Hypertension Subtypes Research Articles

Effects Of Hypertensive Disorders In Pregnancy On Preterm Delivery And Anthropometric Indices In The Resultant Newborn Infants

This prospective study aimed at examining the effect of maternal hypertension in pregnancy on rate of preterm delivery and anthropometric indices in the resultant newborn infants. The gestational ages and anthropometric indices of 265 live-born babies of hypertensive mothers (BHM) were determined and the results compared with those of 804 live-born babies of normotensive mothers (BNOM). The mean birth weight of male babies born to hypertensive mothers was significantly lower than that of their counterparts born to normotensive mothers (2.8 &#61617; 0.40kg vs 3.10 &#61617; 0.30kg; p < 0.01). Similar trend was observed in females (2.75 &#61617; 0.30kg; vs 3.0 &#61617; 0.75kg; p < 0.01). Rates of delivery of low birth weight infant were 38.6% and 17.9% among hypertensive and normotensive mothers respectively. Sixty percent of babies delivered by mothers with chronic hypertension with or without superimposed pre-eclampsia were small-for-gestational age (SGA) compared to 3.8% for the other remaining subtypes of hypertension in pregnancy. Rate of preterm delivery was significantly higher among hypertensive (29.3%) than normotensive (12.2%) mothers (p

Inadequate Control of Hypertension in US Adults With Cardiovascular Disease Comorbidities in 2003-2004

Cardiovascular risks associated with hypertension (HTN) and the importance of its control are well established; however, the prevalence and adequacy of its treatment and control in persons with cardiovascular comorbidities (CVCs) are uncertain. To examine the prevalence, treatment, and control of HTN among US adults with and without CVCs, we analyzed data from adults at least 18 years of age (n = 4646, N [projected sample size] = 192.4 million) in the National Health and Nutrition Examination Survey 2003-2004, a nationally representative cross-sectional survey of the noninstitutionalized civilian US population. Prevalence, treatment, and control rates of HTN in patients with CVCs vs those without, including coronary artery disease, congestive heart failure, stroke, chronic kidney disease, peripheral artery disease, and diabetes mellitus, and distance to blood pressure goal in those whose HTN was not controlled were the main outcomes. The overall prevalence rate of HTN was 31.4% (n = 1671, N = 60.5 million), ranging from 23.1% in those without CVCs to 51.8% to 81.8% in those with CVCs (P < .01). Despite HTN treatment rates for diabetes mellitus, stroke, heart failure, and coronary artery disease that are higher (83.4%-89.3%) than the rates of those without these conditions (66.5%) (P < .01), control rates for treatment remained poor (23.2%-49.3%) (P < .001 to P = .048). Isolated systolic HTN was the most common hypertensive subtype in those with CVCs (> or = 63.5%) with systolic blood pressure averaging at least 20 mm Hg from goal. Nearly three-fourths of adults with CVCs have HTN. Poor control rates of systolic HTN remain a principal problem that further compromises their already high cardiovascular disease risk.

Stroke Risk in Systolic and Combined Systolic and Diastolic Hypertension Determined Using Ambulatory Blood Pressure: The Ohasama Study

To investigate the risk of stroke in subjects with isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and combined systolic and diastolic hypertension (SDH) in a Japanese general population, we used 24-h ambulatory blood pressure (ABP) and casual-screening blood-pressure (CBP) readings. Subtypes of hypertension were defined based on systolic blood pressure (SBP) >135 mm Hg or diastolic blood pressure (DBP) >80 mm Hg for 24-h ABP, and SBP >140 mm Hg or DBP >90 mm Hg for CBP. We obtained 24-h ABP and CBP data for 1271 (40% male) subjects aged > or =40 years (mean age, 61 years) without a history of symptomatic stroke; their stroke-free survival was then determined. The prognostic significance of each subtype of hypertension was determined by Cox proportional hazard analysis. There were 113 symptomatic strokes during follow-up (mean time, 11 years). Compared with normotension, among the hypertension subtypes determined by 24-h ABP, the adjusted relative hazards (RHs) of stroke were 2.24 for ISH (P = .002) and 2.39 for SDH (P = .0004). The association was less marked among subtypes determined by CBP (RH = 1.40 and P = .13 for ISH; RH = 2.07 and P = .017 for SDH). The IDH group was excluded from the Cox analysis because both the prevalence and the number of events were low in this group. Isolated systolic hypertension, as determined by 24-h ABP measurements, was associated with a high risk of stroke, similar to that found in SDH subjects; this suggests that the prognosis of hypertensive patients would be improved by focusing treatment on 24-h systolic ABP.

