Hypothyroidism Research Articles

Особливості біохімічних показників крові та цитокінового профілю у хворих на неалкогольну жирову хворобу печінки залежно від форми гіпотиреозу

Мета роботи: вивчити особливості біохімічних показників крові та цитокінового профілю у хворих на неалкогольну жирову хворобу печінки (НАЖХП) залежно від форми гіпотиреозу. Матеріали та методи. Обстежено 188 хворих на НАЖХП (середній вік — 53,6 ± 12,34 року). Серед обстежених у 20 хворих на НАЖХП, окрім захворювання печінки, був діагностований субклінічний гіпотиреоз, у 24 пацієнтів — маніфестний гіпотиреоз. У групу порівняння увійшли 144 пацієнти із НАЖХП із нормальною функціональною активністю щитоподібної залози. Контрольну групу становили 45 практично здорових осіб, репрезентативних за віком та статтю щодо пацієнтів досліджуваних груп. У крові обстежених пацієнтів та практично здорових осіб досліджували біохімічні показники, визначали рівень фактора некрозу пухлин α, інтерлейкіну-10, лептину, адипонектину. Результати. Установлено, що активність загальної лактатдегідрогенази в крові хворих на НАЖХП із субклінічним та маніфестним гіпотиреозом перевищувала таку в пацієнтів із НАЖХП та нормальною функціональною активністю щитоподібної залози на 13,5 % (p = 0,02 і p = 0,01 відповідно). У хворих із поєднанням НАЖХП та маніфестного гіпотиреозу зафіксовано вірогідно вищу активність лужної фосфатази (на 12,0 %, p = 0,03) порівняно з пацієнтами групи порівняння. Концентрація лептину в крові в пацієнтів із НАЖХП як із субклінічним, так і з маніфестним гіпотиреозом перевищувала таку у хворих на НАЖХП із нормальною функціональною активністю щитоподібної залози на 35,7 % (p = 0,04) та 72,1 % (p = 0,009) відповідно. Рівень адипонектину в крові у хворих на НАЖХП та маніфестний гіпотиреоз був вірогідно меншим, ніж у пацієнтів із НАЖХП і нормальною функціональною активністю щитоподібної залози та хворих на субклінічний гіпотиреоз, у 2,1 раза (p = 0,004) та на 50,0 % (p = 0,009) відповідно. При поєднанні НАЖХП та маніфестного гіпотиреозу у хворих виявляли вірогідно більший вертикальний розмір печінки по середньоключичній лінії в середньому на 9,1 мм (p = 0,004) порівняно з пацієнтами з НАЖХП та незміненою функціональною активністю щитоподібної залози та на 8,6 мм (p = 0,04) порівняно з хворими на НАЖХП та субклінічний гіпотиреоз. Висновки. У хворих на НАЖХП із субклінічним та маніфестним гіпотиреозом спостерігаються вища активність загальної лактатдегідрогенази та вищий рівень лептину, а в останніх — ще й більша активність лужної фосфатази та нижчий рівень адипонектину в крові порівняно з відповідними показниками у хворих на НАЖХП та нормальною функціональною активністю щитоподібної залози. За наявності маніфестного гіпотиреозу у хворих на НАЖХП відмічається вірогідне збільшення вертикального розміру печінки по середньоключичній лінії порівняно з таким у пацієнтів із нормальним функціональним станом щитоподібної залози чи субклінічним гіпотиреозом.

Вплив додаткового призначення вітаміну D на інсулінорезистентність та жорсткість артерій у хворих на гіпотиреоз

