Implantation Surgery Research Articles

Comparison of Implant Surgery Methods of Cortical Tapping and Cortical Widening in Bone of Various Density: A Three-Dimensional Finite Element Study.

The primary stability of a dental implant is critical for successful osseointegration during immediate loading. The cortical bone should be prepared to achieve enough primary stability, but not overcompressed. In this study, we investigated the stress and strain distribution in the bone around the implant induced by the occlusal force applied during immediate loading at various bone densities by the FEA method to compare cortical tapping and widening surgical techniques. A three-dimensional geometrical model of a dental implant and bone system was created. Five types of bone density combination (D111, D144, D414, D441 and D444) were designed. Two surgical methods-cortical tapping and cortical widening-were simulated in the model of the implant and bone. An axial load of 100 N and an oblique load of 30 N were applied to the crown. The maximal principal stress and strain were measured for comparative analysis of the two surgical methods. Cortical tapping showed lower maximal stress of bone and maximal strain of bone than cortical widening when dense bone was located around the platform, regardless of the direction of the applied load. Within the limitations of this FEA study, it can be concluded that cortical tapping is biomechanically more advantageous to the implants under occlusal force during immediate loading, especially when the bone density around the platform is high.

Radiological assessment of facial recess and correlation with surgical measurement in cochlear implantation

BackgroundThe facial recess (FR) is the crucial landmark in posterior tympanotomy approach which is the conventional approach for cochlear implantation surgery. This work aimed to measure the facial recess width and length radiologically and correlate these measurements with the surgical measurements in cochlear implantation procedure. An observational cross-sectional study was conducted on one hundred patients with sensorineural hearing loss prepared for cochlear implantation according to health insurance regulations. Patients included in the study were subjected to the following protocol: a routine ENT examination formed the initial part of the evaluation, audiological tests for adults and children were done, and the radiological evaluation for the patients included high-resolution computed tomography (HRCT) scanning [axial plane, oblique sagittal plane, and curved multiplanar reconstruction (MPR CT)]. These HRCT images were used to measure the facial recess width and length. Measurement of the FR width and length was done intraoperative by using a sterile ruler. Radiological measurements were correlated with the surgical measurements.ResultsThere was a statistically significant correlation between FR width surgically and FR width radiologically (p-value < 0.001). FR width measured in CT axial cuts, curved MPR images, and oblique sagittal cuts could predict FR width surgically. There was a statistically significant correlation between FR length surgically and FR length radiologically (p-value < 0.001). There was no statistically significant correlation between age and sex on one hand and surgical and radiological measurements on the other hand.ConclusionPreoperative HRCT axial plane, oblique sagittal plane, and curved MPR CT can predict actual facial recess width and length.

Eta polycaprolactone (ε-PCL) implants appear to cause a partial differentiation of breast cancer lung metastasis in a murine model