Invited Commentary: Identifying Women with Hypertension during Pregnancy--Is High Specificity Sufficient?

Hypertensive complications of pregnancy contribute to the burden of maternal morbidity and subsequently have an impact on neonatal morbidity and mortality. Although codes from the International Classification of Diseases should delineate the specific subtypes of pregnancy-related hypertension, how diagnoses are applied and how these codes are used in clinical settings are largely unknown. This commentary discusses the implications of using administrative codes to identify women with preeclampsia syndromes, especially when used to define outcomes or exposures for etiologic research.

Prevalence and patterns of hypertension in Peruvian Andean Hispanics: the PREVENCION study

Cardiovascular disease is emerging as a leading cause of morbidity and mortality in Latin America. Population-based data regarding the prevalence of hypertension and hypertension subtypes in Andean Hispanic populations are scarce. The authors performed a population-based study that included 1878 Peruvian Andean adults to determine: (1) the prevalence, awareness, and control of hypertension and (2) the relative frequency of hypertension subtypes (systolic vs. diastolic). The prevalence of hypertension was 15.7% (95% confidence interval [CI], 14.0%–17.4%), did not differ by gender, and increased steeply with age, particularly in women. Awareness, treatment, and control rates were 47.9%, 39.5%, and 14%, respectively. Diastolic blood pressure increased until age 50 years and reached a plateau thereafter, whereas mean arterial pressure continued to increase with age even after age 50 years. Furthermore, in sharp contrast with the United States population, the predominant type of hypertension was systodiastolic (41.7%; 95% CI, 35.1%–48.5%). Isolated systolic hypertension accounted for only 29.3% of cases (95% CI, 23.9%–35.4%) and was responsible for a minority of cases in all age groups before age 70 years. Hypertension subtypes in this Andean population seem to differ significantly from those present in the United States population, with a much larger proportion of systodiastolic and diastolic hypertension even with advanced age. These differences result from interactions between hemodynamic and structural factors, and further studies aimed at characterizing their genetic and environmental determinants and implications in end-organ damage and prognosis in this population may contribute to understanding the pathophysiology of hypertension.

The prevalence and risk factors associated with isolated untreated systolic hypertension in Korea: The Korean National Health and Nutrition Survey 2001

Although isolated systolic hypertension (ISH) increases the risk of coronary heart disease and stroke, more than any other hypertension subtype, the prevalence and risk factors associated with ISH in the Korean population are not known. The 2001 Korean National Health and Nutrition Survey was a cross-sectional and nationally representative survey conducted in 2001. The prevalence of ISH by age and body mass index (BMI) was examined in 6601 Korean adults over 20 years of age. After adjusting for age, 4.32+/-0.32% of Korean adults had ISH, 5.28+/-0.37% had isolated diastolic hypertension and 5.82+/-0.36% had systolic/diastolic hypertension. The overall prevalence of ISH was found to increase directly with advancing age and increasing BMI. Although the ISH was found to be more common in men overall (4.81+/-0.50% in men, 4.12+/-0.37% in women), it was more common in women over 70 years of age. Independent variables associated with risk for ISH included advanced age, BMI, triglyceride (TG) levels, monthly income and alcohol intake. However, gender, fasting blood glucose, total cholesterol and high-density lipoprotein cholesterol levels, residential area, education level and smoking were found not to be significantly associated with ISH risk. The findings of the present study demonstrate that the prevalence of untreated ISH in Korea was lower than in Western countries. Age, BMI, TG levels, monthly income and alcohol intake were associated with ISH.

