Impact Response Research Articles

Trastuzumab Deruxtecan in Advanced Solid Tumors With Human Epidermal Growth Factor Receptor 2 Amplification Identified by Plasma Cell-Free DNA Testing: A Multicenter, Single-Arm, Phase II Basket Trial.

HERALD/EPOC1806 was conducted as a multicenter phase II trial assessing trastuzumab deruxtecan (T-DXd) therapy for patients with human epidermal growth factor receptor 2 (HER2)-amplified progressive stage solid tumors detected by cell-free DNA (cfDNA) testing. Patients exhibited advanced solid tumors with HER2 amplification that was identified via next-generation sequencing of cfDNA testing, without the requirement for immunohistochemical HER2 testing. The studied group was administered T-DXd at 5.4 mg/kg once every 3 weeks until onset of disease progression or intolerable toxicity. Overall, 4,734 patients underwent cfDNA testing from December 2019 to January 2022, and 252 demonstrated HER2 amplification. Finally, the study included 62 patients with 16 cancer types with a median baseline plasma HER2 copy number (CN) of 8.55 (range, 2.4-73.9). Confirmed overall response rate (ORR) by investigator assessment was 56.5% (95% CI, 43.3 to 69.0), thus showing a value beyond the 5% threshold. Responses were evaluated for 13 cancer types, including KRAS-mutant colorectal (1/3), PIK3CA-mutant endometrial (5/6), and tissue HER2-negative gastric (1/2) cancers. Plasma HER2 CN above versus below the baseline median value did not differ for impact response; however, clearance of HER2 amplification in cfDNA on cycle 2 day 1 had higher response values compared with persistence. Median progression-free survival and response duration were 7.0 (95% CI, 4.9 to 9.7) and 8.8 (95% CI, 5.8 to 11.2) months, respectively, with the majority of complications being mild to moderate. Interstitial lung diseases were identified in 16 (26%) patients, including 14 patients with grade 1 disease, one patient with grade 2 disease, and one patient with grade 3 disease. T-DXd treatment demonstrated high ORR with durable response in patients with advanced HER2-amplified solid tumors determined with cfDNA testing.

Investigating the low velocity impact response of additively manufactured tri-material composite structure with application on helmet

Additively manufactured composite structures can be utilized in the production of engineering materials with enhanced mechanical properties. In this work, mono-, bi-, and tri-material structures (MMS, BMS, and TMS, respectively) were fabricated using additively manufactured PLA (poly-lactic acid) lattice frames embedded with Polyurethane (PU) foam and milled glass fibers (MGFs). TMS samples were reinforced with MGFs at 1.25, 2.5, 3.75, and 5.0 vol%, indicated as TMS-1, TMS-2, TMS-3, and TMS-4, respectively. The mechanical response of these composite structures was tested by applying a low-velocity impact load. The effects of MGF content and variations in applied impact energy, and variation in microstructure on the composite samples were investigated. Results revealed an enhanced mechanical response of TMS samples compared to MMS and BMS. Additionally, with increasing applied impact energy, the TMS samples showed an improved corresponding response, with a peak absorbed energy of 96.03% of the applied 60 J energy. Furthermore, to study the applicability of the composite structures in real-life applications, helmet prototypes made of MMS, BMS, and TMS were designed and tested under the applied low-velocity load, showing an improved response of TMS helmet samples compared to the other composite structures.

Ab initio simulation of the dynamic shock response of single crystal and lightweight multicomponent alloy

The dynamic response of shock wave impact on single crystal aluminium and lightweight multicomponent alloy Al-Cu-Li-Mg is simulated by using the combination of Ab initio Molecular Dynamics (AIMD) and Multi-Scale Shock Technique (MSST), with the analysis carried out at the atomic/electronic levels. The simulation is verified by comparing the particle velocity of single crystal obtained in this work with the data in literature. The shock compression process not only involves the migration of atoms, but also is related to electronic transition. Two stages could be found in the shock compression process: oscillatory compression of the crystal cell and oscillatory migration of the atoms. The crystal structure of the multicomponent alloy could be disordered even at low shock speed, due to the difference in the ability to migrate between different kinds of atoms. As the sample is shock-compressed, the contribution proportion of crystal orbitals shows a sharp decrease for D orbital, while it increases significantly for S orbital and P orbital. The electron structure shows a quicker response to the shock wave compression process than the crystal structure. The orbital contribution from P orbital of the crystal is mainly due to the P orbital of Al atoms, while the orbital contribution from D orbital of the crystal is mainly due to the D orbital of Cu atoms. Total Density of States (TDOS) is mainly contributed by the Projected Density of State (PDOS) of Cu atoms in the occupied state of energy levels, while it is close to the PDOS of Al atoms in the non-occupied state of energy levels.

