Impact Of Chronic Disease Research Articles

Características clínico-epidemiológicas de los pacientes hospitalizados por COVID-19 y enfermedades crónicas durante los primeros siete meses de la pandemia en Paraguay-2020

Introduction: COVID-19, a respiratory infection caused by SARS-CoV-2, has demonstrated varying severity across populations, with approximately 20% of patients developing complications and less than 5% experiencing severe disease requiring hospitalization. The impact of chronic diseases on COVID-19 outcomes remains particularly relevant in developing countries, where healthcare resources and population characteristics differ from well-studied settings. Objective: Describe the clinical and epidemiological characteristics of patients hospitalized with COVID-19 during the first seven months of the pandemic in Paraguay, analyzing how chronic non-communicable diseases (NCDs) influenced disease progression and outcomes. Material and Methods: We conducted a cross-sectional analytical study examining medical records from patients hospitalized with confirmed SARS-CoV-2 infection across five major referral hospitals in Paraguay from March to September 2020. Using bivariate and multivariate logistic regression analyses with likelihood ratio criterion, we identified factors associated with ICU admission and mortality, considering p<0.05 statistically significant. Results: Among 1,690 hospitalized patients, 797 (47.2%) met inclusion criteria, with a median age of 51 years and male predominance (53.8%). Chronic diseases were present in 61.9% of patients, with hypertension (29.6%) and diabetes (25.6%) being most prevalent. Multivariate analysis revealed that age over 80 years (OR=7.70), presence of COPD (OR=2.58), and having three or more NCDs (OR=2.78) significantly increased mortality risk. ICU admission was required for 29.6% of patients, with an overall mortality rate of 29.1%. Conclusion: The severity of COVID-19 outcomes among hospitalized patients in Paraguay showed strong associations with advanced age, multiple chronic conditions, and specific comorbidities like COPD. These findings emphasize the need for targeted preventive strategies and enhanced monitoring of high-risk patients, particularly those with multiple NCDs.

Spatial and Temporal Patterns of Chronic Disease Burden in the U.S., 2018–2021

Chronic diseases are primary causes of mortality and disability in the U.S. Although individual-level indices to assess the burden of multiple chronic diseases exist, there is a lack of quantitative tools at the population level. This gap hinders the understanding of the geographical distribution and impact of chronic diseases, crucial for effective public health strategies. This study aims to construct a Chronic Disease Burden Index (CDBI) for evaluating county-level disease burden, to identify geographic and temporal patterns, and investigate the association between CDBI and social vulnerability. A total of 20 health measures from CDC's PLACES database (2018-2021) were used to construct annual county-level CDBIs through principal component analysis. Geographic hotspots of chronic disease burden were identified using Getis-Ord Gi*. Multinomial logistic regression models and bivariate maps were used to assess the association between CDBI and CDC's social vulnerability index. Analyses were conducted in 2023-2024. Counties with high chronic disease burden were predominantly clustered in the southern U.S. High persistent chronic disease burden was prevalent in Kentucky and West Virginia, while increased burden was observed in Ohio and Texas. Chronic disease burden was highly associated with social vulnerability index (ORQ5 vs Q1=7.6, 95% CI: [6.6, 8.8]), with nonmetro-urban counties experiencing elevated CDBI (OR=14.6, 95% CI: [9.7, 21.9]). The CDBI offers an effective tool for assessing chronic disease burden at the population level. Identifying high-burden and vulnerable communities is a crucial first step toward facilitating resource allocation to enhance equitable healthcare access and advancing understanding of health disparities.