Blood pressure categories, hypertensive subtypes, and the metabolic syndrome

Elevated blood pressure (BP) is one element of metabolic syndrome (MetS); however, the relation of various BP categories and hypertension subtypes to the likelihood of having MetS is not well defined. We determined the odds of MetS, defined by the National Cholesterol Education Program, in various BP categories from a cross-sectional study of 5968 individuals aged at least 18 years and untreated for hypertension (weighted to 124.7 million) in the National Health and Nutrition Examination Survey, 1999-2002. Nonhypertensive BP categories were optimal, normal, and high-normal BP, according to JNC-VI classification. Hypertension consisted of three subtypes: isolated diastolic hypertension (IDH), systolic-diastolic hypertension (SDH), and isolated systolic hypertension (ISH). Among those with hypertension and MetS, 25.3% had IDH, 20.2% had SDH, and 54.5% had ISH. The MetS prevalence in nontreated persons was 5.8% for optimal BP, 9.1% for normal BP, 38.2% for high-normal BP, 45.9% for IDH, 44.3% for SDH, and 43.9% for ISH. Risk factor odds ratios (95% confidence intervals; reference group, optimal BP), adjusted for age, sex, total cholesterol, and smoking, were 1.6 (1.2-2.2) for normal BP, 9.4 (6.9-12.7) for high-normal BP, 14.7 (8.9-24.0) for IDH, 12.2 (7.2-20.8) for SDH, and 10.2 (7.0-14.9) for ISH (all P < 0.01); odds ratios were higher for women in all categories. Despite having the lowest mean age, IDH subtype is associated with greatest likelihood of MetS. The high frequency of ISH in the hypertensive population, however, makes ISH the most common hypertensive subtype in persons with MetS.

Alcohol and Hypertension

in which some of the key issues surrounding the topic were discussed. Compared with lifetime abstainers, those who reported drinking on a daily basis or apart from food had a significantly higher risk of hypertension, but this effect disappeared after accounting for the amount of alcohol consumed in the previous 30 days. When current drinkers only were studied and adjustment made for the amount of alcohol consumed in the previous 30 days, the risk of being hypertensive increased (64%) only in those who said they drank without food. Preference for any one type of beverage did not influence the association but the important potential confounder of dietary habits was not assessed. Nevertheless this finding was consistent with an earlier study of Italian wine drinkers coming from a different cultural background,4 and a follow-up in that population showed drinking alcohol outside of meals was associated with higher risk of death from all causes and cardiovascular disease. Similar relationships were seen between drinking outside of meals or snacks and increased risk of myocardial infarction in a recent case control study in men.5

Hypertension: a new look at an old problem

This review reports the specific impact that hypertension, identified by its component subtype classification, has on perioperative outcomes. Most importantly, we review the risk of systolic hypertension and pulse pressure hypertension independent of elevated diastolic blood pressure on patients undergoing cardiac surgery. Systemic hypertension is identified as a major risk factor for cardiovascular morbidity in most larger population-based studies. Nearly a third of the population in the United States has or will have some form of hypertension disease, with many under-diagnosed or under-treated. Classification of hypertensive subtypes has been well recognized as an important component for risk stratification in the ambulatory population in recent years, but remains poorly recognized in the surgical setting. We present recent data unveiling the importance of pulse pressure above that of systolic and diastolic pressures. The evidence is compelling that wide pulse pressure hypertension is a strong and an independent predictor of adverse perioperative renal, cerebral and mortality outcomes. We discuss the physiology for this important novel observation in an acute surgical patient population and provide an explanation.