Ballistic impact response of reinforced concrete panels subjected to diverse multiple projectile impact scenarios: A numerical study

Concrete has wide applications in civil and military infrastructures. Thorough ballistic damage evaluation of these structures is crucial to safeguard these structures against potential threats. Past studies on reinforced concrete (RC) panels primarily focused on single-impact scenarios. However, real-world situations often involve multiple impacts that need to be examined. Hence, this paper critically examines multiple impact scenarios on RC panels to provide a realistic understanding of their ballistic resilience. A three-dimensional finite element model was developed and validated with the experimental data from the literature to simulate the impact of a 2 kg hemispherical-nosed projectile on an RC panel. Extended analyses further investigated the RC panel subjected to multiple impact scenarios. Four distinct scenarios were studied: (1) single impacts at four separate locations, (2) simultaneous impacts at these four locations, (3) sequential impacts of four projectiles, and (4) single projectile impact with energy equivalent to the combined impact of the four projectiles. The study assessed local damage failures, including penetration depth, crater formation, energy absorption, deceleration and reaction forces on projectiles. Results revealed reduced ballistic performance of RC panels under multiple impacts compared to single impacts. Specifically, simultaneous impacts (case 2) and the equivalent single impact (case 4) caused more damage in terms of spalling and scabbing than single impacts (case 1) and sequential impacts (case 3). Additionally, cases 2 and 4 exhibited similar performance in terms of projectile penetration. This study is useful in understanding RC panels’ ballistic performance under multiple impacts.

Effect of Degradation of Polylactic Acid (PLA) on Dynamic Mechanical Response of 3D Printed Lattice Structures.

Material-extrusion-based 3D printing with polylactic acid (PLA) has transformed the production of lightweight lattice structures with a high strength-to-weight ratio for various industries. While PLA offers advantages such as eco-friendliness, affordability, and printability, its mechanical properties degrade due to environmental factors. This study investigated the impact resistance of PLA lattice structures subjected to material degradation under room temperature, humidity, and natural light exposure. Four lattice core types (auxetic, negative-to-positive (NTP) gradient in terms of Poisson's ratio, positive-to-negative (PTN) gradient in terms of Poisson's ratio, and honeycomb) were analyzed for variations in mechanical properties due to declines in yield stress and failure strain. Mechanical testing and numerical simulations at various yield stress and failure strain levels evaluated the degradation effect, using undegraded material as a reference. The results showed that structures with a negative Poisson's ratio exhibited superior resistance to local crushing despite material weakening. Reducing the material's brittleness (failure strain) had a greater impact on impact response compared to reducing its yield stress. This study also revealed the potential of gradient cores, which exhibited a balance between strength (maintaining similar peak force to auxetic cores around 800 N) and energy absorption (up to 40% higher than auxetic cores) under moderate degradation (yield strength and failure strain at 60% and 80% of reference values). These findings suggest that gradient structures with varying Poisson's ratios employing auxetic designs are valuable choices for AM parts requiring both strength and resilience in variable environmental conditions.

Destruction mechanism of anterior cervical discectomy and fusion in frontal impact.

The aim of this study was to quantitatively study the effect of anterior cervical discectomy and fusion (ACDF) on the risk of spinal injury under frontal impact. A head-neck finite element model incorporating active neck muscles and soft tissues was developed and validated. Based on the intact head-neck model, three ACDF models (single-level, two-level and three-level) were used to analyze the frontal impact responses of the head-neck. The results revealed that various surgical approaches led to distinct patterns of vertebral damage under frontal impact. For single-level and three-level ACDFs, vertebral destruction was mainly concentrated at the lower end of the fused segment, while the other vertebrae were not significantly damaged. For two-level ACDF, the lowest vertebra was the first to suffer destruction, followed by severe damage to both the upper and lower vertebrae, while the middle vertebra of the cervical spine exhibited only partial damage around the screws. Fusion surgery for cervical spine injuries predominantly influences the vertebral integrity of the directly fused segments when subjected to frontal impact, while exerting a comparatively lesser impact on the cross-sectional properties of adjacent, non-fused segments.

