Implantable Energy Harvesting Research Articles

Green-in-green biohybrids as transient biotriboelectric nanogenerators

Green self-powered devices based on biodegradable materials have attracted widespread attention. Here, we propose the construction of the transient biotriboelectric nanogenerator (TENG) using green-in-green bionanocompoites. The green-in-green nanocomposites, cellulose nanocrystal (CNC)/polyhydroxybutyrate (PHB), are prepared with a high-pressure molding method. The CNC promotes the degradation and enhances the dielectric constant of CNC/PHB. It further allows for the significant improvement of the triboelectric output of CNC/PHB-based TENG. The voltage output and current output of CNC/PHB-based TENG are 5.7 and 12.5 times higher than those of pristine PHB-based TENG, respectively. Also, the bio-TENG exhibits admirable signal stability in over 20000 cycles. Despite the high hardness of CNC/PHB, a soft but simple-structured arch sensor is successfully assembled using CNC/PHB-based TENG. It can attain the precise real-time monitoring of various human motions. This study may provide new insights into the design/fabrication of green functional materials, and initiate the next wave of innovations in eco-friendly self-powered devices.

Nanogenerator-Based Sensors for Energy Harvesting From Cardiac Contraction

Biomedical electric devices provide great assistance for health and life quality. However, their maintainable need remains a serious issue for the restricted duration of energy storage. Therefore, scientists are investigating alternative technologies such as nanogenerators that could harvest the mechanical energy of the human heart to act as the main source of energy for the pacemaker. Cardiac contraction is not a source for circulation; it utilizes body energy as an alternative energy source to recharge pacemaker devices. This is a key biomedical innovation to protect patients’ lives from possible risks resulting from repeated surgery. A batteryless pacemaker is possible via an implantable energy collecting tool, exchanging the restriction of the current batteries for a sustainable self-energy resource technique. In this context, the physiology of heart energy in the preservation of blood distribution pulse generation and the effects of cardiac hormones on the heart’s pacemaker shall be outlined. In this review, we summarized different technologies for the implantable energy harvesters and self-powered implantable medical devices with emphasis on nanogenerator-based sensors for energy harvesting from cardiac contraction. It could conclude that recent hybrid bio-nanogenerator systems of both piezoelectric and triboelectric devices based on biocompatible biomaterials and clean energy are promising biomedical devices for harvesting energy from cardiac and body movement. These implantable and wearable nanogenerators become self-powered biomedical tools with high efficacy, durability, thinness, flexibility, and low cost. Although many studies have proven their safety, there is a need for their long-term biosafety and biocompatibility. A further note on the biocompatibility of bio-generator sensors shall be addressed.

Piezoelectric materials and systems for tissue engineering and implantable energy harvesting devices for biomedical applications

ABSTRACT Recently, the development of smart materials and the study of their properties has provided an innovative approach to the field of tissue engineering. Piezoelectrics, which are able to generate electric charge in response to mechanical stress or strain have been utilised in the stimulation of electrophysiologically responsive cells , including those found in bone, muscle, and the central and peripheral nervous systems. This area of study has experienced tremendous growth in the past decade in terms of both the array of piezoelectric materials and analytical methods by which they are evaluated in relation to specific tissue types. This review provides a critical and comprehensive overview of the most recent advances in this emerging field. Furthermore, it will extend the scope to examine the most recent developments in piezoelectric biomedical devices that extract energy from physiological processes to either power biomedical implants or act as biomedical sensors .

Development of a resonance generator utilizing incomplete tetanus of skeletal muscle.

Implantable energy harvesting system utilizing contraction of an electrically-stimulated skeletal muscle is proposed for alternative batteries of implantable medical devices. In order to realize high conversion efficiency, we propose a resonance generator utilizing vibration of the skeletal muscle, which is called as incomplete tetanus. Experimental results showed the incomplete tetanus was a suitable form for the energy harvesting and the stimulation at the frequency of 10 Hz was maximized the work of the muscle. Dimensions of the springs of the generator were designed so that its natural frequency was 10 Hz. On the simulation, the maximum generated power was achieved 122.5 μW, which is enough to power the IMDs.Clinical Relevance-The proposed system has a potential to eliminate conventional batteries in the implantable medical devices. It will be beneficial for patients since the periodical surgery for the battery replacement will be avoided.

