Currently, no systematic approach exists for the safety assessment method of hydrogen transmission low-strength pipeline, it is necessary to study the effect of hydrogen embrittlement (HE) on the method of failure assessment diagram (FAD) for the defective pipe. The hydrogen charging experiments of tensile and Charpy impact specimens for the L245 pipe steel were carried out with charging time of 0, 30, 90, and 120 h, and then the tensile and Charpy impact tests were immediately conducted. The HE indexes of tensile and Charpy impact properties were presented to quantitatively analyze the effect of HE under tensile and impact deformation processes. Subsequently, the FAD method coupled with the effect of HE was investigated to analyze the difference in the safety assessment method between hydrogen and non-hydrogen environments. Finally, the fracture morphology of tensile and Charpy impact specimens was observed to analyze the responses of microscopic fracture modes between hydrogen and non-hydrogen environments. The results show that the effect of HE on the tensile properties of the base material is more sensitive than that of the weld joint. The FAC with the effect of HE for safety assessment of defective pipes shrinks by reducing the safe zone. The decrease ratio of safety factors affected by HE presents an increasing tendency as the increase of crack depth while showing a decreasing tendency as the increase of internal pressure.