The impact of chronic diseases on the health-related quality of life of middle-aged and older adults: the role of physical activity and degree of digitization

BackgroundThe incidence of chronic diseases is on the rise worldwide, with a high mortality rate in China, posing a serious threat to the health-related quality of life (HRQoL) of middle-aged and older adults. This study explores the association between chronic diseases and the HRQoL of middle-aged and older adults, as well as the role of physical activity (PA) and degree of digitization in this relationship.MethodsThe data used in this study was obtained from the 2018 China Health and Retirement Longitudinal Study (CHARLS), which included 13,620 middle-aged and older Chinese adults (≥ 45 years). The study utilized correlation analysis, and bootstrapping to investigate the mediating role of PA and the moderating influence of the degree of digitization. Data analysis was conducted using SPSS 26.0.ResultsThe study findings indicate that the severity of chronic disease has a significant negative predictive effect on HRQoL (PCS, physical component summary; MCS, mental component summary) (PCS: β = -2.515, p < 0.01, MCS: β = -0.735, p < 0.01). Further analysis revealed that PA plays a mediating and masking role in the impact of chronic disease on PCS and MCS. Additionally, the degree of digitization moderates the relationship between chronic disease and PA, chronic disease and PCS, and PA and PCS.ConclusionFor middle-aged and older persons, chronic diseases have a detrimental effect on their HRQoL; nevertheless, PA can help. Furthermore, proper internet usage can help older individuals to some extent in mitigating the negative impact of chronic diseases. Therefore, it is encouraged to promote PA among the elderly with chronic diseases to improve their physical health, as well as to guide them in the proper use of the Internet to establish healthy behaviors.

Analysis of Impact and Sustainability in Chronic Diseases Prevention Program in XXX Highschool Balikpapan (Systematic Review)

A healthy lifestyle requires discipline. It's not easy, particularly adolescent who feel free and are looking for their existence. Its implementaiton needs to be applied to adolescent due to many cases of chronic diseases developing among them, following their lifestyle. Sedentary/lazy to move, smoking, alcohol, lack of rest and not being able to manage mental health. Generally, adolesecent at the educational level of Junior and Senior High School. The objective of this study is to analyze aspects of the impact and sustainability of chronic disease prevention programs for adolescents. This study is a systematic review using the PRISMA (Preferred Reporting Items for Systematic Reviews &amp; Meta Analyses) method combined with open-source search engine. The database used for searching data and information is PubMed. The keywords used during the search process are "Prevention of Chronic Disease" AND "Chronic Disease" OR "Non-communicable Disease" OR "Infectious Disease" AND “Impact of Chronic Diseases” AND “Teenagers” OR “Adolescents” AND “School”. The most variable aspects of disease prevention are more information related to chronic diseases, knowledge, attitudes and stakeholder support. The CERDIK program provides knowledge, education and information among adolescents. These factors must be taken into consideration to improve lifestyle, maintain health so that you are not vulnerable to health problems during the teenage period

Exploring the role of vitamin D in cognitive function: mediation by depression with diabetes modulation in older U.S. adults, a NHANES weighted analysis.

The relationship between vitamin D levels, depressive symptoms, and cognitive function has yet to be definitively understood in the elderly, particularly when considering the impact of chronic diseases. This study focuses on how depression mediates the impact of 25-hydroxyvitamin D3 (25(OH)D3) on cognitive performance in older U.S. adults. We analyzed data from 2,745 elderly individuals extracted from the NHANES 2011-2014 cycles, applying weighted processing to account for the complex multi-stage sampling design characteristic of NHANES data. Utilizing weighted data for covariate and model selection, we conducted mediation analyses on both the overall population and subgroup data. Significant mediation pathways were validated using a stratified weighted bootstrap approach. For significant subgroup pathways, we explored interactive mechanisms through interactive mediation analysis. Mediation analyses, thoroughly accounting for the impact of chronic conditions, revealed significant pathways in both the weighted overall population and the weighted diabetes subgroup. After 1,000 stratified weighted bootstrap replications, the proportion of mediation effects were 10.6% [0.040, 0.268] and 20.9% [0.075, 0.663], respectively. Interactive mediation analysis for diabetes indicated that the interaction between diabetes and depression was not significant in the direct pathway (estimates = 0.050, p = 0.113) but was significant in the mediation pathway, yielding the largest effect size compared to other covariates (estimates = 0.981, p < 0.001). This study highlights the mediating role of depression in the relationship between vitamin D levels and cognitive function in the elderly, particularly emphasizing diabetes as a key moderator. Our findings suggest targeted interventions addressing both vitamin D sufficiency and depression could significantly benefit cognitive health, especially in diabetic individuals.

The Impact of Chronic Diseases on Mental Health: AnOverview and Recommendations for Care Programs.

