Background: A correct information about most common causative organism and it sensitivity pattern in that clinical setup is essential for designing empirical therapy. Present study has been designed to study the microbiological prole and antibiotic sensitivity pattern of post-operative orthopaedic Implant infections in tertiary care teaching hospital. Material and Method: This prospective observational study. Patients who presented with the signs and symptoms of infections, conrmed by laboratory and other routine investigations, were included in present study. The demography, microbiological data sensitivity to antimicrobial agent of organism was recorded. Result: The most common pathogen isolated was pseudomonas aeruginosa that is 37 (41.1%), followed by staphylococcus aureus that is 36 (40%). Pseudomonas aeruginosa was sensitive to Piperacillin tazobactam 28(77.7%), Imipenem 26(72.2%), Imipenem+cilastatin 28(77.7%) and Meropenem 30(83.3%). Methicillin resistant staph aureus were sensitive to Cotrimoxazole 4(44.4%), Clindamycine 6(66.6%), Vancomycin 8(88.8%) and Linazolid 7(77.7%). Conclusion: Implant of femur was most commonly infected. Staphylococcus Aureus (MSSA) was commonly associated with biolm formation followed by Staphylococcus Aureus (MRSA). Pseudomonas aeruginosa isolated from implant infections were sensitive to Piperacillin+ tazobactam, Imipenem, Imipenem+cilastatin and Meropenem