BackgroundCells in every epithelium can be roughly divided in three compartments: stem cell (SC) compartment, transient amplifying cell (TA) compartment and terminally differentiated (TD) compartment. Maturation of stem cells is characterized by epithelial stromal interaction and sequential maturational movement of stem cell’s progeny through those compartments. In this work we hypothesize that providing an artificial stroma, which murine breast cancer metastatic cells can infiltrate, will induce their differentiation.MethodsBALB/c female mice were injected with 106 isogenic 4T1 breast cancer cells labeled with GFP. After 20 days primary tumors were removed, and artificial ε-PCL implants were implanted on the contralateral side. After 10 more days mice were sacrificed and implants along with lung tissue were harvested. Mice were divided in four groups: tumor removal with sham implantation surgery (n = 5), tumor removal with ε-PCL implant (n = 5), tumor removal with VEGF enriched ε-PCL implant (n = 7) and mice without tumor with VEGF enriched ε-PCL implant (n = 3). Differentiational status of GFP + cells was assessed by Ki67 and activated caspase 3 expression, thus dividing the population in SC like cells (Ki67+/dim aCasp3−), TA like cells (Ki67+/dim aCasp3+/dim) and TD like cells (Ki67− aCasp3+/dim) on flow cytometry.ResultsLung metastatic load was reduced by 33% in mice with simple ε-PCL implant when compared to tumor bearing group with no implant. Mice with VEGF enriched implants had 108% increase in lung metastatic load in comparison to tumor bearing mice with no implants. Likewise, amount of GFP + cells was higher in simple ε-PCL implant in comparison to VEGF enriched implants. Differentiation-wise, process of metastasizing to lungs reduces the average fraction of SC like cells when compared to primary tumor. This effect is made more uniform by both kinds of ε-PCL implants. The opposite process is mirrored in TA like cells compartment when it comes to averages. Effects of both types of implants on TD like cells were negligible. Furthermore, if gene expression signatures that mimic tissue compartments are analyzed in human breast cancer metastases, it turns out that TA signature is associated with increased survival probability.Conclusionε-PCL implants without VEGF can reduce metastatic loads in lungs, after primary tumor removal. Both types of implants cause lung metastasis differentiation by shifting cancer cells from SC to TA compartment, leaving the TD compartment unaffected.

Utility of Intraoperative Radiographs in Pediatric Cochlear Implant Surgery.

To evaluate the role of intraoperative radiographs to confirm electrode position following pediatric cochlear implantation (CI). Retrospective chart review. Single tertiary care pediatric center. A retrospective chart review was conducted, including all pediatric patients undergoing CI at UPMC Children's Hospital of Pittsburgh over a 13-year period. We identified 326 patients undergoing 492 procedures. Across the cohort, there were 7 cases that required intraoperative electrode reinsertion due to malposition or presumed malposition. For 6 of the 7 cases, intraoperative X-ray identified electrode malposition. Neural response telemetry (NRT) testing was also abnormal for 4 of these cases prior to reinsertion. Implantation of Cochlear's Slim Modiolar electrode was associated with an abnormal perioperative X-ray (odds ratio [OR]: 9.2, p = 0.03) and increased change in management (OR: 9.2, p = 0.03) compared to Cochlear's Contour Advance (CA). Incidence of abnormal X-rays was 1.24% overall, 4% in the Slim Modiolar group, and 0.3% in the CA group. The Slim Modiolar electrode accounted for 4 of 7 cases requiring reinsertion, and in all 4 of these cases, electrode fold-over was identified on the X-ray. NRT was normal in 1 of these 4 cases. The use of Cochlear's Slim Modiolar electrode was associated with a significantly increased risk of abnormal intraoperative X-ray compared to the CA electrode. Given the risk of fold-over with routine insertion and normal electrical testing using the Slim Modiolar electrode, we recommend routine use of intraoperative skull X-ray to confirm electrode position.

Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening

Background: Stratification is required to ensure that only patients likely to benefit receive autologous chondrocyte implantation (ACI). It would be advantageous to identify biomarkers to predict ACI outcome that are measurable in blood, avoiding the need for an invasive synovial fluid harvest. Purpose: To assess if proteomic analyses can be used to identify novel candidate blood biomarkers in individuals who respond well or poorly to ACI. Study Design: Controlled laboratory study. Methods: Isobaric tagging for relative and absolute quantitation (iTRAQ) mass spectrometry was used to assess the proteome in plasma pooled from ACI responders (mean Lysholm improvement after ACI, 33; n = 10) or nonresponders (mean, −13; n = 10), collected at the time of surgery for cartilage harvest (stage 1) or implantation of culture-expanded chondrocytes (stage 2). An alternative proteomic method, label-free quantitation liquid chromatography–tandem mass spectrometry, was used to analyze plasma samples (majority matched to iTRAQ) individually. Differentially abundant proteins (±2.0-fold) were analyzed from both proteomic data sets, and markers of interest identified via pooled iTRAQ were validated via immunoassay of individual samples. Results: Protein differences could be detected in the plasma preoperatively between ACI responders and nonresponders (16 proteins; ≥±2.0-fold change; P < .05) using iTRAQ proteomics. The most pronounced plasma proteome shift was evident in response to stage 1 surgery in ACI nonresponders, with 48 proteins being differentially abundant between the procedures. Label-free quantitation liquid chromatography–tandem mass spectrometry analysis of these same plasma samples (nonpooled) resulted in very few proteins being identified that were significantly differentially abundant. However, this work highlighted cartilage acidic protein 1 as being increased preoperatively in nonresponders as compared with responders. Conclusions: This study is the first to use proteomic techniques to profile the plasma of individuals treated with ACI. Despite iTRAQ analysis of pooled plasmas indicating that there are differences in the plasma proteome between responders and nonresponders to ACI, these findings were not replicated when assessed using an alternative nonpooled technique. This study highlights some of the difficulties in profiling the plasma proteome in an attempt to identify novel biomarkers. Regardless, cartilage acidic protein 1 has been identified as a protein candidate, which is detectable in plasma and can predict outcome to ACI before treatment. Clinical Relevance: Candidate plasma protein biomarkers identified in this study have the potential to help determine which patients will be best suited to treatment with ACI.

Binocular 3-D otolith-ocular reflexes: responses of chinchillas to natural and prosthetic stimulation after ototoxic injury and vestibular implantation.

The otolith end organs inform the brain about gravitational and linear accelerations, driving the otolith-ocular reflex (OOR) to stabilize the eyes during translational motion (e.g., moving forward without rotating) and head tilt with respect to gravity. We previously characterized OOR responses of normal chinchillas to whole body tilt and translation and to prosthetic electrical stimulation targeting the utricle and saccule via electrodes implanted in otherwise normal ears. Here we extend that work to examine OOR responses to tilt and translation stimuli after unilateral intratympanic gentamicin injection and to natural/mechanical and prosthetic/electrical stimulation delivered separately or in combination to animals with bilateral vestibular hypofunction after right ear intratympanic gentamicin injection followed by surgical disruption of the left labyrinth at the time of electrode implantation. Unilateral intratympanic gentamicin injection decreased natural OOR response magnitude to about half of normal, without markedly changing OOR response direction or symmetry. Subsequent surgical disruption of the contralateral labyrinth at the time of electrode implantation surgery further decreased OOR magnitude during natural stimulation, consistent with bimodal-bilateral otolith end organ hypofunction (ototoxic on the right ear, surgical on the left ear). Delivery of pulse frequency- or pulse amplitude-modulated prosthetic/electrical stimulation targeting the left utricle and saccule in phase with whole body tilt and translation motion stimuli yielded responses closer to normal than the deficient OOR responses of those same animals in response to head tilt and translation alone.NEW & NOTEWORTHY Previous studies to expand the scope of prosthetic stimulation of the otolith end organs showed that selective stimulation of the utricle and saccule is possible. This article further defines those possibilities by characterizing a diseased animal model and subsequently studying its responses to electrical stimulation alone and in combination with mechanical motion. We show that we can partially restore responses to tilt and translation in animals with unilateral gentamicin ototoxic injury and contralateral surgical disruption.

Imaging of Temporal Bone - A Road Map for Cochlear Implant Surgery

Imaging of Temporal Bone - A Road Map for Cochlear Implant Surgery

Efficacy Comparison Between Steep-Meridian Incision and Non-Steep-Meridian Incision in Implantable Collamer Lens Surgery with Low-to-Moderate Astigmatism.