Актуальність. У нещодавніх епідеміологічних дослідженнях виявлено вірогідні зворотні взаємозв’язки між рівнями вітаміну D, інсулінорезистентністю (ІР) і серцево­судинними захворюваннями. Однак лише в декількох інтервенційних дослідженнях було проведено оцінку впливу додаткового призначення вітаміну D на серцево­судинний ризик, жорсткість артерій у хворих на гіпотиреоз. Мета дослідження — визначити вплив додаткового призначення вітаміну D на серцево­судинний ризик у хворих на гіпотиреоз, у тому числі метаболічні параметри, ІР і жорсткість артерій. Матеріали та методи. Під спостереженням перебувало 55 хворих на гіпотиреоз, які отримували замісну терапію левотироксином. З дослідження виключили пацієнтiв, які отримували препарати вітаміну D або кальцію. Учасники дослідження були розподілені в групу, якій було призначено вітамін D (холекальциферол у дозі 4000 МО в день; n = 30), і контрольну групу (отримувала лише левотироксин; n = 25). Проведено порівняння показників ІР (оцінка моделі гомеостазу (HOMA­IR), кісточково­плечового індексу) до і після спостереження впродовж 12 тижнів. Результати. Характеристики хворих двох груп на початку дослідження вірогідно не відрізнялися. П’ятдесят п’ять учасників завершили дослідження згідно з протоколом. Наприкінці спостереження показники 25­гідроксивітаміну (25(ОН)D) були вірогідно вищими в групі, що отримувала вітамін D, аніж у контрольній групі (32,7 ± 7,2 нг/мл проти 17,1 ± 6,3 нг/мл, p < 0,05). У той же час не встановлено відмінностей за показниками індексу HOMA­IR і змін жорсткості артерій між групами хворих. Висновки. Додаткове призначення вітаміну D впродовж 12 тижнів ефективно підвищує вміст 25(ОН)D в крові. Однак впливу такого лікування на показники серцево­судинного ризику (ІР та жорсткість артерій) у хворих на гіпотиреоз не встановлено.

Risk of neurally mediated syncope in hypothyroidism and obesity

Introduction and rationale: Thyroid hormones participate in several known mechanisms of cardiac function, being compromised in hypothyroidism (HPT), when uncontrolled, is associated with weight gain. HPT and Obesity participate in autonomic dysfunction.

Тактика ведения больных с манифестным, субклиническим и послеоперационным гипотиреозом (обзор литературы)

В обзоре приведены данные о наиболее распространенных видах тиреоидной патологии — субклиническом, манифестном гипотиреозе (особенно у лиц пожилого возраста) и гипотиреозе как осложнении после проведения гемитиреоидэктомии. Приведены данные по послеоперационному гипотиреозу (субклиническому и манифестному): частота возникновения, диагностирование после операции, факторы, влияющие на развитие после­операционного гипотиреоза, среди основных — предоперационный уровень тиреотропного гормона, возраст и наличие антитиреоидных антител. Также проанализированы риски узлообразования в викарной доле щитовидной железы после гемитиреоидэктомии. В целом в краткосрочной перспективе развитие узлов в остаточной доле не отмечалось.

Вплив гіпотиреозу в чоловіків на андрогенну функцію

Актуальність. Результати сучасних досліджень вказують на роль тиреоїдних гормонів, метаболічного дисбалансу, психічного стресу в підтриманні загального й гормонального гомеостазу організму. У той же час взаємодія тиреоїдних і статевих гормонів при гіпотиреозі в чоловіків залишається предметом дискусій. Мета: вивчити частоту клінічних і лабораторних ознак андрогенного дефіциту, а також вплив недостатнього рівня тиреоїдних гормонів на андрогенну функцію в чоловіків із гіпотиреозом. Матеріали та методи. Під спостереженням перебувало 55 чоловіків із первинним гіпотиреозом віком від 36 до 60 років, а також 25 практично здорових чоловіків. Результати. У хворих на гіпотиреоз спостерігалося вірогідне зниження вмісту глобуліну, що зв’язує статеві гормони (ГЗСГ), загального тестостерону, а також вільного й біодоступного тестостерону порівняно зі здоровими чоловіками. У хворих на гіпотиреоз сироваткова концентрація вільного тироксину позитивно корелює із ГЗСГ. Виявлені негативні кореляції середнього ступеня вираженості між ГЗСГ і вільним і біодоступним тестостероном. Висновки. У чоловіків середнього віку з гіпотиреозом рекомендується визначення вмісту андрогенів в крові для виявлення синдрому андрогенного дефіциту.

A STUDY ON ASSESSMENT OF RISK FACTORS, COMPLICATIONS AND QUALITY OF LIFE OF PATIENTS WITH HYPOTHYROIDISM IN A TERTIARY CARE HOSPITAL