The current achievement of medical advancement is noteworthy; however, the occurrence of chronic diseases is increasing day by day, with a significant percentage of affected people aresuffering from a mental health crisis. This article aims to present a thorough yet brief review of methods that can be employed to build the emotional wellness of chronic patients. The mental health carestrategies include resilience-building, coping skills training, professional counseling, and lifestyle adaptations. Additionally, the article highlightsthe efficacy of several modern interventions, such as mindfulness-based therapies, cognitive behavioral therapy, eye movement desensitization, andrecovery from stress therapy. The global burden of chronic illness emphasizes the pressing need to mitigate mental health problems among chronic patients. By providing actionable insights, our study clears the path for targeted interventions and holistic approaches for chronic disease patients. Moreover, the article suggests to policymakers and clinicians the need for collaboration and multifaceted interventions.

Impact of chronic diseases on the periapical health of endodontically treated teeth: A systematic review and meta-analysis.

Systemic diseases affecting the immune system can influence the body's response time to endodontic treatment, potentially necessitating a longer duration for the complete resolution of existing infections when compared to healthy controls. This systematic review aims to evaluate the association between the presence of chronic diseases and periapical status after endodontic treatment through a systematic and comprehensive assessment of existing literature on this topic. The search strategy covered seven electronic databases and grey literature, encompassing articles published until October 2023. Two reviewers independently assessed potentially eligible studies based on the following criteria: Included were studies involving populations exposed to pre-existing chronic diseases who underwent endodontic treatment in permanent teeth. These studies evaluated periapical health status, making comparisons with healthy individuals. There were no language or publication date restrictions. Additionally, two reviewers independently extracted data regarding the characteristics of the included studies. The risk of bias was assessed using the Joanna Briggs Institute Critical Assessment Checklist. Meta-analysis was conducted using random effects models. The certainty of evidence was assessed using the GRADE tool. Twenty-three studies were included in the synthesis. Patients with diabetes were found to have about half the odds of having periapical health compared to non-diabetic patients (OR = 0.46; 95% CI = 0.30-0.70%; I2 = 58%) in teeth that underwent endodontic treatment. On the other hand, other systemic diseases like HIV, cardiovascular disease, and rheumatoid arthritis did not demonstrate significant differences concerning the outcome. In conclusion, diabetic patients showed a lower likelihood of maintaining periapical health. Conversely, patients with HIV, cardiovascular disease, and rheumatoid arthritis did not exhibit significant differences, although the existing evidence is still considered limited. It is crucial to manage these patients in a multidisciplinary manner to provide appropriate care for this population.

The mediating role of health literacy between the presence of chronic disease and psychological distress among older persons in Xi’an city of China

BackgroundThe increased number of older persons in China, and the prevalence of most chronic diseases raised with age significantly increased the total disease burden. When a person ages, psychological distress happens when they are faced with stressors that they cannot cope with. Psychological distress refers to non-specific symptoms of depression, anxiety, and stress. Health literacy influences several health outcomes, such as emotional functioning among the population. The primary purpose of this study is to examine the mediator role of health literacy between the presence of chronic disease and psychological distress among older persons living in Xi’an city. Thus, this study used the Cognitive Behavior Theory (CBT) as a combination of the basic behavioral and cognitive psychology principles to explain the cognitive processes associated with psychological distress.MethodsThis study employs a quantitative research design using a cross-sectional survey of 300 older persons over 60 years living in the six urban districts of Xi’an city. Data were collected using the Health Literacy Questionnaire (HLQ) and the Depression Anxiety Stress Scale (DASS-21). This study employed descriptive statistics and inferential methods to analyze the data. The inferential methods applied structural equation modeling (SEM) to test the hypothesis of the mediator role of health literacy between the presence of chronic disease and psychological distress.ResultsIn this study, chronic disease had an effect on health literacy among older persons living in Xi’an city (β=-0.047, p < 0.01); chronic disease impact on psychological distress among older persons living in Xi’an city (β = 0.047, p < 0.01); health literacy was identified effect on psychological distress among older persons in Xi’an city (β=-0.738, p < 0.001); health literacy as a partial mediator between chronic disease and psychological distress (β = 0.07, p < 0.01).ConclusionPsychological distress among older persons is affected by chronic disease and health literacy. Health literacy had a partial mediating effect on the presence of chronic disease and psychological distress. Improved health literacy measures should be considered when treating older persons with psychological distress.

