The way library services are delivered has changed dramatically as a result of the integration of information and communication technology into academic libraries' daily operations. However, this is referred to as cloud computing. The majority of library services relating to information resources, dissemination, and delivery that are currently provided by libraries are either reproduced or replicated by ICT and mostly facilitated by the internet. This study looks into how ICT literacy affects the adoption of cloud computing in South-West, Nigeria's private university libraries. In this study, the survey research design was used. 262 librarians from 35 private university libraries in South-West Nigeria make up the study's population. All 35 private university libraries' library staff members were sampled using total enumeration. To collect data, a verified structured questionnaire was employed as the instrument. The constructions' Cronbach-alpha scores varied from 0.82 to 0.96. 95.8% of respondents responded. Both descriptive and regression analysis were used to analyze the data. The data were examined using SPSS version 24.0, Statistical Package for the Social Sciences. The findings demonstrated that library staff in South-West Nigeria's utilization of cloud computing was strongly influenced by ICT literacy levels. To improve the use of cloud computing by library staff in private universities in South-West, Nigeria, the study found that ICT literacy skills indicators, particularly proficiency in using hardware, proficiency in word processing, proficiency in web-based functions, and proficiency in data processing, should be improved. The study suggested implementing the required ICT literacy programs and training to improve their staff for efficient library service delivery.