Various physical processes that ensue within protoplanetary disks - including vertical settling of icy and rocky grains, radial drift of solids, planetesimal formation, as well as planetary accretion itself - are facilitated by hydrodynamic interactions between H/He gas and high-Z dust. The Stokes number, which quantifies the strength of dust-gas coupling, thus plays a central role in protoplanetary disk evolution and its poor determination constitutes an important source of uncertainty within the theory of planet formation. In this work, we present a simple model for dust-gas coupling and we demonstrate that for a specified combination of the nebular accretion rate, Ṁ, and turbulence parameter a, the radial profile of the Stokes number can be calculated in a unique way. Our model indicates that the Stokes number grows sublinearly with the orbital radius, but increases dramatically across the water-ice line. For fiducial protoplanetary disk parameters of Ṁ = 10−8 M⊙ per year and α = 10−3, our theory yields characteristic values of the Stokes number on the order of St ~ 10−4 (corresponding to ~mm-sized silicate dust) in the inner nebula and St ~ 10−1 (corresponding to icy grains of a few cm in size) in the outer regions of the disk. Accordingly, solids are expected to settle into a thin subdisk at large stellocentric distances, while remaining vertically well mixed inside the ice line.