Hypercrosslinked Polymers Research Articles

Dipolar Microenvironment Engineering Enabled by Electron Beam Irradiation for Boosting Catalytic Performance.

Creating a diverse dipolar microenvironment around the active site is of great significance for the targeted induction of intermediate behaviors to achieve complicated chemical transformations. Herein, an efficient and general strategy is reported to construct hypercross-linked polymers (HCPs) equipped with tunable dipolar microenvironments by knitting arene monomers together with dipolar functional groups into porous network skeletons. Benefiting from the electron beam irradiation modification technique, the catalytic sites are anchored in an efficient way in the vicinity of the microenvironment, which effectively facilitates the processing of the reactants delivered to the catalytic sites. By varying the composition of the microenvironment scaffold structure, the contact and interaction behavior with the reaction participants can be tuned, thereby affecting the catalytic activity and selectivity. As a result, the framework catalysts produced in this way exhibit excellent catalytic performance in the synthesis of glycinate esters and indole derivatives. This manipulation is reminiscent of enzymatic catalysis, which adjusts the internal polarity environment and controls the output of products by altering the scaffold structure.

Zwitterionic sulfobetaine-based hypercrosslinked hydrophilic materials for bioanalysis

Analysis of bioactive polar molecules is crucial for different fields, including biology, clinic medicine, and separation science. However, the design of the separation materials remains a huge challenge due to their tedious preparation process and limited chromatographic performances of traditional hydrophilic materials. New-generation hydrophilic polymer materials prepared via a sole-monomer system exhibit excellent reproducibility and chromatographic efficiency; however, such polymers reported to date have a high swelling propensity and risk of low surface exposure of functional groups, which limit their application as separation materials. In this study, N,N-bis(methacryloxyethyl)-N-methyl-N-(3-sulfopropyl)ammonium betaines (BMMSB), a zwitterionic sulfobetaine, was used to rapidly fabricate the zwitterionic hypercrosslinked hydrophilic polymer materials via the sole-monomer system. The novel hypercrosslinked hydrophilic materials exhibited high porosity and permeability, superhydrophilicity, low protein adsorption, and excellent capillary column efficiency (up to 134,950 plates/m for thiourea). It was able to enrich 28 N-glycopeptides from hIgG tryptic digests with a higher efficiency than that of traditional poly(SPE-co-EDMA) monolith and commercial ZIC-HILIC materials. Additionally, the polyBMMSB hydrophilic materials demonstrated superior selectivity and column efficiency to the poly(SPE-co-EDMA) monolith for the separation of various small bioactive molecules, including nucleobases and nucleosides, phenol derivatives, benzoic acid derivatives, urea and allantoin. Especially, high performance bioanalysis of Alzheimer’s disease biomarkers plasma Aβ42 and Aβ40, or some steroid hormones in human plasma were also achieved by the polyBMMSB monolith combined with nano liquid chromatography-mass spectrometry. As such, these sulfobetaine-based zwitterionic polymers may serve as a prototypical next-generation zwitterionic hydrophilic materials for rapid and efficient bioanalysis.

Hypercrosslinked porous polymer as catalyst for efficient biodiesel production

While porous organic polymers (POPs) are known for their unique properties, their application in basic biodiesel catalysis is innovative. This study introduces a novel catalyst, hypercrosslinked polymer (HCP-SB-K), synthesized through mechanochemical polymerization of styrene and benzaldehyde with a cross-linking agent and FeCl3, followed by calcination of the previous polymer impregnated with KNO3. The synthesis costs 3.328 euros per gram of catalyst, covering energy and reagent expenses. The catalyst's basic character is explored, demonstrating efficient transesterification with diverse feedstocks. Under optimal conditions, the HCP-SB-K catalyst exhibits exceptional catalytic activity, yielding 99.9% FAME (Fatty Acid Methyl Esters) at 60 °C, 2 h and 3% w/w catalyst. Investigation of free fatty acid (FFA) content highlights the catalyst's effectiveness with oils varying FFA levels: oils with acid value of 0.44 mgKOH goil−1 reached 92.1% FAME at 60 °C, 1 h and 3% w/w catalyst; oils with an acid value of 1.11 mgKOH goil−1, reached 75.9% FAME, under the same conditions. Catalyst leaching evaluation indicates no discharge of basic sites. The regenerated catalyst (impregnation with KNO3 and calcination, after the first use) exhibits a 98.2% FAME like the fresh catalyst. This suggests that HCP-SB-K can be regenerated without noticeable deactivation, emphasizing its industrial potential.

