Impact Of Specificity Research Articles

The Performance Impact of Content and Process in Product Innovation Charters

The significance of product innovation charters (PICs) cannot be overemphasized, as they provide understanding and a tool for setting organizational goals, charting strategic direction, and allocating resources for new product portfolios. In a unique way, a PIC represents a sort of mission statement mutation for new products. With the backdrop of strategy formulation and product innovation literatures, this article investigates the impact of both content specificity within PICs and satisfaction with the PIC formulation process on new product performance in North American corporations. A survey was undertaken among executives knowledgeable about their organization's new product development process. The respondents included chief executive officers, vice presidents, directors, and managers. The findings demonstrate that significant differences exist both in PIC content specificity and process satisfaction between highly innovative and low innovative firms. The study also shows that PIC specificity in terms of the factors mission content and strategic directives positively influences new product performance. Further, the study demonstrates that satisfaction with the process of formulating PICs plays a positive and powerful mediating role in the PIC specificity–performance relationship. The results suggest that product innovation charters, like their mission statement cousins, may be of more value than most managers realize. The study shows that achieving a state of organizational satisfaction with a PIC's formulation process is critical for obtaining better new product performance. Directions for future research also are suggested.

Recall of Financial Information for Investment Decisions: The Impact of Encoding Specificity and Mental Imagery

Given the volume of data analyzed in investment decisions, analysts and investors often must rely on their memory of financial information. Prior research suggests that differences in the amount of information used by investors may affect their valuation of securities and market prices. Thus, factors influencing the amount and accuracy of information recalled could impact estimates of stock value and market prices. Financial information is often presented in different formats. This study examines whether differences in format presentation at encoding and retrieval affect the recall of financial data. We also investigate whether memory for financial information can be improved with a simple technique that uses mental imagery to reinstate the original encoding conditions. We find that even a minor change in the presentation format has significant effects on memory for financial information. Our results also suggest that the use of mental imagery to reinstate the original format may significantly improve memory for financial data.

Time Course of Mechanical and Neuromuscular Characteristics of Cyclists and Triathletes during a Fatiguing Exercise

This study examined the impact of sport specificity on the time course of fatigue during maximal voluntary eccentric, concentric and isometric torque production following a submaximal isokinetic fatiguing exercise. Seven cyclists and seven triathletes performed a fatiguing exercise consisting of nine sets of 31 isokinetic concentric knee extensions at 1.05 rad . s (-1). Fatigue was assessed pre-exercise, after three and six sets, and post-exercise. The maximal knee extension torque associated with electromyographic (EMG) activity was recorded during voluntary contractions and electrically induced contractions (single and paired twitches). The maximal voluntary eccentric torque production declined in cyclists (18 +/- 3.5 %, p < 0.05) and was not significantly affected in triathletes (5 +/- 2.5 %, p > 0.05). The decrease in cyclists was associated with an increase in the sum of the normalized EMG (nRMS) values of the three agonist muscles (p < 0.01). Although no significant difference was observed between groups, the two-way repeated-measure analysis of variance revealed a time effect on maximal concentric and isometric torque, twitch contractile and electrophysiological response (M (max)) properties. No modification in the activation and coactivation levels was observed. In conclusion, these results indicate that the time course of fatigue, especially during eccentric contractions, is mediated by sport-specific adaptations likely due to the mode of muscle contraction used in the activity.

