Impact Of Blue Light Research Articles

A Study on the Impact of Blue Light and Its Brightness on Long-Term Memory

A Study on the Impact of Blue Light and Its Brightness on Long-Term Memory

Blue light inhibits cell viability and proliferation in hair follicle stem cells and dermal papilla cells.

Hair loss is a prevalent issue worldwide, which, though not life-threatening, can result in psychological problems, low self-esteem, and social anxiety. Previous studies have shown that ultraviolet radiation can have negative effects on hair follicle cells, leading to hair loss, while the impact of blue light on hair and hair follicle has largely been overlooked. This study aimed to examine the effects of blue light on hair follicle stem cells (HFSCs) and primary dermal papilla cells (DPCs), which are essential components of hair follicles. Human HFSCs and primary DPCs were exposed to blue light (457nm) at various intensities (1, 4, 8, and 16 mW/cm2) for 3 days. Subsequently, cell viability, cell proliferation, and intracellular reactive oxygen species (ROS) were assessed. The results showed that blue light (457nm) significantly reduced the cell viability and proliferation of HFSCs and DPCs in vitro, with the inhibition being intensity-dependent. Additionally, blue light triggered the overproduction of ROS in the DPCs. While the exact mechanisms by which blue light affects hair follicle cells remain unclear, these findings suggest that blue light could impede the growth of these cells. This insight may offer a new approach to protecting hair by avoiding exposure to high-intensity blue light.

Impact of blue light on cutaneous barrier structures and properties: NPLC/HR-MSn and Raman analyses.

Skin health relies heavily on a well-maintained cutaneous barrier. While the detrimental effects of UV radiation on the epidermis are established, the impact of blue light, a significant component of sunlight and artificial sources, is less clear. This study aims to explore blue light's influence on the reconstructed human epidermis (RHE) using two complementary analytical approaches: Raman microspectroscopy and normal phase liquid chromatography coupled with high-resolution mass spectrometry (NPLC/HR-MSn). RHE samples were exposed to blue light (415 nm and 455 nm) during different stages of their maturation. Raman spectra were acquired for both irradiated and non-irradiated (control) samples. Raman descriptors were analyzed to assess potential alterations in the structural organization of proteins and lipids' conformational changes. Additionally, lipids from RHE samples were extracted and analyzed using NPLC/HR-MSn. Blue light exposure led to changes in the structural organization of RHE lipids and proteins, as well as changes in the lipid composition. These changes varied depending on the wavelength and exposure dose. Exposure to blue light could disrupt the integrity of the skin's protective barrier, leading to increased sensitivity to environmental stressors and potential skin damage.

0195 The association of electronic device use before bedtime on objective sleep quality measured with Odds Ratio Product

Abstract Introduction Previous research has shown mixed results when it comes to electronic device use and the impact on sleep quality. The use of electronic devices before bedtime can impact sleep quality through engaging content and the impact of blue light on melatonin secretion. In the present study, we assessed the relationship between electronic device use and sleep under real-world conditions. Methods Nineteen participants (age 41.1±10.9; 9 females) recorded their sleep with in-home PSG using the Cerebra Sleep System for 18 to 31 nights (21.5±3.4). Sleep quality was measured using odds ratio product (ORP) derived from spectral analysis of the frontal EEG channels during wake, NREM and REM sleep. Participants completed a nighttime questionnaire within one hour of bedtime where they were asked “Did you do any of these activities today” and indicated “social media or surfed the internet in the last hour before bedtime”. The Karolinska Sleepiness Scale (KSS) was also completed during the before bedtime test battery. Results Across the 19 participants, 17 participants reported using social media or surfing the internet within an hour before bedtime for at least one night. Participants reported usage for 9.6 ± 8.2 nights on average (n=165) but no usage for 11.7 ± 7.9 nights on average (n=210). On nights that internet or social media usage before bedtime was reported, participants had lower levels of evening sleepiness on the Karolinska Sleepiness Scale than on nights where no usage was reported (p <.001). On these nights, participants also had higher ORPNREM (p <.001), higher ORPREM (p<.001), higher ORPTRT (p<.001), higher ORP-9 (p<.001) which is an indication of poorer sleep depth after an EEG arousal. Conclusion On the nights when electronic devices were used before bedtime, participants experienced less sleepiness and had worse objective sleep quality during the night. These results indicate the utility of ORP to be sensitive enough to detect changes in sleep quality after electronic device use. Support (if any)

The impact of blue light and digital screens on the skin.

