Imipramine Response Research Articles

Predicting Imipramine Response

Back to table of contents Previous article Next article ArticleNo AccessPredicting Imipramine ResponseRICHARD E. MINTERRICHARD E. MINTERSearch for more papers by this authorPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.136.5.731AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail "Predicting Imipramine Response." American Journal of Psychiatry, 136(5), p. 731 Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited ByThe World Journal of Biological Psychiatry, Vol. 10, No. 4-2Journal of Affective Disorders, Vol. 14, No. 1 Volume 136Issue 5 May 1979Pages 731-731 Metrics PDF download History Published online 1 April 2006 Published in print 1 May 1979

Predicting imipramine response

Predicting imipramine response

Prediction of Antidepressant Responses to Imipramine

45 patients hospitalized for depression who had received double-blind trials with imipramine were examined for possible associations between pretreatment responses to the Minnesota Multiphasic Personality Inventory (MMPI) and their behaviorally-rated responses to this drug. Each patient was randomly assigned to one of two groups with the restriction that the number of responders and nonresponders be balanced for sex. Results from the group A patients suggest that responders and nonresponders to imipramine were best identified by using two sex-specific, empirically-derived, MMPI scales. In contrast, 12 of 13 regular validity and clinical scales and all 49 of the selected special scales of the MMPI failed to separate responders from nonresponders. In the cross-validation study with the group B patients, we were able to predict female and male responders from nonresponders by the new imipramine response scale with accuracy rates of 93 and 100%, respectively. The implications of these results are discussed.

Imipramine response in deluded depressive patients

The authors examined how delusions and other psychotic features influenced treatment outcome with imipramine in patients with primary depression. Global improvement scores indicated that delusions or other evidence of psychosis do not contraindicate imipramine treatment. This finding does not support a recent report suggesting that deluded depressive patients should not be treated with imipramine. Possible explanations of the discrepancy between these two studies are discussed.

Antidepressant effect of lithium

The efficacy of lithium in the acute manic phase of manic-depressive disorder is well established. 1 There is also evidence indicating a prophylactic effect for this ion in manic-depressive disorder. 2 The efficacy of lithium carbonate in the acute depressive phase is uncertain. Early observations tended to discount any antidepressant effect of lithium; 3 however, recent evidence derived from controlled trials, although conflicting, tends to suggest that an antidepressant effect may occur in some patients. 4,5 Fieve, 6 in comparing lithium and imipramine response, concluded that the antidepressant effect of lithium was mild. Dyson and Mendels, 7 first in an uncontrolled study and later in a controlled study comparing lithium with desipramine, 5 concluded in the later study that lithium showed marked antidepressant properties equivalent to desipramine. As part of our investigative program with lithium, we undertook a single-blind evaluation of the efficacy of lithium carbonate in depressive illness.