Empirical and numerical analysis of damage tolerance in multifunctional hybrid sandwich fiber reinforced polymers composite structures for aerospace applications using compression after impact (CAI) testing

AbstractThis study presents a novel hybrid‐sandwich composite structure, customized for nose radomes applications, incorporating a foam core and distinct opposite face sheets composed of Kevlar and S‐Glass materials. Addressing in‐phase electromagnetic properties, UV protection and low velocity impact responses in our previously published work, this paper empirically and numerically investigates the damage tolerance response of the proposed structures through compression after impact (CAI) testing. The low velocity impacts (LVIs) on S‐Glass face sheets exhibited unique energy dispersion and absorption mechanisms, resulting in variations in indent damage depths and widths across all impact energy levels as compared with LVIs on Kevlar face sheets. After experimentally assessing the CAI behavior, a FE model is developed to predict CAI behavior, which closely aligned with experimental findings. This study, unprecedented in existing literature, proposes hybrid sandwich structures for nose radome aerospace applications, with superior specific impact and residual strength compared to various composite sandwich structures documented in the published literature expanding its utility beyond radomes.Highlights Innovative composites with superior low velocity impact response, tested for compression after impact performance. Designed for nose radomes found suitable for other impact prone applications. Experimental and numerical modeling showed comparable results. Major differences observed in damage mechanics, resistance, and tolerances.

Numerical investigation of impact response of bridge pier subjected to off-center vehicle collision

The increased risk of vehicle collisions on bridge piers causes damage to bridge structures and traffic congestion. In extreme cases, severe collisions caused by trucks lead to bridge collapse and loss of lives. Many studies have been conducted to investigate the dynamic responses of bridge piers subjected to vehicle collisions. Most of them focused on head-on (center-to-center) collisions based on the assumption that they represented the worst scenarios. However, off-center collisions were most often observed in vehicle collision accidents. In this study, bridge piers with different cross-section geometries (i.e., circular, and square) subjected to off-center vehicle collisions are numerically investigated. The results show that off-center vehicle collisions result in more severe spalling damage to the circular piers than head-on collisions. However, the curved surface of the circular piers effectively avoids inducing torsional response under off-center collisions. On the other hand, off-center collisions on square piers induce torsional response, thus more significant deformation, and damage than head-on collisions. Further mechanism analyses are conducted to explain the influence of off-center collisions, focusing on truck type and rectangular cross-section. Furthermore, some meaningful suggestions are put forward to resist off-center vehicle collisions for bridge piers in design process or in service.

Shear-thickening-fluid-based meta-material for adaptive impact response

Lattice and Triply-Periodic-Minimal-Surface (TPMS) structures are widely employed in different engineering disciplines, combining interesting designs with optimal mechanical properties thanks to the capabilities of Additive Manufacturing. In this framework, a technique based on filling a 3D-printed flexible structure with a shear-thickening fluid (STF) is proposed to improve the mechanical response of the resulting bi-phase composite under impact loads in the low-velocity regime up to around 3 m/s. Test data indicate that once the critical shear rate threshold for the fluid is reached, the STF-filled structure can effectively smooth the peak acceleration by 50%, decrease the penetration depth and significantly enhance the energy absorption capability by a remarkable 85%. The proposed hybrid composite paves the way to novel functional applications, exploiting the adaptive behavior of non-Newtonian fillers. To this end, a Finite-Element model is proposed to further investigate and optimize the underlying fluid-structure interaction responsible for improvement of the dynamic compressive response.

Lagrangian Split-Step Method for Viscoelastic Flows.

This research addresses and resolves current challenges in meshless Lagrangian methods for simulating viscoelastic materials. A split-step scheme, or pressure Poisson reformulation of the Navier-Stokes equations, is introduced for incompressible viscoelastic flows in a Lagrangian context. The Lagrangian differencing dynamics (LDD) method, which is a thoroughly validated Lagrangian method for Newtonian and non-Newtonian incompressible flows, is extended to solve the introduced split-step scheme to simulate viscoelastic flows based on the Oldroyd-B constitutive model. To validate and evaluate the new method's capabilities, the following benchmarks were used: lid-driven cavity flow, droplet impact response, 4:1 planar sudden contraction, and die swelling. These findings highlight the LDD method's effectiveness in accurately simulating viscoelastic flows and capturing large deformations and memory effects. Even though the extra stress was directly modeled without any regularization approach, the method produced stable simulations for high Weissenberg numbers. The stability and performance of the the Lagrangian numerics for complex temporal evolution of material properties and stress responses encourage its use for industrial problems dealing with polymers.

