Immunization History Research Articles

The Decay of Pertussis Antibodies in Children Aged 0-14 Years in Jiangsu Province, China.

The purpose of this study was to investigate possible influencing factors based on the distribution of the pertussis toxin (PT) and filamentous hemagglutinin (FHA) antibody levels in 0-14-year-old children in Jiangsu Province, China, and to analyze changes in IgG antibody levels after pertussis vaccination in children over time via a restricted cubic spline (RCS)-fitted binary logistic regression model. We collected surveillance data on pertussis through the National Notifiable Disease Reporting System (NNDRS). Serum samples were collected, and PT IgG/FHA IgG antibody levels were determined via an enzyme-linked immunosorbent assay (ELISA). A binary logistic regression model was fitted with an RCS. Peak incidence occurred in children aged 0-1 years from 2007 to 2022, and a second peak emerged in children aged 5 years and older from 2018 onwards which shifted towards older age groups. The geometric mean concentrations (GMC) of the anti-PT IgG antibody and anti-FHA IgG antibody in 1129 patients were 15.13 (13.49-16.76) IU/mL and 22.99 (21.17-24.81) IU/mL, respectively. The seropositivity rates of the anti-PT IgG and anti-FHA IgG antibodies in the group receiving a full vaccination course (four doses) were significantly higher than those of other groups (24.6% vs. 43.3%). The RCS fitting model showed a non-linear relationship between the duration after immunization and the odds ratio (OR) of having PT-IgG and FHA-IgG antibody concentrations ≥20 IU/mL in children with documented immunization histories (1-4 doses) (Poverall < 0. 001; Pnonlinear ≤ 0.001). The children with histories of immunization demonstrated antibody levels that decreased to very low levels around 17 months after the last dose of the vaccine. Therefore, it is recommended that pertussis-containing vaccines be administered as booster immunizations for older children.

Edukasi Gizi Isi Piringku dan Perilaku Hidup Bersih dan Sehat (PHBS) Sebagai Upaya Penurunan dan Pencegahan Stunting Di Desa Suka Menanti Kecamatan Bukit Kemuning Kabupaten Lampung Utara

Stunting is a condition of failure to thrive in children under five due to chronic malnutrition. Stunting occurs due to multifactors, namely household and family factors such as knowledge, upbringing, food availability and poor sanitation, inadequate breastfeeding and complementary breastfeeding, infection factors such as history of malaria, diarrhea and incomplete immunization, as well as community and social factors such as economic conditions, health services and culture, so efforts to reduce stunting are not only a task for the health sector, but also across sectors.&#x0D; The purpose of this Community Service Implementation is to increase the knowledge of mothers, prospective brides, pregnant women and cadres about stunting prevention through education on Fill My Plate and PHBS. Target activities for pregnant women, prospective brides and mothers with children under five, and family companions.&#x0D; The method used is counseling about stunting and demonstrations of the contents of my plate and PHBS. The results obtained by all participants increased knowledge and awareness about stunting and participants were able to practice My Plate Fill and PHBS. It is hoped that the village government can carry out periodic outreach and monitor and assist stunting toddlers. Health workers are also expected to improve health services for prospective brides, pregnant women, babies and toddlers by providing support to catin to get education about health, pregnant women to check their pregnancies regularly, encouraging exclusive breastfeeding and providing additional food. The community also needs to contribute to preventing stunting by adopting a clean and healthy lifestyle.

Understanding Diversity of Policies, Functionalities, and Operationalization of Immunization Information Systems and Their Impact: A Targeted Review of the Literature.

