Relevance. Epidemiological studies of oncological diseases of the respiratory system show that this nosological form is one of the leading causes of death among all other pathologies detected in most regions of the Russian Federation and around the world. Over the past decade, there has been a significant increase in the incidence of this pathology. The aim of the study is analysis of morbidity and mortality rates among the population of the Komi Republic, identification of features of medical care and prevention of malignant neoplasms of the respiratory system in the studied area. Materials and methods. The analysis was carried out on the basis of information materials from the Unified Interdepartmental Information and Statistical System, the Federal State Statistics Service, and documents from regional executive authorities in the field of healthcare. Statistical indicators of morbidity and mortality from cardiovascular diseases from 2011 to 2021 (per 100,000 population) were studied; the results obtained in the region were compared with those in the Russian Federation as a whole. To assess the general and annual trend, its degree of reliability, a trend line was constructed and the value of the approximation coefficient R2 was calculated, which in all cases turned out to be acceptable. The results of the study. Regional indicators differed from the national average - morbidity and mortality from malignant neoplasms of the respiratory system in the Komi Republic is significantly higher than the average in Russia. In dynamics over the past 10 years, mortality from malignant neoplasms of the respiratory system in the region tends to decrease, but less noticeable in comparison with the average in the Russian Federation. The incidence among women has not changed much, and among males has decreased compared to 10 years. The detection rate of malignant neoplasms in the early stages in the Komi Republic is significantly lower compared to the Russian Federation. The conclusion was made about the need to develop the regional program "Fight against cancer", its continuous improvement and exchange of experience with other regions.