Absorption air-conditioning system is a green choice for buildings for sustainable development. However, comparatively low performance impedes its development, as much energy is wasted in the heat regeneration process. To improve, a capacitive deionization (CDI) regeneration method has been proposed: it regenerates absorbent solution with electrode pairs and achieves better performance by cutting the energy loss. The COP could reach 6 under certain working conditions. Nevertheless, the present research has not fully explored the actual performance, which is strongly affected by the varieties and concentrations of different absorbents. On the purpose of selecting an ideal absorbent for optimization, theoretical and experimental research has been made on the actual performance with different absorbent solutions. Considering both the regeneration effect and cost-effectiveness, it has revealed the influence of different parameters. The results show that the system with LiBr solution has the highest COP. It can approach 2 with a 50% concentration; while MgCl2 and CaCl2 solution have better cost-effectiveness. Mixed absorbent could be a better alternative plan by reducing the cost without sacrificing the performance. These progresses could make the absorption air-conditioning system based on the capacitive deionization regeneration method more promising for future application.