The COVID-19 pandemic has focused attention on the use of immunization information systems (IIS) to record and consolidate immunization records from a variety of sources to generate comprehensive patient immunization histories. Operationalization of IIS in the United States is decentralized, and as such, there are over 60 different IIS with wide variations in enabling policies and functionalities. As such, the policies that inform the development and operation of those sub-national IIS exist at the state and sometimes city levels. A targeted literature review was conducted to identify IIS policies and functionalities and assess their impact. The authors identified articles published from 2012 to 2022 that discussed or evaluated IIS policies and functionalities and screened titles, abstracts, and full text for inclusion. When selected for inclusion, authors extracted IIS policy/functionality characteristics and qualitative or quantitative outcomes of their implementation, where applicable. The search terms yielded 86 articles, of which 39 were included in the analysis. The articles were heterogeneous with respect to study design, interventions, outcomes, and effect measures. Out of the 17 IIS policies and functional components identified in the targeted literature review, the most commonly evaluated were provider-based patient reminder/recall, IIS-based centralized reminder/recall, and clinical decision support. Patient reminder/recall had the most published research and was associated with increased vaccination rates and vaccine knowledge. Despite the lack of quantitative evidence, there is a consensus that immunization data interoperability is critical to supporting IIS data quality, access, and exchange. Significant evidence gaps remain about the effectiveness of IIS functionalities and policies. Future research should evaluate the impact of policies and functionalities to guide improved utilization of IIS, increase national interoperability and standardization, and ultimately improve vaccination coverage and population health.

Immunogenicity and safety of revaccination of 23-valent pneumococcal polysaccharide vaccine in people aged 60 years and above

Objective: To evaluate the immunogenicity and safety of revaccination of 23-valent pneumococcal polysaccharide vaccine (PPV23) in elderly people aged ≥60 years. Methods: The elderly aged ≥60 years with 1 dose of PPV23 vaccination were selected as revaccination group and those without history of pneumococcal vaccine immunization were selected as the first vaccination group. One dose of PPV23 was administered to both groups, and the first blood samples were collected before vaccination while the second blood samples were collected on day 28-40 after vaccination. ELISA was used to detect the concentrations of anti-specific serotype Streptococcus pneumoniae podocyte polysaccharide immunoglobulin G, and the safety of the vaccination was evaluated after 30 days. Results: The geometric mean concentration (GMC) of antibody to 23 serotypes before the vaccination (0.73-13.73 μg/ml) was higher in revaccination group than in the first vaccination group (0.39-7.53 μg/ml), the GMC after the vaccination (1.42-31.65 μg/ml) was higher than that before the vaccination (0.73-13.73 μg/ml) in the revaccination group, and the GMC after the vaccination (1.62-43.76 μg/ml) was higher than that before the vaccination (0.39-7.53 μg/ml) in the first vaccination group; the geometric mean growth multiple in revaccination group (2.16-3.60) was lower than that in the first vaccination group (3.86-16.13); The mean 2-fold antibody growth rate was lower in revaccination group (53.68%, 95%CI: 52.30%-55.06%) than in the first vaccination group (93.16%, 95%CI: 92.18%- 94.15%), all differences were significant (P<0.001). After the vaccination, 13 serotypes of GMC were higher in the first vaccination group than in revaccination group (P<0.001), the differences were not significant for 10 serotypes of GMC (P>0.05). The incidence of local adverse reaction was 19.20% and 13.27% in revaccination group and the first vaccination group, respectively (P=0.174). Conclusions: The antibody level in ≥60 years people who received one dose of PPV23 after a 5-year interval was still higher than that in unvaccinated people. The antibody level decreased after 5 years of the first vaccination, and the antibody level could be rapidly increased by one more dose vaccination, but the overall immune response was lower than that of the first vaccination; revaccination with PPV23 has a good safety.

Analysis on the epidemiological characteristics of varicella and breakthrough case from 2014 to 2022 in Qingyang City

