Actual hypoid gear tooth surfaces do deviate from the theoretical ones either globally due to manufacturing errors or locally due to reasons such as tooth surface wear. A practical methodology based on ease-off topography is proposed here for loaded tooth contact analysis of hypoid gears having both local and global deviations. This methodology defines the theoretical pinion and gear tooth surfaces from the machine settings and cutter parameters, and constructs the surfaces of the theoretical ease-off and roll angle to compute for the unloaded contact analysis. This theoretical ease-off topography is modified based on tooth surface deviations and is used to perform a loaded tooth contact analysis according to a semi-analytical method proposed earlier. At the end, two examples, a face-milled hypoid gear set having local deviations and a face-hobbed one having global deviations, are analyzed to demonstrate the effectiveness of the proposed methodology in quantifying the effect of such deviations on the load distribution and the loaded motion transmission error.