Double seismic zones (DSZs) of intermediate-depth intraslab seismicity are observed in many subduction zones around the globe, and have been related to dehydration reactions in the downgoing crust and mantle lithosphere. These reactions occur at, to first order, constant temperatures, which explains the observed linear arrangements of seismicity that appear to follow isotherms of thermal models.Intermediate-depth seismicity in Northern Chile, however, exhibits a pattern of intraslab seismicity that substantially deviates from a classical DSZ. Whereas two parallel seismicity planes are present in the updip part of the slab, these abruptly change into a 25–30 km thick, homogeneously seismogenic volume at a depth of ∼80–100 km. Seismicity rate and moment release significantly increase in this depth interval. In order to understand which processes evoke this configuration and what distinguishes the Northern Chile subduction zone from more conventional subduction zone settings (e.g. Japan), we performed a detailed seismological investigation of slab seismicity in Northern Chile using data from the IPOC permanent network. We determined >600 moment tensors of intraslab earthquakes, processed and evaluated location uncertainties for 8 years of high-resolution earthquake hypocenter data, and performed statistical analysis of the different seismicity populations.We observe that earthquakes both in the highly active cluster and the DSZ above exhibit consistently downdip extensive source mechanisms that align with the dip angle and direction of the slab. This implies strong slab pull, which is also evident from slab steepening outlined by hypocenters towards the downdip termination of the highly active cluster. Moreover, events in the cluster show a very weak aftershock productivity and a high background event rate, which leads to a temporal distribution of seismicity that is close to a purely random process. We find that the position of the highly seismogenic volume spatially coincides with: 1) the disappearance of the velocity contrast between oceanic crust and the underlying mantle in receiver function images, 2) the transition from the “cold nose” (i.e. the stagnant part) to the hot part of the mantle wedge, as evidenced by seismic attenuation images, and 3) with an increase of the slab dip angle. Based on these different pieces of evidence, we speculate that high tensile stresses and heat input from above could lead to a sudden burst of kinetically delayed metamorphic reactions there that then enables the observed increased seismicity rates. Since these reactions have overall a negative volume change that leads to slab densification and hence further increases slab pull, the spatial pattern of seismicity we observe could result from a runaway-type process, which would explain its abrupt start and high moment release rates.