ABSTRACT We analyze the epidemiological characteristics of varicella and breakthrough cases in Qing Yang City, Gansu Province, and provide a basis for the formulation of varicella prevention and control policies. Varicella and breakthrough cases, public health emergency events in Qing Yang City during 2014–2022 were obtained from the China Disease Prevention and Control information System, and the immunization history of the cases were collected from the Gansu Provincial Immunization Planning Information System, descriptive epidemiological analysis of the obtained information was then performed. A total of 6961 cases of varicella were reported in Qing Yang City from 2014 to 2022, yielding an annual incidence of 36.99 cases per 100 000 population. The incidence increased from 19.74/100,000 in 2014 to 35.97/100,000 in 2022; the incidence peaks were observed from May to July and from November to January of the next year. The reported incidence is higher in males (37.70/100,000) than in females (31.54/100,000), and the main age groups were 4 ~ 6 years old (241.98/100,000), 7 ~ 9 years old (142.39/100,000), 10 ~ 14 years old (101.99/100,000). There were 1975 breakthrough cases, accounting for 28.4% of the total reported cases; the majority of patients were students, children in nursery care and scattered children; a total of 10 outbreaks of varicella were reported in primary schools (40.0%), secondary schools (30.0%), kindergartens (20.0%) and high schools (10.0%). The incidence of varicella showed an increasing trend, children and students are high-risk population. It is suggested that varicella vaccine should be included into the immunization program, and the vaccination rate of two-dose of varicella vaccine should be increased for age-eligible children, and varicella surveillance should be strengthened.

Is alveolar osteitis more prevalent since COVID-19? A cross-sectional study

Objectives: The aim of the study was to analyze the association between post-extraction alveolar osteitis and coronavirus disease 2019 (COVID-19) in a single center. Material and Methods: A monocentric cross-sectional study was carried out at NSVK Sri Venkateshwara Dental College and Hospital located in Bannerughatta, Bengaluru in the Department of Oral and Maxillofacial Surgery from January 2021 to August 2022. The study sample comprised 50 participants; an extraction of one or more teeth was performed on women and men between the age group of 15–83 years and returned with complication of alveolar osteitis. Demographic details such as age, gender, medical history, personal habits, COVID-19 immunization history, history of COVID-19, and its complications were acquired from the patient’s case history files throughout the study and recorded. Descriptive statistics were used to analyze the collected data. Chi-square test was used to check for association between the groups. Results: Females (62%) were majority of the study participants with an average age of 40 years. Of the patients reported to the hospital, 46% were COVID-positive, 38% were smokers, 48% consumed alcohol, and 80% presented with some underlying systemic condition. A statistically significant association was seen between history of COVID-19 positive patients and systemic condition with P = 0.014 (P ≤ 0.05). Conclusion: Patients with systemic conditions were more prone to dry socket; however, personal habits such as smoking, alcohol, and use of tobacco showed no direct relationship. According to study, previous history of COVID-19 infection did not have significant effects in regards to alveolar osteitis. Thus, more research on recovered COVID-19 patients should be done to understand the etiology of dry socket.

History of infantile BCG immunization did not predict lamina propria invasion and/or high-grade in patients with non-muscle invasive bladder cancer

To evaluate the utility of infantile BCG vaccination history in predicting stage and grade of tumours in non-muscle invasive bladder cancer (NMIBC). We retrospectively analyzed data from patients from a single center who were diagnosed with new NMIBC and underwent transurethral resection of bladder tumour (TURBT) between 2017 and 2022. We assessed BCG immunization status with various demographics and comorbidities, as well as tumour recurrence, progression, stage, and grade. A total of 188 patients met the inclusion criteria for our study. The mean age of patients at the time of diagnosis was significantly lower in those that had been immunized with BCG (71 ± 9) than those who had not (77 ± 10) (p < 0.0001). History of BCG immunization did not correlate with sex, history of diabetes mellitus (DM), prior history of intravesical BCG treatment, and tumour recurrence, progression, stage, and grade. History of infantile BCG vaccination did not correlate with the depth of invasion and/or the grade in patients with non-muscle invasive bladder cancer. Patients that received infantile BCG vaccination were significantly younger at the time of diagnosis of NMIBC.

Faktor Determinan Kejadian Stunting pada Balita di Provinsi Kalimantan Barat (Studi Data Riskesdas Tahun 2018)

Stunting toddlers is a chronic nutritional problem caused by many factors, such as socioeconomic conditions, maternal nutrition during pregnancy, illness in infants, and a lack of nutritional intake in infants. West Kalimantan has a high prevalence of stunting compared to the national prevalence of 36.5%. The purpose of this study was to determine the determinants associated with the incidence of stunting in West Kalimantan. This type of research uses a quantitative approach with a cross-sectional study design. The population is 2,064 people, and the sample in this study is 335 respondents by random sampling. The statistical test used was chi-squared with a 95% confidence level. The results showed that there was no relationship between PMT (p-value of 1.000), history of breastfeeding (p-value of 0.052), history of immunization (p-value of 0.640), history of infection (p-value of 0.474), and access to health services with stunting events (p-value of 0.902) in West Kalimantan. Suggestions for the government and health agencies: it is expected to increase awareness, dissemination, and information to the public regarding incomplete immunization history with a risk factor of 1.704 and a history of non-exclusive breastfeeding with a 1.326 times greater risk of influencing stunting.

