Cognitive Impact Research Articles

Supervising the self-driving car: Situation awareness and fatigue during highly automated driving

Vehicle automation promises to reduce the demands of the driving task, making driving less fatiguing, more convenient, and safer. Nevertheless, Level 3 automated vehicles rely on a human driver to be ready to resume control, requiring the driver to reconstruct situation awareness (SA) and resume the driving task.Understanding the interaction between non-driving-related task (NDRT) use, SA, and takeover capacity is important because an effective takeover is entirely dependent on, and scaffolds from, effectively reconstructed SA. While a number of studies have looked at the behavioural impact of being ‘in- or on-the-loop’, fewer consider the cognitive impact, particularly the consequences for SA.The present study exposed participants to an extended simulated automated drive involving two critical takeover scenarios (early- and late-drive). We compared automated vehicle (AV) operators who were required to passively monitor the vehicle to those engaging with self-selected NDRTs. Monitoring operators demonstrated lower total- and schema-specific SA count scores following a fatiguing drive compared to those engaging with self-selected NDRTs. NDRT engagement resulted in no significant difference in SA count scores early- and late-drive. Assessment of differences in the type and sensory modality of NDRTs indicated operators make fundamentally different selections about the NDRTs they engage with in an automated driving environment compared to a manual environment.The present study provides further evidence linking SA and AV operator behaviour and underscores the need to understand the role of SA in takeover capacity. Our findings suggest that although SA declines over time regardless of driving task requirements (Monitoring versus NDRT engagement), NDRT use may facilitate better SA construction, with implications for the regulation of NDRT use in AVs as the technology progresses.

Language Skills' Acquisition on the Reading Comprehension and Performance in English Core Subject of Senior High School (TVL) Students in Modular Modality of Learning: Basis for Curriculum Intervention

English as a subject in the Senior High School Curriculum has always been the center for assessment and evaluation activities to measure its cognitive and academic impact to the students. Like many other language researches done in the past, this paper aims to investigate the reading comprehension and academic performance of Senior High students in English Core Subject such as the Reading and Writing. Further, it investigates the level of Language Skills Acquisition using the theory established by DeKeyser in 2007. The respondents of this study are the students of Technical-Vocational and Livelihood Strand or TVL. The data gathered were interpreted through statistical methods in order to explain the relationships and differences of these factors in the learning process of the students during the advent of Covid-19 pandemic.

Impact of cognitive capacity on physical performance in chronic obstructive pulmonary disease patients: A scoping review.

Background: Chronic obstructive pulmonary disease (COPD) is often accompanied by impaired cognitive and physical function. However, the role of cognitive function on motor control and purposeful movement is not well studied. The aim of the review was to determine the impact of cognition on physical performance in COPD. Methods: Scoping review methods were performed including searches of the databases: MEDLINE, EMBASE, Cochrane Systematic Reviews, Cochrane (CENTRAL), APA PsycINFO, and CINAHL. Two reviewers independently assessed articles for inclusion, data abstraction, and quality assessment. Results: Of 11,252 identified articles, 44 met the inclusion criteria. The review included 5743 individuals with COPD (68% male) with the forced expiratory volume in one second range of 24-69% predicted. Cognitive scores correlated with strength, balance, and hand dexterity, while 6-min walk distance (n = 9) was usually similar among COPD patients with and without cognitive impairment. In 2 reports, regression analyses showed that delayed recall and the trail making test were associated with balance and handgrip strength, respectively. Dual task studies (n = 5) reported impaired balance or gait in COPD patients compared to healthy adults. Cognitive or physical Interventions (n = 20) showed variable improvements in cognition and exercise capacity. Conclusions: Cognition in COPD appears to be more related to balance, hand, and dual task function, than exercise capacity.

Neurocognitive test performance following cancer among middle-aged and older adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and the SOL-Investigation of Neurocognitive Aging Ancillary Study.

