve hCG/ET) for the PGT-M cycles was 68.2% and the for the PGT-A (blastocyst and cleavage biopsy cycles) 64.5% and 65% respectively. Characteristic patient specific metabolic profiles after screening for >100 primary metabolites were observed which differed between normal embryos that had resulted in a viable pregnancy and aneuploid and chaotic embryos although it was more difficult to find clear patterns in embryos with monogenic disorders. Logistic regression analysis revealed a number of metabolites with high predictive value which in combination with embryo score could serve in the future as non-invasive markers for the detection of chromosomal abnormalities before embryo transfer. TEM analysis revealed differences in the quality of cells and organelle activity which were reflected in the embryo metabolic profiles. Abnormal but well developed hatching blastocysts had mainly cells with good mitochondrial morphology/ activity, nice Golgi apparatus and well developed rough and smooth endoplasmic reticulum but depending on the aneuploidy or gene mutation involved, inner cell mass cells with limited organelles and occasionally lipofuscin droplets in the trophectoderm were evident. Chaotic poor quality embryos showed a lower number of mitochondria, often with no cisternae, increased number of vacuoles, and frequently problems in junctions between cells. Limitations, reasons for caution Although metabolic profiles were compared between normal and abnormal embryos, all the normal embryos were transferred to the uterus or remain vitrified for clinical purposes. Therefore the ultrastructure analysis is based only on biopsied abnormal embryos and as control unbiopsied embryos from egg-donation cycles with high chance of being normal. Wider implications of the findings This study shows high implantation rates after PGT—M and PGT-A and identified distinct differences in the metabolic profiles of normal and abnormal embryos providing unique metabolites which in the future could serve as non-invasive biomarkers for the detection of abnormalities before embryo transfer. Trial registration number Not applicable

A Positron Implantation Profile Estimation Approach for the PALS Study of Battery Materials

Positron annihilation spectroscopy is a powerful probe to investigate the interfaces in materials relevant for energy storage such as Li-ion batteries. The key to the interpretation of the results is the positron implantation profile, which is a spatial function related to the characteristics of the materials forming the battery. We provide models for the positron implantation profile in a cathode of a Li-ion battery coin cell. These models are the basis for a reliable visualization of multilayer geometries and their interfaces in thin cathodes of lithium-ion batteries.

Spatial control of skyrmion stabilization energy by low-energy Ga+ ion implantation

Magnetic skyrmions are candidates for information carriers in Brownian and stochastic computers. Developing a technique for fabricating a film with a suitable potential landscape, wherein the information carrier may diffuse freely, is essential for these probabilistic computers. In this study, to build the desired local potential into magnetic films, a 1.2 nm-thick Co-Fe-B film with a 5.2 nm-thick cap layer was irradiated by a focused ion beam (FIB) using Ga+ as the ion source under a low acceleration voltage of 5 keV. The fluences ranged from 0 to 25 × 1012 ions/cm2. Consequently, the critical temperature at which skyrmions appear or disappear is shifted by several 1–10 K depending on the ion fluence. The origin of this effect is discussed by observing the ion implantation profile and the surface sputtering depth using time-of-flight secondary ion mass spectrometry (TOF-SIMS) and atomic force microscopy (AFM). The results of TOF-SIMS measurements show that most of the Ga atoms exist in the Co–Fe–B layer. If all Ga atoms exist in the Co–Fe–B layer, the Ga concentration is 7 × 10−3 at. % after irradiation of 0.8 × 1012 ions/cm2. The AFM results show a sputtered pattern with 0.2 nm depth after irradiation of 16 × 1012 ions/cm2. Finally, the effect of irradiation on the diffusion coefficient was examined. It was determined that small fluences of 1.6 × 1012 and 0.8 × 1012 ions/cm2 can construct a potential barrier controlling skyrmions while maintaining diffusion coefficients as high as 10 μm2/s. The FIB process can be used to draw a circuit of probabilistic computers with skyrmions as information carriers.

Influence of implant restorative emergence angle and contour on peri-implant marginal bone loss: A systematic review and meta-analysis.

Implant restorative emergence angle and profile may have a negative impact on peri-implant marginal bone level and may increase the risk of developing peri-implantitis. However, the role of these prosthetic features on peri-implant health is still unclear. The aim of this systematic review and meta-analyses was to evaluate the long-term outcomes of implant restorations with an emergence angle of >30° in comparison to those with ≤30° in terms of changes in peri-implant marginal bone level, periodontal parameters, and prevalence rate of peri-implantitis. Electronic databases were searched to identify observational studies that compared implant restorations with an emergence angle of >30° to those with ≤30°. The risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool. Four studies with 912 dental implants in 397 participants were included in the present review. Of these, 455 implants had restorations with an emergence angle of >30°, while the remaining implants had restorative emergence angle of ≤30°. The follow-up time varied between 3.8 and 10.9 years. Implant restorations with an emergence angle of ≤30° were associated with less changes in peri-implant marginal bone level compared to those with emergence angle of >30°. The difference, however, was not statistically significant (mean difference 0.80; 95% confidence interval (CI) -0.13 to 1.72; p = 0.09). In platform-matched implants, the difference between the two groups was statistically significant in favor of implant restorations with emergence angle of ≤30°. In terms of emergence profile, implant restorations with convex profile had significantly higher rate of peri-implantitis (57.8%) compared to implant restorations with concave or straight profile (21.3%) (risk ratio 2.32; 95% CI 1.12-4.82; p = 0.02). Within the limitation of this review, implant restorations with an emergence angles of >30° or ≤30° seem to have no significant influence on peri-implant marginal bone level. Platform-matched implants with an emergence angle of ≤30° may have positive effects on the peri-implant marginal bone level changes, but the evidence support is of low to moderate certainty.