Factors Associated with Vaccine Refusal (Polio and Routine Immunization) in High-Risk Areas of Pakistan: A Matched Case-Control Study.

Pakistan has subpar childhood immunization rates and immunization activities have faced several challenges over the past years. We evaluated the social-behavioral and cultural barriers and risk factors for refusal of polio, Routine Immunization (RI), or both in high-risk areas of poliovirus circulation. A matched case-control study was conducted from April to July 2017 in eight super high-risk Union Councils of five towns in Karachi, Pakistan. A total of 3 groups, each with 250 cases, including refusals for the Oral Polio Vaccine (OPV) in campaigns (national immunization days and supplementary immunization activities), RI, and both, were matched with 500 controls and identified using surveillance records. Sociodemographic characteristics, household information, and immunization history were assessed. Study outcomes included social-behavioral and cultural barriers and reasons for vaccine refusal. Data were analyzed in STATA using conditional logistic regression. RI refusal was associated with illiteracy and fear of the vaccine's adverse effects, while OPV refusals were linked to the mother's decision authority and the assumption that the OPV caused infertility. Conversely, higher socioeconomic status (SES) and knowledge of and willingness to vaccinate with Inactivated Polio Vaccine (IPV) were inversely associated with RI; and lower SES, walking to the vaccination point, knowledge of IPV, and an understanding of contracting polio were inversely associated with OPV refusals, with the latter two also inversely associated with complete vaccine refusal. Education, knowledge and understanding of vaccines, and socioeconomic determinants influenced OPV and RI refusals among children. Effective interventions are needed to address knowledge gaps and misconceptions among parents.

Demographical, clinical, and complication differences between vaccinated and unvaccinated hospitalized children with measles in mogadishu somalia: a hospital-based retrospective cohort study.

A hospital-based retrospective cohort study was implemented between 10 October and 10 November 2022 by reviewing case record files following a well-structured checklist of admitted clinical features, demographic characteristics, history of measles immunization, and measles complication status. Descriptive statistics were used by presenting frequency and percentage for categorical and the mean score for continuous variables. χ2 and Fisher's exact test at P =0.05 were used to identify the proportions differences between vaccinated and unvaccinated cases. A total of 93 hospitalized measles children participated in the study. Over half were boys, the mean age in months was 20.9 (SD±7.28), and over two-thirds of the mothers/caregivers did not have formal education. Almost 9.7% of hospitalized measles children had one dose of the measles-containing vaccine, while none had two doses. The vaccinated cases had fewer ill with fewer complications than the unvaccinated cases. Fever, cough, rash, and Koplik's spots were clinical features associated with measles immunization status. Around one in ten hospitalized children had one dose of the measles vaccine. Vaccinated cases had fewer illnesses with few complications than unvaccinated cases. The paper highly emphasizes providing booster doses, improving vaccine logistics and storage, and following immunization schedules. In addition, conducting further multicentral high sample-size studies is highly required to identify whether vaccine inadequacy was due to host-related or vaccine-related factors.

Clinical Characteristics of SARS-CoV-2 Omicron Cases in Pune, Maharashtra, India.