Cancer patients and survivors often experience acute cognitive impairments; however, the long-term cognitive impact remains unclear particularly among Hispanics/Latinos. We examined the association between cancer history and neurocognitive test performance among middle-aged and older Hispanic/Latinos. Participants included 9639 Hispanic/Latino adults from the community-based and prospective Hispanic Community Health Study/Study of Latinos. At baseline (2008-2011; V1), participants self-reported their cancer history. At V1 and again at a 7-year follow-up (2015-2018; V2), trained technicians administered neurocognitive tests including the Brief-Spanish English Verbal Learning Test (B-SEVLT), Word Fluency Test (WF), and Digit Symbol Substitution Test (DSS). We used survey linear regression to estimate the overall, sex-specific, and cancer site-specific [i.e., cervix, breast, uterus, and prostate] adjusted associations between cancer history and neurocognitive test performance at V1 and changes from V1 to V2. At V1, a history of cancer (6.4%) versus no history of cancer (93.6%) was associated with higher WF scores (β = 0.14, SE = 0.06; p = 0.03) and global cognition (β = 0.09, SE = 0.04; p = 0.04). Among women, a history of cervical cancer predicted decreases in SEVLT-Recall scores (β = -0.31, SE = 0.13; p = 0.02) from V1 to V2, and among men, a history of prostate cancer was associated with higher V1 WF scores (β = 0.29, SE = 0.12; p = 0.02) and predicted increases in SEVLT-Sum (β = 0.46, SE = 0.22; p = 0.04) from V1 to V2. Among women, a history of cervical cancer was associated with 7-year memory decline, which may reflect the impacts of systemic cancer therapies. Among men, however, a history of prostate cancer was associated with improvements in cognitive performance, perhaps due in part to engaging in health promoting behaviors following cancer.

Pediatric Lyme disease: systematic assessment of post-treatment symptoms and quality of life.

Lyme disease is common among children and adolescents. Antibiotic treatment is effective, yet some patients report persistent symptoms following treatment, with or without functional impairment. This study characterized long-term outcome of pediatric patients with Lyme disease and evaluated the case definition of post-treatment Lyme disease (PTLD) syndrome. The sample included 102 children with confirmed Lyme disease diagnosed 6 months-10 years prior to enrollment (M = 2.0 years). Lyme diagnosis and treatment information was extracted from the electronic health record; parent report identified presence, duration, and impact of symptoms after treatment. Participants completed validated questionnaires assessing health-related quality of life, physical mobility, fatigue, pain, and cognitive impact. Most parents reported their child's symptoms resolved completely, although time to full resolution varied. Twenty-two parents (22%) indicated their child had at least one persistent symptom >6 months post-treatment, 13 without functional impairment (PTLD symptoms) and 9 with functional impairment (PTLD syndrome). Children with PTLD syndrome had lower parent-reported Physical Summary scores and greater likelihood of elevated fatigue. In the current study, most children with Lyme disease experienced full resolution of symptoms, including those who initially met PTLD syndrome criteria. Effective communication about recovery rates and common symptoms that may persist post-treatment is needed. The majority of pediatric patients treated for all stages of Lyme disease reported full resolution of symptoms within 6 months. 22% of pediatric patients reported one or more symptom persisting >6 months, 9% with and 13% without accompanying functional impairment. Effective communication with families about recovery rates and common symptoms that may persist post-treatment of Lyme disease is needed.

수학 마인드셋에 초점을 둔 초등학교 교사들의 수학 신념 조사

Based on the fact that teachers' mathematical mindsets have a great cognitive and emotional impact on students, this study attempted to examine the tendency of mathematical beliefs including mathematical mindsets for elementary school teachers and derive implications for teacher education. To this end, a survey was conducted, and the data of 62 elementary school teachers who responded to this were processed using the SPSS statistics program. As a result of the survey, it was found that elementary school teachers' mathematical beliefs were moderate, and more than half had a neutral mind set. In addition, there are no differences by gender and high school class in mathematical beliefs and mathematical mindsets, but there are differences by teaching period and university grade self-evaluation. Implications for teacher education were proposed through the above contents.