Background: Hypothyroidism is a syndrome which results from decreased production of thyroid hormones from thyroid gland and hence it can also be termed as underactive thyroid disease. Objectives: To assess the quality of life in patients with denovo hypothyroidism. To assess risk factors, complications in patients with hypothyroidism. Materials and methods: There was a total (N=100) number of participants enrolled in the study and are evaluated for risk factors and complications and among 100, 40 patients are Denovo hypothyroid who are assessed for quality of life. This is a prospective observational study in which the risk factors, complications and quality of life of patients is evaluated for those patients who are willing to give informed consent and meet the inclusion criteria. Results and Discussion: Referring to the ndings, the patients with high BMI, females and age around 20-30 are more prevalent. Patients who do not adhere to medications develop complications such as goiter and cvs problems but mostly obesity is seen and QOL of patients was studied using SF-36 and HADS scales. The initial mean was found to be less compared to the nal mean in SF-36 whereas in HADS the initial mean is high compared to the nal mean. The Patient's BMI was high initially and then reduced to normal.This implies that after educating the patient about the disease and need of medication the nal result shows there is improvement in the patient's QOL. P values of SF 36 and HADS are 0.0001 and 0.0314 respectively, which by conventional criteria was found to be statistically signicant. Conclusion: This study simply showed that the females, patients with high BMI and age around 20-30 are the major risk factors. Proper patient education, care and medication adherence are the cornerstones to help avoid complications and improve patients quality of life.

High Incidence of Hypothyroidism Within a Month in Neonates with Down Syndrome Who Are Euthyroid at Birth: Results of A Prospective Study

The objective was to test for hypothyroidism (HYT) in infants with Down Syndrome (DS) who tested euthyroid on state newborn screening for congenital HYT. In 39 infants with DS who were euthyroid at birth, serum TSH, total T4 (TT4) and free T4 (FT4) levels were measured during 15 to 120 days of age. TSH, TT4 and FT4 were measured by standard techniques. Depending up on age specific TSH and thyroid hormone (TH) levels, babies were classified as: Euthyroid (normal TSH and normal TH), Primary HYT (high TSH and low TH), compensated HYT (high TSH and normal TH) and sick thyroid (low TSH and low TH). Comparisons among different groups were performed using two-sample t-tests. Twenty-nine babies (72%) remained euthyroid (TSH 6.1 ± 2.6 mIU/ml, TT4 10.8 ± 1.8 µg/ dl and FT4 1.57 ± 0.4 ng/dl). Six (18%) babies developed primary HYT (TSH 23.5 ± 10, TT4 5.1 ± 1.2, FT4 1.17 ± 0.2) within a month of life needing T4 therapy. While 4 (10%) babies developed compensated HYT (TSH 29.3 ± 10, TT4 10.6 ± 3.6 and FT4 1.83 ± 0.3), one (2.5%) had sick thyroid syndrome (TSH 4.6, TT4 4.6 and FT4 1.1). All four babies with compensated HYT were euthyroid by four months of age. Despite normal newborn screening at birth, the incidence of any HYT was much higher (28 %) than the normal neonatal population (1/2000-4000). More importantly, HYT developed within a month of age. Recommendations by the AAP about retesting TH function in infants with DS should be revised.

The positive effect of black seed (Nigella sativa L.) essential oil on thyroid hormones in rats with hypothyroidism and hyperthyroidism.

In our study, the effect of essential oil obtained from Nigella sativa L. (NSE) on thyroid hormones and antioxidant balance in hypothyroidism (HT) and hyperthyroidism (HP) models induced by propylthiouracil(PTU) and L-thyroxine(LT4 ), respectively, in rats were investigated for 4weeks. NSE was administered by gastric gavage at a dose of 200mg/kg body weight. In this study, 48 male Wistar albino rats with an average weight of 180-290g and age 5-6months were divided into eight groups, as follows: groups with HT, (1) control, (2) HT, (3) NSE, and (4) HT+NSE; groups with HP, (1) control, (2) HP, (3), and NSE (4) HP+NSE. As a result, we found that NSE administration increased total triiodothyronine (TT3 ) and decreased nitric oxide in HT+NSE. Besides, it decreased TT3 in HP+NSE and increased total antioxidant capacity. Our findings suggest that NSEmayhavebeneficial effectson thyroid gland abnormalities owing to its antioxidant properties. PRACTICAL APPLICATIONS: Essential oils derived from Nigella sativa L. seed contain many bioactive substances such as thymoquinone and cymene. This paper emphasizes the effect of NSE on thyroid hormone abnormalities and negative oxidative state that occurs in HT and HP models. The present study provides evidence of a positive effect of NSE particularly on TT3 levels in the HT and HP models. It can therefore be assumed that NSE could be used as a supportive natural alternative source to improve thyroid hormone levels and relieve increased oxidative stress.