Background The SARS-CoV-2Omicron variant, within two months of its detection, replaced the Delta variant to become the dominant circulating variant globally. Therefore, it is essential to understand the characteristics of the disease caused by the variant and its impact on vaccination. Methods A total of 165 confirmed Omicron cases attending a tertiary care hospital in Pune, Maharashtra, between December 2021 to February 2022 were studied. Their demographic, clinical, and immunization history was recorded. Results Among the 165 cases, 7.88% were B.1.1.529 Omicron cases, 25.45% were BA.1 Omicron cases, and 66.67% were BA.2 Omicron cases. Of these 165 patients, 146 (88.48%) were discharged after treatment, 12 (7.27%) died during hospitalization, and seven (4.24%) were brought dead. The presence of one or more comorbid conditions was seen in 15.15%, of which diabetes mellitus and hypertension (28% each) were the most common conditions. Older age (greater than 60 years), an important risk factor for poor outcomes, was present in 9.1% of cases. Among the 165 cases, vaccination with at least one dose of vaccine was found in 80.61% of cases. Out of 165 cases, clinical data was available for 158 cases. Of these 158 cases, 86.71% had symptoms, and 13.29% were asymptomatic. Fever, followed by cough, myalgia, runny nose, and headache, were the most common presenting symptoms. The mean duration of illness was 2.69 days, with 91.14% of cases having the illness for less than five days, and 89.24% of cases had a National Early Warning Score (NEWS) of 1-4, suggesting a good prognosis. In 93.90% of cases, the chest X-ray findings were normal. Of the 158 cases, 92.41% of cases recovered with supportive treatment, and only 7.59% of cases required oxygen therapy. Conclusion The current study shows that the Omicron variant caused mild disease with reduced need for hospital admission and oxygen therapy in India.

History of influenza immunization in COVID-19 patients: impact on mortality.

In the context of the COVID-19 pandemic, there is concern regarding the impact of the influenza season. To analyze the impact of influenza immunization history on patients with SARS-CoV-2 infection. Patients older than 18 years with COVID-19, registered between March and August 2020, were included. Data were analyzed using Fisher's exact test and Student's t-test. To evaluate the impact on mortality, a logistic regression model was used; the relationship between the percentage of patients who received the influenza vaccine and mortality was determined with Pearson's correlation coefficient. 16,879 participants were included; 17 % had a history of influenza vaccination. Mortality was lower in the group with a history of vaccination (3.5 % vs. 7 %, p < 0.0001). The vaccination rate had an inverse relationship with the mortality rate (Pearson's r: -0.922, p = 0.026). Previous influenza immunization was an independent protective factor for mortality in patients with COVID-19. Although further studies are needed to determine a causal relationship, it would be reasonable to increase influenza immunization in the general population.

IL6 as prognostic factor for severity of COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the viral illness known as coronavirus disease 2019. Several inflammatory and biochemical markers are elevated, and blood indices are altered, in COVID-19, a sign of a cytokine storm.(50) COVID-19 patients at Marjan medical city and Imam Sadiq Teaching hospitals between December -2021 and April -2022 were studied for the connection of IL-6 levels. Results of blood tests varied significantly depending on the severity of the condition. Interleukin-6 (IL-6) and SPO2 (percent) were significantly different between the two measurement periods at day 1 and day 3. Nearly three out of four patients had severe illness (N=34, 68.0 percent), and there was no one with moderate disease (N=16, 32.0 percent). According to the level of illness severity, there were large variations in the distribution of age groups. This study found a strong correlation between illness severity and immunization history and previous medical records.

History of vaccine and immunization: Vaccine-hesitancy discussion in Germany in XIX century.

Vaccination is the most celebrated and denigrated achievement of medicine and public health - not only today, but since Edward Jenner's time (1798). In fact, the idea of injecting a mild form of "disease" into a healthy person was attacked even earlier than the discovery of vaccines. The forerunner of Jenner's vaccination with bovine lymph was the inoculation of smallpox material from person to person, which, known in Europe since the beginning of the eighteenth century, was a target of harsh criticism. The reasons for criticizing the Jennerian vaccination and its mandatory practice were medical, anthropological, biological (vaccination is not safe), religious and ethical (it is wrong to inoculate a healthy person with disease), and political (vaccination is a threat to individual freedom). As such, anti-vaccination groups emerged in England, where inoculation was adopted early, as well as overall in Europe and in the United States. This paper focuses on the lesser known debate that arose in Germany in the years 1852-53 about the medical practice of vaccination. This is an a important topic of public health that has aroused a wide debate and comparison especially in recent years and now with pandemic on Sars-Cov-2 (Covid-19) and will probably be the subject of further reflection and consideration in the coming years.

