Illicit Market Research Articles

Primary Care Physicians' Knowledge and Attitudes Regarding Prescription Opioid Abuse and Diversion.

Physicians are a key stakeholder in the epidemic of prescription opioid abuse. Therefore, we assessed their knowledge of opioid abuse and diversion, as well as their support for clinical and regulatory interventions to reduce opioid-related morbidity and mortality. We conducted a nationally representative postal mail survey of 1000 practicing internists, family physicians, and general practitioners in the United States between February and May 2014. The adjusted response rate was 58%, and all physicians (100%) believed that prescription drug abuse was a problem in their communities. However, only two-thirds (66%) correctly reported that the most common route of abuse was swallowing pills whole, and nearly one-half (46%) erroneously reported that abuse-deterrent formulations were less addictive than their counterparts. In addition, a notable minority of physicians (25%) reported being "not at all" or "only slightly concerned" about the potential for opioid diversion from the licit to the illicit market when this practice is common at all levels of the pharmaceutical supply chain. Most physicians supported clinical and regulatory interventions to reduce prescription opioid abuse, including the use of patient contracts (98%), urine drug testing (90%), requiring prescribers to check a centralized database before prescribing opioids (88%), and instituting greater restrictions on the marketing and promotion of opioids (77% to 82%). Despite this, only one-third of physicians (33%) believed that interventions to reduce prescription opioid abuse had a moderate or large effect on preventing patients' clinically appropriate access to pain treatment. Although physicians are unaware of some facets of prescription opioid-related morbidity, most support a variety of clinical and regulatory interventions to improve the risk-benefit balance of these therapies.

Early detection of emerging street drugs by near infrared spectroscopy and chemometrics

Near-infrared spectroscopy (NIRs) is spreading as the tool of choice for fast and non-destructive analysis and detection of different compounds in complex matrices. This paper investigated the feasibility of using near infrared (NIR) spectroscopy coupled to chemometrics calibration to detect new psychoactive substances in street samples. The capabilities of this approach in forensic chemistry were assessed in the determination of new molecules appeared in the illicit market and often claimed to contain “non-illegal” compounds, although exhibiting important psychoactive effects. The study focused on synthetic molecules belonging to the classes of synthetic cannabinoids and phenethylamines. The approach was validated comparing results with officials methods and has been successfully applied for “in site” determination of illicit drugs in confiscated real samples, in cooperation with the Scientific Investigation Department (Carabinieri-RIS) of Rome. The achieved results allow to consider NIR spectroscopy analysis followed by chemometrics as a fast, cost-effective and useful tool for the preliminary determination of new psychoactive substances in forensic science.

Cigarette Taxes and Illicit Trade in Europe

Cigarettes are highly taxed in Europe to discourage tobacco use and to fund public-health measures to mitigate the harms from tobacco consumption. At higher prices (more precisely, at higher differentials between licit and black-market prices) consumers substitute more toward illicit cigarettes. Illicit retail trade in cigarettes (IRTC) includes counterfeiting and smuggling — either of legally purchased products, from lower-tax to higher-tax jurisdictions, or of entirely non-tax-paid cigarettes. The existing literature includes claims that taxes are not an important factor determining the scale of IRTC. We investigate these claims with data from 1999-2013 in the European Union. We find that while the simple correlation between licit cigarette prices and the market share of illicit cigarettes in consumption is negative, raising prices in any one country would, on average, lead to substantial increases in the expected illicit market share and volume in that country. A one euro increase in tax per pack in a country is expected to increase illicit market share by 5 to 12 percentage points and increase illicit cigarette sales by 25% to 120% of the average consumption. We also find that the role of prices in stimulating IRTC is, empirically, far more important than the role of corruption. The results are robust to a host of alternative specifications and sources of data.

Discriminative Stimulus Properties of Phytocannabinoids, Endocannabinoids, and Synthetic Cannabinoids.