The skin is frequently subjected to a variety of environmental trauma and stress. It is unavoidably subjected to blue light due to the increased use of electronic equipment, including indoor lighting and digital gadgets like smartphones and laptops, which have a range of detrimental effects. The method of action and numerous harmful consequences of blue light on the skin are the main subjects of this review. A literature search has been performed using PubMed, GoogleScholar and EmBase databases and an updated review on the topic has been presented. Numerous studies have shown that being exposed to blue light accelerates the aging process and produces cutaneous hyperpigmentation. It also modifies the circadian rhythm. The two main molecules that mediate cellular responses to blue light are nitric oxide (NO) and reactive oxygen species. However, the precise process is still not fully known. These negative consequences may eventually cause more general skin damage, which may hasten the aging process. At times, skin protection may be crucial for protection against blue light.

Impact of Blue Light on Plant Growth, Flowering and Accumulation of Medicinal Flavones in Scutellaria baicalensis and S. lateriflora

Scutellaria baicalensis Georgi (Baikal skullcap) and S. lateriflora (American skullcap) are two ethnobotanical medicinal plants used to treat gastrointestinal, respiratory, and inflammatory disorders, in addition to demonstrated anti-cancer properties. The predominant bioactive compounds produced in these species are unique 4′-deoxyflavones, in roots of S. baicalensis and leaves of S. lateriflora, making these two species suitable to study the effects of light quality on flavone accumulation in aerial and underground tissues. Light emitting diodes were used to study the impact of blue-dominated spectrum on the accumulation of bioactive flavones. Eight major flavones, including 4′-deoxyflavones baicalein, wogonin, baicalin, wogonoside and chrysin, along with 4′-hydroxyflavones scutellarein, scutellarin and apigenin, were quantified using HPLC in high flavone accumulating tissues. Aerial tissues directly exposed to blue light in S. lateriflora showed an increase in the concentrations of scutellarein by 18.7%, scutellarin by 296%, and baicalin by 31.6%. While the roots in S. baicalensis also had significant increases in baicalein by 154% and wogonin by 76% in response to blue light, there was a slight reduction in their respective glycosides baicalin and wogonoside as well as a decrease in total flavone content. Blue light resulted in compact skullcap plants with early flowering and modified flavone profiles.

Impact of blue light on the biological properties of aqueous extracts during the cultivation of the Inonotus rheades mycelium

The aim was to determine whether the antioxidant, cytotoxic and virucidal properties of aqueous extracts isolated from the Inonotus rheades basidiomycete depend on the illumination of the mycelium during cultivation. Effects of blue light illumination on the mycelium of I. rheades, which was cultivated on birch wood at 25±1 ºC in the dark and under a constant illumination of 12.8 W/m 2 were studied. In the course of the work, two fractions of water-soluble polysaccharides were obtained: ВР-5 – isolated from the mycelium grown under blue light; BP-6 – isolated from mycelium grown in the dark. Two fractions of water-soluble pol- ysaccharides were obtained during the study: ВР-5 – water-soluble polysaccharides isolated from the mycelium grown under blue light; ВР-6 – water-soluble polysaccharides isolated from the mycelium grown in the dark. The extract from the mycelium grown under blue light showed a greater antioxidant activity than that from the mycelium grown in the dark. An analysis of the effect of the extracts under study on a test culture of tumour cells showed that the extracts cause the death of some amount of the cells on the 6th day of coincubation. The cytostatic effect of the extracts was also manifested following 6 days. In comparison with the control, the density of the culture at maximum concentrations decreased to 60% and 20% for BP-6 and BP- 5, respectively. The results of measuring the antiviral activity of the extracts showed that BP-5 and BP-6 completely destroy tick-borne encephalitis viruses. It was experimentally shown that, after normalisation of the pH values, both extracts contain components exhibiting a significant antiviral effect. The inhibition index for BP-5 and BP-6 comprised 3 and 2 lg PFU/ ml, respectively. This suggests that the concentration of virucidal components in the extract from mycelium grown under blue light is approximately 10 times higher than that in the extract from the mycelium grown in the dark. Thus, the extracts from the mycelium of I. rheades grown on birch discs contain substances exhibiting antioxidant, cytostatic and virucidal properties. The accumulation of these properties can be stimulated by blue light illumination.

