INTRODUCTION AND OBJECTIVES: Herein we describe various preoperative, operative and pathological variables associated with an improvement in EPIC urinary symptom scores following a robotic prostatectomy. METHODS: From October 2003 to June 2009 Expanded Prostate cancer Index Composite (EPIC) scores and demographic information were prospectively obtained from 623 patients who underwent a robotic radical prostatectomy. Patients received EPIC questionnaires preoperatively 6, 12, 24, 36, 48 and 60 months post-surgery. Two binary outcome variables were created: improvement in urinary incontinence and improvement in urinary bother. Improvement is defined by comparing the value at each post-operative time point to the subject’s baseline value on that subscale, and coding the subject as “improved” if his value at that time point was at least .5 standard deviations greater than his baseline value; otherwise he was considered as “not improved”. This longitudinal data was analyzed with the use of generalized estimating equations (GEE) models that relate the proportion of patients with improvement since procedure to various variables. RESULTS: The highest proportions reporting improvement was 14% at 5 years post-procedure for urinary incontinence and 37.8% at 4 years for urinary bother. The final model with proportion showing improvement in urinary incontinence score included recovery time, African-American race, employment status, nerve-sparing, and prostate weight. Recovery time (P 0.01), African-American race (P 0.01, OR 0.375), and increased prostate weight (P 0.01;OR 2.677) were significantly associated with improvement in urinary incontinence score. The final model with the outcome of proportion showing improvement in urinary bother score included recovery time, body mass index (BMI) category, smoking status, employment category, presence of hypertension, nerve-sparing, and prostate weight. However only recovery time, (p 0.0001), BMI, (P 0.03), (OR 1.108 for overweight compared to low-normal and 0.695 for obese compared to low-normal), and prostate weight had a significant positive association (P 0.0049, estimated odds ratio 1.891). CONCLUSIONS: Various demographic variables are associated with improved urinary quality of life measures. These factors may better identify ideal surgical candidates for a robotic prostatectomy.