Psychoactive cannabinoids from the marijuana plant (phytocannabinoids), from the body (endocannabinoids), and from the research lab (synthetic cannabinoids) produce their discriminative stimulus effects by stimulation of CB1 receptors in the brain. Early discrimination work with phytocannabinoids confirmed that Δ9-tetrahydrocannabinol (Δ9-THC) is the primary psychoactive constituent of the marijuana plant, with more recent work focusing on characterization of the contribution of the major endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG), to Δ9-THC-like internal states. Collectively, these latter studies suggest that endogenous increases in both anandamide and 2-AG seem to be optimal for mimicking Δ9-THC's discriminative stimulus effects, although suprathreshold concentrations of anandamide also appear to be Δ9-THC-like in discrimination assays. Recently, increased abuse of synthetic cannabinoids (e.g., "fake marijuana") has spurred discrimination studies to inform regulatory authorities by predicting which of the many synthetic compounds on the illicit market are most likely to share Δ9-THC's abuse liability. In the absence of a reliable model of cannabinoid self-administration (specifically, Δ9-THC self-administration), cannabinoid discrimination represents the most validated and pharmacologically selective animal model of an abuse-related property of cannabinoids - i.e., marijuana's subjective effects. The influx of recent papers in which cannabinoid discrimination is highlighted attests to its continued relevance as a valuable method for scientific study of cannabinoid use and abuse.

Principal-Agency Theory in Illegal Markets: Cooperation and Conflict Among Chinese Loansharks

There are management and organizational problems common to both legal and illegal businesses, such as moving one party to act in the interest of another rather than his own. In principal-agency theory, the party that wants someone else to do a job on his behalf is called the “principal” and the other party is called the “agent”. Principal-agency theory tries to find solutions to real and potential conflicts that arise from such transactional arrangements. We believe principal-agency theory has great potentials for understanding the operation and interpersonal relationships of criminal enterprises, in addition to the structural arrangements (e.g., a disorganized crime market) and the social network perspectives. Using a case study of Chinese loan sharking and cannabis cultivation in the Netherlands, we seek to make a theoretical contribution to existing literature on organized crime by focusing on how different individuals within a criminal enterprise negotiate the most efficient transactional arrangement in a principal-agent relationship amidst the uncertainties of an illicit market environment. We specifically look at four phases of the criminal enterprise studied: the selection of agents by the principal, attempts to bind these agents to the principal, potential conflicts and finally the solution of any problems. Incidentally, our study also gives insight in the less well-researched topic of loansharking.

Synthetic cannabinoid 3-benzyl-5-[1-(2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]-1,2,4-oxadiazole. The first detection in illicit market of new psychoactive substances

We were the first to detect 3-benzyl-5-[1-(2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]-1,2,4-oxadiazole (given name BzODZ-EPyr) as a new synthetic cannabinoid, in illegal market of new psychoactive compounds (NPS). The compound was known only from pharmaceutical literature so far. BzODZ-EPyr was identified by means of gas chromatography/mass spectrometry (GC/MS) including high resolution mass spectrometry (GC/HRMS), ultra-high performance liquid chromatography/high resolution tandem mass spectrometry (UHPLC/HRMS2), Fourier-transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR) 1H and 13C. The peculiarities of mass-spectral fragmentation in experiments in electronic ionization (EI) and collision-induced dissociation (CID) modes were studied. Herewith we report analytical characteristics of BzODZ-EPyr enabling its (and possible analogues thereof) determination in criminal seizures.

A survey of adulterants used to cut cocaine in samples seized in the Espírito Santo State by GC–MS allied to chemometric tools

Cocaine is a stimulant drug of the central nervous system (CNS) extracted from the leaves of Erytroxylum coca. It is defined as a tropane alkaloid containing 1R-(exo,exo)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl esther. However, despite its defined composition, a wide variety of chemical additives are present in cocaine found in the illicit market, such as benzocaine, lidocaine, caffeine, procaine and phenacetin. In this work, 512 cocaine samples seized by the Civil Police of Espirito Santo state (PC-ES, Brazil) were analyzed by gas chromatography mass spectrometry (GC–MS) allied to principal component analysis (PCA) in order to classify the samples as a function of seizure year (2008, 2009, 2010, 2011 and 2012) and location (metropolitan, north, south and central). The cocaine content (wt.%) and its adulterants were also estimated. Analyzing the samples seized between 2008 and 2011, three sample sets are clearly grouped according to the degree of adulteration with caffeine and lidocaine: 100–50wt.% of cocaine; 50–20wt.% of cocaine; and 20–80wt.% of lidocaine and 60–80wt.% of caffeine, simultaneously. The last group is formed by samples seized between 2008 and 2009, which proves the higher degree of adulteration during this period. In 2012, higher cocaine content was observed for the 191 analyzed samples than in samples from previous years. The PCA data also suggests that the metropolitan region samples had a higher degree of adulteration than the state countryside samples.

