Fatigue Impact Research Articles

Navigating the digital divide: the impact of social media fatigue on work-life balance

In today's interconnected world, social media has transformed the way we communicate, share information, and interact with others. However, alongside the benefits of social media usage come challenges that can affect individuals' work-life balance. With the pervasive integration of social media into everyday life, individuals increasingly face challenges in managing their online presence alongside their professional and personal responsibilities. Social media fatigue, characterized by feelings of exhaustion, overwhelm, and disengagement resulting from excessive use of social media, has emerged as a significant concern. Drawing upon existing literature and empirical studies, this article delves into the mechanisms through which social media fatigue influences work-life balance and provides insights into potential coping strategies. By critically analyzing the various dimensions of this phenomenon, this paper aims to contribute to a deeper understanding of the complexities involved and offers recommendations for individuals, organizations, and policymakers.

The effects of mental fatigue on explicit and implicit contributions to visuomotor adaptation.

The goal of the current research was to establish the impact of mental fatigue on the contributions of explicit (i.e., conscious strategy) and implicit (unconscious) processes to visuomotor adaptation. Participants were divided into two groups, a Mental Fatigue (MF) group who completed a cognitively demanding 32-minute time load dual back task (TLDB), and a Control group who watched a documentary for a similar length of time. Following the TLDB task or documentary watching, participants trained to reach with a visuomotor distortion, such that cursor feedback was rotated 40º clockwise relative to hand motion. Explicit and implicit contributions to visuomotor adaptation were assessed following 3 blocks of 45 rotated reach training trials and again following a 20-minute rest. Levels of mental fatigue, as indicated on a self-report scale, increased significantly for the MF group following the TLDB task. The Control group did not display a similar increase in mental fatigue following the documentary watching. Results then revealed a decrease in visuomotor adaptation early in training for the MF group compared to the Control group, as well as decreased retention of visuomotor adaptation immediately following the 20-minute rest. Furthermore, correlational analyses revealed that greater levels of mental fatigue reported by participants in the MF group were associated with less explicit adaptation and greater implicit adaptation. Similar trends were not observed for the Control group. Taken together, the decreased visuomotor adaptation observed early in training, as well as the moderate correlation between increased mental fatigue and decreased explicit adaptation, suggest that mental fatigue decreases one's ability to engage in explicit processing, limiting the overall extent of initial visuomotor adaptation achieved.

Unravelling the Impact of Psychological Burnout and Compassion Fatigue on Turnover Intentions among Nursing Staff in Egypt's Governmental Sector: A Mediation Study

Unravelling the Impact of Psychological Burnout and Compassion Fatigue on Turnover Intentions among Nursing Staff in Egypt's Governmental Sector: A Mediation Study

Correlation between postural stability and fall risk in trans-femoral amputees due to muscle fatigue.

[Purpose] This study aimed to establish a connection between postural stability and falling in individuals with transfemoral amputation (TFA), particularly with muscle fatigue. [Participants and Methods] Fourteen participants were recruited. Muscle fatigue was induced using a sit-to-stand (STS) fatigue protocol. Pre-fatigue and post-fatigue assessments were conducted using the Biodex Balance System (BBS). [Result] The findings of the study revealed significant increases in the postural stability index between the pre-fatigue and post-fatigue conditions for the TFA group, particularly in the overall stability index (OSI) and anterior-posterior stability index (APSI) components. The mean postural stability index scores for the TFA group exhibited a percentage increase of 65.2% for OSI, 52.7% for APSI, and 50% for medial-lateral stability index (MLSI). Furthermore, the TFA fall risk index surged by 61.4%. Regarding the relationships observed, a significant correlation emerged between fall risk and both OSI and APSI. [Conclusion] These findings underscore the impact of muscle fatigue on postural stability and an increase in fall risk among TFA. By mitigating the effects of muscle fatigue, therapists can play an important role in reducing the risk of falls and promoting better postural stability in this population.

Voyage of Stress: Assessing the Impact of Fatigue and Work Conditions on Indian Merchant Navy Officers.