Correlation between Basic Immunization Status and IHC Visits to Stunting Incidents on Toddlers

Stunting could be found in a circumstance where children's height is unusual compared to their age. There are multifactor that cause stunting which some of them are repeated infections and the utilization of health services. Recurrent infections can be prevented if the child's basic immunization is complete. A complete history of immunization status can lower the incidence of recurrent infections. In addition, ANC examinations and measurements of weight and height as the form of the utilization of health services are perceivable by the frequency of visits of mothers and toddlers to integrated healthcare. The more frequently mothers and toddlers go to integrated healthcare, the faster stunting symptoms will be detected thus the toddler is less likely to experience stunting. This study aims to examine associations between toddlers' basic immunization status and visits to integrated healthcare regarding the stunting incidence among toddlers at the stunting locus in Sukamulya Village, Bandung Regency. The study used a quantitative correlation design with a secondary data approach. Respondents are acquired from secondary data, which is the society in Sukamulya Village, Bandung Regency. Samples were selected through purposive sampling technique with specific criteria which is mother with children under five, resulting 96 people in total. The variables in the study consisted of basic immunization status, visits to integrated healthcare, and stunting. Data processing uses univariate and bivariate analysis. The instrument consists of a toddler’s immunization history, ANC examination, also toddler’s weight and height measurement. Statistical test using Chi square with 5% significance level. This study results that there are no associations between basic immunization status (p value = 0.284) with stunting incident and visits to integrated healthcare is associated with (p value = 0.001) the incidence of stunting. These findings are caused by the variety of immunity levels of toddlers and there are multifactor that cause infectious diseases.

Knowledge and Attitude Regarding HPV Vaccination among Late Adolescent Girls Studying in Selected Colleges

Introduction Human Papillomavirus (HPV) is the most common sexually transmitted infection in both sexes. In Spite of the vaccines which are highly immunogenic, safe, well tolerated and highly effective in preventing HPV infection the interest shown to receive the vaccine is least. The major reason is the lack of awareness and knowledge about HPV, vaccines and cervical cancer among people resulting in only a small number of immunizations being reported. The investigators decided to know the vaccination knowledge and attitude on their own settings and conducted a study. Aims: To determine the knowledge and attitude regarding HPV vaccination among late adolescent girls Methods: A Descriptive Research Design was adapted in this study. The study was conducted among First year undergraduate female students studying in the following colleges Physiotherapy, occupational therapy and Optometry of Sri Ramachandra University. Non Probability Convenience Sampling Technique was used to select the samples during the study period. Demographic Variables consist of Age, Year of study, previous knowledge on HPV Vaccination, Immunization History. PART II- Section A: Structured Knowledge questionnaire on HPV Vaccination. Results Out of 122 participants 68% of students have heard about HPV vaccine and 32% of students have not heard about HPV vaccine. 10.7% of the students have received HPV vaccination and 89.3% of the students have not received HPV vaccination; among 89.3% who have not received HPV vaccine, only 60.6% are willing to receive HPV vaccine in future and 28.6% are not willing to receive HPV vaccine in future. The study revealed that 51% had inadequate knowledge and 49% of students had moderately adequate knowledge on HPV vaccination. Conclusion The study results concluded that the majority of adolescents require the knowledge of human papillomavirus vaccination. The urge of vaccination needs to be inculcated among adolescents through educational institutions.

Isolated right peroneal mononeuropathy after silent SARS-CoV-2 infection in a child: Case report and review of the literature

Introduction: Peroneal neuropathy is considered as the most common mononeuropathy of the lower extremities, albeit with limited medical documentation. Risk factors include local injuries or recurrent minor trauma, surgery, weight loss, habitual leg crossing, other prolonged postures, or application of inappropriately fitted orthopedic devices that lead to uninterrupted pressure at the fibular head, intoxication, bicycle riding, prolonged anesthesia, lengthy hospitalization, other underlying neuropathies, diabetes mellitus, exposure to cold and irradiation and infection by neurotropic viruses. Case Report: We present a 4-year-old non-immunocompromised boy with an isolated right foot drop. At presentation, he had a characteristic walking that resulted from the inability to bend his right foot upward at the ankle. The foot drop developed gradually over the last week and was not accompanied by other symptoms. A careful history and appropriate serologic and imaging studies ruled out common causes of peroneal neuropathy except for SARS-CoV-2. Indeed, a high titer of specific IgG antibodies to this new coronavirus was detected, despite no history of prior immunization. Conclusion: Peroneal neuropathy may represent one of the many neurological sequelae of infection with SARS-CoV-2; physicians should be aware of this.