Implantable Energy Harvesters: Implantable Cardiac Kirigami‐Inspired Lead‐Based Energy Harvester Fabricated by Enhanced Piezoelectric Composite Film (Adv. Healthcare Mater. 8/2021)

Implantable Energy Harvesters: Implantable Cardiac Kirigami‐Inspired Lead‐Based Energy Harvester Fabricated by Enhanced Piezoelectric Composite Film (Adv. Healthcare Mater. 8/2021)

Self-Powered Implantable Medical Devices: Photovoltaic Energy Harvesting Review.

Implantable technologies are becoming more widespread for biomedical applications that include physical identification, health diagnosis, monitoring, recording, and treatment of human physiological traits. However, energy harvesting and power generation beneath the human tissue are still a major challenge. In this regard, self-powered implantable devices that scavenge energy from the human body are attractive for long-term monitoring of human physiological traits. Thanks to advancements in material science and nanotechnology, energy harvesting techniques that rely on piezoelectricity, thermoelectricity, biofuel, and radio frequency power transfer are emerging. However, all these techniques suffer from limitations that include low power output, bulky size, or low efficiency. Photovoltaic (PV) energy conversion is one of the most promising candidates for implantable applications due to their higher-power conversion efficiencies and small footprint. Herein, the latest implantable energy harvesting technologies are surveyed. A comparison between the different state-of-the-art power harvesting methods is also provided. Finally, recommendations are provided regarding the feasibility of PV cells as an in vivo energy harvester, with an emphasis on skin penetration, fabrication, encapsulation, durability, biocompatibility, and power management.

Emerging Implantable Energy Harvesters and Self-Powered Implantable Medical Electronics.

Implantable energy harvesters (IEHs) are the crucial component for self-powered devices. By harvesting energy from organisms such as heartbeat, respiration, and chemical energy from the redox reaction of glucose, IEHs are utilized as the power source of implantable medical electronics. In this review, we summarize the IEHs and self-powered implantable medical electronics (SIMEs). The typical IEHs are nanogenerators, biofuel cells, electromagnetic generators, and transcutaneous energy harvesting devices that are based on ultrasonic or optical energy. A benefit from these technologies of energy harvesting in vivo, SIMEs emerged, including cardiac pacemakers, nerve/muscle stimulators, and physiological sensors. We provide perspectives on the challenges and potential solutions associated with IEHs and SIMEs. Beyond the energy issue, we highlight the implanted devices that show the therapeutic function in vivo.

Implantable Energy Harvesting Stents for Transcutaneous Wireless Monitoring of Peripheral Artery Disease

More than five million adults in U.S. are affected by the peripheral artery disease. Current wireless stent monitors are unsuitable to use in the thigh. In this paper, wireless powering and communication with implanted stents were investigated. Specifically, we investigated the effects of thigh tissue morphology and tissue thickness variations on wireless power gain and electromagnetic safety when using skin-contact touch probe antennas. Thigh simulation models were derived from anthropometric data for the diseased population. Power gain and specific absorption rate were determined for each variation. To corroborate human model simulation results, a power-to-frequency converter was designed, benchmarked, and implanted within ex vivo porcine tissue. The experiments showed the most realistic simulations reported so far that have the best agreement with measured results. This paper indicates that touch probe powered stent systems can safely deliver significant power to an implant. This research enables frequent at-home monitoring to replace costly in-hospital quarterly check-ups.

Functional fusion of living systems with synthetic electrode interfaces.

