<h3>Purpose</h3> Although surgical Impella device implantation is often associated with fevers, the incidence of clinically significant infection is unknown. Since many patients are implanted as a bridge to transplant or durable mechanical circulatory support, the etiology of these fevers is important. In the present study, we investigate the incidence and clinical consequences of Impella related fever. <h3>Methods</h3> We retrospectively reviewed consecutive patients who underwent surgical Impella implantation (Impella 5.0 or 5.5) at a single center from 2012 to 2020. Patients were managed in accordance with their multidisciplinary team who evaluated fever (defined as temperature > 100.4 F) as clinically indicated. Pre- and post-implantation fever curve and infectious work-up, when performed, were reviewed. Summary statistics were reported. <h3>Results</h3> A total of 49 patients underwent Impella implantation. The median age was 66 (56-71), and 44/49 (90%) were male. Baseline patient information, including indication for Impella support and clinical outcomes, is summarized in Table 1. Following Impella implantation, 21/49 (43%) patients had a documented fever. Of these, 3/21 (14%) had pre-implantation fever with a known source of infection, none of whom had new infections post-implantation. Of the remaining patients with a post-implantation fever, only 1/18 (5.5%) had an identifiable infectious etiology for their fever. An additional 2/18 (11%) patients had positive cultures (1 blood, 1 BAL), but these were clinically managed as contaminants. <h3>Conclusion</h3> Although fever after Impella implantation was common, an infectious etiology for a post-implantation fever was rarely identified. Therefore, Impella-related fever should not be considered a barrier to advanced heart failure therapies including transplant or LVAD. Further investigation of post Impella fever is warranted to determine the source of this phenomena.