The maritime industry, a cornerstone of global trade, relies on the dedicated efforts of seafarers who often work in challenging and physically demanding conditions. As a vital component of the shipping sector, Indian seafarers are no exception, facing the rigors of extended periods at sea and the relentless demands of maritime duties. The physical aspects of their work environment, such as noise, vibration, long working hours and prevalence of fatigue, can extremely influence their well-being and stress levels. Within this context, studying the impact of physical factors, specifically fatigue and physical work environment, on the stress levels of Indian seafarers emerges as a matter of critical significance. This study aimed to explore the complex relationship between the physical factors and the stress experienced by Indian seafarers. Employing a descriptive research design, data were collected from 395 Indian merchant navy officers. For data analysis SPSS and SEM were used. The findings of the study revealed a significant relationship between physical factors (fatigue, physical work environment) and stress of Indian Merchant Navy officers.

Mental Fatigue in Parkinson's Disease: Systematic Review and Evaluation of Self-Reported Fatigue Scales.

Fatigue is a common and debilitating symptom affecting a significant proportion of individuals with Parkinson's disease (PD), often overshadowing even motor symptoms in its impact on quality of life. The accurate definition and assessment of mental fatigue in PD is crucial for both clinical management and research, yet it remains a challenge due to the subjective nature of the symptom and the heterogeneity of assessment scales. This systematic review examined the existing measures of self-reported mental fatigue in PD by searching through PubMed, Embase, and Scopus databases using specific keywords from 2001 to 2024. Out of the 4182 articles found, 40 met the inclusion criteria, and 14 different scales were identified to measure self-reported fatigue in PD patients. However, most of these scales lack a consistent definition of fatigue, indicating a need for validated combinations of unidimensional and multidimensional scales to accurately assess mental fatigue in PD. The review found that it is best to use Fatigue Severity Inventory (FSI) and Multidimensional Fatigue Inventory (MdFI) to screen for severity of PD mental fatigue and Neuro-QoL Item Bank v1.0 (Neuro-QoL) to evaluate its impact on patients' lives. Furthermore, multidimensional scales Parkinson's Disease Questionnaire (PDQ) and Functional Assessment of Chronic Illness Therapy-Fatigue Scale (FACIT-F) are frequently coupled with Fatigue Severity Scale (FSS), Parkinson's Fatigue Scale (PFS), and/or Modified Fatigue Impact Scale (MFIS) due to their short length and holistic coverage of variables in patients' quality of life. Combining fatigue scales can be used for screening and scoring methods. The review also recommends validating fatigue scales translation and combining them with biomarkers to improve the accuracy and effectiveness of fatigue assessment in clinical practice. Future research should analyze correlations between fatigue scales, expand language types, and explore the link between fatigue scales and the pathophysiological basis of PD. Our findings underscore the need for a standardized approach to the measurement of fatigue in PD and set the stage for future research to consolidate assessment tools that can reliably guide treatment strategies and improve patient outcomes.

Head and Neck Paraganglioma (HNPGL) Registry: A study protocol for prospective data collection in patients with Head and Neck Paragangliomas.

There is a lack of comprehensive and uniform data on head and neck paragangliomas (HNPGLs), and research is challenging due to its rarity and the involvement of multiple medical specialties. To improve current research data collection, we initiated the Head and Neck Paraganglioma Registry (HNPGL Registry). The aim of the HNPGL Registry is to a) collect extensive data on all HNPGL patients through a predefined protocol, b) give insight in the long term outcomes using patient reported outcome measures (PROMs), c) create uniformity in the diagnostic and clinical management of these conditions, and thereby d) help provide content for future (randomized) research. The HNPGL Registry is designed as a prospective longitudinal observational registry for data collection on HNPGL patients and carriers of (likely) pathogenic variants causative of HNPGLs. All patients, regardless of the received treatment modality, can be included in the registry after informed consent is obtained. All relevant data regarding the initial presentation, diagnostics, treatment, and follow-up will be collected prospectively in an electronic case report form. In addition a survey containing the EuroQol 5D-5L (EQ-5D-5L), European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), Modified Fatigue Impact Scale (MFIS), Short QUestionnaire to Assess Health-enhancing physical activity (SQUASH), Cancer Worry Scale (CWS) and Hospital Anxiety and Depression Scale (HADS) will be sent periodically. The registry protocol was approved by the Medical Ethical Review Board of the University Medical Center Utrecht. The HNPGL Registry data will be used to further establish the optimal management for HNPGL patients and lay the foundation for guideline recommendations and the outline of future research.

Usefulness of the MFIS-K, FSS, and FACIT-F Fatigue Scales in Korean Patients With MS, NMOSD, and MOGAD.