Improving the Quality of Life of Patients with an Underactive Thyroid Through mHealth: A Patient-Centered Approach.

Background: Three hundred fifty million people worldwide suffer from underactive thyroid conditions, which can lead to infertility, obesity, heart disease, and impaired mental health when poorly managed. Although mobile health (mHealth) applications can be a useful solution for self-managing one's condition, the impact of digital solutions for improving the health of thyroid patients remains unknown.Methods: We used a mixed methods analysis to assess the ways in which a digital approach might benefit thyroid patients. A cross-sectional study was conducted among users of BOOST Thyroid, an mHealth application for patients with an underactive thyroid. We collected data using a modified Short Form 36 Health Survey Questionnaire to measure the impact of in the app on participants' perceived health and quality of life. Participants were asked to (1) score their quality of life before and after using the app, and (2) describe whether and how using the app helped them.Results: We enrolled 406 users (380 females and 26 males), aged 18–78 years. Most participants (95.8%) reported using the app was helpful; of which 68% reported it improved their quality of life and 70.8% reported it had a positive impact on their health. Participants who found the app useful experienced less symptoms and a lower intensity of remaining symptoms. A key factor reported by these participants as helping with managing their health is the information provided in the app.Conclusions: The results support the idea that a patient-centered treatment would benefit from including mHealth tools for a daily self-management of underactive thyroid condition, as it can increase health literacy and improve both one's health status and quality of life.

Abstract #1003650: Carbamazepine: An Under-recognized Cause of Hypothyroidism in Patients Receiving Levothyroxine

Abstract #1003650: Carbamazepine: An Under-recognized Cause of Hypothyroidism in Patients Receiving Levothyroxine

Predicting the risk of severe menopausal syndrome in perimenopausal women with hypothyroidism

Background. Every year the number of menopausal women increases. At this age, the prevalence of hypothyroidism (HT) reaches its peak. The problem of menopausal syndrome (MS) is relevant for patients with HT, concomitant endocrine disorders create a background for combination with dyshormonal factors. The purpose of the study: to propose an approach to predicting the risk of severe MS in perimenopausal women with HT according to the developed algorithm and mathematical model. Materials and methods. To predict the development of MS, 146 perimenopausal women with autoimmune HT were surveyed. Using multiple regression analysis, a prognostic model of the risk of severe MS was created. Results. Logistic regression analysis revealed the following most significant multicollinear risk factors for MS: smoking, alcohol consumption, adverse environmental conditions, physical activity, history of stress and anxiety, thyroid disease. A correlation matrix with calculation of regression coefficients and coefficient of determination was constructed, a mathematical model was created to determine the risk factor for the progression of MS. The predicted value of the risk factor for severe MS with a high degree of probability was determined in 72 (49.32%) women, with an average probability— in 58 (39.73%), and with a low probability— in 16 women (10.95%) with HT. The correspondence of the predicted results with the theoretically expected ones in the high-risk group was recorded in 104.37%, in the average-risk— in 94.73%, and in the low-risk— in 89.65% of cases. Conclusions. The developed algorithm and mathematical model for predicting severe MS on the background of HT are highly informative and allow determining in advance the group of women at high risk of severe MS for the timely implementation of appropriate preventive measures.

Unraveling the Role of Hypothyroidism in Non-alcoholic Fatty Liver Disease Pathogenesis: Correlations, Conflicts, and the Current Stand.

Non-alcoholic fatty liver disease (NAFLD) has become one of the most common causes of chronic liver diseases globally. Because thyroid hormones play a crucial role in lipid metabolism, thyroid dysfunction has been implicated in NAFLD pathogenesis in the past decade, with hypothyroidism-induced NAFLD being regarded as a distinct disease entity. However, there has been no common consensus yet, and several studies have found contradictory results. Hence, we conducted this systematic review to represent the current view on the role of hypothyroidism (HT) and individual thyroid function parameters such as thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) in NAFLD pathogenesis. We searched PubMed, PubMed Central, and Semantic Scholar databases from inception until January 2021 to identify relevant observational (case-control, cross-sectional, and longitudinal) studies. A total of 699 articles were recognized through our database search. After applying the eligibility criteria and performing quality assessment, 10 studies involving 42,227 participants were included in the final systematic review. Each of these studies assessed different thyroid function parameters, and NAFLD was found to be associated with HT in two studies, elevated TSH in three studies, suppressed T4 in three studies, elevated T3 in one study, and elevated TPOAb in one study. There was also a wide heterogeneity in HT definition, study population characteristics, and study design among these studies, making a direct comparison difficult. Because the recognition of HT-induced NAFLD has possible diagnostic, therapeutic, and prognostic implications, we recommend that comprehensive, long-term prospective studies be carried out to determine if HT or thyroid function parameters are causally associated with NAFLD.