Global sensitivity analysis of a coupled multiphysics model to predict surface evolution in fusion plasma–surface interactions

We construct a global sensitivity analysis framework for a coupled multiphysics model used to predict the changes in material properties and surface morphology of helium plasma-facing components in future fusion reactors. The model combines the particle dynamics simulator F-TRIDYN, that predicts the helium implantation profile, with the cluster dynamics simulator Xolotl, that predicts the growth and evolution of subsurface helium gas bubbles. In order to keep the sensitivity analysis tractable, we first construct a sparse, high-dimensional polynomial chaos expansion surrogate model for each output quantity of interest, which allows the efficient extraction of sensitivity information. The sensitivity analysis is performed for two problem settings: one for ITER-like conditions, and one that resembles conditions inside the PISCES-A linear plasma device. We present a systematic comparison of important parameters, for both F-TRIDYN and Xolotl in isolation as well as for the coupled model, and discuss the physical interpretation of these results.

Secondary ion mass spectrometry quantification: Do you remember when a factor of 2 was good enough?

Well, do you remember when a factor of 2 was good enough? Probably, not unless you have been around secondary ion mass spectrometry (SIMS) since the early 1960s, like one of us has been. This paper will give many references back to the early days of quantification when a local thermal equilibrium model was used to obtain the first results that were accurate to within a factor of 2, but only 60% of the time. It only worked for bulk silicate matrixes. People were not even using SIMS on semiconductors in those days. Several early references showing profiles of ion implants in Si will be referenced, but it was not until 1980 that the first paper was published that explicitly showed how to use ion implants as SIMS standards. People were using ion implants as standards before 1980, but only in limited cases, and with no formal published equations specifying how to use them. But, the samples for which ion implants were used as standards were for dilute concentrations in a single matrix, which had a uniform matrix composition with depth. The rest of the paper will show how we at Eurofins EAG Laboratories tackled the problem of quantification of both major and minor elements in nonuniform, multi-element matrices with continuously graded composition changes using point-by-point CORrected-SIMS. These include SiGe heterostructure bipolar transistors, AlGaAs vertical cavity surface emitting lasers, and B plasma-implanted poly-silicon gates.

Verification Makhov,s profile for slow positron in Germanium

In this paper the mean penetration depths z0 and Makhov (Implantation) profile I(z,E) were evaluated for low energies positrons(1.5-30/keV)by using a distribution function of Valkealahti - Nieminen for Germanium for different thicknesses:0.2, 0.4,0.8,1.2,1.4,1.6 μm. The obtained results reveals that the values of Makhov,s profile decreased exponentialy with increasing the positron energy and profile depths increasing linearly with increasing the incident energy. The shape of the Makhov,s profile reflects the shape of the energy spectrum of the positrons, which indicates the annihilation of positrons inside the material where its wavefunction is delocalized.

Influence of the positron implantation profile on the study of the defect depth distribution by the positron annihilation technique

The formulas obtained for deconvolution of positron mean lifetime results in the sequential etching technique for detecting defect depth profiles are presented. In this experiment, only the conventional positron lifetime measurement with radioisotope-based positrons is used. The important role of the positron implantation profile is discussed. These formulas were successfully used to describe the depth profile of defects formed in sliding contact in pure vanadium. Two different layers were detected below the surface.

Detection of Energetic Ions Based on Tapered Optical Fiber

Single-mode tapered optical fibers (TOF) are well-known for applications in sensing. In this work, we demonstrate the use of tapered optical fibers to detect charged particles (ions) irradiated at various energies, fluences, and species. In this experiment, two different ion species, namely, Ar+ and N+, have been used to irradiate tapered optical fibers at various fluences and energies. The variations in the free spectral range (FSR), period, and transmission power loss from the ion beam irradiated TOFs are picked up by the optical spectrum analyzer (OSA). We were able to identify ions with energy as low as 80 keV because of the change in the refractive index of the cladding material caused by the implanted ions. The observed changes in spectra are explained using the results of COMSOL simulations. Using Monte Carlo-based TRI3DYN ion–solid interaction simulation, the surface modification and defect formation caused by ion beams as well as the implantation profile in the TOF have been predicted. These results are further corroborated by experimental studies such as scanning electron microscopy and Raman scattering spectroscopy. Such a tapered optical fiber-based detection method will aid in the creation of portable equipment to identify charged particles in nuclear reactors and in space exploration.