Prevalence and correlates of stress, anxiety, and depression in patients with chronic diseases: a cross-sectional study

BackgroundMany chronic diseases, including diabetes, heart disease, cancer, and respiratory problems, can lead to emotional distress, anxiety, and depression among patients. Likewise, psychological conditions such as anxiety and depression can elevate the risk of developing chronic diseases. The objective of the study was to examine the prevalence of stress, anxiety, and depression in individuals with chronic diseases, as well as to identify the chronic disease with the highest prevalence among all chronic conditions and the factors associated with stress, anxiety, and depression.ResultsIn our study, the prevalence rate of stress, anxiety, and depression in patients having chronic diseases was found to be 68.7%, 51.1%, and 58.8%, respectively. The chronic diseases which are included in this study are cardiovascular diseases, metabolic disorders, cancer, respiratory disorders, degenerative disorders, chronic kidney disease, and chronic liver disorders. Among these diseases, cardiovascular disease patients were found to have the highest prevalence of stress, anxiety, and depression. The psychosocial determinants that can trigger stress, anxiety, and depression were analyzed. The factors like age, marital status, primary caretakers of the patient, social isolation, length of hospital stay, social relationships, number of frequent visits to the hospital/month, and the lifestyle of the patient have a significant association with the levels of stress, anxiety, and depression. Factors like monthly income and educational status were also found to be statistically significant with the stress levels, and length of intensive care unit (ICU) stay was significantly associated with the levels of anxiety.ConclusionIn conclusion, this study found a high prevalence of stress, anxiety, and depression among patients with chronic disease(s). Among all the chronic diseases, cardiovascular disease patients were found to have the highest prevalence of stress, anxiety, and depression. In addition, our study also identified several psychosocial factors that contribute to the development of these mental health conditions which exacerbate the present chronic condition of the patient. These findings highlight the importance of considering the impact of chronic disease on mental health problems.

Applying latent profile analysis to identify adolescents and young adults with chronic conditions at risk for poor health-related quality of life

ABSTRACT The impact of chronic diseases on health-related quality of life (HRQOL) in adolescents and young adults (AYAs) is understudied. Latent profile analysis (LPA) can identify profiles of AYAs based on their HRQOL scores reflecting physical, mental, and social well-being. This paper will (1) demonstrate how to use LPA to identify profiles of AYAs based on their scores on multiple HRQOL indicators; (2) explore associations of demographic and clinical factors with LPA-identified HRQOL profiles of AYAs; and (3) provide guidance on the selection of adult or pediatric versions of Patient-Reported Outcomes Measurement Information System® (PROMIS®) in AYAs. A total of 872 AYAs with chronic conditions completed the adult and pediatric versions of PROMIS measures of anger, anxiety, depression, fatigue, pain interference, social health, and physical function. The optimal number of LPA profiles was determined by model fit statistics and clinical interpretability. Multinomial regression models examined clinical and demographic factors associated with profile membership. As a result of the LPA, AYAs were categorized into 3 profiles: Minimal, Moderate, and Severe HRQOL Impact profiles. Comparing LPA results using either the pediatric or adult PROMIS T-scores found approximately 71% of patients were placed in the same HRQOL profiles. AYAs who were female, had hypertension, mental health conditions, chronic pain, and those on medication were more likely to be placed in the Severe HRQOL Impact Profile. Our findings may facilitate clinicians to screen AYAs who may have low HRQOL due to diseases or treatments with the identified risk factors without implementing the HRQOL assessment.