A Rare Case of a Toxic Thyroid Nodule Found in a Hypothyroid Patient on Levothyroxine Therapy

Introduction: A hyperfunctional thyroid nodule can lead to symptoms of overt or subclinical hyperthyroidism but the association between a hyperfunctional thyroid nodule and hypothyroidism has not been well reported. We present a patient with a prior history of hypothyroidism previously controlled on Levothyroxine who later presented with an enlarging hot nodule. Case Presentation: A 62-year-old female with a history of factor V Leiden, hypothyroidism on levothyroxine therapy, and a meningioma presented to an outpatient clinic with complaints of fatigue, constipation, and 37-pound weight loss in one year. She was diagnosed with hypothyroidism 7 years ago after delivering her third child, but the underlying cause of her disease was unknown. She began taking levothyroxine 50mcg every morning after her diagnosis. She reported compliance and proper pill taking technique. Physical examination revealed a palpable thyroid nodule. The patient had a previous work up for thyroid nodules with a thyroid uptake and scan a few years prior, which showed a 1.42 x 0.96 x 1.87 cm hot nodule at the right middle lobe with a 24-hour uptake of 15.3%. The patient was asymptomatic at that time and thyroid function tests were within normal limits. She was instructed to continue taking levothyroxine. Repeat RAI Uptake scan at the time of her presentation to our office again showed the right middle lobe hot thyroid nodule with an increased 24-hour uptake of 27.5%. Ultrasound showed bilateral thyroid nodules and a hypervascular solid nodule measuring 2.28 x 1.27 x 1.9 cm that has increased in size. Lab work at this visit revealed a TSH of 0.329 uIu/mL, and free T4 of 1.25 ng/dL. Due to her low TSH and clinical presentation, the levothyroxine was discontinued. Anti-thyroid peroxidase antibodies were obtained to assess for Hashimoto’s Thyroiditis but were found to be normal. The patient was later referred to an endocrine surgeon for a total thyroidectomy. Conclusion: Although uncommon, hyperfunctional nodules in hypothyroid patients can create a confusing clinical picture with overlapping symptoms of underactive and overactive thyroid disease. It has been reported that patients with Hashimoto’s Thyroiditis can have hot nodules and coexisting hypothyroidism but the prevalence of hyperfunctional nodules in hypothyroid patients without Hashimoto’s Thyroiditis, as in this case, is not well-documented. Patients with hypothyroidism are treated with Levothyroxine but if coexisting hyperfunctional nodules are not detected, the patient may develop thyrotoxicosis. Clinicians should be aware of this rare but potentially life-threatening clinical condition.

Risk of cancer in long-term levothyroxine users: Retrospective population-based study.

Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. The relationship between levothyroxine use and cancer risk is largely underdetermined. To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective case‐control study was conducted using Taiwan’s Health and Welfare Data Science Center database. Cases were defined as all patients who were aged ≥20 years and had a first‐time diagnosis for cancer at any site for the period between 2001 and 2011. Multivariable conditional logistic regression models were used to calculate an adjusted odds ratio (AOR) to reduce potential confounding factors. A total of 601 733 cases and 2 406 932 controls were included in the current study. Levothyroxine users showed a 50% higher risk of cancer at any site (AOR: 1.50, 95% CI: 1.46‐1.54; P < .0001) compared with non–users. Significant increased risks were also observed for brain cancer (AOR: 1.90, 95% CI: 1.48‐2.44; P < .0001), skin cancer (AOR: 1.42, 95% CI: 1.17‐1.72; P < .0001), pancreatic cancer (AOR: 1.27, 95% CI: 1.01‐1.60; P = .03), and female breast cancer (AOR: 1.24, 95% CI: 1.15‐1.33; P < .0001). Our study results showed that levothyroxine use was significantly associated with an increased risk of cancer, particularly brain, skin, pancreatic, and female breast cancers. Levothyroxine remains a highly effective therapy for hypothyroidism; therefore, physicians should carefully consider levothyroxine therapy and monitor patients’ condition to avoid negative outcomes. Additional studies are needed to confirm these findings and to evaluate the potential biological mechanisms.

