Deep pits and fissures in partially erupted permanent molars are vulnerable to dental caries. To assess the clinical effectiveness of resin-modified glass ionomer-based fluoride varnish (RMGI-F varnish: Clinpro XT™ varnish) in preventing occlusal caries lesions in partially erupted permanent first molars. In this randomised active-controlled superiority trial with a single-blind parallel design, 74 children with 182 partially erupted first permanent molars were allocated into two groups: Group 1: RMGI-F varnish; and Group 2: GI sealant (active control), with an application of 0.1% sodium fluoride varnish for all other teeth. The primary outcome was ICDAS score ≥1 at 12months of follow-up. Data were analysed using adjusted Chi-square test and GEE regression for binary outcomes. Group 1 (15.7%) and Group 2 (13.8%) did not differ significantly in ICDAS ≥1 scores at 12months of follow-up (adjusted χ2 =0.373, p=.541). There was no significant difference in retention between Group 1 (48.3%) and Group 2 (20.7%) at 12months of follow-up (adjusted χ2 =0.1, p=.752). Mean application time per tooth (16±5.9 vs 20.2±5.4min) was significantly different (t=5.26, p=.014). RMGI-F varnish was not superior to GI sealant in preventing occlusal caries lesions in partially erupted molars.
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