To compare the visual outcomes of astigmatism correction with implantable collamer lens (ICL) surgery with low-to-moderate astigmatism through a steep-meridian corneal relaxing incision (SM-CRI) and non-steep-meridian corneal relaxing incision (NSM-CRI). Seventy eyes of 70 patients with myopia and myopic astigmatism who underwent ICL V4c implantation were classified into two groups: SM-CRI and NSM-CRI. Refractive outcomes and vector analysis were evaluated preoperatively and 6months postoperatively. At the postoperative 6month visit, all participants in both groups achieved an uncorrected distance visual acuity (UDVA) of 20/20 or better. The difference vector (DV) showed that the residual astigmatism in the SM-CRI group was much smaller than that in the NSM-CRI group (P = 0.021), and the correction index (CI) was 0.84 ± 0.30 and 0.67 ± 0.35 for the SM-CRI and NSM-CRI groups, respectively, with a significant statistical difference (P = 0.013). Approximately 71% of eyes in the SM-CRI group had an angle of error (AE) within ± 15°, whereas 55% of eyes in the NSM-CRI group were within that range. The absolute mean AE was 10.13 ± 14.57° in the SM-CRI group, compared with 23.88 ± 28.22° in the NSM-CRI group (P = 0.038). SM-CRI can alleviate corneal astigmatism and decrease the cylindrical diopter of the ICL, thus improving postoperative visual quality compared with NSM-CRI.

451 Interactions between tumor, age, and chemotherapy in cognitive impairments and neuroinflammation

OBJECTIVES/GOALS: We will use a novel syngeneic model of prostate cancer to examine impairments and uncover potential changes in inflammatory signaling in the brains of animals with and without tumors. We will then investigate the interaction between peripheral tumor, age, and chemotherapy on cognitive impairments and any accompanying neuroinflammation METHODS/STUDY POPULATION: Male Copenhagen rats (aged 3 or 10 months) were subjected to tumor fragment implantation (Dunning R2237G cells) or sham surgery. Once tumors were palpable, animals received either docetaxel (4.5mg/kg, intraperitoneal) or it’s vehicle once every other day for 5 days (3 injections total) followed by a two-week recovery period. During this time, TNFa and IL-6 was quantified in plasma samples obtained once per week for two weeks. Hippocampal-mediated visuospatial and working memories were assessed using the novel object task and percent alternation in a y-maze, respectively. Afterwards, trunk blood and hippocampal tissue were isolated. TNFa and IL-6 protein was quantified in plasma. Hippocampal tissue was probed for markers of neuroinflammation, including increases in TNFa, IL-6, and reactive microglia RESULTS/ANTICIPATED RESULTS: The presence of a tumor alone produces deficits in hippocampal-mediated visuospatial memory and working memory regardless of treatment and persistent elevations in TNFa and IL-6 in plasma. Docetaxel administration also produces impairments in hippocampal-mediated visuospatial memory, but not in working memory. We anticipate these cognitive impairments will be accompanied by hippocampal neuroinflammation. We expect age and docetaxel chemotherapy to exacerbate working memory deficits and markers in hippocampal neuroinflammation, including increases in TNFa, IL-6 and reactive microglia DISCUSSION/SIGNIFICANCE: This study will provide insight into the interaction between tumor, age, and chemotherapy in impairments in visuospatial memories. This model provides a substrate upon which interventions can be tested to ensure the efficacy of the cancer treatment is maintained when treating these cognitive impairments.

Breast Implant Surgery: An Overview of the Risks and Health Complications.

Breast Implant Surgery: An Overview of the Risks and Health Complications.

Antibiotics for Dental Implant Surgery: Extracting Available Evidence, Risks, Benefits, and Insights to Consider.

Antibiotics for Dental Implant Surgery: Extracting Available Evidence, Risks, Benefits, and Insights to Consider.