Parathyroid Hormone Monitoring during Total Parathyroidectomy for Renal Hyperparathyroidism: Pilot Study of the Impact of Renal Function and Assay Specificity

Commonly used assays for intact parathyroid hormone (iPTH) detect not only the biologically active 84-amino acid hormone [PTH1-84], but cross-react with an N-terminal-truncated fragment. Because iPTH assays often fail to predict success of parathyroidectomy in patients with renal hyperparathyroidism (rHPT), we compared results of a 3rd-generation PTH1-84 assay (Bio-iPTH; Nichols Institute Diagnostics) with two 2nd-generation iPTH assays (from Nichols and Roche Diagnostics) by evaluating the PTH clearance kinetics during surgical treatment. We collected blood samples in short time intervals from 35 consecutive surgical patients with rHPT. Three patients had to be excluded from further calculations; the remainder were grouped according to kidney function and postoperative outcome. All samples were analyzed with the 3 automated PTH assays, which have different specificities. Twenty minutes after removal of the last gland, the PTH1-84 values decreased to within the reference intervals in all patients with total and subtotal resection; however, iPTH concentrations normalized in only one half of these patients. In patients with poor renal function, the half-life of PTH1-84 was shorter than the half-lives obtained with the iPTH assays. The accuracy of PTH monitoring during surgery for rHPT depends on renal function and assay specificity. All assays tested showed similar effectiveness in detecting missed glands, but the assay for PTH1-84 gave more reliable results than the iPTH assays, which overestimated the concentration of PTH and hampered the intrasurgical diagnosis of resection sufficiency.

Growth hormone: Historical notes

A brief review of important contributions to our present knowledge of growth hormone is given. In 1887 it had been noted that a pituitary tumor was present in most patients with acromegaly. Even at the beginning of the 20. Century relationship between growth disorders and the pituitary was contested. From 1908 pituitary surgery became established treatment in GH hypersecretion. In 1922 it was demonstrated that injection of pituitary extract to animals caused excessive growth and soon after the opposite: removal of the pituitary caused growth retardation. A huge number of studies on the effects of GH were subsequently reported as were trials with GH treatment. They were impeded by failure to recognize the impact of species specificity of GH. After this issue was clarified in 1957, treatment with human growth hormone proved effective. In 1985 it was realized that Creutzfeldt-Jakob's disease might be transmitted through human growth hormone. At this time recombinant GH had become available. In 1971 the structure of human GH was established. In the same period both GH releasing and inhibiting hormones were identified and an analogue of somatostatin had evolved into the first effective pharmacological treatment for acromegaly.

Relationship between index term specificity and relevance judgment

Concurrent concepts of specificity are discussed and differentiated from each other to investigate the relationship between index term specificity and users’ relevance judgments. The identified concepts are term-document specificity, hierarchical specificity, statement specificity, and posting specificity. Among them, term-document specificity, which is a relationship between an index term and the document indexed with the term, is regarded as a fruitful research area. In an experiment involving three searches with 175 retrieved documents from 356 matched index terms, the impact of specificity on relevance judgments is analyzed and found to be statistically significant. Implications for index practice and for future research are discussed.

The Interactive Effects of Goal Orientation and Feedback Specificity on Task Performance

This study examined the impact of goal orientation and feedback specificity on performance. Ninety undergraduate management students completed 3 phases of a computerized management decision-making simulation in conditions of low, moderate, or high feedback specificity. Learning orientation interacted with feedback specificity to predict performance in Phase 1, such that feedback specificity had a greater impact on performance for persons low in learning orientation. Performance orientation interacted with feedback specificity to predict performance in Phase 3, such that feedback specificity had a greater impact on performance for persons high in performance orientation.

How to integrate the specificities of some food departments into a retail store organization?

PurposeTo understand the impact of product specificity on organizational practices of retailers at the store level.Design/methodology/approachAn Aokian framework is used that enables one to discriminate between food products according to their informational properties, and to connect these properties with organizational choices of centralization/decentralization.FindingsEmphasizes the existing tension between the dominant “assimilation” organization pattern and the “encapsulation” pattern which fits better in with some specific product departments.Research limitations/implicationsProposals are confronted with empirical data coming from professional press and experts interviews. Further empirical research is needed to consolidate the findings.Practical implicationsThe paper points out the need to differentiate the management of departments according to their product specificity.Originality/valueThe paper stresses the impact of product specificity on department organization. It can be useful for the design of organizational mechanisms: work organization, incentives and career paths.