Subtype Hypertension and Risk of Stroke in Middle-Aged and Older Chinese

Hypertension is the most important indicator of stroke. We aim to compare the long-term effects of the subtypes of hypertension on the risk of stroke in a Chinese cohort. A total of 26,587 subjects > or =35 years of age and free of stroke were recruited in 5 cities in 1987. The subtypes of hypertension were defined as isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), systolic and diastolic hypertension (SDH), as well as managed hypertension (MHT), according to the criteria of systolic blood pressure > or =140 or diastolic blood pressure >90 mm Hg or under antihypertensive treatment. The relative risks of stroke with the subtypes of hypertension, compared with normotensives, were estimated using the Cox model after adjustments for age, sex, and other confounders. The prevalence of hypertension was: ISH 7.1%, SDH 18.4%, IDH 6.7%, and MHT 3.9%. During a total of 233 437 person years of follow-up, 1107 subjects developed stroke (614 ischemic and 451 hemorrhagic events and 42 unclassified). SDH patients were at the highest risk of stroke among all the hypertensives. The hazard ratio and 95% CI was 2.96 (2.49 to 3.52) for all stroke, 4.05 (3.10 to 5.30) for hemorrhagic, and 2.33 (1.84 to 2.95) for ischemic stroke. Although the incidence of stroke was higher in the older population, the effect of hypertension, especially SDH, on hemorrhagic stroke is stronger in the middle-aged population. ISH and IDH are similarly prevalent in the population; both are independent predictors of stroke. Patients with SDH are at the highest risk of stroke and should be treated more aggressively.

Genome-Wide Scan for Linkage to Obesity-Associated Hypertension in French Canadians

Essential hypertension is a heterogeneous disorder that is thought to develop because of several overlapping subsets of underlying mechanisms. One such causal pathway may involve pathophysiological alterations induced by obesity. In the present study, we examined whether investigating clinically defined subtypes of hypertension, such as obesity-associated hypertension, facilitates the search for its genes. Fifty-five extended families were selected on the basis of having > or =2 siblings affected by hypertension from a geographically remote French-Canadian population. Fifteen of these families showed a high prevalence (> or =70%) of obesity. Genome-wide scan using qualitative multipoint linkage analysis (GeneHunter 2.1; marker density <10 cM) was performed in the entire set of hypertensive families and the subset with high prevalence of obesity. In the scan involving all 55 families, the most significant loci (logarithm of odds [LOD] score=2.5) were identified on chromosomes 1 (D1S1597) and 11 (D11S1999). In the scan including only the subset of families with obesity-hypertension, the most significant locus (LOD score=3.1) was found on chromosome 1 in the same region as the scan involving all families (D1S1597). Genotyping additional markers increased the significance of this locus (LOD score=3.5) and refined its position (D1S2672). Several candidate genes of obesity-hypertension are located in close proximity; these include the tumor necrosis factor receptor 2 and atrial natriuretic peptide genes. These results suggest that investigating clinically defined subtypes of hypertension, such as obesity-associated hypertension, may facilitate the search for genes of this complex disorder.

Evaluation and management of patients with uncontrolled systolic hypertension: Is another new paradigm really needed?

Cardiovascular disease is emerging as a leading cause of morbidity and mortality in Latin America. Population-based data regarding the prevalence of hypertension and hypertension subtypes in Andean Hispanic populations are scarce. The authors performed a population-based study that included 1878 Peruvian Andean adults to determine: (1) the prevalence, awareness, and control of hypertension and (2) the relative frequency of hypertension subtypes (systolic vs. diastolic). The prevalence of hypertension was 15.7% (95% confidence interval [CI], 14.0%–17.4%), did not differ by gender, and increased steeply with age, particularly in women. Awareness, treatment, and control rates were 47.9%, 39.5%, and 14%, respectively. Diastolic blood pressure increased until age 50 years and reached a plateau thereafter, whereas mean arterial pressure continued to increase with age even after age 50 years. Furthermore, in sharp contrast with the United States population, the predominant type of hypertension was systodiastolic (41.7%; 95% CI, 35.1%–48.5%). Isolated systolic hypertension accounted for only 29.3% of cases (95% CI, 23.9%–35.4%) and was responsible for a minority of cases in all age groups before age 70 years. Hypertension subtypes in this Andean population seem to differ significantly from those present in the United States population, with a much larger proportion of systodiastolic and diastolic hypertension even with advanced age. These differences result from interactions between hemodynamic and structural factors, and further studies aimed at characterizing their genetic and environmental determinants and implications in end-organ damage and prognosis in this population may contribute to understanding the pathophysiology of hypertension.

