Oxygen plays a central role in wound healing. It is required for angiogenesis, collagen deposition, epithelization, and superoxide production for intracellular bacterial killing. Wound oxygen concentration depends upon the complex interactions of blood perfusion, intercapillary distance, local oxygen consumption, arterial oxygen concentration, and oxyhemoglobin dissociation conditions. Accurate determination of wound p02 during hyperbaric oxygen (HBO) treatment requires direct measurement. Transport of oxygen to the hypoxic center of a wound, or to a wound with impaired perfusion, is often only possible with HBO exposure. Several studies have shown that HBO promotes wound healing, especially in hypoxic wounds.