Experimental investigation on the horizontal impact response of precast RC bridge piers with grouted sleeve connections considering defects

To investigate the behaviour of precast bridge piers with grouted sleeve connections under horizontal low-velocity impact loads, twelve precast reinforced concrete (RC) bridge pier specimens and two cast-in-place reference specimens were tested to study the effect of grouting defect degree, impact velocity and fabricated method (precast vs. cast-in-place) on the impact response of RC piers. The failure modes, rebar strains, impact forces, displacement, and energy dissipation capacity of both cast-in-place and precast specimens were compared and analyzed. The results indicate that due to inertial effects induced by impact loading, the peak impact forces were three to seven times greater than the peak static loads. Transverse cracks were more likely to initiate in the grout layer for precast specimens, with diagonal cracks extending from the loading position to the pier bottom after impact. As horizontal impact velocity increased, the impact force, maximum displacement, and energy absorption ratio also significantly increased. The impact force-time curves of the pier specimens with grouting fullness ranging from 30 % to 100 % showed minimal differences compared to the cast-in-place specimen. A decrease in grouting fullness led to an increase in the maximum displacement of the pier specimens and reduced the transmission of impact waves between the reinforcement bars.

Elevated human impact on islands increases the introduction and extinction status of native insular reptiles

In the Anthropocene, the ranges of introduced species are expanding, while extinction‐prone species are contracting. Introductions and extinctions are caused by how species respond to human impacts, but it is unknown why the ranges of some species expand and some contract. Here, we test whether this opposite response of human impact is due to introduced and extinction‐prone species falling at opposite ends of geographic, evolutionary, or ecological trait continua. We constructed a database of native range maps, traits, phylogenetic relationships, and the introduction and extinction‐prone status of squamate reptiles with ranges native to the Western Hemisphere. Across > 3000 snake and lizard species (88% of known native squamates), 142 had been introduced elsewhere and 483 were extinction‐prone (i.e. vulnerable, endangered, critically endangered, extinct in the wild, extinct). To explain variation in status, we first tested if the same human‐impacted regions in the Americas contained the native ranges of species of either status. Second, we tested for phylogenetic signal in species status. Finally, we tested the explanatory power of multiple trait continua. The native ranges of introduced and extinction‐prone reptiles were clustered in island regions with high human impact versus mainland regions with lower human impact. Phylogenetic signal was weak for status, but introduced and extinction‐prone species were clustered in different clades. All geographic and ecological traits that explained each status supported the opposite ends hypothesis. Introduced species had larger, edgier ranges, while extinction‐prone species had smaller, simpler ranges. Introduced species were mostly herbivorous/omnivorous, while extinction‐prone species were mostly carnivorous. Introduced species produced larger clutches, while extinction‐prone species had smaller body sizes. In the Anthropocene, the native ranges of introduced and extinction‐prone species are in the same human‐impacted regions where trait continua, having opposite effects, determine whether species ranges expand or contract in the continuing face of global change.

An Index System for the Evaluation of the Effectiveness of Forest Ecological Product Value Realization in China

Forest Ecological Product Value Realization (FEPVR) is an important way for China to promote the transition and development of forestry and realize common prosperity. It is critical to assess the effectiveness of FEPVR rationally to obtain a comprehensive understanding of the progress of ecological civilization. Based on the Driver–Pressure–State–Impact–Response (DPSIR) model, in this study, we developed an evaluation index system for FEPVR effectiveness containing five subsystems and 37 indicators and assessed the effectiveness of FEPVR in China from 2011 to 2022 by using the linear weighted sum method, the coupling degree of coordination model, and Spearman’s correlation analysis. The results showed that the composite index increased from 0.1980 in 2011 to 0.6501 in 2022, with a general upward trend, but there is still great potential for improvement. The main contribution was from the Response subsystem. The year 2017 was an important turning point for FEPVR in China because its development started to speed up; the status of coupling coordination between different subsystems was gradually improving but was still at a low level. The relationship between all indicators was dominated by a non-significant correlation (52.4%), and the overall synergistic effect (27.8%) was greater than the trade-off effect (19.8%). This study provides a new perspective for evaluating the effectiveness of FEPVR and a decision-making reference for clarifying the direction of FEPVR optimization.