Fatigue is common in demyelinating disorders of the central nervous system (CNS), including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). We aimed to validate the usefulness of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and the Fatigue Severity Scale (FSS) relative to the Korean version of the Modified Fatigue Impact Scale (MFIS-K) in Korean patients with MS, NMOSD, and MOGAD. There were 294 patients with MS (n=120), NMOSD (n=103), or MOGAD (n=71) enrolled in a prospective demyelinating CNS registry. Fatigue was measured using the FACIT-F, MFIS-K, and FSS. Sleep quality, quality of life, depression, and pain were evaluated using the Pittsburgh Sleep Quality Index (PSQI), 36-item Short-Form Survey (SF-36), and Beck Depression Inventory-II (BDI-II). The MFIS-K, FACIT-F, and FSS scores showed high internal consistencies and strong correlations with each other in the MS, NMOSD, and MOGAD groups. The scores on all three fatigue scales were correlated with PSQI, SF-36, and BDI-II results in the three groups. The areas under the receiver operating characteristic curves for the FSS and FACIT-F were 0.834 and 0.835, respectively, for MS, 0.877 and 0.833 for NMOSD, and 0.925 and 0.883 for MOGAD. These results suggest that the MFIS-K, FSS, and FACIT-F are useful and valuable assessment instruments for evaluating fatigue in Korean patients with MS, NMOSD, and MOGAD.

Amantadine and/or transcranial magnetic stimulation for fatigue associated with multiple sclerosis (FETEM): study protocol for a phase 3 randomised, double-blind, cross-over, controlled clinical trial

IntroductionFatigue is one of the most disabling symptoms of multiple sclerosis (MS), and effective treatments are lacking. Amantadine is one of the most used treatments, although its efficacy is under...

Rapid Recovery with Physiotherapy in An Adult with Surgically managed Torticollis and Associated Cervical Myelopathy

Torticollis which is a relatively temporary condition rarely seen till adulthood. However, if untreated during childhood may develop complications later which may include musculoskeletal or neurological structures around neck. It may range from contracture of soft tissue to involvement of neural structures. However neurological complications are rare and may require surgical correction. Case description: Here, a 16-year-old male patient who reported physiotherapy department with chief complaint of difficulty in movement of bilateral upper and lower limb difficulty in standing and difficulty in walking independently and breathlessness on exertional activity. Result: After 2 months of physiotherapy treatment berg balance scale score improved from 20/56 to 51/56, dynamic gait index score improved from 10/24 to 15/24, Modified fatigue impact scale score improved from 51/84 to 12/84. Conclusion: Neurological complication of Torticollis in a 16-year-old patient could be reversed partially resulting in functional improvement, with surgery and appropriate Physiotherapy treatment.

Effect of pilates training on balance, muscular endurance, fatigue, and quality of life among women with multiple sclerosis

Purpose. This research aimed to investigate the effect of eight weeks of Pilates exercises on balance, muscle endurance, fatigue, and quality of life of women with MS.
 Material and methods. In this research, which is of applied type and with a pre-test-post-test design with a control group, 40 women aged 25 to 50 with multiple sclerosis living in Alborz province were selected by random sampling. Sampling was done purposefully and available, and the samples were randomly divided into two experimental (20 people) and control (20 people) groups. The research exercise program was performed three days a week (one hour per session) and gradually increased from one hour to 90 minutes per session over 8 weeks. Fatigue was measured with the Fatigue Impact Scale (FIS), balance with the Berg Balance Test (BBS), general endurance with the 6-minute walk test (6MWT), the endurance of the core muscles of the body with the sit-up test, and quality of life with the Multiple Sclerosis Quality of Life (MSQOL)-54 Instrument.
 Results. In relation to the variables of balance and fatigue, the results of the analysis showed that Pilates exercises had a positive effect on the fatigue of the subjects in the experimental group and caused a significant reduction in their fatigue (P=0.000). Nevertheless, the data related to muscle endurance in the corezone (P=0.723) did not show a significant effect and regarding general endurance, it showed a significant effect (P=0.010). Also, in the variable of quality of life, the datashowed that Pilates exercises had a significant effect on both physical and mental dimensions of quality of life (P=0.000 and P=0.042).
 Conclusion. Overall, the research findings indicate that Pilates exercises have a significant effect on the fatigue and balance of women with multiple sclerosis, but to ensure the effectiveness of these exercises on endurance and quality of life, more studies are needed.

