Annotation. The purpose was to study the key aspects of the functioning of domestic dairy cattle breeding and to determine the strategic directions of state support for this industry segment in order to increase efficiency, innovation and sustainability of development. The materials of publications of Russian scientists in the field of improving methods and approaches to the management of the livestock sector in Russia, in particular, dairy cattle breeding, were used in the work. Various regulatory documents (programs, strategies, reports, summaries) of the Ministry of Agriculture of the Russian Federation, official statistics of Rosstat were also used. The following scientific approaches were used: system, situational, logical, dialectical, functional. Among the scientific methods it is worth noting: abstraction, analysis, synthesis, induction, deduction, analogy, generalization, scientific explanation, dialectic, idealization, mental experiment, hypothetical-deductive method, method of axiomatization and formalization, description and comparison. The scientific novelty lies in the development and justification of strategic directions of state regulation of sustainable development of the sphere of domestic dairy cattle breeding. The results are as follows: a study of the state and dynamics of the development of the sphere of domestic dairy cattle breeding (raw milk production, livestock, milk yield), as well as trends in the consumer market of milk and dairy products (capacity, structure, consumption volumes, price), was also considered the mechanism of state support for this the industry segment of the agro-industrial complex, which included the following tools: regulatory support; investments; customs and tariff regulation. In conclusion, the key risks and threats that hinder the sustainable and balanced development of this industry were highlighted, as well as a list of strategic directions of state support for the development of dairy cattle breeding in Russia in order to increase efficiency, investment activity, quality and safety of dairy products.