Alcohol intake and hypertension subtypes in Chinese men

To examine the associations between alcohol intake and isolated systolic hypertension (ISH), systolic-diastolic hypertension (SDH), and isolated diastolic hypertension (IDH). Cross-sectional study of Chinese adults. We analyzed data from 5317 Chinese males who were not on antihypertensive medications from a nationally representative sample of Chinese adults aged 35-74 years. ISH was defined as a mean systolic blood pressure (SBP) >/=140 mmHg and a mean diastolic blood pressure (DBP) < 90 mmHg, SDH as a SBP >/= 140 mmHg and DBP >/= 90 mmHg, and IDH as SBP < 140 mmHg and DBP >/= 90 mmHg. Alcohol intake was determined using an interviewer-administered questionnaire and participants were categorized either as non-drinkers (<12 drinks in the prior year) or by tertile of alcohol intake. The odds ratios of all three hypertension subtypes were higher at higher levels of alcohol intake, with those in the highest alcohol intake category (>/=30 drinks/week) 2.0 (95% confidence interval: 1.3, 3.0), 2.2 (1.6, 3.1), and 2.1 (1.4, 3.1) times more likely to have ISH, SDH, or IDH, respectively, than non-drinkers. The population attributable risk percentage due to heavy drinking (>/=30 drinks/week) was 13.9% for ISH, 13.4% for SDH, and 12.0% for IDH. Liquor drinking, specifically, was associated with a higher odds ratio of ISH, while SDH and IDH associations did not differ by type of alcoholic beverage. In Chinese males, higher intake of alcohol is associated with higher risk of ISH, SDH, and IDH. Efforts to reduce hypertension in China should include a strong focus on decreasing heavy alcohol consumption.

Natural History of Hypertension Subtypes

The relation between blood pressure (BP) and the risk of cardiovascular disease is direct, graded, and continuous over a wide range, apparently beginning at 115 mm Hg systolic and 75 mm Hg diastolic.1 Despite such a continuous relation, some working definitions, or subtypes, of hypertension have gained wide clinical acceptance. Experimental and clinical data support the notion that the hypertension subtypes defined by isolated or combined elevations of systolic and diastolic BP reflect distinct pathophysiological mechanisms, have different prognostic implications, and may require a different therapeutic approach.2–4 See p 1121 An increase in the stiffness of the aorta and large elastic arteries not accompanied by a rise in arteriolar resistance may lead to isolated systolic hypertension (ISH). In contrast, a predominant rise in arteriolar resistance may lead to combined systo-diastolic hypertension (SDH) if large artery stiffness also increases, or to isolated diastolic hypertension (IDH) if arterial stiffness is normal or low. Thus, IDH might be viewed as a marker of a good elasticity of aorta and large arteries, possibly because of a paucity of atherosclerotic lesions.5 In contrast, because the rigidity of the aorta and large arteries tends to increase with age, systolic BP also tends to increase with age, leading to an elevated frequency of ISH in the elderly.6,7 The decline of diastolic BP with age has been associated with progression of aortic atherosclerosis, defined in one study by the appearance of new calcifications or enlargement of old calcified areas.8 A confounding factor in the assessment of hypertension subtypes is the progressive amplification of the pressure wave during transmission from aorta to peripheral arteries, a phenomenon that is predominant in the young and decreases with aging.2–4 Thus, brachial diastolic BP may overestimate aortic BP, particularly in young subjects. Although ISH is an important …