2.3: Invited Paper: Visual Fatigue and Comfort Evaluation of the Different Proportions of Blue Light on the Same Display by Visual Research Task

Under the same indoor light condition, using visual search tasks, the study tested the effects of liquid crystal display (LCD) with different blue light ratio (the proportion of blue lightwere 20%, 40%, 60%, 80%, 100%) which were adjusted by software on users' visual fatigue and comfort. The test task time of each condition was 40 minutes. The evaluation methods were mainly based on ISO 9241‐304 Ergonomics of human‐system interaction‐User performance test methods for electronic visual displays, etc. The evaluation indexes mainly included the performance of visual search tasks, critical flicker frequency (CFF), visual fatigue subjective perception scale and EEG. The research results showed that the changes of task conditions in different indicators showed a non‐linear trend. 60% of blue light accounted for better performance in the performance of visual search and emotional state, while 40% of blue light accounted for the most serious fatigue. The EEG results showed that compared with 60% and 80%, 100% blue light condition had the best performance, lower attention control and workload, which to some extent verified the previous research results that blue light improved the brain arousal. The results showed that the impact of blue light on users involves many aspects, not a single dimension. The results of this study will provide a reference to adjust the standard of blue light ratio by software.

Cryptochrome 1 is modulated by blue light in human keratinocytes and exerts positive impact on human hair growth.

Photoactivation of cryptochrome-family proteins by blue light is a well-established reaction regulating physiology of plants, fungi, bacteria, insects and birds, while impact of blue light on cryptochrome synthesis and/or activity in human non-visual cells remains unknown. Here, we show that 453nm blue light induces cryptochrome 1 (CRY1) accumulation in human keratinocytes and the hair follicle. CRY1 is prominently expressed in the human anagen hair follicle, including epithelial stem cells. Specific silencing of CRY1 promotes catagen, while stimulation of CRY1 by KL001 prolongs anagen ex vivo by altering the expression of genes involved in apoptosis and proliferation. Together, our study identifies a role for CRY1 in sustaining human hair growth. Previously, we demonstrated positive effects of 453nm blue light on hair growth ex vivo. Taken all together, our study suggests that CRY1 might mediate blue light-dependent positive effects on hair growth.

PENGARUH PEMAKAIAN LENSA BLUE CUT TERHADAP KENYAMANAN PEMAKAIAN KACAMATA DI OPTIK JAYA PASAMAN BARAT

Impaired vision makes someone have to use visual aids so that vision becomes clear. Various ways are done by people, such as using glasses, contact lenses and even lasik surgery. The addition of blue cut lenses to glasses is generally used to help human vision against eye weakness due to nearsightedness or other visual reasons and protect the eyes from UV rays. The research objectives were (1) to determine the effect of using blue cut lenses on the comfort of wearing glasses in West Pasaman optics. (2) To determine the advantages of blue cut lenses on eye health for eyeglass users at Optic Zal Pondok Padang. The type of research used is descriptive quantitative, the research process was carried out by interviewing by distributing questionnaires, this study aims to obtain an overview of the effect of using blue cut lenses on the comfort of wearing glasses in West Pasaman Jaya optics. The population in this study were all patients at an early age who experienced refractive errors in the study, amounting to 30 people. Considering the population under study was less than 100 people, the sample in this study were all consumers of Jaya Pasaman Barat optics totaling 30 people. The study was conducted on early age patients at Optik Jaya Pasaman Barat. The results showed that the respondents that 61.7% of the respondents know the effect of wearing blue cut lenses on the comfort of wearing glasses, this is because they do not know the impact of UV rays on eye health and 60.1% of blue cut lenses have the advantage of maintaining eye health. Based on the results of this study, it was concluded that as much as 61.7% response to know the effect of using blue cut lenses on the comfort of wearing glasses in West Pasaman Jaya optics. This is due to the lack of knowledge of respondents about the impact of blue light on eye health. Based on the results of the research the effect of using blue cut lenses on the comfort of wearing glasses in West Pasaman optics, the results showed that as many as 60.7% of respondents knew the advantages of blue cut lenses and it was suggested to the public that when dealing directly with patients, they must wear anti-radiation lenses that are familiar with blueray lenses.