Porous organic polymers from cashew nut shell liquid: Derived carbonized material for carbon dioxide capture

AbstractThe fast developing world is in search of measures to control the accumulation of unused by‐products and waste materials generated during the production of useful commodities. Accordingly, wastes from agro‐industrial sectors can form raw materials for the production of various resources that are extensively used in many areas such as gas sorption and energy production. In the present work, cashew nut shell liquid (CNSL), the vesicant liquid present in the outer shell of cashew seed, forms the source material for the synthesis of porous organic polymers for carbon dioxide capture. Herein, novel types of hypercrosslinked polymers (HCPs) are synthesized via a simple Friedel–Crafts reaction with CNSL as the starting material. Polymerization of natural CNSL with dimethoxymethane/bis‐(chloromethyl)‐biphenyl as external crosslinker provides products in quantitative yield. One of the synthesized HCP is tuned to attain the required high porosity by carbonization at elevated temperatures using an activator. Thus, activated carbon material prepared at 700°C is found to have a high surface area of 880 m2/g with a good carbon dioxide adsorption capacity of 14.72 wt%. These porous materials had moderate isosteric heat of adsorption (23–31 kJ/mol) with excellent recycling capability.

The hyper-crosslinked aniline polymer@MOFs hybrid materials reinforced with active ionic sites for efficient and fast Cr(VI) removal

The adsorption of toxic metal ions by composite materials of metal–organic frameworks (MOFs) has attracted significant attention in recent years. In this work, a series of hybrid materials HPAN@M−x consisting of protonated hyper-crosslinked aniline polymer (HPAN) and MOFs were synthesized via the Friedel-Crafts reaction between aniline and dimethoxymethane in the presence of MIL-101(Cr), followed by protonation with hydrogen bromide. These hybrid materials exhibited enhanced adsorption rate and capacity for Cr(VI) ions compared to both individual MIL-101(Cr) and HPAN. The effects of the ratio of aniline to MIL-101(Cr), solution pH, adsorption temperature, impurity ions on the removal of Cr(VI) ions were systematically investigated. Notably, HPAN@M−b not only achieved an adsorption capacity up to 290.9 mg·g−1 in 7 min but also exhibited excellent cycling stability by maintaining a high Cr(VI) removal efficiency of 95.6 % after five cycles. The enhanced adsorption performance is attributed to the synergistic effect between MIL-101(Cr) and HPAN. Mechanism studies indicated that the removal for Cr(VI) ions involved a combination of ion exchange and electrostatic adsorption processes. Additionally, the desorbed Cr(VI) ions were transformed into added-value barium chromate (BaCrO4) precipitates, allowing for resource utilization of Cr(VI) ions. This study represents a significant advancement towards developing MOFs-based hybrid materials for practical treatment of chromium-containing wastewater.

Hydrophobic hypercrosslinked polymers prepared by secondary pore-forming method as excellent toluene adsorbents

In this work, inspired by molecular imprinting technology, we developed a secondary pore-forming method to chemically etch three hypercrosslinked polymers which are constructed from three novel hexapolar monomers containing imine groups, resulting in three novel hydrophobic porous hyper-crosslinked polymers (HCPs) pGly-TPA, pP-TPA and pBP-TPA. The structures were determined by FT-IR and solid-state 13C NMR spectroscopic techniques. The specific surface areas of pGly-TPA, pP-TPA and pBP-TPA are 694.1, 197.9 and 497.7 m2/g, respectively. All three porous polymers exhibit high hydrophobic properties with wetting angles of much greater than 90°. The breakthrough adsorption experiments revealed that the three prepared polymers exhibited significant adsorption capacity for toluene (322.05 mg/g for pGly-TPA, 114.43 mg/g for pP-TPA and 279.14 mg/g for pBP-TPA), but showed almost no adsorption for ethyl acetate, cyclohexane, and n-hexane, exhibiting certain molecular size and polarity selectivity. The adsorption behaviors of toluene on pGly-TPA, pP-TPA and pBP-TPA can be fit by the Boltzmann model and the Yoon-Nelson model, suggesting that the fixed bed has low mass transfer resistance. The adsorption rate is controlled by both external diffusion and intraparticle diffusion, as shown by the intraparticle diffusion model analysis. In addition, the adsorption capacity of toluene on pGly-TPA is almost unchanged under high humidity (70 %) or five adsorption–desorption processes, which demonstrates exceptional water-resistance and stability. This work is a reference for preparing novel hydrophobic HCPs using the secondary pore-forming method for removing VOCs from humid air.

