The purpose of the study is to increase the effectiveness of treatment of young people with idiopathic mitral valve prolapse (IMVP) and clinical signs of autonomic dysfunction.Materials and methods. We examined 79 patients (mean age 35.7±4.3 years) with PMK and phenotypic signs of undifferentiated connective tissue dysplasia (DST). The control group consisted of 20 practically healthy persons, comparable by gender and age. All patients were evaluated for clinical status, echo doppler cryography on the «LOGIQ 5» («Medical System», Germany) ultrasound diagnostic scanner. To identify vegetative dysfunction, «Questionnaire used to identify signs of vegetative changes» (Wayne A. M., 2003). To assess situational and personal anxiety, an anxiety questionnaire by C. D. Spielberger (1973) was used in the adaptation of Yu. L. Hanin. Non-specific changes in the functional state of the central nervous system were studied by the indirect registration of the heart rate variability in the cardiographic complex of Holter monitoring «Cardiosens» («KhAI Medica», Ukraine). After the survey at baseline, patients were divided into 2 groups. In the I group 39 patients were enrolled, which was prescribed a complex therapy, which included β-adrenoblocker and mebirum – Adaptol (JSC «Olain KhFZ» «Olainfarm», Latvia) 500 mg 3 times a day for 3 months. In group II, 40 people were enrolled with monotherapy with β-blockers. These groups of patients with PMP and autonomic dysfunction were comparable in age and gender. Statistical processing of the results of the study was conducted using the software package Statistica 6.0 for Windows.Results. After course treatment in the main group, a significant (p <0.05) decrease in the frequency of clinical manifestations of neurolective disorders was noted in 94.9 % of the examined patients. Clinically significant reduction of the expression of the syndrome of vegetative dystonia was noted in 79.5 % of patients in group I and in 47.5 % of group II (p<0.05). According to self-esteem for AM Wayne (2003), the amount of points in group I decreased from 45.7±2.5 to 16.8±2.1 points (p <0.001), in group II – from 45.9±2.3 to 29.3±2.1 (p <0.001) points. The reduction of the voltage index in the I group was established by 66.9% (p <0.05), in the II group – by 47.3 % (p<0,05); the index of fashion amplitude - by 33.3 % (p<0,05) and 16,5 % (p<0,01); an increase in the variational scale by 64.1 % (p<0.05) and 38.4 % (p<0.01) respectively. In SD group, SDNN increased by 27.5 % (p <0.05), in group II – by 8.8 % (p>0.05), the RMSSD in group I increased by 27.9 % (p<0,05), in group II – by 8,47% (p> 0,05); the pNN 50 in the I group increased by 27.3 % (p<0.05), in the II group – by 11.7% (p>0.05), respectively. There was a marked decrease in reactive anxiety level by 36.7 % (p<0.001) and personal anxiety by 38.9 % (p<0.001), with the addition of adaptol therapy was the most effective in the group with high and average anxiety. Undesirable effects of adaptol during the course of treatment have not been noted.Conclusions. The inclusion of an adaptol in the complex therapy of young people with idiopathic PMC leads to a complete or almost complete reduction of clinical symptoms, a significant improvement in the parameters of the heart rate variability, which is manifested in lowering the stress index and restoring the autonomic balance with the temporal parameters of the heart rate variability, as well as reducing the level of reactive anxiety, which allows to increase the functional capabilities of the body against the background of improving the psycho-emotional state, along with a good tolerability profile and without pitchers