Effect of additively manufactured polymeric inserts on impact response of construction safety helmets

Purpose Struck-by accidents (i.e. being hit by a falling object) are a leading cause of traumatic brain injuries in the construction industry. Despite the critical role of hard hats in minimizing such injuries, their overall design has not appreciably changed in decades. Therefore, this study aims to explore the potential benefits of modifying commercially available hard hat designs by incorporating a compliant cantilever and a sacrificial, energy-absorbing structure to enhance their protective capabilities against impacts. Design/methodology/approach This study involved conducting experimental impact tests to obtain the head acceleration attenuation using hard hats with a variety of compliant cantilever lattice insert designs. These lattice inserts were additively manufactured using three polymeric materials, including polylactide (PLA), acrylonitrile butadiene styrene, high-impact polystyrene and three porosity levels. A Hybrid III head/neck assembly was fitted with each hard hat design, and experimental drop tests were conducted using a 1.8-kg steel impactor dropped from 1.83 m. The maximum acceleration and head injury criterion (HIC) values were obtained for each test. Findings Analysis of variance revealed that HIC was significantly reduced for all lattices with 56% porosity (p < 0.023) compared to the control (unmodified) hard hat. The most effective insert was found to be a PLA insert with 56% porosity, which reduced the HIC value by 38% compared to the control (unmodified) hard hat, with a statistically significant p-value of 0.018. Originality/value The data present in this study reveals that simple and inexpensive modifications can be made to existing hard hat designs to reduce injury risk from overhead impacts.

Optimal PLA+ 3D Printing Parameters through Charpy Impact Testing: A Response Surface Methodology

Additive manufacturing (AM) has revolutionized the manufacturing sector, particularly with the advent of 3D printing technology, which allows for the creation of customized, cost-effective, and waste-free products. However, concerns about the strength and reliability of 3D-printed products persist. This study focuses on the impact of three crucial variables—infill density, printing speed, and infill pattern—on the strength of PLA+ 3D-printed products. Our goal is to optimize these parameters to enhance product strength without compromising efficiency. We employed Charpy impact testing and Response Surface Methodology (RSM) to analyze the effects of these variables in combination. Charpy impact testing provides a measure of material toughness, while RSM allows for the optimization of multiple interacting factors. Our experimental design included varying the infill density from low to high values, adjusting printing speeds from 70mm/s to 100mm/s, and using different infill patterns such as cubic and others. Our results show that increasing infill density significantly boosts product strength but also requires more material and longer processing times. Notably, we found that when the infill density exceeds 50%, the printing speed can be increased to 100mm/s without a notable reduction in strength, offering a balance between durability and production efficiency. Additionally, specific infill patterns like cubic provided better strength outcomes compared to others. These findings provide valuable insights for developing stronger and more efficient 3D-printed products using PLA+ materials. By optimizing these parameters, manufacturers can produce high-strength items more efficiently, thereby advancing the capabilities and applications of 3D printing technology in various industries.

Nonlinear similarity characterisation and validation of dynamic response of ship stiffened plate structure under explosion load impacts

The similarity test of ship stiffened plate structures under underwater explosions is a cost-effective and efficient method to evaluate the vitality of ships and guide the design of their shock resistance. This study focuses on the nonlinear impact response model tests of ship stiffened plate structures and their similarity laws with actual ships. The vertical motion of the ship stiffened plate structure is characterized by the Hurst index, and an equivalent relationship between the Hurst index of the model and the prototype is derived from classical similarity law. Based on the Hurst index, a similarity transformation relationship between the strain signals of the model and prototype is established. To verify the conclusions, similarity experiments of underwater explosions were conducted on both the model and the prototype. The original signals were grouped by the natural vibration period to determine the variation of the Hurst index over time. The model experiment strain signals for each natural vibration period were converted and compared with the prototype experiment results to verify the method's effectiveness. Simultaneously, the Hurst index of the stiffened plate structure under explosive shock load and its similarity transformation relationship with the prototype were simulated and analyzed. This provides theoretical and technical support for conducting analogous nonlinear response experiments for ship underwater explosions.

A Parameter-Driven Methodology of Wheel Flat Modeling for Wheel–Rail Impact Dynamics

A wheel flat is a typical wheel defect that significantly impacts the wheel–rail system, posing substantial challenges to vehicle operation safety. In the existing literature, the wheel flat plane model does not account for the contribution of the width direction to the impact response and thus cannot accurately reveal the wheel–rail contact state with a flat. This paper systematically proposes a three-dimensional analytical model that considers multiple worn stages and constructs a spatial complex surface reconstruction model for flats based on NURBS technology. A vehicle–track coupled dynamics model, considering the geometry of the flat, is established to investigate the effects of flat geometry on the wheel–rail impact response and contact relationship in detail. The results show that in the subcritical regime, the wear degree of the flat predominantly affects the impact force, while in the transcritical regime, both the wear degree and velocity together determine the magnitude of the wheel–rail impact force. As the wear degree increases, the moment of wheel lateral jump occurs earlier. The spatial modeling method for flats proposed in this paper offers a novel technical approach for accurately simulating the dynamic behavior of wheel–rail contact when a flat is present.