Goal-Setting Paradoxes? Trade-Offs Between Working Hard and Working Smart: The United States Versus China

This article proposes a model of the impact of goal difficulty and goal specificity on selling behaviors (selling effort, adaptive selling, and sales planning) and hence sales and behavior performance. The model suggests that goal-setting factors may have opposing effects on different sales behaviors. The empirical findings suggest that goal difficulty positively influences selling effort while negatively influencing adaptive selling behaviors. The results show that goal difficulty and goal specificity both have opposite effects on the two dimensions of working smart: adaptive selling and sales planning. The findings support the need for sales managers to account for the cultural context of the salesperson when determining optimal goal-setting strategies. With data collected from salespeople in the United States and China, the cross-cultural differences regarding the effects of goal-setting factors are also proposed and empirically supported.

Multiple Facets of Risk for Violence: The Impact of Judgmental Specificity on Structured Decisions About Violence Risk

Among the many advances that have occurred in the field of violence risk assessment over the past decade has been the realization that violence is multifaceted. Violence and the risk for violence include many facets including the severity, density, imminence, target and nature of violence. Despite advances in the understanding and conceptualization of violence and risk, very few empirical risk assessment studies have considered the multifaceted nature of violence. Using a structured professional judgment model of risk assessment, the present study evaluated whether more highly specific judgments of violence (i.e., low, moderate, or high risk for short-term violence, or serious violence, versus violence generally) could be made with reasonable reliability and incremental validity. The findings suggested that more specific judgments about particular facets of violence were not made with the same reliability and validity as either the numerical scores or the omnibus structured clinical risk ratings for general violence. The possible reasons for the findings are discussed with suggestions for future research to continue to study this important area.

The impact of site specificity and needle manipulation on changes to pain pressure threshold following manual acupuncture: a controlled study

Objectives: To investigate the contribution of two principal features that underlie traditional Chinese acupuncture: site specificity and application of needle manipulation. Design: Thirteen volunteers completed a randomised, dual blind (subject and assessor) repeated measures study involving five interventions. Pressure pain threshold (PPT) was measured with an algometer, before and after intervention at 10 sites (acupoints and nonacupoints) across the body. Interventions: Deep needling, with or without manual needle rotation, applied to the acupoint Large Intestine 4 (LI4) or to a nonacupoint located on the medial side of the second metacarpal. Inactive laser to LI4 was used as a control. All interventions were administered for 21 min. Main outcome measures: Percentage change in PPT from preintervention baseline at the 10 sites during the 18 min immediately following intervention. Results: Statistically significant increases from preintervention PPT means were obtained at all 10 sites following needling of LI4 with manipulation compared with one site after needling LI4 without manipulation. Needling the nonacupoint led to statistically significant increases at six sites when manipulation was present compared with none in the absence of manipulation. No significant changes in mean PPT followed inactive laser. Needling LI4 with manipulation produced mean increases that were statistically significantly greater than those for the other interventions with one exception: needling the nonacupoint with manipulation was as effective as needling LI4 with manipulation at one measurement site only. Conclusions: Both manipulation and site of needling contributed significantly to the elevation of PPT following acupuncture. Distribution of effects on PPT did not support either neural segmental or Traditional Chinese Medicine channel theories. Psychological and physiological nonspecific effects appeared to play a minimal role in changes to PPT.

EEG differences in ADHD-combined type during baseline and cognitive tasks

This study examines the relation between neurologic, behavioral, and performance indicators of attention-deficit–hyperactivity disorder. Twenty-three males age nine to 11 years with attention-deficit–hyperactivity disorder, including symptoms of hyperactivity, and 23 matched controls served as participants. Differences between groups were investigated using referential 19-channel quantitative electroencephalogram, behavioral rating scale data, and continuous performance test data. Results from the behavioral data were consistent with previous research. Behavioral ratings for participants with attention-deficit–hyperactivity disorder were significantly more negative than controls. Control participants performed significantly better on the continuous performance test, with fewer errors, faster reaction times, and less variability in reaction time. Electroencephalogram results indicated differences between participants with attention-deficit–hyperactivity disorder and control participants primarily in the alpha bandpass, with evidence of increased alpha in posterior regions during baseline for the group with attention-deficit–hyperactivity disorder. Additionally, participants with attention-deficit–hyperactivity disorder manifested decreased alpha in left frontal regions when reading. The results are discussed in terms of possible differences in electroencephalographic data as a function of degree of hyperactivity, as well as the impact of task specificity on the electroencephalogram.