Customized in-vivo tissue engineering for bone grafting

Relevance. Jaw bone volume restoration during dental implantation and reconstructive oral surgery is a relevant problem in modern dentistry. In recent years, the needs of daily dental practice determined the search for new osteoplastic materials with desired properties, including cellular technologies, to stimulate bone regeneration and accelerate bone repair processes.Materials and methods. The study used third molar area gingival specimens to create tissue-engineered constructs for bone matrix colonization, subject to in vitro expansion. Octacalcium-phosphate-based materials (OCP), used as the carrier matrix, were characterized by a larger particle surface area for a more developed microrelief, a bioresorption rate, and a hydrophilic surface. The finished tissue-engineered construct, consisting of multipotent mesenchymal stromal cells colonized on the matrix, was implanted into an artificially created tibial defect in 8 Chinchilla male rabbits. Animal experiments were conducted according to ethical standards. Rabbits were sacrificed on days 8 and 12 for histological testing.Results. In the early follow-up period (8 weeks), there were areas of mature bone with incorporated osteoblasts. Besides, there were areas of primary bone with adhesion lines. Later (12 weeks), such granules fully integrated into the diaphysis cortical part. The results showed the preservation of the low-mineralized bone girdle, osteoid - a bone substance formation precursor, between the octacalcium phosphate granule and the bone.Conclusion. The results of the experimental study allow us to conclude that the customized tissue-engineered construct developed by us contributes to bone grafting.

Determining the Frequency, Severity and Complications After Surgery of Uncomplicated Implants in Patients Referred to the Implant Department of the Faculty of Dentistry of Tehran University of Medical Sciences in the Academic Year of 2020-2021

Introduction: This prospective analytical study was conducted with the aim of determining the prevalence, severity and factors affecting the short-term complications of implant surgery.&#x0D; Methods: In a descriptive cross sectional study, patients referring to the implant department of Tehran University of Medical Science from 2020 to 2021 were included (292 implants in 152 patients). Patients underwent Simple implant placement without hard and/or soft tissue grafts were included. After 7 and 14 days, ecchymosis, bleeding, swelling, delayed wound healing, infection, and trismus were recorded. Pain, the most common outcome after surgeries was assessed based on the number of days the patient had pain, the number of analgesics used and the severity of pain (Numeric pain intensity scale) using SPSS software version 16. The relationship between complications and measured variables was examined by logestic regression analyses.&#x0D; Results: The most common complications on the 7th day follow up were ecchymosis (3.9%) and delayed wound healing (3.9%). The mean pain score was 1.61 ± 1.32. No patient had pain more than 3 days after surgery. The mean number of analgesic used was 2.23 ± 1.82. Based on logistic regression analyses, only patient age and the number of days of analgesics use showed a significant relationship with the number of analgesics used (P˂0.001). Neither the level of expertise of the surgeon nor the patients' gender had nosignificant effect on the degree of complications pain and amount of patient pain and the consumption of analgesics (P˃0.05). Patients with poor oral hygiene used more analgesics in comparison to patients with favorable oral hygiene.&#x0D; Conclusion: The overall prevalence of post-operative complications after simple implant surgeries was less than 4%. The older the patient, the higher the consumption of analgesics.

Cone Beam Computed Tomography-Based Evaluation of the Accuracy of Implant Surgery with Conventional (Free Hand) Implant Placement vs Computer Fabricated 3D Guide Implant Placement.

Dental implants have been used in a variety of conventional technique-based forms for many years which had its own drawbacks. With the advent of cone beam CT, proper surgical and prosthetic planning is possible now a days. To achieve ideal implant placement, good prosthetic fabrication and overall successful prognosis computer fabricated guide aided surgery have been developed. The aim of this study was to compare and evaluate the accuracy of implant placement in partially edentulous patients with conventional free hand technique and computer fabricated guide of implant placement by comparing pre- and post-CBCT data. The present split mouth study design was conducted with forty sample size on twenty randomly selected patients who were treated with bilateral partially edentulous sites requiring dental implants. Patients were treated with both conventional (free hand) technique and computer fabricated 3D guide aided technique of implant placement. Comparison of accuracy of implant placement was done by comparing the pre- and postoperative CBCT data in terms of mean coronal deviation, mean apical deviation and mean angular deviation. The results showed that there is no statistically significant difference between mean coronal deviation, mean apical deviation and mean angular deviation of planned and placed implants in both conventional technique (free hand technique) and computer fabricated 3D guide aided implant placement technique. Hence, this study concluded that conventional technique of implant placement is equally efficient in comparison with computer fabricated guide aided surgery in terms of accuracy of implant placement.