Experimental and numerical investigation on low-velocity impact damage and parametric study of composite rotor blades

Modern helicopter rotor blades are made of composite materials. Due to the harsh service environment, the blades may be impacted by hail and other falling objects at low velocity. The damage behavior of composite rotor blades subjected to low-velocity impact is studied here. Low-velocity impact experiment is conducted on a composite helicopter rotor blade, and the impact force and the damage are measured. Based on the experiment, a finite element model is developed and validated to predict the impact damage of the blade. With the model, a parametric study is performed to investigate the effects of impact energy, impact locations, and foam core on impact responses of the composite blades. The results show that the rib is the most vulnerable part to damage, associated with severe deformation, and delamination rapid expanding under low-velocity impact. The foam crush region is close to the blade top surface below the impact point. The interface between the skin and internal part is especially sensitive to increase in impact energy. Impacts near the leading edge produce higher impact force, while impacts near the trailing edge cause large deformation and small impact force. Better impact performance will be achieved when modulus and density of the foam are increased.

Experimental and numerical investigations on impact response of reinforced concrete beams with a sandwich panel protective layer

This paper investigates the response of reinforced concrete beams protected by an aluminium foam sandwich panel under impact loadings. A series of impact tests were conducted on one reinforced concrete beam and five beams with a protective layer, focusing on their dynamic responses and failure patterns. Test parameters included the type of protective layers (unprotected, aluminium foam and sandwich panel) and impact energy. Test results showed that the aluminium foam and sandwich panel could effectively protect the reinforced concrete beam from severe damage under impact loadings and converted the failure pattern of beams from shear failure to flexure-shear failure. Compared with the unprotected beam, the beams with a protective layer exhibited a lower peak force and developed a smaller mid-span deformation. Besides, the protective effects of the aluminium foam and sandwich panel were found to be nearly the same. Moreover, the peak force, plateau force and deformation of the beams were increased with the increasing impact energy. A numerical model was developed to investigate the energy distribution of beams with a sandwich panel protective layer. Based on the validated model, the effects of longitudinal reinforcement ratio and shear-span ratio on the impact response of beams were further studied. It was found that the deformation of beams increased significantly with the increasing shear-span ratio, whereas an increase in the longitudinal reinforcement ratio led to a decreased deformation. This study provides an important reference for designing reinforced concrete beams with a sandwich panel protective layer to resist impact loads.

High-speed multi-camera videogrammetric measurement of full-field 3D motion and deformation in full-scale crash testing of typical civil aircraft

Crashworthiness has been and will continue to be the main concern in aircraft design. Crash tests are essential approaches to investigate the crashworthiness of civil aircraft. Videogrammetric methods have been employed in crash tests to overcome the disadvantages of laborious, time-consuming measurement data collection using contact sensors. However, previous methods using a single pair of cameras still face challenges in large-scale applications due to the inherent contradiction between measurement range and accuracy. In this paper, a videogrammetric method using four high-speed cameras is proposed to measure the full-field three-dimensional (3D) dynamic deformation for evaluating the impact response characteristics of the full-scale crash test aircraft. Increasing the number of high-speed cameras not only can enhance the resolution and then measurement accuracy of object, but also expands the measurement range significantly. To ensure the performance of digital image correlation (DIC) used for large-scale measurement range, a speckle pattern optimization design and fabrication method is presented to generate the random speckle with uniform spraying size and density. A global calibration method based on the high-precision total station is proposed to unify the data of different stereovision subsystems. The implementation of the proposed method is illustrated through a 6.0 m/s full-scale crash test using a civil aircraft approximately 24 m in length. The impact velocity, full-field displacement and strain of the fuselage structure are measured. The results show that the test data are complete and reliable. After the vertical crash at 5.71 m/s, the lower structure of the cabin floor is seriously deformed, and the upper structure of the fuselage in the central wing area is obviously deformed due to the inertia effect of the wing. The stiffness difference of the different fuselage segments results in significant differences in dynamic response. The higher the stiffness is, the smaller the deformation. This work may provide some valuable technical insights that could support the crashworthy design, verification, and certification of civil aircraft.