The pharmacology and toxicology of kratom: from traditional herb to drug of abuse.

Mitragyna speciosa (Rubiaceae), commonly known as kratom, is a tropical tree with a long history of traditional use in parts of Africa and Southeast Asia. In recent years, kratom has gained popularity for use as a recreational drug across the globe. Relatively new to the illicit market and used in a manner different from its traditional applications, preparations of kratom are touted by many as a safe and legal psychoactive product that improves mood, relieves pain, and may provide benefits in opiate addiction. Available literature was reviewed for M. speciosa via PubMed, Google Scholar, CINAHL, and EBSCO to summarize its traditional uses, phytochemical composition, pharmacology and toxicology of proposed active constituents, and potential for misuse and abuse. Research has demonstrated that both stimulant and sedative dose-dependent effects do exist, but a growing concern for the drug's effects and safety of use has resulted in national and international attention primarily due to an increase in hospital visits and deaths in several countries that are said to have been caused by extracts of the plant. The main active alkaloid substances in kratom, mitragynine and 7-hydroxymitragynine, present with a range of CNS stimulant and depressant effects mediated primarily through monoaminergic and opioid receptors. Recently, Palm Beach County, located in the southeastern corridor of Florida, has considered regulating kratom due to public safety concerns following the death of a young adult. At the local, state, and even federal levels, governments are now being confronted with the task of determining the safety and the possible regulation of kratom extracts. There are currently no standard analytical screening techniques for mitragynine and its metabolites following ingestion limiting its detection to more sophisticated techniques like liquid chromatography-mass spectrometry to determine kratom use. The growing concern of the abuse potential of kratom requires careful evaluation of its benefits and potential toxicities.

Quality of antiepileptic drugs in Africa: Results from a pilot study (Quaeda) in Kenya and Gabon

Background: Epilepsy is a common neurological disorder affecting about 70 million people worldwide, with 80% in resource-limited countries. The primary healthcare in these countries is extremely under-resourced, few standard antiepileptic drugs (AEDs) are commonly used and there are concerns about the quality of these AEDs. Objective: We aimed to assess the quality of AEDs gathered from delivery structures, where patients could buy these drugs, in rural and urban areas in Kenya and Gabon. Methods: It was a cross-sectional study assessing AEDs gathered from public, private and illegal circuits. Analyses were carried out in France following Pharmacopeia recommendations. Several tests (active ingredients assay, related substances screening, mass uniformity, dissolution, disintegration and friability) were conducted to assess the quality of the AED. A further screening with mass spectrometry and nuclear magnetic resonance was performed for fake AEDs and/or those found containing unknown compounds. Results: In both countries, 61 boxes of AEDs were gathered (5% of diazepam, 25% of carbamazepine, 33% of phenobarbital, 10% of phenytoin and 28% of sodium valproate). Of the 61 boxes, 72% (44) have been completely analysed. Of these 44 boxes analysed, 95% met the required quality standards and 5% were fake-drugs. In particular, one batch of phenobarbital and one of phenytoin from illicit market in Kenya did not have active ingredients, but unknown compound (unidentified as yet). Conclusion: A small proportion of poor quality AEDs was found in these African countries. Illicit circuit appeared to be the most involved, this might be due to poor storage conditions.

Identification and characterization of α-PVT, α-PBT, and their bromothienyl analogs found in illicit drug products