The Impact of Vertical Coordination on Ex Post Transaction Costs in Domestic and International Buyer–Seller Relationships

Even though the transaction costs framework has evolved considerably in the past decade, there is still only modest empirical knowledge about the governance performance implications of the theory. This article focuses on the governance performance of vertical coordination in relationships between manufacturing firms. On the basis of transaction cost analysis and related works in international marketing, the authors examine the impact of asset specificity and vertical coordination on ex post transaction costs in domestic and international buyer–seller relationships. In accordance with current literature in international marketing, performance measurement problems are expected to be more evident in international business trade than in domestic business-to-business relationships. The empirical findings show that under conditions with substantial asset specificity, vertical coordination reduces ex post transaction significantly more in international buyer–seller relationships than in domestic channel dyads.

Impact of Antibody Specificity and Calibration Material on the Measure of Agreement between Methods for Cardiac Troponin I

Available assays for cardiac troponin I (cTnI) yield numerically different results. The aim of this study was to compare patient values obtained from four cTnI immunoassays. We studied the Stratus(R) II assay, the Opus(R) II assay, the Access(R) assay, and a research-only cTnI heterogeneous immunoassay that uses the Dade Behring aca(R) plus immunoassay system equipped with two new noncommercial monoclonal antibodies. Because the aca plus cTnI assay is for research only, we first evaluated and analytically validated it for serum and citrated plasma. Initially, each method was calibrated using the method-specific calibrator supplied by each manufacturer; however, the aca plus cTnI assay was calibrated using patient serum pools containing cTnI and selected on the basis of increased creatine kinase MB isoenzyme and with values assigned by use of the Stratus cTnI assay. For method comparisons, individual patient sample cTnI values were determined and compared with the Stratus II assay. Passing and Bablock regression analysis yielded slopes of 1.44 (r = 0.96; n = 72) for the Opus II vs Stratus II assays; 0.07 (r = 0.91; n = 72) for the Access vs Stratus II assays; and 0.90 (r = 0.91, n = 72) for the aca plus vs Stratus II assays. The recalibration of each method with a Stratus II-assigned serum pool improved, but did not entirely eliminate, the slope differences between the different assays (range, 1.00-1.16). The observed scatter in the correlation curves remained. There is a need to further explore the specificities of these assays with respect to the different circulating forms of cTnI.

Quantitative antibody responses to structural (Core) and nonstructural (NS3, NS4, and NS5) hepatitis C virus proteins among seroconverting injecting drug users: impact of epitope variation and relationship to detection of HCV RNA in blood.