Training of novice surgeons using dynamic computer assisted dental implant surgery: An exploratory randomized trial

Dynamic Computer Assisted Implant Surgery (CAIS) systems have been shown to improve accuracy of implant placement, thus training in the use of such systems is becoming increasingly important. There is a scarcity of research on how to implement dynamic CAIS training in the settings of postgraduate university education. To determine the effectiveness of two modes of CAIS training programs on motor skill acquisition of novice surgeons. Thirty-six postgraduate students without experience in dynamic CAIS systems were randomly assigned to a distributed training program (3 training sessions over 3 days) or a massed training (3 training sessions over the same day). A post-test involving the placement of one implant was conducted for both groups, 7 days after completion of the training. Surgical time and implant accuracy were recorded and analyzed, using independent t-tests, with 0.05 significant level. Both groups reached the accuracy benchmarks expected by current standards in the use of CAIS. No significant differences with regards to accuracy were found between the groups, but a trend was documented favoring performance of distributed (mean difference-0.4, 95% confidence interval-0.7-0.1) in the accuracy at platform level. Distributed training students performed faster than massed for the third trial (mean difference-95.0, 95% confidence interval-178.8 to -11.2). Novice students reached the accuracy benchmarks with the use of CAIS through both a massed and a distributed training program, while there was a strong but marginally not significant trend for higher accuracy in the distributed group. Students who received the training in the distributed format over the process of different days, performed faster. Trial registered in Thai Clinical Trials Registry: https://www.thaiclinicaltrials.org/show/TCTR20230109002. This clinical trial was not registered prior to participant recruitment and randomization.

A Pilot Study of Ex Vivo Human Prefrontal RNA Transcriptomics in Parkinson's Disease.

Parkinson's disease (PD) can dramatically change cortical neurophysiology. The molecular basis for PD-related cortical changes is unclear because gene expression data are usually derived from postmortem tissue collected at the end of a complex disease and they profoundly change in the minutes after death. Here, we studied cortical changes in tissue from the prefrontal cortex of living PD patients undergoing deep-brain stimulation implantation surgery. We examined 780 genes using the NanoString nCounter platform and found that 40 genes were differentially expressed between PD (n = 12) and essential tremor (ET; n = 9) patients. One of these 40 genes, STAT1, correlated with intraoperative 4-Hz rhythms and intraoperative performance of an oddball reaction-time task. Using a pre-designed custom panel of 780 targets, we compared these intraoperative data with those from a separate cohort of fresh-frozen tissue from the same frontal region in postmortem human PD donors (n = 6) and age-matched neurotypical controls (n = 6). This cohort revealed 279 differentially expressed genes. Fifteen of the 40 intraoperative PD-specific genes overlapped with postmortem PD-specific genes, including CALB2 and FOXP2. Transcriptomic analyses identified pathway changes in PD that had not been previously observed in postmortem cases. These molecular signatures of cortical function and dysfunction may help us better understand cognitive and neuropsychiatric aspects of PD.

