Objective: This study aimed to measure the prevalence of mental health problems (MHPs) and their relationship with help-seeking behavior among college students at Imam Mohammad Ibn Saud Islamic University (IMSIU) in Riyadh, Saudi Arabia. Methods: A cross-sectional study was conducted using an online self-completed electronic question-naire distributed to IMSIU students. The questionnaire contained items related to barriers preventing from seeking help and the Kessler Psychological Distress Scale (K6) to evaluate the distress. Results: The prevalence of MHPs among IMSIU students with severe distress, mild to moderate dis-tress, and no/less distress was 54.8%, 31.2%, and 14.0%, respectively. The prevalence of stu-dents who planned to seek help for MHPs was 53.7%. Being a female, single, smoker, with a family history of MHPs had a significantly higher mean perceived K-6 mental distress score. Conclusion: The competent authorities should develop programs that enhance students\' mental health and provide psychosocial support.