Persistent Symptoms of Severe and Critical COVID-19: A Cross-Sectional Study After more than 120 Days from Disease Onset

Objective: The objective of this study is to assess the prevalence and predictors of symptom persistence associated with severe and critical coronavirus disease-2019 (COVID-19) after more than 120 days from the onset of the disease. Materials and Methods: This is a single-center, cross-sectional study of 125 adults who were admitted to King Khalid University Hospital (Riyadh, Saudi Arabia) with severe and critical COVID-19 between March 4 and December 1, 2020. Telephone interviews were conducted between April 1 and May 31, 2021, to collect data on COVID-19 symptoms persisting after more than 120 days from the onset of the disease. All of the participants had been discharged from the hospital and had resumed their normal lives. Symptoms of COVID-19 that had not been present before the onset of the disease were considered to be persistent if participants confirmed their continued presence at the time of the interview. The impact of chronic disease on persistent symptoms was considered. Results: About 42.4% (53/125) of patients had at least one or more persistent symptoms; 27.2% (34/125) had breathlessness, 5.6% (7/125) cough, and 4.8% (6/125) chest pain. These three symptoms had been present from the first presentation. Hair loss was reported by 14.4% (18/125), forgetfulness by 8% (10/125), difficulty in concentrating by 6.4% (8/125), and lack of energy by 4% (5/125). Those had manifested after more than 120 days from the symptom’s onset. The major factors in suffering from persistent symptoms were intensive care unit (ICU) admission or/and fever (temperature &gt;38°), or/and diarrhea. There was no correlation between persistent symptoms and chronic diseases. Conclusions: After more than 120 days from the confirmation of severe and critical COVID-19, more than one-third of discharged adults were found to have one or more persistent symptoms. These were mainly associated with the need for ICU admission, fever (temperature &gt;38°), and diarrhea. More care needs to be given to COVID-19 patients in the presence of these factors and prolonged medical care would appear to be essential.

Impact of Chronic Diseases on Labour Force Participation among South African Women: Further Analysis of Population-Based Data

The impact of chronic diseases on labour force participation is not frequently examined or considered as part of cost-of-illness studies. The aim of this study was to determine the impact of chronic diseases on labour force participation among South African women. This study included 6126 women from the 2016 South African Demographic and Health Survey. Labour force participation/employment was the outcome variable. Data were analyzed in percentage and multivariable binary logistic regression. Results showed that approximately 28.7% of women participated in the labour force and about 5.0% had diabetes. The prevalence of diabetes among women who are not in the labour force was 5.5%, whereas those in the labour force reported 3.8% prevalence of diabetes. The diabetic women had 35% reduction in labour force participation when compared with non-diabetic women (aOR = 0.65; 95% CI: 0.48 to 0.89). Geographical region was associated with labour force participation. Rural women and those currently in union/living with a man had 35% (aOR = 0.65; 95% CI: 0.56 to 0.76) and 27% (aOR = 0.73; 95% CI: 0.64 to 0.85) reduction in labour force participation, respectively, when compared with their urban and single counterparts. The findings of this study revealed that diabetes was significantly associated with reduction in labour force participation among women.

Exploring Strategies for Developing Enabling Environments for People with Chronic Heart Disease: An Ethnographic Study Protocol.

The impact of chronic diseases on people's daily lives and the exponential number of people affected is a major public health issue. The consequences on individuals and their families is significant, particularly in terms of quality of life. In the literature, this phenomenon is well described in terms of care policy and cost. Although there is a link between a supportive environment and empowerment, there is little literature describing a supportive environment and the daily lives of people living with cardiovascular disease. The objectives of this study are to identify the strategies people use to develop an enabling environment. It will be a qualitative ethnographic study that will address both human behavior and the notion of culture in a broad sense. In the context of this study, an orientation towards critical ethnography will be considered for its particular interest in vulnerable people and in the power relations that may exist in the socio-cultural system. Data will be collected directly in people's homes through observations and interviews with 10 people with cardiovascular disease. For each person, the data collection will take place over three days and will represent approximately 210 h of observation. This protocol was registered in the Research Register on 30 June 2021 and its number is 6933. This study will explore strategies for developing an enabling environment for people living with heart disease and eventually provide recommendations for nursing practices in terms of support.

