Idiopathic Hypercalcemia Research Articles

Idiopathic hypercalcemia of infancy, with failure to thrive; report of three cases, with a consideration of the possible etiology.

THE syndrome of idiopathic hypercalcemia of infancy, with failure to thrive has been reported with some frequency in the United Kingdom during the past few years. It appears to be relatively uncommon in North America, only 2 cases having been recorded in some detail1 , 2 and 2 others briefly noted.3 The reasons for this discrepancy in incidence among two populations, similar in many ways, are not understood. Three infants with this condition, which was severe in 1 and mild in 2, have been observed at the Children's Hospital of Philadelphia within a period of two years. This communication is presented to . . .

The Pathogenesis of Idiopathic Hypercalcemia in Infancy

The Pathogenesis of Idiopathic Hypercalcemia in Infancy

The radiographic features of severe idiopathic hypercalcemia of infancy.

Idiopathic hypercalcemia in infants is a disorder of calcium metabolism generally unknown to the radiologist, but being recognized with increasing frequency by our pediatric colleagues as a specific abnormality. The disease usually has an abrupt onset in early infancy, after several months of normal development. It is manifested clinically by loss of weight, anorexia, constipation, vomiting, and hypotonia. Laboratory studies disclose hypercalcemia, elevation of the blood urea, and occasionally evidence of renal acidosis. These features are present in the two recognized forms (1) of the disease, the one transient and the other chronic and severe. In the more common transient type the disease is benign and self-limiting after a course of several months, and there are no distinctive roentgen findings. All reported cases (2–6) of the severe chronic form, on the other hand, have shown signs of physical and mental retardation, hypertension, systolic heart murmur, fretfulness, and radiographic evidence of osteosclerosis. It is the purpose of this paper to bring to the attention of the radiologist the roentgen features of the severe form of idiopathic hypercalcemia. A more detailed account of the clinical and laboratory features of the case has appeared elsewhere (7). Case Report N. H., a 17-month-old white female infant, was admitted to the Texas Children's Hospital on April 5, 1954, because of failure to develop normally. She was born prematurely on Nov. 2, 1952, after a precipitous labor of thirty minutes at about seven and one-half months of an uncomplicated second pregnancy. Her birth weight was 3 pounds 14 ounces. Development had been normal until the age of six months, at which time the weight was 12 pounds 2 ounces. There had then occurred an abrupt cessation of growth. At four months of age the child became irritable, and constipation developed, requiring daily suppositories. From birth to three months of age she was given Alactin, and then an evaporated milk formula. At ten months of age this was changed to Similac 1:1. Solid baby foods, which were begun at three months, were taken readily on occasion but poorly after the age of six months. Supplemental vitamins had been given in normal quantities. Teething began at approximately seven months, and between that age and seventeen months six incisor teeth had made their appearance. At ten months of age the child could roll from side to side but could not sit alone or crawl. At thirteen months a partial paralysis of the left side of the face occurred. Recovery ensued within thirty days but was followed by a gradual weakness of the right side of the face. Physical examination at seventeen months showed the patient to be about the size of a six-month infant, both physically and mentally retarded. She cried fretfully and was unable to sit or crawl. She could not talk but uttered an occasional unintelligible sound.

MANAGEMENT OF " IDIOPATHIC " HYPERCALCÆMIA IN INFANCY

MANAGEMENT OF " IDIOPATHIC " HYPERCALCÆMIA IN INFANCY

Calcium metabolism in idiopathic hypercalcaemia of infancy with failure to thrive.

Calcium metabolism in idiopathic hypercalcaemia of infancy with failure to thrive.

Idiopathic hypercalcaemia in an infant; clinical and post-mortem findings in one case.

Omental pregnancy is a rare form of ectopic pregnancy, and can be seen primarily or secondary to a tubal pregnancy. A 25-year-old woman presented with abdominal distention with pain and anemia without vaginal bleeding. After a provisional diagnosis of ruptured ectopic pregnancy, laparotomy was performed. On surgical exploration, the bilateral tubes and ovaries were intact, however, an omental pregnancy was detected as the cause of hemoperitoneum. Partial omentectomy was performed. Although most cases are secondary, presented here is an additional case of primary omental pregnancy at 12 weeks according to Studdiford9s criteria. Histological evidence of neovascularization into the supporting tissue confirmed our diagnosis. A primary omental pregnancy should always be considered as a possible explanation for severe hemoperitoneum in ectopic pregnancies presenting with acute abdomen, and with intact adnexes on surgical exploration.

Biochemical changes and osteosclerosis after sulphamezathine therapy in idiopathic hypercalcaemia of infancy.

Biochemical changes and osteosclerosis after sulphamezathine therapy in idiopathic hypercalcaemia of infancy.

IDIOPATHIC HYPERCALCÆMIA OF INFANTS

IDIOPATHIC HYPERCALCÆMIA OF INFANTS