The impact of blue light in monolayers representing tumorigenic and nontumorigenic cell membranes containing epigallocatechin-3-gallate

Natural products such as epigallocatechin-3-gallate (EGCG) have been suggested for complementary treatments of cancer, since they lower toxic side effects of anticancer drugs, and possess anti-inflammatory and antioxidant properties that inhibit carcinogenesis. Their effects on cancer cells depend on interactions with the membrane, which is the motivation to investigate Langmuir monolayers as simplified membrane models. In this study, EGCG was incorporated in zwitterionic dipalmitoyl phosphatidyl choline (DPPC) and anionic dipalmitoyl phosphatidyl serine (DPPS) Langmuir monolayers to simulate healthy and cancer cells membranes, respectively. EGCG induces condensation in surface pressure isotherms for both DPPC and DPPS monolayers, interacting mainly via electrostatic forces and hydrogen bonding with the choline and phosphate groups of the phospholipids, according to data from polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS). Both monolayers become more compressible upon interaction with EGCG, which may be correlated to the synergy between EGCG and anticancer drugs reported in the literature. The interaction with EGCG is stronger for DPPC, leading to stronger morphological changes in Brewster angle microscopy (BAM) images and higher degree of condensation in the surface pressure isotherms. The changes induced by blue irradiation on DPPC and DPPS monolayers were largely precluded when EGCG was incorporated, thus confirming its antioxidant capacity for both types of membrane.

Dissecting the Response to Blue Light

AbstractAs more display users express concern about the impact of blue light on health, manufacturers have offered multiple ways to reduce exposure. However, experts say, achieving a true solution is a bit more complicated.

A Comparison of Blue Light and Caffeine Effects on Cognitive Function and Alertness in Humans

The alerting effects of both caffeine and short wavelength (blue) light have been consistently reported. The ability of blue light to enhance alertness and cognitive function via non-image forming neuropathways have been suggested as a non-pharmacological countermeasure for drowsiness across a range of occupational settings. Here we compare and contrast the alerting and psychomotor effects of 240 mg of caffeine and a 1-h dose of ~40 lx blue light in a non-athletic population. Twenty-one healthy subjects performed a computer-based psychomotor vigilance test before and after each of four randomly assigned trial conditions performed on different days: white light/placebo; white light/240 mg caffeine; blue light/placebo; blue light/240 mg caffeine. The Karolinska Sleepiness Scale was used to assess subjective measures of alertness. Both the caffeine only and blue light only conditions enhanced accuracy in a visual reaction test requiring a decision and an additive effect was observed with respect to the fastest reaction times. However, in a test of executive function, where a distraction was included, caffeine exerted a negative effect on accuracy. Furthermore, the blue light only condition consistently outperformed caffeine when both congruent and incongruent distractions were presented. The visual reactions in the absence of a decision or distraction were also enhanced in the blue light only condition and this effect was most prominent in the blue-eyed participants. Overall, blue light and caffeine demonstrated distinct effects on aspects of psychomotor function and have the potential to positively influence a range of settings where cognitive function and alertness are important. Specifically, despite the widespread use of caffeine in competitive sporting environments, the possible impact of blue light has received no research attention.