How do institutional environment and entrepreneurial cognition drive female and male entrepreneurship from a configuration perspective?

PurposeThe purpose of this paper is to examine the gender differences in entrepreneurship driven by configurations of institutional environment and entrepreneurial cognition, and provide theoretical guidance and practical reference for promoting female and male entrepreneurship.Design/methodology/approachBased on a configuration perspective, six antecedents of institutional environment and entrepreneurial cognition are integrated to explore multiple concurrent factors and causally complex relationships affecting female and male entrepreneurship.FindingsThis study indicates that the configurations of institutional environment and entrepreneurial cognition can achieve high female and male entrepreneurship. There are similarities and differences between female and male entrepreneurship from a configuration perspective. Perceived opportunity plays an important role in entrepreneurship for both women and men, and the absence of fear of failure is also important for male entrepreneurship. There is a complementary effect among entrepreneurial cognitions in the absence of institutional environment. In the configurations of institutional environment and entrepreneurial cognition, female entrepreneurship benefits more from informal institutions, whereas regulative and cognitive institutions play a greater role in male entrepreneurship.Practical implicationsPolicymakers and individuals should take a holistic and complex view of the impact of institutional environment and entrepreneurial cognition, and differentiated measures should be taken for female and male entrepreneurship.Originality/valueThis research responds to the call for multilevel transnational entrepreneurship research, enriches research on institutional environment and entrepreneurial cognition, deepens the application of fuzzy-set qualitative comparative analysis to the field of entrepreneurship and strengthens the understanding of the similarities, differences and complexities of female and male entrepreneurship.

Literature and Understanding: The Value of a Close Reading of Literary Texts

Detailed, precise and ridden with excellent examples, Jon Phelan’s Literature and Understanding: The Value of a Close Reading of Literary Texts is an inviting and inspiring book that seeks to establish a novel account of the cognitive value of literature. It does this by providing a variety of arguments supporting the educative, cognitive and moral value of literature. Phelan positions himself within the literary cognitivist camp and joins the minority within it who argue that it is through literary devices, and not through its fictional dimension, that literature gives us knowledge. As he claims in the first chapter, philosophers are all too quick to run literature and fiction together, making it unclear how precisely the learning takes place, attributing the cognitive impact of fiction to the literary dimension of a work and vice versa. To overcome this problem, Phelan establishes a category of literary fiction, taking inspiration from Ken Walton’s (1970) notion of categories of art (each with its own set of standard features) and Stacie Friend’s (2012) account of fiction as a genre. As he sees it, literary fiction includes those works that exhibit the standard features of literature and of fiction.

The cumulative effect of socioeconomic status and dyslexia on linguistic, cognitive and reading skills among Arabic‐speaking children

Research has shown that children with dyslexia and children with a low socioeconomic status (SES) fall behind in terms of literacy acquisition, but a question remains regarding the cumulative effect of dyslexia and SES on linguistic, cognitive and reading skills. To examine the impact of cognition and environment on literacy development, we returned to the data set of 1,441 elementary school children (223 dyslexic readers and 1,241 typical readers) from low and medium-high SES backgrounds within Palestinian society in Israel who had participated in the development study of a comprehensive battery of tests in oral and written Arabic. The findings of this retrospective study reveal that, across grade levels, dyslexic readers from a low SES background showed similar performance to those from a medium-high SES background on most linguistic, cognitive and reading measures. As for typical readers, SES contributed to individual differences in all linguistic, cognitive and reading indices, with the exception of RAN. Finally, a cumulative effect of dyslexia and SES was found in relation to morphology, vocabulary, listening comprehension and text-reading accuracy.

First-Line Immunotherapy with Check-Point Inhibitors: Prospective Assessment of Cognitive Function.