Risk Factors and Prevention of Needlestick Instruments in the Medical Field: Systematic Review

Introduction: Needlestick and sharp object injuries represent a significant occupational hazard faced by healthcare workers worldwide. A systematic review focusing on needlestick and sharp object injuries among healthcare workers is essential due to the heterogeneous nature of existing research. The aim of this systematic review is to comprehensively synthesize existing literature to provide a comprehensive understanding of the prevalence, risk factors, and prevention strategies related to needlestick and sharp object injuries among healthcare workers. Methods: This thorough examination adheres to PRISMA principles and implements a pre-planned research plan to promote transparency and minimize partiality. It encompasses investigations involving medical personnel (such as nurses and physicians) centered on puncture wounds and sharp instrument mishaps, exploring contributing factors, occurrence rate, aftermaths, and preventative measures. A thorough exploration is conducted through various databases, with two separate evaluators examining and evaluating the studies. Suitable studies encompass both observational and intervention-based studies without constraints on publication dates. Information is extracted using a standardized format, and ethical clearance is not required as the review solely relies on already published data. Results: In our systematic review, we initially identified 1,523 articles through a database search, which underwent a stepwise screening process, resulting in 198 articles after assessing titles and abstracts. Subsequently, these 198 articles underwent a rigorous full-text evaluation. After this thorough assessment, 14 studies were included that met our predefined eligibility criteria. Our synthesis of the observational studies revealed recurring risk factors for needlestick and sharp object injuries among healthcare workers, including inadequate training, the impact of fatigue and extended working hours, and insufficient personal protective equipment (PPE). Additional factors like job category, experience level, and compliance with safety protocols were also highlighted in specific studies. Conclusions: This systematic review highlights the importance of standardized approaches to enhance healthcare worker safety, particularly in addressing risk factors like inadequate training, fatigue, and inadequate personal protective equipment (PPE). The effectiveness of prevention strategies, as demonstrated in our meta-analysis, underscores the value of comprehensive programs in reducing injury rates, emphasizing the need for more standardized and multifaceted safety measures across healthcare settings.

Impact of Users’ Comprehension of the Privacy Policy of FemTech Apps on their Information Disclosure Intentions: The Mediating Effects of Privacy Fatigue and Privacy Data Control

FemTech stands for female technology, which encompasses a wide range of software, products, and services designed to improve women's health through technology. Personal data used in this type of app are intimate, which highlights the importance of privacy, and therefore, comprehensibility of the privacy policies of such apps. This study explores the effect of user comprehension of privacy policies on their information disclosure intention through mediators such as privacy fatigue and privacy data control, which have rarely been studied. A scenario-based questionnaire was used to collect data from 236 females and SMART PLS 4.0 was used to conduct the analysis. Findings indicate that both mediators have an indirect-only mediation effect; however, the direction of the impact of privacy fatigue on disclosure intention was opposite to what was hypothesised. Privacy data control was found to be the stronger mediator. This study entails implications for privacy policymakers and mobile health application providers.

“A sprained ankle is the biggest sign of mental fatigue”: A qualitative study of the perceptions and experiences of mental fatigue in professional ballet

Mental fatigue is known to influence endurance, skill, and tactical performance in sport. Research investigating the impact of mental fatigue on tasks that combine physical, cognitive, and aesthetic performance such as professional ballet does not exist. Objective: To understand the perceptions and experiences of mental fatigue in professional ballet. Design: Qualitative, focus groups and semi-structured interviews. Setting: The Australian Ballet. Participants: Thirty-nine professional ballet dancers (53% of the company) and six dance staff members aged 18 years or above (53% female). Main outcome measures: N/a. Results: The average focus group and interview length was 48 ± 7 min and 41 ± 8 min. Key categories were; (1) Dancers and dance staff perceive that new learning contributes to mental fatigue, (2) Dancers perceive changes to their mood and perception of effort when they are mentally fatigued, and (3) Dancers and dance staff perceive that mental fatigue negatively affects their physical and cognitive performance and, increases their risk of injury. Conclusion: This is the first study where participants associated mental fatigue with injury risk and provides a springboard to measure the impact of mental fatigue on learning, injury, and performance in professional ballet.

Impact of mother's care burden, fatigue and child's functional level on quality of life in spastic cerebral palsy.

