Identification Of Amphetamine Research Articles

Postmortem toxicology of drugs of abuse

Conducting toxicology on post-mortem specimens provides a number of very significant challenges to the scientist. The range of additional specimens include tissues such as decomposing blood and other tissues, hair, muscle, fat, lung, and even larvae feeding on the host require special techniques to isolate a foreign substance and allow detection without interference from the matrix. A number of drugs of abuse are unstable in the post-mortem environment that requires careful consideration when trying to interpret their significance. Heroin, morphine glucuronides, cocaine and the benzodiazepines are particularly prone to degradation. Moreover, redistributive process can significantly alter the concentration of drugs, particularly those with a higher tissue concentration than the surrounding blood. The designer amphetamines, methadone and other potent opioids will increase their concentration in blood post-mortem. These processes together with the development of tolerance means that no concentration of a drug of abuse can be interpreted in isolation without a thorough examination of the relevant circumstances and after the conduct of a post-mortem to eliminate or corroborate relevant factors that could impact on the drug concentration and the possible effect of a substance on the body. This article reviews particular toxicological issues associated with the more common drugs of abuse such as the amphetamines, cannabinoids, cocaine, opioids and the benzodiazepines.

Update on Clandestine Amphetamines and Their Analogues Recently Seen in Japan.

Amphetamines and their analogues have undergone a cycle of popularity as recreational drugs in Japan. The current wave of popularity began in the early 1990s and spread throughout the country. More recently, not only 3,4methylenedioxymethamphetamine (MDMA) but also other designer amphetamines analogues, including pmethoxyamphetamine (PMA), 2,5-dimethoxy-4-ethylthiophenethylamine (2C-T-2), etc., have been extensively and increasingly abused, mainly among juveniles. This minireview presents an update on the amphetamines and their analogues by focusing on clandestine tablets encountered in Japan recently.

Use of the Apparent Content Curves for the spectrophotometric identification of substances: identification of amphetamines

The possibility of identification of substances which have similar spectral behaviour by means of Apparent Content Curves has been studied. This study is carried out with absorption, excitation and emission spectra of several amphetamines of widespread pharmaceutical use. Results obtained show that amphetamine, phenylpropanolamine, pseudoephedrine, phenylephrine, epinephrine, dopamine and methoxyamphetamine can be identified with a probability of >95%.

Detection and identification of amphetamine and methamphetamine in urine by GC/MS

Detection and identification of amphetamine and methamphetamine in urine by GC/MS

Identification of Amphetamine and Related Compounds in Urine Using the Bio-Rad REMEDI Drug Profiling System

Identification of Amphetamine and Related Compounds in Urine Using the Bio-Rad REMEDI Drug Profiling System

Identification of Two New “Designer” Amphetamines by NMR Techniques

Two new designer amphetamines (4-chloro-2, 5-dimethoxyamphetamine and 2, 5-dimethoxy-4-methylthioamphetamine) were identified by nuclear magnetic resonance (NMR) techniques. Nuclear Overhauser Effect (NOE) difference spectra provided all the necessary structural information to identify the unknowns. Lanthanide shift reagent (LSR) studies provided an alternate method to prove positional substitution for the structures.

Identification of amphetamine and related illicit drugs by second derivative ultraviolet spectrometry

Identification of amphetamine and related illicit drugs by second derivative ultraviolet spectrometry

Identification of Amphetamines and Related Sympathomimetic Amines

Abstract The IR, UV, and NMR spectral data as well as the pKa′ values of a series of 18 phenylpropyl amines are presented and discussed. The series includes the amphetamines and many of the commercially available phenylpropyl amines being used in the field of medicine as sympathomimetic agents. These data provide a basis for rapid identification of samples from biological, forensic, and medical research.

Investigation of Drug Addiction in the Routine Clinical Biochemistry Laboratory; Detection and Identification of Amphetamine and Morphine in Urine

Investigation of Drug Addiction in the Routine Clinical Biochemistry Laboratory; Detection and Identification of Amphetamine and Morphine in Urine

DETERMINATION AND IDENTIFICATION OF AMPHETAMINE IN URINE.

DETERMINATION AND IDENTIFICATION OF AMPHETAMINE IN URINE.