Recently, thienyl derivatives of cathinones have appeared on the market as new psychoactive substances (NPS). In this study, identification and characterization of 2-(pyrrolidin-1-yl)-1-(thiophen-2-yl)pentan-1-one (α-PVT), 2-(pyrrolidin-1-yl)-1-(thiophen-2-yl)butan-1-one (α-PBT), and their bromothienyl analogs disclosed in illicit products are described. In our analysis, some analogous compounds of α-PVT, which had a bromine substitution on the thiophene ring, were identified in the samples containing α-PVT; 1-(4-bromothiophen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one, 1-(5-bromothiophen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one, and 1-(4,5-dibromothiophen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one by comparing the analytical data with synthetic reference standards. We also observed 1-(4-bromothiophen-2-yl)-2-(pyrrolidin-1-yl)butan-1-one and 1-(5-bromothiophen-2-yl)-2-(pyrrolidin-1-yl)butan-1-one from a powder product, in which α-PBT was detected. The brominated α-PVTs were also found when overbrominated 1-(thiophen-2-yl)pentan-1-one reacted with pyrrolidine, and they are suspected to be the by-products of α-PVT synthesis. In Japan, cathinone derivatives with a phenyl group as the aromatic ring have been widely controlled by generic scheduling. To escape from such a regulation, analogs with different aromatic groups such as α-PVT and α-PBT appeared on the illicit market of psychoactive compounds. To our knowledge, this is the first report describing identification of α-PBT, and bromothienyl analogs of both α-PVT and α-PBT in illicit drug products. The synthetic method and analytical data shown in this study will be useful for identification of the thienyl derivatives of cathinone analogs.

High-throughput screening for new psychoactive substances (NPS) in whole blood by DLLME extraction and UHPLC-MS/MS analysis.

The increasing number of new psychoactive substances (NPS) present in the illicit market render their identification in biological fluids/tissues of great concern for clinical and forensic toxicology. Analytical methods able to detect the huge number of substances that can be used are sought, considering also that many NPS are not detected by the standard immunoassays generally used for routine drug screening. The aim of this work was to develop a method for the screening of different classes of NPS (a total of 78 analytes including cathinones, synthetic cannabinoids, phenethylamines, piperazines, ketamine and analogues, benzofurans, tryptamines) from blood samples. The simultaneous extraction of analytes was performed by Dispersive Liquid/Liquid Microextraction DLLME, a very rapid, cheap and efficient extraction technique that employs microliters amounts of organic solvents. Analyses were performed by a target Ultrahigh Performance Liquid Chromatography tandem Mass Spectrometry (UHPLC-MS/MS) method in multiple reaction monitoring (MRM). The method allowed the detection of the studied analytes with limits of detection (LODs) ranging from 0.2 to 2ng/mL. The proposed DLLME method can be used as an alternative to classical liquid/liquid or solid-phase extraction techniques due to its rapidity, necessity to use only microliters amounts of organic solvents, cheapness, and to its ability to extract simultaneously a huge number of analytes also from different chemical classes. The method was then applied to 60 authentic real samples from forensic cases, demonstrating its suitability for the screening of a wide number of NPS.

Before the ban--an exploratory study of a local khat market in East London, U.K.

BackgroundKhat is a green leaf with amphetamine-like effects. It is primarily used among people in Africa, the Middle East and in the diaspora communities from these countries. Prior to the prohibition of khat in the UK on 24 June 2014, there was almost no information available on key aspects of the local khat market.MethodsA cross-sectional study was conducted in 2012 using snowball sampling, Privileged Access Interviewing and area mapping in order to identify khat sale establishments. Data was collected via face-to-face interviews using mixed methods for data collection. This included information about the establishments selling khat, khat pricing and its use among different ethnic minority groups, in addition to the potential sale of khat to children and risk assessment (e.g. use of pesticides on khat).ResultsFive out of seven sellers identified agreed to participate. Sellers described their khat sale establishments as ‘community centres’ which included, for example, a restaurant basement. The sellers’ history of selling khat ranged between 1–15 years and khat’s sale took place between 2pm-10pm. Miraa (e.g. Lara) from Kenya was the most popularly used khat variety, sold in pre-wrapped bundles of approximately 250 g costing £3 each and delivered four days a week. Harari (e.g. Owdi) from Ethiopia was sold in 200 g, 400 g and 1 kg bundles, priced between £5 and £20 and delivered two days a week. The primary benefit of khat use was reported to be social interaction. The customers were predominantly adult males of Somali origin. Most sellers claimed a self-imposed ban on sales to children under 18 years old. Khat bundles had no labelling describing variety or weight and sellers had no knowledge of the use of pesticides on khat and did not advertise the risks associated with khat use.ConclusionsKhat selling establishments were businesses that did not adhere to trade standards regulations (e.g. labelling khat bundles). They claimed to provide a community service (facilitating social interaction) to their predominately Somali customers. Without a better understanding of the dynamics of the khat market there is a risk that both health and social needs of the vulnerable populations involved in the market continue to go unaddressed. Future research should track changes in the now illicit khat market in order to evaluate the social and public health implications following the recent changes to the current UK regulatory environment regarding khat.Electronic supplementary materialThe online version of this article (doi:10.1186/s12954-015-0048-z) contains supplementary material, which is available to authorized users.