Approximately 40% of patients with cancer are eligible for check-point inhibitor (CPI) therapy. Little research has examined the potential cognitive impact of CPIs. First-line CPI therapy offers a unique research opportunity without chemotherapy-related confounders. The purpose of this prospective, observational pilot was to (1) demonstrate the feasibility of prospective recruitment, retention, and neurocognitive assessment for older adults receiving first-line CPI(s) and (2) provide preliminary evidence of changes in cognitive function associated with CPI(s). Patients receiving first-line CPI(s) (CPI Group) were assessed at baseline (n = 20) and 6 months (n = 13) for self-report of cognitive function and neurocognitive test performance. Results were compared to age-matched controls without cognitive impairment assessed annually by the Alzheimer's Disease Research Center (ADRC). Plasma biomarkers were measured at baseline and 6 months for the CPI Group. Estimated differences for CPI Group scores prior to initiating CPIs (baseline) trended to lower performance on the Montreal Cognitive Assessment-Blind (MOCA-Blind) test compared to the ADRC controls (p = 0.066). Controlling for age, the CPI Group's 6-months MOCA-Blind performance was lower than the ADRC control group's 12-months performance (p = 0.011). No significant differences in biomarkers were detected between baseline and 6 months, although significant correlations were noted for biomarker change and cognitive performance at 6 months. IFNγ, IL-1β, IL-2, FGF2, and VEGF were inversely associated with Craft Story Recall performance (p < 0.05), e.g., higher levels correlated with poorer memory performance. Higher IGF-1 and VEGF correlated with better letter-number sequencing and digit-span backwards performance, respectively. Unexpected inverse correlation was noted between IL-1α and Oral Trail-Making Test B completion time. CPI(s) may have a negative impact on some neurocognitive domains and warrant further investigation. A multi-site study design may be crucial to fully powering prospective investigation of the cognitive impact of CPIs. Establishment of a multi-site observational registry from collaborating cancer centers and ADRCs is recommended.

Social cognition and Relevance: How stereotypes impact the processing of definite and indefinite descriptions

This paper focuses on the impact of social cognition on thes processing of linguistic information. More specifically, it brings some insights to Relevance theory's construal of MeaningNN, which seeks to account for non-propositional meanings. It shows, through two experiments, how gender and nationality-related stereotypes guide the processing of definite and indefinite descriptions. Experiment 1 consists of a self-paced reading task (with 59 French native speakers), introducing information confirming vs. violating gender stereotypes within a nominal phrase (NP). The NP (e.g., “chirurgien/chirurgienne”, “surgeonmale/female”) was itself introduced either by a definite article (presupposition) or an indefinite article (assertion). Results showed that information violating gender stereotypes was costlier to process than stereotype-congruent information. Moreover, when information violated gender stereotypes, definite descriptions became significantly costlier than indefinite ones, because they required the identification of a salient referent which contradicted stereotypical expectations. Experiment 2 tested the effects of definite vs. indefinite NP on processing nationality-related stereotypes in a self-paced reading task (with 49 French native speakers). Participants read definite vs. indefinite NPs referring to representatives of a country. The NP was subsequently paired with information that confirmed vs. contradicted nationality stereotypes. Results showed that information contradicting nationality stereotypes were significantly costlier to process than information confirming stereotypes. Furthermore, when information contradicted nationality stereotypes, indefinite descriptions (which promote a single occurrence reading) failed to facilitate information processing compared to definite descriptions (which promote a generalized representation of the social category). Overall, the present findings are consistent with research on stereotypes, in that they show that stereotype-incongruent information affect sentence processing. Importantly, while Experiment 1 revealed that stereotypes affected the processing of linguistic markers, Experiment 2 suggested that linguistic markers could not modulate the processing of stereotypes.

