Event Abstract Back to Event Impact of Hyperuricemia on the Progression of Renal Disease among Patient in a tertiary renal center Mohammad Zulkarnain Bidin1, Christopher T. Lim1, 2*, Anim Md Shah1, 2, Johnson Stanslas1 and Bak Leong Goh2 1 Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia 2 Serdang Hospital, Malaysia Background Chronic Kidney Disease (CKD) is associated with the estimation of 188 million cases of catastrophic health expenditure in the low and middle-income countries, thus seriously affecting a country health and productivity. Studies have reported association of hyperuricemia and other comorbidities with the progression of CKD, but their conclusions often contradict with one another. We analyzed the association between the serum uric acid, etiologies of CKD, co-morbidities, laboratory parameters with the rate of decline in eGFR. Methods This is an ambispective study conducted in the nephrology clinic, Serdang Hospital. A preliminary 100 out of an intended cohort of 400 patients that were referred to nephrology were followed up for a minimum of 6 months from 2007 until June 2018. Data was collected via proforma sheet and extracted from the Hospital eHIS system. This research is registered with NMRR (NMRR-18-866-41231). The Kaplan-Meier survival curve were used to analyze the renal outcomes, namely the decrease of 50% rate of eGFR decline, doubling serum creatinine and need for renal replacement therapy (RRT) with regards to the effects of hyperuricemia. Cox regression model was used to assess the influence of hyperuricemia, age, gender, weight, height, smoking and laboratory parameters on the renal outcomes. A P-value < 0.05 was considered as significant. Results There is no association of renal outcome (decline in eGFR (p = 0.427), doubling serum creatinine (p = 0.117), RRT initiation (p = 0.332) with the presence of hyperuricemia. Moreover, multivariate cox regression analysis did not show any significant association with the renal outcome (50% reduction in GFR (p= 0.855, HR: 1.073), doubling serum creatinine (p= 0.095, HR: 0.354), and initiation of RRT (p= 0.087, HR: 0.548) with hyperuricemia. Conclusion Hyperuricemia is not associated with worsening of renal function in our interim analysis. A larger cohort study which is on-going will be able to provide more information on the relationship of uric acid with renal function. Keywords: Hyperuricemia, CKD, EGFR, serum creatinine., RRT - renal replacement therapy Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Poster Presentation Topic: Miscellaneous Citation: Bidin M, Lim CT, Md Shah A, Stanslas J and Goh B (2019). Impact of Hyperuricemia on the Progression of Renal Disease among Patient in a tertiary renal center. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2019.63.00022 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Sep 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Christopher T Lim, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia, drchrislim@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mohammad Zulkarnain Bidin Christopher T Lim Anim Md Shah Johnson Stanslas Bak Leong Goh Google Mohammad Zulkarnain Bidin Christopher T Lim Anim Md Shah Johnson Stanslas Bak Leong Goh Google Scholar Mohammad Zulkarnain Bidin Christopher T Lim Anim Md Shah Johnson Stanslas Bak Leong Goh PubMed Mohammad Zulkarnain Bidin Christopher T Lim Anim Md Shah Johnson Stanslas Bak Leong Goh Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.