Age-Dependent Associations Between Sleep-Disordered Breathing and Hypertension

Sleep-disordered breathing (SDB) is associated with hypertension in the middle-aged. The association is less clear in older persons. Most middle-aged hypertensives have systolic/diastolic hypertension, whereas isolated systolic hypertension (ISH) is common among persons over 60 years. Mechanistically, only systolic/diastolic hypertension is expected to be associated with SDB, but few studies of SDB and hypertension distinguish systolic/diastolic hypertension from ISH. Prior investigations may have underestimated an association between SDB and systolic/diastolic hypertension in the elderly by categorizing individuals with ISH as simply hypertensive. We conducted cross-sectional analyses of 6120 participants in the Sleep Heart Health Study, stratified by age: 40 to 59 (n=2477) and > or =60 years. Outcome measures included apnea-hypopnea index (AHI; average number of apneas plus hypopneas per hour of sleep), systolic/diastolic hypertension (> or =140 and > or =90 mm Hg), and ISH (> or =140 and <90 mm Hg). With adjustment for covariates, ISH was not associated with SDB in either age category. In those aged<60 years, AHI was significantly associated with higher odds of systolic/diastolic hypertension (AHI 15 to 29.9, OR=2.38 [95% CI 1.30 to 4.38]; AHI > or =30, OR=2.24 [95% CI 1.10 to 4.54]). Among those aged > or =60 years, no adjusted association between AHI and systolic/diastolic hypertension was found. SDB is associated with systolic/diastolic hypertension in those aged <60 years. No association was found between SDB and systolic/diastolic hypertension in those aged > or =60 years or between SDB and ISH in either age category. These findings have implications for SDB screening and treatment. Distinguishing between hypertensive subtypes reveals a stronger association between SDB and hypertension for those aged <60 years than previously reported.

Prevalence of isolated systolic hypertension in Chinese adult population

To evaluate prevalence of isolated systolic hypertension and other subtypes of hypertension, as well as their distribution in Chinese adults. A cross-sectional survey was conducted in the mainland China during 2000-2001 with a multistage cluster sampling to select a nationally representative sample of 15,540 Chinese adults aged 35-74, by InterASIA project. Hypertension subtypes were defined among individuals not receiving antihypertensive therapy as follows: isolated systolic hypertension as a systolic blood pressure > or = 140 mm Hg and a diastolic blood pressure < 90 mm Hg, isolated diastolic hypertension as a systolic pressure < 140 mm Hg and a diastolic pressure > or = 90 mm Hg, and combined systolic/diastolic hypertension as a systolic pressure > or = 140 mm Hg and a diastolic pressure > or = 90 mm Hg. Blood pressure for each subject was measured for three readings at sitting position after rest for at least five minutes and an average reading was recorded. A standardized structured questionnaire was used to collect history of hypertension and antihypertensive treatment. Overall, 7.6% (1,181 cases) of adults had isolated systolic hypertension, 7.4% (1,150 cases) combined systolic/diastolic hypertension and 4.4% (683 cases) isolated diastolic hypertension in the sample of 15,540 adults at age 35-74. Prevalence of systolic hypertension increased with age, and was more common in the older women than in the older men. There was no significant difference in prevalence of isolated systolic hypertension between north and south China, but, rural residents had a higher prevalence than urban residents. There existed a higher prevalence of systolic hypertension in China, to which enough attention should be paid.

Prevalence of isolated systolic and isolated diastolic hypertension subtypes in China

Isolated systolic hypertension (ISH), more so than any other hypertension subtype, increases the risk for stroke and coronary heart disease. The prevalence of ISH versus other hypertension subtypes in the general Chinese adult population is not known. The prevalence of isolated systolic and isolated diastolic hypertension (IDH) was examined in a representative national sample of 15,540 Chinese adults aged 35 to 74 years. Three seated blood pressure (BP) measurements taken after 5 min of rest were averaged and hypertension subtypes were defined among individuals not receiving antihypertensive therapy as follows: ISH as systolic BP >/=140 mm Hg and diastolic BP <90 mm Hg; IDH as systolic BP <140 mm Hg and diastolic BP >/=90 mm Hg; and combined systolic/diastolic hypertension (SDH) as a systolic BP >/=140 mm Hg and diastolic BP >/=90 mm Hg. Overall, 7.6% of the Chinese adult population had ISH, 7.4% had SDH, and 4.4% had IDH. The prevalence of ISH increased with age and was more common in older women than in older men. Stage 1 hypertension was much more prevalent than stage 2 hypertension among all hypertension subtypes. The prevalence of SDH, IDH, and ISH (women, only) were higher in northern China than southern. The prevalence of ISH and SDH (women, only) were higher among rural residents versus urban residents. These data document high rates of ISH in China. Given the risk of cardiovascular disease associated with ISH, our findings underscore the critical need for enhanced hypertension screening and treatment programs in China.

