The World Heritage Committee has been meeting to discuss the arrangements of existing World Heritage Sites, and, on 22–26 October, the area from Giza to the Dahshur was included in the list of World Heritage Sites. According to the Egyptian Antiquities Authority (EAA), the groundwater levels at the Pyramids Plateau are too shallow, which threatens the ancient Sphinx and Pyramids in Giza, Egypt. In addition, many geophysical studies have been carried out in the archaeological area of Giza, which prove that the area is facing the risk of a high level of groundwater, specifically threatening the Sphinx. Recent developments in Earth observation have helped in the field of land monitoring such as land use changes, risk observation, and the creation of models for protecting cultural heritage sites. This study aimed to examine the impact of land use changes on on the archaeological sites of the Giza Necropolis area by integrating various data sources including optical satellite imagery and SRTM data during the period of 1965–2019. A historical database of Corona 1965 and Landsat 2009 data was investigated along with the new acquisitions of Sentinel-2 2016 and Sentinel-1 2016 and 2019. In addition, the radar Sentinel-1 SLC data were collected and analyzed for calculating the land subsidence value in the area of interest through two periods between 6–30 July 2016 and 30 July–15 December 2016. Various methods were implemented, including cluster outliers, the Moran index, and spatial autocorrelation to examine the changes in urban masses. Additionally, the relationship between groundwater leakage and land subsidence in the region was investigated. The analysis was carried out using Envi5.3, ArcMap10.6.1, and SNAP6.0 software to extract spatial data from the raw data. The results from our investigation highlighted rapid changes in urban areas between 1965 and 2019. The data obtained and analyzed from optical and radar satellite imagery showed that changes in land use can cause changes in the topographic situation by decreasing the level of groundwater, which adversely affects Egyptian monumental pyramids and the Sphinx. Land use analysis showed that the urban area represented 7.63% of the total area of the study area in 1965, however it reached 32.72% in 2009, approximately half of the total area in 2016, and in 2019, the urban mass area increased to nearly two-thirds of the total area. The annual growth rate between 1965 and 2019 was estimated by nearly 0.642 km2/year. These land-use changes possibly affected the land subsidence value (−0.0138 m), causing the rising groundwater level close to the Sphinx. Using the information obtained from our RS- and GIS-based analysis, mitigation strategies have also been identified to support archaeological area preservation.