ContextDecades of intensifying human activities have led to drastic changes in land use and land cover (LULC) in the Poyang Lake Basin (PLB), resulting in significant changes in landscape pattern and ecosystem service value (ESV), thereby affecting regional sustainability.ObjectivesWe focused on understanding the impact of LULC changes on the landscape pattern and ESV of the PLB and used the Patch-generating Land Use Simulation model (PLUS) to predict LULC changes in 2050.MethodsWe evaluated landscape patterns using landscape metrics and calculated ESV using the ecosystem service equivalent factor method. The Pearson correlation coefficient was used to analyze the correlation between landscape patterns and ESV from 1990 to 2020. Then, we combined the PLUS model and the ecosystem service equivalent factor method to calculate the ESV under multiple scenarios from 2020 to 2050.ResultsFrom 1990 to 2020, the LULC of the PLB changed to varying degrees. The PLB has undergone a rapid process of landscape fragmentation, and the total ESV of the PLB has decreased. The total ESV was positively correlated with the CONTAG index and negatively correlated with the SHDI index. Between 2020 and 2050, the ESV of the PLB is projected to decrease under the NDS (nature development scenario) and EDS (economic development scenario) and increase under the EPS (ecological protection scenario).ConclusionsESV responded to changes in landscape pattern. We recommend that the PLB should increase patch connectivity. Additionally, future development in the PLB should prioritize ecological protection to prevent further declines in ESV.