Impact of Chronic Disease and Its Burden on Aspects of Quality of Life in a Unique Sub-Population of Myeloproliferative Neoplasm Patients

Impact of Chronic Disease and Its Burden on Aspects of Quality of Life in a Unique Sub-Population of Myeloproliferative Neoplasm Patients

The impact of chronic diseases on depressive symptoms among the older adults: The role of sleep quality and empty nest status

BackgroundDepression is the most prevalent mental disorder among older adults. This study aimed to explore the mediating effect of sleep quality on the relationship between chronic diseases and depressive symptoms, and the moderating role of empty nest status in the mediating model. MethodsA cross-sectional survey was conducted among 3637 older adults from Taiyuan, China, using a multi-stage random cluster sampling method. The data was collected with the general questionnaire for the elderly, with the Short Form Geriatric Depression Scale (GDS-15), and the Pittsburgh Sleep Quality Index (PSQI). The Bootstrap program and simple slope method were used to test the mediating effect of sleep quality and the moderating effect of empty nest status. ResultsThe overall prevalence of depressive symptoms in the population was 33.4%. The mediating effect analysis showed that chronic diseases had a significant direct impact on depressive symptoms in the elderly (β = 0.431, P < 0.001). Sleep quality as a mediation effect of 43.4% between chronic diseases and depressive symptoms was proven. The further moderating effect found that chronic diseases had a more significant impact on the sleep quality of the elderly who are in the empty nest status than those who are not (β = -0.431, P < 0.05 ). LimitationsGiven the cross-sectional study, the results cannot explain the causal relationships among the study variables. ConclusionsChronic diseases had a major impact on the depressive symptoms of the elderly. Sleep quality mediated the relationship between chronic diseases and depressive symptoms, and the empty nest status moderated the first half of the path in the mediation model. Therefore, to reduce the incidence of the depressive symptoms of the elderly, sleep quality and empty nest status should be the primary concern.

The impact of chronic disease and accompanying bio-psycho-social factors on health-related quality of life.

Most chronic illnesses lead to poor health outcomes. Bio-psycho-social sequelae and accompanying depression lead to further deterioration in health-related quality of life (HRQoL). This study explored the HRQoL of patients with major chronic diseases in a public tertiary health care institution in Trinidad and Tobago. This cross-sectional study was conducted on a convenience sample of adult patients with chronic illnesses in a public health institute in Trinidad. Data were collected using face-to-face interviews and consenting patients' records. A 43-item questionnaire comprising demographic, medical, and lifestyle questions, the nine-item patient health questionnaire (PHQ-9) on depression, and the EQ-5D-5L HRQoL questionnaire were used. Psychological and social variables were divided into six groups: Group 1 (community attachment variables), Group 2 (family and friends), Group 3 (life satisfaction), Group 4 (depression symptoms), Group 5 (social support), and Group 6 (lifestyle variables). The impact of these variables on HRQoL was investigated using regression and canonical correlation analysis. Patients were primarily female (70.3%), Indo-Trinidadian (63.9%), having diabetes mellitus (46.0%) or cancer (35.8%). The quality of life was lower than Trinidad and Tobago EQ-5D-5L population norms. Females and older patients had worse HRQoL than males and younger patients, respectively. Furthermore, kidney failure, all cancer patients, and middle-aged female cancer patients fared worse than other categories. Life satisfaction and exercise were significantly associated with better HRQoL. Depressive symptoms were consistently and significantly negatively associated with HRQoL. HRQoL was lower among participants with chronic disease than in the general population. Depressive symptoms led to worse HRQoL, whereas life satisfaction and exercise significantly improved HRQoL. The EQ-5D dimension most frequently affected was anxiety/depression.

Quality of Life, Sexual Functioning and Chronic Disease: A Comparative Study with Portuguese Women without Chronic Disease, and Women with Diabetes Type 1 and 2, and Arterial Hypertension

Aims: Previous research has focused on the impact of chronic diseases on men's sexual functioning and quality of life; however, little is known about the association between chronic disease and women’s sexual functioning and quality of life. Current study aimed at exploring the differences in quality of life and sexual functioning between women without chronic disease, and women with type 1 diabetes, with type 2 diabetes, and with arterial hypertension. Methods: A web-survey was completed by 313 Portuguese women (167 without chronic disease, 48 with type 1 diabetes, 48 with type 2 diabetes, and 50 with arterial hypertension). Results: Women without chronic disease scored significantly higher than women with chronic disease in quality of life and sexual functioning, adjusting for age. Conclusions: Quality of life and sexual functioning in women with chronic diseases is impaired.