Investigation on the carriage prevalence of Neisseria meningitidis in healthy population in Jiangsu Province in 2019 and 2020

In order to investigate carriage status and serum groups distribution of Neisseria meningitidis(Nm) among healthy population in Jiangsu Province, four counties were selected as monitoring sites by random sampling method for cross-sectional study. Throat swab specimens were collected from four monitoring sites in October to November 2019 and November to December 2020 for bacterial culture and Real-time PCR detection. Chi-square test was used to compare the positive rate of Neisseria meningitidis, and multiple logistic regression model was used to analyze the influencing factors of Neisseria meningitidis carrier rate. The results showed that among 1 512 samples, 57 strains of Nm were isolated, and the carrier rate was 3.77%. Serogroup B was the dominant group (36.84%), followed by un-known serogroups (33.33%), serogroup C was the third (17.54%), serogroup W135 and serogroup A were 7.02% and 5.26%, respectively. The carriage rate (8.60%) of 15-20 years old was significantly higher than others (1.77%-3.74%)(Pearson χ2=18.211, P<0.05). Region, age and immunization history were risk factors for Neisseria meningitidis carrier rate. In summary, the Nm carrier rate of healthy population in Jiangsu Province is relatively low, which indicates that the epidemic cases will continue to be sporadic in the future. However, the prevention and control of meningococcal epidemics on campus should be strengthened, and the monitoring of neisseria meningitidis group B should be maintained as it has become the dominant epidemic strain.

Gambaran Capaian Imunisasi Dasar dan Lanjutan Sebelum, Selama dan Saat Transisi Pandemi COVID-19 di Wilayah Puskesmas Kecamatan Cempaka Putih

Immunization is an action that provides immunity to individuals so that when exposed to a disease they will only experience mild illness or no pain. Immunizations are carried out mainly in children. Immunizations carried out on children are basic immunization and advanced immunization. Due to the COVID-19 pandemic, immunization cannot run properly. This study aims to find out about the achievements of basic and follow-up immunizations between before, during, and the transition period of the COVID-19 pandemic in the Cempaka Putih sub-district. Research Methods: This research is an observational descriptive study in the work area of the Cempaka Putih District Health Center. The research sample in this study was a history of basic and follow-up immunizations from children living in the working area of the Cempaka Putih District Health Center. The results showed that the achievement of basic immunization and children under two in 2019 (before the COVID-19 pandemic) reached the target, then in 2020 (pandemic COVID-19) the achievement of basic immunization and children under two did not meet the target. In 2021 (COVID-19 pandemic) the achievement of basic and under-five immunizations reached the target, then in 2022 (COVID-19 transition period) the achievement of basic and under-five immunizations was achieved.&#x0D; &#x0D;

Potentially avoidable tetanus booster in the emergency department: a service evaluation.

Tetanus infection is caused by the Clostridium tetani bacterium, which can enter the body through a wound or puncture in the skin. Patients who present to an emergency department (ED) with a laceration, wound or bite require a risk assessment to determine whether the wound is clean, tetanus prone or high-risk tetanus prone. Those assessed as tetanus prone or high-risk tetanus prone, with an uncertain or inadequate immunisation history, should receive tetanus prophylaxis treatment. However, some patients receive this treatment unnecessarily. This article describes a service evaluation that explored whether practice in one ED was contributing to potentially avoidable tetanus prophylaxis treatment. The article outlines the results of a five-year retrospective database review, which determined that 18% of all tetanus prophylaxis treatments delivered in the ED during that period were unnecessary. The author makes some recommendations to improve practice.