Objective: To evaluate the outcomes of Central Venous Access (CVAs) performed by junior residents (i.e. first-year residents) using the Subclavian (SC) and Internal Jugular (IJ) approaches. Methods: A comparative study was carried out in a prospective cohort of patients who consecutively underwent SC or IJ CVAs performed by junior residents at our Department of General Surgery. Additionally, we examined the impact of learning curve on the success of the venipunctures. Statistical analyses were developed using conventional nonparametric methods. Results: Overall, success and morbidity rates in our sample were 81% and 18%, respectively. Successful rates did not significantly differ between IJ and SC approaches (80.35% and 81.81%, respectively; p = 0.942), among procedures performed from first to fourth quartile periods (72% vs. 80% vs. 80% vs. 92%, respectively; p = 0.854) or regardless of which junior residents performed it (p = 0.662). Similarly, morbidity rates did not differ significantly according to CVA techniques (17.85% vs. 18.18%; p = 0.825), quartile periods (28% vs. 16% vs. 20% vs. 8%; p = 0.832), or which junior residents performed it (p = 0.743). There were significantly more arterial punctures/ hematoma using the IJ approach (7% vs. 1%, p = 0.024) and catheter malpositions/nonprogression after the SC technique (1% vs. 6%, p = 0.012). Conclusions: There was a different profile of complication rates with no differences between the techniques in term of either successful or early morbidity. Our study suggests that both approaches may be used for surgical training of junior residents in general surgery.