Prevention and Rehabilitation: Preventing heart disease by controlling hypertension: Impact of hypertensive subtype, stage, age, and sex

BackgroundHypertension is related to significant morbidity and mortality rates from coronary heart disease (CHD). This report examines the relative and absolute impact on risk for CHD by controlling hypertension to high normal and optimal levels. MethodsAmong all subjects with untreated or inadequately treated hypertension in the National Health and Nutrition Examination Survey (NHANES) III who were 30 to 74 years of age and without prior CHD, the 10-year risk of CHD was calculated. With the use of sampling weights, the number of CHD events by age group, hypertension subtype (isolated diastolic hypertension [IDH], systolic-diastolic hypertension [SDH], and isolated systolic hypertension [ISH]), and stage of hypertension was estimated. Risk was recalculated and the number of events reestimated, assuming a reduction in blood pressure (BP) to high normal and optimal levels. The number and proportion (population-attributable risk, or PAR%) of events that could be prevented were determined from the differences in events and risk between uncontrolled and controlled BP levels. Derived from this was the number of persons needing treatment per CHD event prevented. ResultsControl of hypertension to high normal levels could prevent approximately one fifth (PAR = 19%) of CHD events in men and one third (PAR = 31%) of CHD events in women, whereas control to optimal levels may prevent 37% and 56% of CHD events, respectively (P < .01 for differences between men and women). Of CHD events that could be prevented, the greatest proportion occurred from controlling BP among older persons, men, and those with stage 1 hypertension (vs stages 2 and 3) or with ISH (vs IDH or SDH). The number of persons with hypertension needing treatment to prevent one CHD event ranged from 20.5 in men to 38.6 in women when controlled to high normal BP and 10.7 in men and 21.3 in women when controlled to optimal BP. ConclusionsThe greatest impact from control of hypertension occurs in older persons, men, and those with ISH, whereas the greatest PAR% occurred in women. Optimal control of BP could prevent more than one third of CHD events in men and more than half of events in women. Greater efforts to control hypertension in these populations may have a substantial impact in preventing CHD events.

Hypertension control rates and hypertensive subtypes in the year 2000: an analysis comparing the clinics-based path and population-based NHANES III surveys

Hypertension control rates and hypertensive subtypes in the year 2000: an analysis comparing the clinics-based path and population-based NHANES III surveys

Hypertension and Neurovascular Compression of the Left Lateral Medulla oblongata in Ischemic Stroke

Hypertension is a major risk factor for stroke. Neurovascular compression (NC) of the left ventrolateral medulla oblongata may cause arterial hypertension. We evaluated the relationship between the two ischemic stroke patients. We classified 69 patients under 50 years old (49 men and 20 women, aged 43.6 ± 7.3 years) based on magnetic resonance imaging findings as follows: NC patients (n = 38; 10 with NC on the right side, 18 with NC on the left side, and 10 with NC on both sides) and non-NC patients (n = 31). We compared the following clinical characteristics between the two groups: (1) risk factors for stroke, including hypertension, diabetes mellitus, hypercholesterolemia, and smoking and (2) stroke subtype. Hypertension was more frequent in the NC group than in the non-NC group (58 vs. 19%, p = 0.001). Hypertension was more frequent in patients with left-side NC than in those with right-side NC (78 vs. 20%, p = 0.005). No other differences were observed between the two groups. Twelve patients presented with atherothrombotic stroke, 16 with cardioembolic stroke, 24 with lacunar stroke and 17 with stroke of miscellaneous etiology. NC was significantly more common in patients with lacunar stroke as compared with those affected by other stroke subtypes (p = 0.015). We found a significant relationship between hypertension and NC of the ventrolateral medulla oblongata on the left side in ischemic stroke patients younger than 50 years of age. Some patients with lacunar stroke may have hyptertension related to NC.