AUROLAB AQUEOUS DRAINAGE IMPLANT IN YOUNG ADULT WITH NEOVASCULAR GLAUCOMA AND TUBERCULOSIS HISTORY: A CASE REPORT

Introduction: Neovascular glaucoma (NVG) is historically known as rubeotic glaucoma, from “rubeosis iridis” that refers to the iris neovascularization. One of several causes that lead to rubeosis iridis is changes in Pigment Epithelium-Derived Growth Factor (PEDF) that may be caused by Mycobacterium tuberculosis. The influence of NVG may cause intraocular pressure (IOP) to rise rapidly. It can be decreased by Aurolab Aqueous Drainage Implant (AADI). Case Report: A 34-year-old male complained of left eye pain and sudden decreased vision for the past 2 months. He had been diagnosed with tuberculosis since 8 months ago. The patient’s blood pressure, blood sugar, cholesterol, and triglycerides were within normal limit. Diabetes Mellitus (-). Human Immunodeficiency Virus (-). Visual acuity of left eye was hand movement. The pupil was dilated and non-reactive, anterior chamber depth is shallow, and rubeosis iridis (+). IOP is 60 mmHg. Medical management was failed to decrease the IOP. Funduscopy image showed cup-disc ratio was 0,7. Ganglion cell complex parameters showed 80,91. On the next day after AADI implantation surgery, the patient’s left eye IOP was reduced to 10 mmHg. On the 14th day post operative visual acuity was 2 meter counting finger. The anterior segment of the conjunctiva bulbi was hyperemic and conjunctival injection was reduced. The camera oculi anterior showed remainder of the implant. In the iris, rubeosis iridis disappeared, pupil was dilated, IOP was increased to 12 mmHg Discussion: Neovascular glaucoma was caused by the growth of the fibrovascular membrane on the surface of the iris and the anterior chamber angle. The three most common causes of neovascular glaucoma were diabetes mellitus, central retinal vein occlusion, and carotid artery occlusion. Conclusion:AADI is a safe and effective option for patients with neovascular glaucoma following tuberculosis.

USE OF CUSTOM ABUTMENTS IN PROSTHETIC TREATMENT WITH IMPLANT-SUPPORTED RESTORATIONS

Today, implantation surgery allows for a predictable result in the rehabilitation of patients with partial or complete absence of teeth. Modern technological capabilities allow dentists and dental technicians to use numerous approaches to the choice of materials, ways of manufacturing individual abutments and their final design. However, there is no definitive protocol for the selection of all components of the structure. The purpose of this study was to review the literature on the mechanical and aesthetic results of using customized implant abutments in the replacement of dentition defects with implant-supported prosthetic structures. A literature search was conducted using the PubMed electronic database using the search term "custom abutment". The search period covered the period from January 2012 to December 2022. The final review included 32 articles. The review of current scientific sources provided preliminary evidence that in most cases, the use of customized implant abutments makes it possible to perform predictable restoration of function in patients with missing teeth. At the same time, dentists have a wide range of materials in their arsenal to achieve highly aesthetic results without significant compromise in mechanical performance compared to classic titanium abutments. Further modernization of approaches to the standardization of the manufacture of individual abutments is likely to lead to the everyday use of such structures not only in areas of the oral cavity where the requirements for aesthetics are increased to the maximum, but also to their use in other situations.

Wirelessly powered deformable electronic stent for noninvasive electrical stimulation of lower esophageal sphincter

Electrical stimulation is a promising method to modulate gastrointestinal disorders. However, conventional stimulators need invasive implantation and removal surgeries associated with risks of infection and secondary injuries. Here, we report a battery-free and deformable electronic esophageal stent for wireless stimulation of the lower esophageal sphincter in a noninvasive fashion. The stent consists of an elastic receiver antenna infilled with liquid metal (eutectic gallium-indium), a superelastic nitinol stent skeleton, and a stretchable pulse generator that jointly enables 150% axial elongation and 50% radial compression for transoral delivery through the narrow esophagus. The compliant stent adaptive to the dynamic environment of the esophagus can wirelessly harvest energy through deep tissue. Continuous electrical stimulations delivered by the stent in vivo using pig models significantly increase the pressure of the lower esophageal sphincter. The electronic stent provides a noninvasive platform for bioelectronic therapies in the gastrointestinal tract without the need for open surgery.

A 3D Video Overlay of Angularly and Linearly graduated scales for precisely indicating accurate measures on the Ocular surface in order to Guide Ophthalmic Surgeons during Toric IOL implantation and Squint Surgeries

A 3D Video Overlay of Angularly and Linearly graduated scales for precisely indicating accurate measures on the Ocular surface in order to Guide Ophthalmic Surgeons during Toric IOL implantation and Squint Surgeries