Cerebral palsy (CP) may be considered one of the most common motor disabilities that require a lot of caregiving from mothers or caregivers; therefore, the mothers of children with CP face a lot of difficulties in their caregiving, which in turn may affect the child's quality of life (QOL). This work was conducted to evaluate the impact of the children's functional level in different types of spastic CP, mothers' care burden (CB), and fatigue on the child's QOL. One hundred thirty-eight children with different types of spastic CP (unilateral and bilateral) with different levels of the gross motor function classification system (GMFCS), with an age range of 6-12years, and their mothers with ages ranged from 25 to 45years, participated in this study. Mother CB, fatigue, and child QOL were measured and compared between different groups by using the Zarit burden Interview (ZBI), Chalder Fatigue Questionnaire (CFQ), and Pediatric Quality of Life Inventory (PedsQL) CP Module, respectively. There were significant differences in all measured variables (ZBI, CFQ, GMFCS, and PedsQL) with p-value <0.001 among the different spastic groups (unilateral and bilateral CP). However, the results revealed a positive impact of the child's GMFCS, mother's CB, and fatigue level on the quality of the child's life, with a greater effect on those with quadriplegic type. The mother's CB and fatigue should be considered in the rehabilitation of spastic CP children based on their GMFCS, as they have a negative impact on child QOL; therefore, helping the mother with her needs should not be ignored, especially in families with severely spastic CP children and low financial income.

The Effects of Selective Serotonin Reuptake Inhibitors on Neurological and Depressive Symptoms in Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Multiple sclerosis (MS) affects the central nervous system and creates plaques by demyelination of neurons. Several studies have investigated the effect of selective serotonin reuptake inhibitors (SSRIs) on MS clinical courses. The current meta-analysis was conducted to determine the effect of SSRIs on neurological and depressive symptoms of MS disease based on a systematic review and meta-analysis of randomized controlled trials. We searched the PubMed/Medline, Scopus, EMBASE, Google scholar, Web of Science, and Cochrane Library until June 2023. The effects of SSRI were assessed through indictors such as symbol digit modalities test (SDMT), expanded disability status scale (EDSS), modified fatigue impact scale (MFIS), and Beck's depression inventory/psychiatric (BDI). Considering the inclusion criteria, seven articles (including eight trials) were included in this review. The meta-analysis results demonstrated that SSRIs treatments did not have significant effects on indicators of neurological and depressive symptoms, such as SDMT (Weighted Mean Difference (WMD)=-0.87; 95% CI, -7.74, 5.99, P=0.35; I2=0.0%), EDSS (WMD=-0.05; 95% CI, -0.24, 0.14, P=0.62; I2=0.0%), MFIS (WMD=5.29; 95% CI, -18.10, 28.68, P=0.21; I2=0.0%), and BDI (WMD=-0.47; 95% CI, -2.61, 1.67, P=0.67; I2=32.05%) in patients with MS compared with controls. This study shows that the consumption of SSRIs in MS patients compared to the control group does not bring about a significant change in the indices related to neurological and depressive symptoms. Further meta-analyses are required in order to provide stronger evidence in the future.

Psychometric properties of an Arabic translation of the chronic pain acceptance questionnaire (CPAQ) in a sample of patients with chronic pain

Purpose Chronic pain (CP) acceptance is a major factor in determining the well-being of patients with chronic pain. The chronic pain acceptance questionnaire (CPAQ) was translated and validated into Arabic (CPAQ-Ar). Methods 244 patients with CP completed the CPAQ-Ar, the Beck Depression Inventory-II (BDI-II), the short form health survey (SF-36), the Pain Catastrophizing Scale (PCS), the Pittsburgh Sleep Quality Index (PSQI), the Modified Fatigue Impact Scale (MFIS), and the Depression Anxiety Stress Scale 21 (DASS-21). 110 patients completed the CPAQ-Ar twice separated by two weeks to investigate test-retest reliability. Results Cronbach’s α was 0.902 while the intraclass correlation coefficient (ICC) was 0.917. The standard error measurement (SEM) was seven points while the minimal detectable change with 95% confidence interval (MDC95) was seventeen points. The CPAQ-Ar showed moderate to high correlations with the PCS, the BDI-II, the SF-36, the MFIS, the PSQI, and the DASS-21 indicating a good concurrent validity. Exploratory factor analysis confirmed that the CPAQ-Ar consists of two subscales. Better pain acceptance associated with male gender, older people, employed participants, low pain intensity, and single pain site. Conclusions The CPAQ-Ar is a valid and reliable tool for the measurement of pain acceptance in Arabic speaking patients with CP.