Assessment of Cognitive Abilities and Impact of Parental Intellectual Level in ASD Children

Autism, now called Autism Spectrum Disorder (ASD), includes children with autism, but also those with Asperger's Syndrome and those with Pervasive Developmental Disorder Not Otherwise Specified.&#x0D; In order to learn more about the subject, we were interested in a population of 30 children with ASD aged 10±5 years from the region of Annaba, Algeria, accommodated as half-boarders at the Centre Médico-Pédagogique pour Enfants Handicapés Mentaux. These children are divided by the psychologist of the center into 4 groups according to their degree of impairment (from mild to severe). To classify them, several criteria had to be considered such as the child's comprehension, independence and responsiveness.&#x0D; The study consists of assessing their cognitive abilities on a daily basis and over a period of 20 days. On the other hand, to collect testimonies from parents and the role they can play to help with these neurodevelopmental anomalies.&#x0D; The results reveal impairments in the ability to establish social interactions and to communicate, as well as cognitive abnormalities, in particular reluctance to change and tendencies to repeat behaviour or speech. Some of them, often isolated in their inner world, show particular sensory reactions (auditory, visual, skin...). We also note that the parents' level of education has a strong impact on their position regarding this disorder. That is, the higher it is, the more likely they are to accept their different children.&#x0D; These advances suggest that, for the coming years, ASD in Algeria should occupy a special place in public health policy. It is therefore time to sound the alarm and invest in multidisciplinary research to understand more about its mechanisms but above all to improve its management.

Documentary Film as Interreligious Dialogue: A Cognitive Perspective

Research and personal experience affirm that watching a movie can change the way someone lives their life. Documentary storytelling is a multidimensional change agent, a digital media artifact that is rooted in real communities, real lives, and real stories. Because documentary is rooted in the human social world, watching it is a cognitively, psychologically, emotionally, socially, and politically complicated act. Thus, it is a potent medium for stimulating discourse, reflection, and behavioral change. This article explores the power of visual storytelling and positive media representation as a Parasocial-Relational form of interreligious dialogue and delves into practical application as it contemplates best practices for how filmmakers might harness that power, reviewing literature on the possible social, cognitive, and neurobiological impact of documentary. This interdisciplinary cognitive-sociological theory of change posits documentary film as a lever for increased interreligious competence because of its unique ability to disarm with visual storytelling and engaging characters, leading to a potentially reflexive experience of humanization and perceptual shift.

Electrophysiological and Neuropsychological Indices of Cognitive Dysfunction in Patients with Chronic Insomnia and Severe Benzodiazepine Use Disorder.

Benzodiazepine (BDZ) misuse is a growing health problem, with 1-2% of patients under BDZ treatment meeting the criteria for use disorder or dependence. Although BDZ addiction potential has been known for decades, much remains unknown its effects on brain functions. The aim of this study was to assess the neuropsychological and neurophysiological profile of a group of chronic insomniacs taking long-term high doses of benzodiazepine. We recruited 17 consecutive patients admitted to our third-level Sleep Medicine Unit for drug discontinuation (7 males, mean age 49.2 ± 11.2 years, mean education 13.7 ± 3.9 years, mean daily diazepam-equivalent BDZ: 238.1 ± 84.5 mg) and 17 gender/age-matched healthy controls (7 males, mean age 46.8 ± 14.1 years, mean education 13.5 ± 4.5 years). We performed a full neuropsychological evaluation of all subjects and recorded their scalp event-related potentials (Mismatch-Passive Oddball-Paradigm and Active Oddball P300 Paradigm). Patients with chronic insomnia and BDZ use disorder showed a profound frontal lobe executive dysfunction with significant impairment in the cognitive flexibility domain, in face of a preserved working, short and long-term memory. In patients, P300 amplitude tended to be smaller, mainly over the frontal regions, compared to controls. BDZ use disorder has a severe cognitive impact on chronic insomnia patients. Long-term high-dose BDZ intake should be carefully evaluated and managed by clinicians in this specific patient population, especially in relation to risky activities.

