Introduction: Gynecological cancer survivors completing chemotherapy has a diverse presentation of pain, neurological disturbances and functional impairments that constitutes several impairments in ICF framework that hinders optimum quality of life. The study intended to determine the impact of Physiotherapy interventions through clinical reasoning procedure by international classification of functioning, disability and health (ICF). Case Report: The case was a uterine carcinoma case completing surgery and chemotherapy and seeks Physiotherapy complaining lower back pain, numbness and decreased strength in both lower limbs with functional and psycho-social impairments. The patient has been managed in three tract reasoning and Hypothetco deductive reasoning process of clinical reasoning. The Interventions focused on strengthening exercise of lower limbs, pelvic floor exercise, aerobic exercise and exercise to improve balance. After two weeks, Mckenzie extension approach for lumbar spine and neural sliding of lower limbs has been added as adjacent therapy. Treatment has been provided for eight sessions in four weeks and continued home exercises for another four weeks. Outcome has been measured and found positive effects on in pain redaction, remission of numbness, improvement of balance, strength of lower limb and quality of life measure.Single session follow up after three months from screening revealed sustainability of improvements that reflects efficacy of physiotherapy interventions in diverse indicator in ICF framework. Conclusion: Chemotherapy induced musculoskeletal complications are certainly manageable through physiotherapy interventions and McKenzie extension approach found effective to remission of lumber radicular symptoms in CIPN. The interventions have positive effect in longer run and upon quality of life in gynecological cancer survivors.