The multiple jets impingement heat transfer is widely applied in the wing anti-icing system. It is challenging to apply the similarity criterion to carry out the anti-icing experiments due to the complex flow and heat transfer behavior. In the present study, the full-scale slat model is used to carry out anti-icing experimental researches in a 2 m × 3 m icing wind tunnel of China Aerodynamics Research and Development Center. The effects of icing parameters Liquid Water Content (LWC) and Median Volume Diameter (MVD) and hot air parameters (mass flow rate and temperature) on the thermal performance of an inner-liner anti-icing system with jets impingement heat transfer are studied. The effects of the experimental parameters are analyzed in detail by combining impingement and evaporation heat transfer mechanisms. The impingement hot air mass flow rate dramatically affects the heat transfer performance of the impingement stagnation region within the range of the experimental parameters. The temperature of impingement hot air and that of wing skin are approximately linear correlated. The experimental results show the effects of LWC and MVD on water film formation and runback ice accretion. The formation of water film is analyzed by an analytical method based on the wing skin temperature difference of dry and wet air conditions.