To gain insight into the natural history of hepatitis C virus (HCV), 13 human immunodeficiency virus (HIV)-seronegative injecting drug users were studied who seroconverted for HCV as determined by third-generation enzyme-linked immunosorbent assay, showed an ensuing antibody response to HCV, and were not treated with any antiviral drugs during follow-up. Subjects included 13 untreated HIV-negative individuals, of whom 5 (38.5%) apparently cleared HCV and were polymerase chain reaction (PCR)-negative in at least 3 consecutive samples, 3 (23.1%) showed transient viremia and were PCR-negative in 1 sample during the study period, and the other 5 (38.5%) showed persistent viremia. Viremia was determined longitudinally by reverse-transcription PCR (RT-PCR) and quantified by branched DNA (bDNA). HCV genotypes were determined on serial samples during follow-up. Quantitative antibody levels to core, NS3, NS4, and NS5 were determined using the Chiron RIBA HCV-titering Strip Immunoblot Assay, which is based on HCV genotype 1. The antibody responses to core, NS3, NS4, and NS5 were erratic. In individuals infected with HCV genotype 1, significantly higher median antibody responses to core (P =.02) and to NS4 (P =.04) were found as compared with those infected with other genotypes, showing a significant impact of HCV genotype specificity of the assay. In groups infected with HCV genotype 1, significantly higher median NS3 antibody titers (2.61 relative intensity [RI] vs. 0.38 RI; P =.003) were found in the individuals with persistent viremia than in those with apparent resolution of HCV RNA in blood. In groups infected with genotypes other than genotype 1, significantly higher median NS3 antibody titers (0.89 RI vs. 0.03 RI; P =.0004) and NS5 antibody titers (1.86 RI vs. 0.01 RI; P =.006) were found in the individuals with persistent viremia than in those with apparent resolution of HCV RNA in blood. Individuals with viral persistence had higher HCV-RNA loads with higher antibody responses as compared with individuals with apparent viral clearance from blood. Apparent viral clearance from blood was observed in an unexpectedly high percentage (38.5%), associated with a significant decrease of antibodies to NS3, independent of HCV genotype, as compared with individuals with persistent viremia (P <.005). Apparent viral clearance from blood with gradual loss of antibodies to various HCV proteins, independent of HCV genotype, was observed in 4 of the 5 individuals within approximately 1 year after HCV seroconversion, whereas 1 of these individuals apparently cleared the virus from blood, with complete seroreversion.

Quantitative estimates of the impact of sensitivity and specificity in mammographic screening in Germany.

STUDY OBJECTIVE: To estimate quantitatively the impact of the quality of mammographic screening (in terms of sensitivity and specificity) on the effects and costs of nationwide breast cancer screening. DESIGN:...

Does magnetic resonance imaging make a difference for patients with musculoskeletal sarcoma?

MR imaging has had an unparalleled impact on the treatment of patients with musculoskeletal sarcoma. Basically, the high accuracy of local staging has made the introduction of reconstructive and limb salvage procedures instead of amputation of disarticulation available to the majority of patients with musculoskeletal sarcoma. Pre-operative work-up with MRI is not only more accurate, but also much faster and cheaper than the conventional work-up. Staging is the single most important reason for performing MR imaging in patients with musculoskeletal tumours. The impact of MR specificity is less dramatic but the benefit to the patient is an increased safety margin. When diagnostic errors with devastating consequences are made nowadays, it is usually because the proper protocol has not been followed. A patient with a potentially malignant, or equivocal, musculoskeletal mass deserves to have a combined radiographic-MRI examination prior to invasive procedures. MRI does not currently have a major impact on chemotherapy decisions and colour Doppler ultrasound has a higher accuracy than MRI. However, selected cases, i.e. intraosseous tumours, dynamic Gd-enhanced MRI, can replace colour Doppler ultrasound.

Classification of osteoporosis in the elderly is dependent on site-specific analysis.

Vertebral osteoporosis accounts for over 500,000 spinal fractures annually, the majority of which occur in older women. Despite these statistics, data regarding the rate of spinal bone loss in this population are conflicting. Moreover, the site of skeletal evaluation may significantly alter classification of osteoporosis in this age group. To examine trabecular-rich spinal bone loss with a measurement less affected by age-related artifacts than the AP spine, we measured lateral lumbar spine bone density (BMD) using dual-energy X-ray absorptiometry in 120 healthy, ambulatory, community-dwelling women 65 years of age and older (mean 70 +/- 5 years, range 65-88). We also examined cortical-rich sites in the forearm and total body along with AP spine and femoral BMD to assess the impact of site specificity using the World Health Organization (WHO) classification of osteoporosis. Significant losses in BMD were observed at the lateral spine (-1.1%/year, P < 0.01), forearm (-0. 77%/year, P </= 0.01), total hip (-0.75%/year, P </= 0.01), femoral neck (-0.70%/year, P </= 0.05), and trochanter (-0.78%/year, P </= 0. 01), but not the AP spine. Using the WHO criteria, lateral spine BMD determinations classified 66% of women with osteoporosis in contrast to 29% using the AP projection. Osteoporosis was diagnosed in 55% of women using measurements of the femoral neck, 43% using the total radius, and 19% using the total body. We conclude that elderly women lose bone at trabecular- and cortical-rich sites (lateral spine and total radius, respectively) in addition to sustaining significant age-related bone loss at mixed cortical/trabecular sites such as the hip. Classification of osteoporosis in this age group more than doubles using lateral versus AP spinal projections, supporting the necessity of developing more uniform agreement on site-specific analyses.