Cognitive biases in surgery: systematic review.

Although numerous studies have established cognitive biases as contributors to surgical adverse events, their prevalence and impact in surgery are unknown. This review aimed to describe types of cognitive bias in surgery, their impact on surgical performance and patient outcomes, their source, and the mitigation strategies used to reduce their effect. A literature search was conducted on 9 April and 6 December 2021 using MEDLINE, Embase, PsycINFO, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews. Included studies investigated how cognitive biases affect surgery and the mitigation strategies used to combat their impact. The National Institutes of Health tools were used to assess study quality. Inductive thematic analysis was used to identify themes of cognitive bias impact on surgical performance. Thirty-nine studies were included, comprising 6514 surgeons and over 200 000 patients. Thirty-one types of cognitive bias were identified, with overconfidence, anchoring, and confirmation bias the most common. Cognitive biases differentially influenced six themes of surgical performance. For example, overconfidence bias associated with inaccurate perceptions of ability, whereas anchoring bias associated with inaccurate risk-benefit estimations and not considering alternative options. Anchoring and confirmation biases associated with actual patient harm, such as never events. No studies investigated cognitive bias source or mitigation strategies. Cognitive biases have a negative impact on surgical performance and patient outcomes across all points of surgical care. This review highlights the scarcity of research investigating the sources that give rise to cognitive biases in surgery and the mitigation strategies that target these factors.

The Role of Cognition and Social Factors in Competition: How Do People with Intellectual Disabilities Respond to Opponents?

Exploring pacing behaviour in people with intellectual disabilities (ID) in competition will help to better understand the impact of cognition and social environment in sports, providing support for the shaping of proper inclusive sports environments. The present experimental study aimed to (1) compare the pacing behaviour and performance between people with and without ID who are inexperienced in cycling and (2) investigate how these are influenced by an opponent. Participants with (n = 8) and without ID (n = 10) performed two randomised 4-km maximal cycling trials, alone and against an opponent. Non-parametric tests for repeated measures data (p ≤ 0.05) revealed that people with ID cycled slower, but with higher inter-individual variation (both conditions) and paced themselves differently compared to people without ID when competing against an opponent. In contrast to the previous literature in athletes without ID, the presence of a faster opponent resulted in a decrease in the performance in the participants with ID. The negative influence of the opponent highlights the potential difficulties people with ID experience to adequately use their opponents to enhance their self-regulatory processes and optimize their pacing and performance in maximal exercise trials. Coaches who want to offer inclusive sports environments for people with ID could take these findings into consideration.

Feasibility and potential cognitive impact of a cognitive-motor dual-task training program using a custom exergame in older adults: A pilot study.

Dual-task training may be relevant and efficient in the context of active aging. An issue in training programs lies in enhancing the adherence of participants. This can potentially be improved using games as support. We designed and developed a custom interactive exergame in this way. The objective of this pilot study was to explore the potential use of this exergame and the feasibility of our intervention, including the level of safety and adherence. The result's trends on cognitive and motor capacities, as well as on the level of motivation for physical activity, fear of falling, and quality of life of participants, were also explored. Older adults aged 65 years or older were recruited and realized 30 min of supervised training in groups of 4, 2-3 times a week for 12 weeks. Exercises consisted of incorporated cognitive and motor dual tasks, with an increased difficulty over the weeks. Our program's safety, engagement, attendance, and completion levels were evaluated. Participants' postural control in single-task and dual-task conditions, as well as their performances in mental inhibition, flexibility, working memory, mobility, and postural control, and their levels of motivation for physical activity, fear of falling, and quality of life were also assessed. We realized a per protocol statistical analysis with a p-value set at 0.05. Thirty-nine participants (aged 84.6 ± 8.5 years) were recruited. No adverse events, and 89% adherence, 88% attendance, and 87% completion rates were observed. A potentially significant effect of our exergame on working memory in single-task conditions and on the cognitive aspect of dual-task conditions was also observed. We observed no differences in other parameters. Our exergame seemed feasible and safe and was enjoyed by participants, mainly due to the gamification of our training program. Moreover, our exergame may be efficient for cognitive training in older adults, as well as for the maintenance of motor functions, motivation for physical activity, fear of falling, and quality of life levels. This constitutes the first step for our solution with interesting results that need to be further studied.