140. Variations in Rates of Antimicrobial Use in Primary Care, in Relation to the Presence of Chronic Diseases, Québec, Canada, 2014-2017

BackgroundChronic diseases may increase one’s risk of infection and ensuing complications, which in turn may lower clinicians’ tolerance threshold for antimicrobial prescription, while potential drug interactions may limit therapeutic options. Objective of the study was to measure the impact of chronic diseases on the rates of antimicrobial use in the Province of Québec.MethodsIndividuals covered by the public drug insurance plan between April 2014 and March 2017 were included in our cohort to describe rates of antimicrobial dispensing per 1,000 person-years, per age group (0-17 years old, 18-64 years old and 65 years old or over) and category of chronic disease (respiratory, cardiovascular, diabetes, mental disorder, none of these). For 2014-2017, ratios of extended-to-narrow spectrum antimicrobials were computed and multivariate Poisson regression was used to measure the impact of categories of chronic diseases on rates of total antimicrobial dispensing (in prescriptions and defined daily doses). ResultsA total of 1 259 833 children-years, 5 281 026 person-years between 18 and 64 years and 3 841 359 person-years 65 years or older were included in the study. Ratios of extended-to-narrow spectrum antimicrobials varied from 3.1 (adults 18-64 years old with no chronic disease) to 14.6 (children with no chronic disease); ratios for individuals with chronic diseases were lower in children but higher in adults. Adults with chronic respiratory diseases were twice more exposed to antimicrobials (increase of 109%) than those with none of the studied diseases (62% increase in children). In adults, antimicrobial use was also 48% higher in presence of a mental disorder (22% in children), 40% higher with diabetes (102% in children) and 31% higher with a cardiovascular disease (no data in children). These differences were all statistically significant (α = 0,05).ConclusionIn Québec, antimicrobial dispensation was more frequent for individuals with at least one chronic disease. This raises the question of how much antimicrobial use can be reduced or improved to limit the selection of resistant bacteria. Disclosures All Authors: No reported disclosures

Challenges in the diagnosis and management of glucocorticoid‐induced osteoporosis in younger and older adults

Glucocorticoids constitute a considerable risk for developing osteoporosis in both younger and older adults. However, currently available bone imaging modalities and fracture-risk assessment tools do not adequately capture the dramatic changes in bone microarchitecture, heterogeneity of glucocorticoid exposure, the impact of chronic disease and other osteoporosis risk factors on the assessment of osteoporosis in these individuals. A narrative review is presented, following a systematic search of the literature from 2000 to 2021. Our current appreciation of glucocorticoid-induced osteoporosis (GIO) is focused on older populations, with limited evidence to guide the investigation, risk assessment and treatment in premenopausal women and men less than 50 years. The impact of the underlying chronic disease on secondary osteoporosis in these younger adults is also poorly understood. Through this narrative review, we provide a comprehensive overview of and recommendations for optimising the management of this common cause of secondary osteoporosis younger and older adults.

An Empirical Study on the Intentional Behaviors of Healthcare Consumers in a Telehealthcare System in Taiwan

Due to an aging population and the impact of chronic disease, health insurance costs in Taiwan have increased year by year. In order to allow people access to great medical care from home or within their community, the Taiwanese government has promoted a number of telehealthcare policies. Most related research emphasizes the technology involved in such policies, but this study considers instead the combination of a technology acceptance model, a health belief model, and measures of trust within the community to probe the Taiwanese telehealthcare system. This study was developed to examine factors that affect the usage, attitudes, and intentions of healthcare consumers within a telehealthcare system. 284 responses were collected via an online survey and analyzed using SPSS 23 and smart PLS2.0. The results showed that perceived ease of use and usefulness were affected by social trust, perceived usefulness was affected by perceived ease of use, users’ attitudes were affected by perceived ease of use and perceived usefulness, and user intention was affected by perceived usefulness, perceived seriousness, perceived benefits, and cues to action.