The Art of Hormone Measurements with Emphasis on Specificity Resulting in Diagnostic and Management Improvements

The Art of Hormone Measurements with Emphasis on Specificity Resulting in Diagnostic and Management Improvements

The Relationship Between Hypothyroidism and Proteinuria

The Relationship Between Hypothyroidism and Proteinuria

Elevated serum thyroid stimulating hormone concentration treated with homoeopathy: A case report

Hypothyroidism is emerging to be one of the most common endocrinological disorders worldwide which when left undetected or untreated leads to severe complications. However, clinical manifestations vary from serious symptoms to certain non-specific symptoms like fatigue, weight gain, depression or aches and pains. It occurs more in women and a positive family history of thyroid diseases where traced frequently. Thyroid stimulating hormone is highly sensitive to thyroid dysfunction and commonly used to evaluate thyroid disorders. The standard treatment of hypothyroidism restores the thyroid function by daily use of the synthetic hormone tablets. Homoeopathic medicine plays a significant role in management of thyroid disorder. A case reported in the OPD of National Homoeopathy Research Institute in Mental Health, Kottayam with reports of raised levels of thyroid stimulating hormone showed its reduction after administration of Homoeopathic medicine. This is documentary evidence showing that an underactive thyroid gland is effectively acted upon by Homoeopathic interventions to bring about desired effects.

Functional Limitations of Hyper and Hypothyroid Patients in INMOL Hospital Lahore, Pakistan

Introduction: Thyroid disease is extremely prevalent than heart diseases or diabetes. Hormones produced by the thyroid gland maintain the muscles, heart, brain, and other organs of the body. Improper performance of the thyroid gland leads to an overactive thyroid (hyperthyroidism) or underactive thyroid (hypothyroidism) that disturbs the metabolic system. The objective of the present study is to investigate the functional limitations of the patients under these two types of thyroid disorders.&#x0D; Methods: A cross-sectional study design is used to collect the data from thyroid disease patients in INMOL hospital Lahore, Pakistan from 23rd November 2020 to 20th January 2021. A total of 201 patients (98 hyperthyroid, 103 hypothyroid) are enrolled in this study. Data is analyzed through frequencies, percentages, and chi-square test of association by using SPSS (version 23).&#x0D; Results: Females over 30 years of ages, married, overweight with family sizes are less than four with a positive family history of brothers and sisters using iodized salt are more at risk of hypothyroidism and faced the problems like speedup in the metabolic system, weight gain, slow heartbeat, low blood pressure, weakness in muscles, constipation, coldness when others do not. Eventually it causes difficulties in routine activities, irregularities in the menstrual cycle and problems in pregnancy.&#x0D; Conclusion: By considering all these evidences, early diagnosis and precautionary steps are needed to avoid the prevalence of thyroid disease specifically in women.

Amiodarone and hypothyroidism

Amiodarone and hypothyroidism

Yagya Therapy as adjunct care tended to normalized level of thyroid hormones in 18 thyroid patients after 40 days of treatment

Yagya Therapy is an ancient Vedic therapy. Using specific herbs for management of the disease, this novel approach can provide a supportive care in various conditions. Besides, it involves a holistic approach with pulmonary inhalation of herbal vapors through Pranayama. In the thyroid condition, hyper and hypo thyroid, there is imbalance of the T3, T4 and TSH hormones along with complains in associated with quality of life. The present study evaluated thyroid hormonal levels and quality of life in 18 thyroid patient after giving 40 days of Yagya Therapy with application of herbal mixtures for hormonal balance as supportive care. Patients were without any change in the drug and dose in past 6 months. The pre and post evaluation after Yagya Therapy revealed that in just 40 days of Yagya Therapy as supportive care, it helped to achieve the desired pattern in the hyperthyroid patients. In hypothyroid patients (n=9), pattern of increase in the T4 and T3 levels and decrease in TSH level and in the hyperthyroid patients (n=3), decrease in the T4 and T3 level and increase in TSH level were observed (p=0.06). In addition patients reported significant improvement in quality of life in physical weakness (p-value 0.0078), breathing issues (p-value 0.0078), sleep issues (p-value 0.0176), stress (p-value 0.002), indicating the potential of Yagya Therapy in treating and managing Thyroid condition. Yagya Therapy has great potential for management of chronic condition of Thyroid through both balancing thyroid hormones as well as by improving quality of life.