Hypoallergenic Research Articles

Is Articaine the Hypoallergenic Anesthetic?

Is Articaine the Hypoallergenic Anesthetic?

Les laits infantiles en 2005

Bottle-feeding can be achieved with three types of commercially prepared formulas. Infant formulas intended for satisfying by themselves the nutritional requirements of infants during the first 4-6 months of life, as an alternative to breast-feeding. Several types of formulas are available beside standard cow's milk formula with recently reduced protein level and which vary in their ratio of casein to whey, their lactose content and the possible adding of pre- or probiotics. Hypoallergenic (HA) formula are especially indicated for infants at risk of developing an allergy, according to a family history of atopy. Thickened formulas (AR) are devoted to regurgitating infants whereas others formula such as semi-elemental diet extensively hydrolysed ones or lactose free formulas are for therapeutic use. The use of soy formulas is discouraged and limited to very few cases. Follow up milks are intended to constitute the milk element in a progressively diversified diet of infants over 4 months and better around 6 months of age. Growing up milk can be used over 9-12 months when the infant's diet is diversified on the family pattern.

The hypoallergenic dog*1Fact or fiction?

The hypoallergenic dog*1Fact or fiction?

The hypoallergenic dog: Fact or fiction?

The hypoallergenic dog: Fact or fiction?

P1125 A RANDOMISED TRIAL TO EVALUATE THE NUTRITIONAL EFFICACY OF A HYPOALLERGENIC INFANT FORMULA CONTAINING A NEW PROTEIN HYDROLYSATE

Introduction: Hypoallergenic (HA) infant formula is widely used to prevent allergy in at risk children. Aptamil HA1 (Milupa GmbH) is currently used for this purpose. A new protein hydrolysate for Aptamil HA1 was developed by the company which was prepared from 100% low threonine whey in place of 50% casein and 50% conventional whey. The two protein hydrolysates otherwise had similar amino acid pattern and molecular weight profiles. Since the change in manufacturing process might influence the nutritional quality, we conducted a study to compare the effect of the new versus the classical formula on growth, acceptability and tolerability. Methods: Healthy newborn term infants were randomised to receive blind either Aptamil HA1 with the standard hydrolysate (formula S) or new hydrolysate (formula N). Median birth weight (range) was respectively 3180g (2150–3960) and 3260g (2470–4420). The primary endpoint was weight gain at weeks 6 and 13. Secondary endpoints included length gain, head circumference gain and mothers’ perceptions of formula performance. Results: Fifty-three children were randomised. The two groups were well balanced for all studied baseline parameters. At week 13 the median weight gain was significantly higher in group N (table). There were no differences in the gains in length or head circumference. We found no differences regarding the intakes of additional food and drink, the characteristics of stools or adverse events. Mothers’ impressions did not differ except concerns about possetting were slightly higher in group N (p<0.05), although regurgitations were observed less frequently in that group by the paediatrician.Table 1: Median gain [range]Conclusion: This study demonstrates that the new formula supports a satisfactory growth pattern and a slightly higher weight gain compared to previous Aptamyl HA1 formula. The weight gains observed are similar to previously published values for formula-fed infants. The acceptability characteristics of the two formulas were similar.

Animal models in food allergy: assessment of allergenicity and preventive activity of infant formulas

Food allergies occur in about 5–10% of the overall infant and small-child population. Cow's milk protein allergy (CMPA) is the most common in young infants, with a 2–4% incidence. When breastfeeding is not possible, hypoallergenic (HA) cow's milk based formulas are usually given during the first months of life for prevention of CMPA. Depending on primary (sensitization) or secondary (triggering) prevention, the requested quality of HA formulas may be different. Besides in vitro methods, in vivo and ex vivo animal models are helpful in assessing residual allergenicity and the preventive effect of HA formulas. The sensitizing capacity of a formula can be examined by either the parenteral rat (IgE), the guinea pig (IgG1a mediated) or the oral mouse (IgE) models. The triggering IgE mediated allergenicity is tested by a parenteral rat model with oral gavage for intestinal mast cell protease (RMCPII) release. These animal models are also used for testing the oral tolerance inducing capacities of formulas. Together with cellular in vitro assays, animal models are very helpful in predicting allergenicity and the tolerogenic potential of HA infant formulas.

Selective removal of beta-lactoglobulin directly from cow's milk and preparation of hypoallergenic formulas: a bioaffinity method.

beta-Lactoglobulin, a major allergen of cow's milk, can pass into the breast milk of mothers consuming dairy products and thus sensitize a predisposed infant with a family history of atopic allergy. beta-Lactoglobulin coupled to Sepharose 4B can be used as a specific affinity matrix to remove beta-lactoglobulin from milk without the use of buffer systems. The tendency of beta-lactoglobulin to polymerize reversibly in milk promotes binding of the soluble protein to the coupled protein and a significant retardation in its elution with respect to the other milk proteins. The matrix can be regenerated with water and used repeatedly. These unique characteristics can be exploited in bioreactors designed to treat milk for the preparation of new hypoallergenic hyposensitizing milk formulas to be used by lactating mothers.

Toward a Better Understanding of Hospital Feeding Formulas

DOI: http://dx.doi.org/10.5915/19-1-12882 Recent advances in the science and technology of human nutrition and human health have made possible the development of a variety of hospital feeding formulas tailored to meet the growing demands for total or supplemental nutrition for prevention, management or treatment of a disease. The use of a great variety of ingredients of plant, animal or chemical origin for their functional or nutritional qualities to fabricate an antidiarrheic, economically feasible, hypoallergenic, isotonic, long shelf-life, palatable, stable hospital feeding formula with electrolyte balance, low renal solute load and osmolality make the task all the more challenging and rewarding. Major nutritional rationale and functional considerations in the fabrication of a versatile hospital feeding formula designed to meet over 90 percent of the needs of any health care facility, fit for total or supplemental feeding - gavage or oral - are outlined. Need for commercial production of such a formula in the developing countries, particularly the Muslim countries, is emphasized.

Formaldehyde in a hypoallergenic non-woven textile acrylate tape.

Formaldehyde in a hypoallergenic non-woven textile acrylate tape.

Eczemas due to plant allergens in manufactured products.

Intolerance to plant allergens in manufactured products is widespread. Results of epidemiological investigations in STRASBOURG are given. The rate of allergy to sesquiterpenic lactones has fallen since 1974, due to the fact that the use of an ointment containing these lactones has decreased. Disguised forms of allergens are reviewed, for instance limonene of Niaouli oil (Biogaze), colophony of "hypoallergenic" tapes or of testing material. Chemical investigations are useful in prevention and in allergological control of medicaments.