The functional fusion of “living” biomaterial (such as cells) with synthetic systems has developed into a principal ambition for various scientific disciplines. In particular, emerging fields such as bionics and nanomedicine integrate advanced nanomaterials with biomolecules, cells and organisms in order to develop novel strategies for applications, including energy production or real-time diagnostics utilizing biomolecular machineries “perfected” during billion years of evolution. To date, hardware–wetware interfaces that sample or modulate bioelectric potentials, such as neuroprostheses or implantable energy harvesters, are mostly based on microelectrodes brought into the closest possible contact with the targeted cells. Recently, the possibility of using electrochemical gradients of the inner ear for technical applications was demonstrated using implanted electrodes, where 1.12 nW of electrical power was harvested from the guinea pig endocochlear potential for up to 5 h (Mercier, P.; Lysaght, A.; Bandyopadhyay, S.; Chandrakasan, A.; Stankovic, K. Nat. Biotech. 2012, 30, 1240–1243). More recent approaches employ nanowires (NWs) able to penetrate the cellular membrane and to record extra- and intracellular electrical signals, in some cases with subcellular resolution (Spira, M.; Hai, A. Nat. Nano. 2013, 8, 83–94). Such techniques include nanoelectric scaffolds containing free-standing silicon NWs (Robinson, J. T.; Jorgolli, M.; Shalek, A. K.; Yoon, M. H.; Gertner, R. S.; Park, H. Nat Nanotechnol. 2012, 10, 180–184) or NW field-effect transistors (Qing, Q.; Jiang, Z.; Xu, L.; Gao, R.; Mai, L.; Lieber, C. Nat. Nano. 2013, 9, 142–147), vertically aligned gallium phosphide NWs (Hällström, W.; Mårtensson, T.; Prinz, C.; Gustavsson, P.; Montelius, L.; Samuelson, L.; Kanje, M. Nano Lett. 2007, 7, 2960–2965) or individually contacted, electrically active carbon nanofibers. The latter of these approaches is capable of recording electrical responses from oxidative events occurring in intercellular regions of neuronal cultures (Zhang, D.; Rand, E.; Marsh, M.; Andrews, R.; Lee, K.; Meyyappan, M.; Koehne, J. Mol. Neurobiol. 2013, 48, 380–385). Employing monocrystalline gold, nanoelectrode interfaces, we have now achieved stable, functional access to the electrochemical machinery of individual Physarum polycephalum slime mold cells. We demonstrate the “symbionic” union, allowing for electrophysiological measurements, functioning as autonomous sensors and capable of producing nanowatts of electric power. This represents a further step towards the future development of groundbreaking, cell-based technologies, such as bionic sensory systems or miniaturized energy sources to power various devices, or even “intelligent implants”, constantly refueled by their surrounding nutrients.

骨格筋収縮を用いた体内エネルギーハーベスティング用発電機構の基礎検討

骨格筋収縮を用いた体内エネルギーハーベスティング用発電機構の基礎検討

Novel Piezoelectric Paper-Based Flexible Nanogenerators Composed of BaTiO3 Nanoparticles and Bacterial Cellulose.

A piezoelectric paper based on BaTiO3 (BTO) nanoparticles and bacterial cellulose (BC) with excellent output properties for application of nanogenerators (NGs) is reported. A facile and scalable vacuum filtration method is used to fabricate the piezoelectric paper. The BTO/BC piezoelectric paper based NG shows outstanding output performance with open‐circuit voltage of 14 V and short‐circuit current density of 190 nA cm−2. The maximum power density generated by this unique BTO/BC structure is more than ten times higher than BTO/polydimethylsiloxane structure. In bending conditions, the NG device can generate output voltage of 1.5 V, which is capable of driving a liquid crystal display screen. The improved performance can be ascribed to homogeneous distribution of piezoelectric BTO nanoparticles in the BC matrix as well as the enhanced stress on piezoelectric nanoparticles implemented by the unique percolated networks of BC nanofibers. The flexible BTO/BC piezoelectric paper based NG is lightweight, eco‐friendly, and cost‐effective, which holds great promises for achieving wearable or implantable energy harvesters and self‐powered electronics.

Emerging trends in bioenergy harvesters for chronic powered implants

ABSTRACT

Fabrication of flexible energy harvesting device based on K0.5Na0.5NbO3 nanopowders

K0.5Na0.5NbO3 (KNN) powder was synthesized by a novel sol–gel method and used to fabricate an energy harvesting device. The precursor gel and KNN powder were studied by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The elemental composition of the KNN powder was characterized by energy dispersive X-ray analysis (EDAX). Well crystallized single phase perovskite KNN powder with an average particle size on the order of 450nm was obtained from the gel after calcining at 750°C for 2h. A flexible and implantable energy harvesting device fabricated using the KNN nanopowder exhibited an output power of up to 0.13μW with a load resistance of 100MΩ. The Young’s modulus of the device was determined to be 10.4GPa by atomic force microscopy (AFM).

Topology Optimization Design of Implantable Energy Harvesting Device

When designing implantable biomedical MEMS devices, we must provide electric power source with long life and small size to drive the sensors and actuators work. Obviously, traditional battery is not a good choice because of its large size, limited lifetime and finite power storage. Living creatures all have non-electric energy sources, like mechanical energy from heart beat and pulse. Piezoelectric structure can convert mechanical energy to electric energy. In the same design condition, the more electric energy is generated, the better the piezoelectric structure design. This paper discusses the topology optimization method for the most efficient implantable piezoelectric energy harvesting device. Finally, a design example based on the proposed method is given and the result is discussed.