The impact of goal specificity on strategy use and the acquisition of problem structure

Theories of skill acquisition have made radically different predictions about the role of general problem-solving methods in acquiring rules that promote effective transfer to new problems. Under one view, methods that focus on reaching specific goals, such as means-ends analysis, are assumed to provide the basis for efficient knowledge compilation (Anderson, 1987), whereas under an alternative view such methods are believed to disrupt rule induction (Sweller, 1988). We suggest that the role of general methods in learning varies with both the specificity of the problem solver's goal and the systematicity of the strategies used for testing hypotheses about rules. In the absence of a specific goal people are more likely to use a rule-induction learning strategy, whereas provision of a specific goal fosters use of difference reduction, which tends to be a non-rule-induction strategy. We performed two experiments to investigate the impact of goal specificity and systematicity of rule-induction strategies in learning and transfer within a complex dynamic system. The results of Experiment 1 indicated that during free exploration of a problem space, greater learning occurred if participants adopted more systematic strategies for rule induction, and that participants come to favor such strategies. Experiment 2 revealed that participants who were provided with a specific goal performed well on the initial problem but were impaired on a transfer test using a similar problem with a different goal. Instruction on a systematic rule-induction strategy facilitated solution for both the initial and transfer problems, but participants' use of this strategy declined if they had a specific goal. Our results support Sweller's (1988) proposal that general problemsolving methods applied to a specific goal foster acquisition of knowledge about an isolated solution path but do not provide an effective way of learning the overall structure of a problem space. We interpret these results in terms of dualspace theories of search through problem space.

The Impact of Goal Specificity on Strategy Use and the Acquisition of Problem Structure

Theories of skill acquisition have made radically different predictions about the role of general problem‐solving methods in acquiring rules that promote effective transfer to new problems. Under one view, methods that focus on reaching specific goals, such as means‐ends analysis, are assumed to provide the basis for efficient knowledge compilation (Anderson, 1987), whereas under an alternative view such methods are believed to disrupt rule induction (Sweller, 1988). We suggest that the role of general methods in learning varies with both the specificity of the problem solver's goal and the systematicity of the strategies used for testing hypotheses about rules. In the absence of a specific goal people are more likely to use a rule‐induction learning strategy, whereas provision of a specific goal fosters use of difference reduction, which tends to be a non‐rule‐induction strategy. We performed two experiments to investigate the impact of goal specificity and systematicity of rule‐induction strategies in learning and transfer within a complex dynamic system. The results of Experiment 1 indicated that during free exploration of a problem space, greater learning occurred if participants adopted more systematic strategies for rule induction, and that participants come to favor such strategies. Experiment 2 revealed that participants who were provided with a specific goal performed well on the initial problem but were impaired on a transfer test using a similar problem with a different goal. Instruction on a systematic rule‐induction strategy facilitated solution for both the initial and transfer problems, but participants' use of this strategy declined if they had a specific goal. Our results support Sweller's (1988) proposal that general problemsolving methods applied to a specific goal foster acquisition of knowledge about an isolated solution path but do not provide an effective way of learning the overall structure of a problem space. We interpret these results in terms of dualspace theories of search through problem space.