The impact of lockdown, fatigue, and social interaction on highway demand during the COVID-19 pandemic: The case of Santiago, Chile

The COVID-19 pandemic, as well as the government measures to curb its spread, have significantly affected mobility. Various studies have investigated behavioral changes across different transport modes accounting for sociodemographic variables, yet the focus has predominantly been on public transportation. This article addresses this gap by quantifying the impact of mobility restrictions on an urban highway in Santiago, Chile. To do so, we develop several econometric models based on panel data, which enable us to assess control measures’ effects while accounting for their spatial heterogeneity. Our computational experiments demonstrate that traffic reductions were more significant among higher-income drivers (1% reduction per each 100,000 pesos increase). Conversely, municipalities with a higher proportion of elderly residents saw less drastic decreases in traffic. Regarding the effectiveness of control measures, we confirm that the lockdown is affected by fatigue and social interaction. The fatigue implies that users do not fulfill the lockdown as time passes, reducing the effect of quarantines by about 50% during October, 2020. The social interaction effect suggests the lockdown is less effective when not all city’s municipalities are restricted to travel, which might be an argument against dynamic or partial lockdowns.

Clinical and radiological correlates of apathy in multiple sclerosis

Background: Although apathy has been associated with fronto-striatal dysfunction in several neurological disorders, its clinical and magnetic resonance imaging (MRI) correlates have been poorly investigated in people with multiple sclerosis (PwMS). Objectives: To evaluate clinical variables and investigate microstructural integrity of fronto-striatal grey matter (GM) and white matter (WM) structures using diffusion tensor imaging (DTI). Methods: A total of 123 PwMS (age: 40.25 ± 11.5; female: 60.9%; relapsing–remitting multiple sclerosis: 75.6%) were prospectively enrolled and underwent neurological and neuropsychological evaluation, including Expanded Disability Status Scale (EDSS), Apathy Evaluation Scale (AES-S), Hospital Anxiety and Depression Scale (HADS), Modified Fatigue Impact Scale (MFIS) and brain 3T-MRI volumes of whole brain, frontal/prefrontal cortex (PFC) and subcortical regions were calculated. DTI-derived metrics were evaluated in the same GM regions and in connecting WM tracts. Results: Apathetic PwMS (32.5%) showed lower education levels, higher HADS, MFIS scores and WM lesions volume than nonapathetic PwMS. Significant differences in DTI metrics were found in middle frontal, anterior cingulate and superior frontal PFC subregions and in caudate nuclei. Significant alterations were found in the right cingulum and left striatal-frontorbital tracts. Conclusions: Apathy in PwMS is associated with higher levels of physical disability, depression, anxiety and fatigue together with lower educational backgrounds. Microstructural damage within frontal cortex, caudate and fronto-striatal WM bundles is a significant pathological substrate of apathy in multiple sclerosis (MS).

Understanding Predictors of Fatigue Over Time in Persons With Inflammatory Bowel Disease: The Importance of Depressive and Anxiety Symptoms.

Fatigue is a complex and frequent symptom in persons with inflammatory bowel disease (IBD), with detrimental impact. We aimed to determine predictors of fatigue over time. Two hundred forty-seven adults with IBD participated in a prospective study conducted in Manitoba, Canada, providing data at baseline and annually for 3 years. Participants reported fatigue impact (Daily Fatigue Impact Scale [DFIS]), depression and anxiety symptoms (Hospital Anxiety and Depression Scale [HADS]), and pain (Pain Effects Scale [PES]). Physician-diagnosed comorbidities, IBD characteristics, and physical and cognitive functioning were also assessed. We tested factors associated with fatigue using multivariable generalized linear models that estimated within-person and between-person effects. Most participants were women (63.2%), White (85.4%), and had Crohn's disease (62%). At baseline, 27.9% reported moderate-severe fatigue impact, 16.7% had clinically elevated anxiety (HADS-A ≥11), and 6.5% had clinically elevated depression (HADS-D ≥11). Overall fatigue burden was stable over time, although approximately half the participants showed improved or worsening fatigue impact between annual visits during the study. On multivariable analysis, participants with a one-point higher HADS-D score had, on average, a 0.63-point higher DFIS score, whereas participants with a one-point higher PES score had a 0.78-point higher DFIS score. Within individuals, a one-point increase in HADS-D scores was associated with 0.61-point higher DFIS scores, in HADS-A scores with 0.23-point higher DFIS scores, and in PES scores with 0.38-point higher DFIS scores. No other variables predicted fatigue. Anxiety, depression, and pain predicted fatigue impact over time in IBD, suggesting that targeting psychological factors and pain for intervention may lessen fatigue burden.