Cognitive and Behavioral Impacts of Two Decision-Support Modes for Judgmental Bootstrapping

The Cognitive Shadow is a decision-support system that uses policy capturing to model human operators’ judgment policies and provide online predictions of their decisions. The system can provide support in reaction to a decision mismatch (shadowing mode) or proactively (recommendation mode). The goal of this study was to compare these two modes of operation in their ability to effectively model and support decision-making and to examine impacts on information processing, workload, and trust. Participants took part in an aircraft threat evaluation simulation without decision support or with the Cognitive Shadow (either shadowing or recommendation mode). Dwell time was collected over different areas of the user interface. While the recommendation mode had no advantage over the control group, the shadowing mode resulted in greater human and model accuracy. This mode led to longer dwell time over the parameters zone presenting key information for decision-making. These benefits were maintained even after the tool was removed. Workload was unaffected by the mode, and while trust was initially higher in the recommendation mode, it quickly became equivalent between both modes, overall supporting shadowing as the better configuration for cognitive assistance. Results are discussed in terms of decision processes, operators support, and automation bias.

Environmental signals perceived by the brain abate pro-metastatic monocytes by dampening glucocorticoids receptor signaling

While positive social-behavioral factors predict longer survival in cancer patients, the underlying mechanisms are unknown. Since tumor metastasis are the major cancer mortality factor, we investigated how an enriched environment (EE) conductive to enhanced sensory, cognitive and motor stimulation impact metastatic progression in lungs following intravasation in the circulation. We find that mice housed in EE exhibited reduced number of lung metastatic foci compared to control mice housed in a standard environment (SE). Compared to SE mice, EE mice increased lung inflammation as early as 4 days after circulating tumor cells extravasation. The impact of environmental signals on lung metastasis is independent of adrenergic receptors signaling. By contrast, we find that serum corticosterone levels are lower in EE mice and that glucocorticoid receptor (GR) antagonist reduces the number of lung metastasis in SE mice. In addition, the difference of the number of lung metastasis between SE and EE mice is abolished when inflammatory monocytes are rendered deficient in GR signaling. This decreased GR signaling in inflammatory monocytes of SE mice results in an exacerbated inflammatory profile in the lung. Our study shows that not only EE reduces late stages of metastatic progression in lungs but disclose a novel anti-tumor mechanism whereby GR-dependent reprogramming of inflammatory monocytes can inhibit metastatic progression in lungs. Moreover, while inflammatory monocytes have been shown to promote cancer progression, they also have an anti-tumor effect, suggesting that their role is more complex than currently thought.

A neuro-cognitive perspective on urban behavior of people with different moods

PurposeThis study aims to investigate the neurocognitive status of people with different moods (depressed and non-depressed) both in a typical urban environment (TUE) and in an urban green environment (UGE).Design/methodology/approachThe study was conducted with the participation of 210 individuals in a real environment. Heart rates of the participants were measured together with EEG and eye-tracking measurements while they were walking in a real urban environment (TUE and UGE). The participants were divided into depressed and non-depressed groups according to different moods. Movements within the city based on these two distinctions and different cognitive moods were investigated, together with the effects of the city plan on these people.FindingsAs a result, the green urban fabric was found to have a positive effect even on people with depression. Yet, it was found that the non-depressed group also spent more time in a green urban environment.Originality/valueThe study shows that urban planners and designers should assume an important role in the design of green spaces, which have a more intense visual and cognitive impact than structures.