Antiretroviral drug diversion links social vulnerability to poor medication adherence in substance abusing populations.

Antiretroviral (ARV) medication diversion to the illicit market has been documented in South Florida, and linked to sub-optimal adherence in people living with HIV. ARV diversion reflects an unmet need for care in vulnerable populations that have difficulty engaging in consistent HIV care due to competing needs and co-morbidities. This study applies the Gelberg-Andersen behavioral model of health care utilization for vulnerable populations to understand how social vulnerability is linked to ARV diversion and adherence. Cross-sectional data were collected from a targeted sample of vulnerable people living with HIV in South Florida between 2010 and 2012 (n = 503). Structured interviews collected quantitative data on ARV diversion, access and utilization of care, and ARV adherence. Logistic regression was used to estimate the goodness-of-fit of additive models that test domain fit. Linear regression was used to estimate the effects of social vulnerability and ARV diversion on ARV adherence. The best fitting model to predict ARV diversion identifies having a low monthly income and unstable HIV care as salient enabling factors that promote ARV diversion. Importantly, health care need factors did not protect against ARV diversion, evidence that immediate competing needs are prioritized even in the face of poor health for this sample. We also find that ARV diversion provides a link between social vulnerability and sub-optimal ARV adherence, with ARV diversion and domains from the Behavioral Model explaining 25 % of the variation in ARV adherence. Our analyses reveal great need to improve engagement in HIV care for vulnerable populations by strengthening enabling factors (e.g. patient-provider relationship) to improve retention in HIV care and ARV adherence for vulnerable populations.

Understanding parrot trafficking between illicit markets in Bolivia: an application of the CRAVED model

The CRAVED model has been used to understand theft variation in a whole host of hot products, including wildlife. Past research, however, has only applied the model at either the theft or illicit market stage to understand why particular products are stolen in high numbers. The CRAVED model has yet to be applied to the trafficking stage of hot products smuggled between illicit markets and, therefore, its applicability at this particular stage remains unknown. Using secondary data from the Los Pozos wildlife market in Santa Cruz, Bolivia, this study applies the CRAVED model to explain why parrot species are trafficked between illicit markets in Bolivia. This research finds that species that are more “available” and less “valuable” are more likely to be trafficked between illicit markets, suggesting that variation at the trafficking stage of the parrot trade can be explained by nearly the same CRAVED concepts as they do at the poaching stage. This study also finds that one-quarter of parrots in the Los Pozos market are trafficked to other cities, of which 99% are to the city of Cochabamba. These findings suggest that shutting down illicit markets and patrolling major roadways between cities can substantially reduce the illegal parrot trade.

Regulatory Foresight

Illicit markets capitalize on the vulnerabilities of trade systems. When these weaknesses involve mechanisms common to several aspects of transnational commerce, the effect of illicit behavior, and conversely of anti-crime policy, can be magnified. This study introduces a script-network method to estimate the impact of targeting illicit behavior within the context of an entire market system. Using the high-value art and antiquities market as a case study, we anticipate the effects of two anti-crime policy directives—movement control and monitoring financial transactions. In addition to advancing a new method, two original metrics are presented—one measures the complexity of sectors in a trade system ( complexity) and the other anticipates the incentive to work around crime control efforts ( transformity). In consideration of these system characteristics, our results suggest that maximum decoupling of illicit\legal trade is more likely with the introduction of safeguards targeting central trade functions that are associated with valuing and gifting objects. Network-oriented research could help the prevailing market reduction approach (MRA) to be more effective in reducing transnational illicit trade because network analytics are specially crafted for dealing with the statistical challenges that are inherent to studying transnational illicit market systems.

