The article attempts to assess the relationship between artificial intelligence (AI), which has become an important part of the life of modern society, and substantial (essential, most significant for humans as a species) values. The relevance of the study is determined by the widespread use of AI and the discussions it constantly causes. On the basis of interdisciplinary, systemic, value-based, dialectical, cultural-historical approaches using methods of observation, analysis, interpretation and others, it was revealed that substantial values are significantly influenced by the spread of AI, but at the same time do not undergo of significant transformations. A number of values (life, freedom of choice, human identity, subjectivity, the possibility of creativity) do not experience real threats, but in the context of the spread of AI they are beginning to be valued higher. Other values (individuality, collectivism, family values, comfort, pleasure) are developing progressively under the influence of AI. Only one substantial value (security) experiences real threats, but its significance for a person only increases as a result. The conclusion is drawn about the significant, but not transformational, influence of AI on the system of substantial values, and therefore about its correspondence to this system.