Capillary electrophoresis (CE) is well suited for the analysis of illicit drug seizures. CE techniques can separate a wide variety of solutes, including compounds that are highly polar, thermally labile and/or nonvolatile, with high efficiency and selectivity. Micellar electrokinetic chromatography (MECC), which can separate basic, acidic and neutral solutes, is an excellent technique for general drug screening and the analysis of heroin, opium, cocaine, LSD, anabolic steroids, and the diastereomers formed from derivatized optical isomers of phenethylamines. Capillary zone electrophoresis (CZE) has been used for the analysis of small ions (cations and anions) in illicit heroin. Cyclodextrin (CD)-modified CZE (i.e. CZE using run buffers containing either charged and/or neutral CDs) has proven successful for both chiral and achiral analyses. Chiral applications include khat, phenethylamines, cocaine, propoxyphene and methorphan, while achiral applications include the analysis of naturally occurring impurities present in illicit cocaine, including truxilline diastereomers and hydroxycocaine endo and exo diastereomers. Capillary electrochromatography (CEC), which is a hybrid between high performance liquid chromatography (HPLC) and CE, also shows great promise for forensic drug analysis.