Violence in Illicit Markets: Unintended Consequences and the Search for Paradoxical Effects of Enforcement

Abstract The textbook competitive model of drug markets predicts that greater law enforcement leads to higher black market prices, but also to the unintended consequences of greater revenue and violence. These predictions are not in accord with the paradoxical outcomes evinced by recent history in some drug markets, where enforcement rose even as prices fell. We show that predictions of the textbook model are not unequivocal, and that when bandwagon effects among scofflaws are introduced, the simple predictions are more likely to be reversed. We next show that even simple models of noncompetitive black markets can elicit paradoxical outcomes. Therefore, we argue that instead of searching for assumptions that lead to paradoxical outcomes, which is the direction the literature has taken, it is better for policy analysis to choose appropriate assumptions for the textbook model. We finish with performing such an analysis for the case of banning menthol cigarettes. Under the most plausible assumptions enforcement will indeed spur violence, although the legal availability of electronic cigarettes may mitigate or reverse this conclusion.

The Market Maven Crowd: Collaborative Risk‐Aversion and Enhanced Consumption Context Control in an Illicit Market

ABSTRACTContemporary culture is characterized by individual and societal efforts to limit exposure to risk. Paradoxically, many consumers actively pursue high‐risk consumption experiences. High‐risk consumption, coupled with a lack of consumption‐orientated information, amplifies consumer vulnerability. However, consumer‐to‐consumer information sharing can help reduce unwarranted risk and enhance consumption context control. This study investigates the ecstasy “market maven crowd”: an online community anonymously bound by acts of collective market mavenism intended to address the void of market information and reduce the risks thereof. Acts of collective market mavenism include the assimilation and dissemination of scientific ecstasy pill content reports and personal ecstasy consumption tales. The diffusion of market‐orientated information provides consumers with an opportunity to identify, and avert, the serious health risks intrinsic to ecstasy consumption and assert consumption context control. Collaborative market mavenism fosters market policing, which enhances the safety structures of the unregulated ecstasy market. This study contributes to marketing and consumer research by developing an understanding of how consumers collectively adapt to risk online; displaying market mavenism as an innovative framework to examine online consumer‐to‐consumer information sharing; showing how Internet technologies facilitate the emergence of market maven crowds; and providing marketers with guidelines for approaching market maven crowds. Finally, the author discusses the societal implications arising and suggests directions for future research.

Synthetic growth hormone releasers detected in seized drugs: new trends in the use of drugs for performance enhancement

Gone are the days when gym users in search of drugs to boost performance and muscular appearance resorted to drug regimes of just oral and injectable versions of anabolic steroids. Today, information gleaned from seizures made by law enforcement agencies, personal anecdotes and hearsay shared both in gyms and on the internet, drug analysis reports, articles in newspapers and muscle genre magazines and observation of illicit suppliers' websites reveals that a host of synthetic peptide hormones are now available on the ‘life-style’ drug market 1. These include growth hormone releasers such as CJC-1295, GHRP-2 and GHRP-6 2-7. These drugs have similar effects on the body, mainly triggering the pulsatile releasing activity of human growth hormone (hGH) from the anterior pituitary gland 8. This hormone, in turn, is involved in the regulation of body composition, due to its anabolic and lipolytic actions, as well as physical performance and wellbeing 9. Custom officers at Copenhagen Airport (Denmark) intercepted a package from China—shipped via FedEx®—containing five identical cardboard boxes, each holding 10 clear glass vials (Fig. 1). The vials were handed over to the medicine regulatory authority in Denmark (the Danish Health and Medicines Authority) and given to us to examine for research purposes. None of the vials were labelled, nothing was printed on the cardboard boxes and there were no accompanying package leaflets, giving the name of the drugs, strength and route of administration. All vials in four of the boxes had orange-coloured plastic caps; the vials in the remaining box had blue caps. Otherwise, there was no way to tell the vials apart. A closer inspection revealed that the vials contained a white lyophilized powder, presumably for the preparation of solutions for injection. To identify the active substance(s), we analysed the contents of one vial from each cardboard box using high-performance tandem mass spectrometry. Unlabelled vials containing the growth hormone releasers CJC-1295 (orange caps) and GHRP-2 (blue caps) seized at Copenhagen Airport (Denmark) Our analysis showed that four vials (with orange-coloured caps) contained CJC-1295 and one vial (with a blue cap) contained GHRP-2. We also found mannitol in the CJC-1295 preparation—a substance previously detected in illicit drugs, where it is mixed in to add bulk 10. These findings add to reports of growth hormone releasers found in illicit preparations in Europe 2-7 and Australia 11, and suggest new drug-using trends. The potential harms relating to the consumption of growth hormone releasers for performance enhancement are unknown. However, users are exposed to risks from a broad range of defects discovered in illicit market products, including unknowing exposure to undeclared active substances, unknown amounts of active substance and/or contamination 12-14. The marketing of growth hormone releasers as improved ways to increase performance and appearance, compared with ‘old’ drugs such as anabolic steroids, can be seen as a sign of the increasing commodification of ‘life-style’ drugs 15. Further, the existence of global shipment options (including well-established delivery services) that are cheap and fast allows transnational distribution of illicit drugs, as highlighted by this study. Systematic intelligence-gathering concerning new trends in substance use for performance enhancement purposes and the harms it may cause is needed urgently, especially as tailored public health responses are limited. Health-care professionals encountering users seeking treatment or health-related advice relating to ‘performance-enhancing drugs’ should be aware of the variety of new drugs on the market. None. The authors thank the Danish Health and Medicines Authority for providing the vials. The authors also thank the Audio Visual Services at Vendsyssel Hospital for providing pictures. This study was supported through the Obelske Family Foundation grants.