ROSE DEVELOPMENT UNDER BLUE LIGHT ENVIRONMENT: BEHAVIOUR OF THREE CULTIVARS OF ROSE BUSHES

Ornamental plant shape is one of the main criteria of plant sale value. Under horticultural practices, plant shape is classically modulated through the use of growth regulators that enhance plant capacity. Increasing concern about environmental preservation encourages for the search of new environmental-friendly practices. Light is known to be the environmental factor that most affects plant architecture and thus plant shape. Using specific light quality rather than chemicals could not only contribute to preserve the environment, but also cause new aesthetical effects on plant shape. With this objective, we studied the impact of blue light on three rose cultivars, Rosa hybrida 'Radrazz', Rosa hybrida 'Meiratcan' and Rosa chinensis 'Old Blush'. Plants were grown from single node cuttings under white (Mastec 36 Watt; white/33 cool neons), or blue light (Philips TL-D 36, Watt/18, blue neons) at an equal photosynthetic efficiency (110 mu mol.m(-2).s(-1)) until the end of flowering of second order axes. Surprisingly, plants grown under blue light had normal vegetative and floral developments: for the cultivars 'Radrazz' and 'Old Blush', morphological and architectural characteristics as length and diameter of first and second order axes, number and localisation of second order axes, number and length of metamers, were similar between the two light treatments. However, for Rosa hybrida 'Meiratcan', both organogenesis and growth were slightly affected by blue light with a decrease of metamer number, axis length and axis diameter for the order 1 axes and a decrease of the number of order 2 axes. These results thus reveal the strong adaptive properties of rose plants to their light environment, but the effects of blue light are cultivar dependent. As far as horticultural practices are concerned, testing the effect of blue light on a cultivar is necessary before deciding if blue light is an efficient treatment to modulate or change rose plant shape.

The impact of blue light on leaf mesophyll conductance

Blue light has many direct and indirect effects on photosynthesis. The impact of blue light on mesophyll conductance (g(m)), one of the main diffusive limitation to photosynthesis, was investigated in leaves of Nicotiana tabacum and Platanus orientalis, characterized by high and low g(m), respectively. Leaves were exposed to blue light fractions between 0% and 80% of incident light intensity (300 micromol photons m(-2) s(-1)), the other fraction being supplied as red light. Leaves exposed to blue light showed reduced photosynthesis and unaltered stomatal conductance. The g(m), measured using the chlorophyll fluorescence-based method, was strongly reduced in both plant species. Such a reduction of g(m) may not be real, as several assumptions used for the calculation of g(m) by fluorescence may not hold under blue light. To assess possible artefacts, the electron transport rate measured by fluorescence (J(f)) and by gas-exchange (J(c)) were compared in leaves exposed to different fractions of blue light under non-photorespiratory conditions. The two values were only equal, a prerequisite for correct g(m) measurements, when the illumination was totally provided as red light. Under increasing blue light levels an increasing discrepancy was observed, which suggests that J(f) was not correctly calculated, and that such an error could also upset g(m) measurements. Blue light was not found to change the absorbance of light by leaves, whereas it slightly decreased the distribution of light to PSII. To equate J(f) and J(c) under blue light, a further factor must be added to the J(f) equation, which possibly accounted for the reduced efficiency of energy transfer between the pigments predominantly absorbing blue light (the carotenoids) and the chlorophylls. This correction reduced by about 50% the effect of blue light on g(m). However, the residual reduction of g(m) under blue light was real and significant, although it did not appear to limit the chloroplast CO(2) concentration and, consequently, photosynthesis. Reduction of g(m) might be caused by chloroplast movement to avoid photodamage, in turn affecting the chloroplast surface exposed to intercellular spaces. However, g(m) reduction occurred immediately after exposure to blue light and was complete after less than 3 min, whereas chloroplast relocation was expected to occur more slowly. In addition, fast g(m) reduction was also observed after inhibiting chloroplast movement by cytochalasin. It is therefore concluded that g(m) reduction under blue light is unlikely to be caused by chloroplast movement only, and must be elicited by other, as yet unknown, factors.