Patients with advanced heart failure exhibit systemic and organ specific neurohumoral activation and inflammation. Similarly, heart transplant recipients present an early and persisting late inflammatory activation following transplantation (CTX) while may be associated with coronary allograft vasculopathy (CAV). Neutrophils mediated inflammatory response plays a significant role in the development of coronary artery diseases. The effects of immunoprophylactic agents on the modulation of the inflammatory response on isolated human neutrophils have not been investigated.