Quality Control of Selected Antimalarials Sold in the Illicit Market: An Investigation Conducted in Porto-Novo City (Republic of Benin)

Malaria is a parasitic disease caused by the bite of female Anopheles mosquito and particularly affects the tropical areas of the world. According to national statistics it is the leading cause of consultations and hospitalizations. Nowadays, despite the surveillance systems for efficient malaria control and access to generic drugs, Benin is witnessing an increased development of illicit drug markets with a large part of the population going towards such markets. However, this is not without adverse impact on the health of individuals, as well as, the economic status of the country. Therefore, the situation needs to be seriously considered by policy makers at various levels, health professionals but also the entire international community in order to thwart this scourge.Regarding the aforementioned situation, the current study was undertaken aiming to perform a quality control of selected antimalarial drugs of the illegal market in Porto-Novo city. Therefore, 40 antimalarial batches were randomly collected in the illicit drug market and submitted to analytical tests such as: macroscopic examination (a visual and critical examination); mass uniformity test; disintegration test; identification test and active ingredients’ content measurement. At the end of the study, the percentages of non-compliance is 97.5%, 5%, 15% and 27.5%, respectively for the content uniformity tests, disintegration, identification and assay. Over-all, 42.5% of noncompliance was recorded. The findings of this study prove that street vended drugs offer no guarantee of good quality and pose a threat to the health of populations. Also, the rate of non-compliance denotes a flaw in the security of the drug distribution system.

2-(4-IODINE-2,5-DIMETHOXYPHENYL)-N-[(2-METHOXYPHENYL)METHYL]ETAMINE OR 25I-NBOMe: CHEMICAL CHRACTERIZATION OF A DESIGNER DRUG

Drug trafficking and the introduction of new drugs onto the illicit market are one of the main challenges of the forensic community. In this study, the chemical profile of a new designer drug, 2-(4-iodine-2,5-dimethoxyphenyl)-n-[(2-methoxyphenyl)methyl]etamine or 25I-NBOMe was explored using thin layer chromatography (TLC), ultraviolet-visible spectrophotometry (UV-Vis), attenuated total reflection with Fourier transform infrared spectroscopy(ATR-FTIR), gas chromatography mass spectrometry (GC-MS) and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FT-ICR MS). First, the TLC technique was effective for identifying spots related to 25C-, 25B- and 25I-NBOMe compounds, all with the same retention factor, Rf ≈ 0.50. No spot was detected for 2,5-dimethoxy-4-bromoamphetamine, 2,5-Dimethoxy-4-chloroamphetamine or lysergic acid diethylamide compounds. ATR-FTIR preserved the physical-chemical properties of the material, whereas GC-MS and ESI-MS showed better analytical selectivity. ESI(+)FT-ICR MS was used to identify the exact mass (m/z428.1706 for the [M + H]+ ion), molecular formula (M = C18H22INO3), degree of unsaturation (DBE = 8) and the chemical structure (from collision induced dissociation, CID, experiments) of the 25I-NBOMe compound. Furthermore, the ATR-FTIR and CID results suggested the presence of isomers, where a second structure is proposed as an isomer of the 25I-NBOMe molecule.