Facile synthesis of anthranilic acid based dual functionalized novel hyper cross-linked polymer for promising CO2 capture and efficient Cr3+ adsorption

A novel hyper cross-linked polymer of 2-Aminobenzoic acid (HCP-AA) is synthesized for the adsorption of Cr3+ and CO2. The Brunauer–Emmett–Teller surface area of HCP-AA is 615 m2 g−1. HCP-AA of particle size 0.5 nm showed maximum adsorption of Cr3+ for lab prepared wastewater (93%) while it was 88% for real industrial wastewater. It is might be due to electrostatic interactions, cation-π interactions, lone pair interactions and cation exchange at pH 7; contact time of 8 min; adsorbent dose 0.8 g. The adsorption capacity was calculated 52.63 mg g−1 for chromium metal ions at optimum conditions. Freundlich isotherm studies R2 = 0.9273 value is the best fit and follows pseudo second order kinetic model (R2 = 0.979). The adsorption is found non-spontaneous and exothermic through thermodynamic calculations like Gibbs free energy (ΔG), enthalpy change (ΔH) and entropy change (ΔS) were 6.58 kJ mol−1, − 60.91 kJ mol−1 and − 45.79 kJ mol−1 K−1, respectively. The CO2 adsorption capacity of HCP-AA is 1.39 mmol/g with quantity of 31.1 cm3/g (6.1 wt%) at 273Kwhile at 298 K adsorption capacity is 1.12 mmol/g with quantity 25.2 cm3/g (5 wt%). Overall, study suggests that carboxyl (–COOH) and amino (–NH2) groups may be actively enhancing the adsorption capacity of HCP-AA for Cr3+ and CO2.

Cycloaddition of Epoxides and CO2 by Cobalt Porphyrin-Based Hypercrosslinked Ionic Polymers

Cycloaddition of Epoxides and CO2 by Cobalt Porphyrin-Based Hypercrosslinked Ionic Polymers

Incorporating porous carbon materials into ionic liquid for high efficiency extraction of polycyclic aromatic hydrocarbons

Ionic liquid is an ideal candidate in the extraction of aromatic compounds. The design and construction of ionic liquids with high extraction efficiency and selectivity towards to the specific aromatics remain crucial question. In this paper, with the aid of orthogonal array experiment, the imidazolium-based ionic liquids with long alkyl chain on the cations were determined to possess high aromatics extraction efficiency. Furthermore, the Lewis acid anion was introduced into the ionic liquid to form 1-dodecyl-3-methylimidazolium ferric chloride ([C12mim][FeCl4]) and performed 62 % and 100 % extractant efficiency of naphthalene (NAP) and anthracene (ANT), respectively. Then the porous carbon materials (P1-1000) derived from hyper-crosslinked porous polymers (HCP) which possessed high BET surface area (1186 m2/g) was dispersed in [C12mim][FeCl4] to form porous ionic liquid. The single extraction efficiency of NAP improved from 62 % to 77 %. The great single extraction efficiency was attributed to the high porosity, additional adsorption sites provided by the Lewis acid anions and the hydrophobic long alkyl chain on the cations. After three times extraction, the concentration of NAP dropped down to 0. The porous ionic liquids also showed good recycle performance. The construction of porous ionic liquids provided an efficient approach for extraction of polycyclic aromatic hydrocarbons from aliphatic hydrocarbon.

Imidazole-based organic polymer frameworks as metal- and halogen-free heterogeneous platforms for efficient CO2 cycloaddition

Developing effective metal- and halogen-free heterogeneous catalysts for the CO2 cycloaddition remains a challenge. In this study, novel imidazole-based hyper-crosslinked polymers (HCP-BZ, HCP-BP and HCP-TBZ) with abundant N sites were constructed via a one-pot polymerization, and employed as heterogeneous catalysts for the CO2 cycloaddition reaction. The special skeletal pore structure with abundant hierarchical pore structures and uniformly distributed active sites were demonstrated by various characterization technologies. The optimal HCP-TBZ(16:1) exhibits a good CO2 selective adsorption performance with a CO2 adsorption capacity of 2.23 mmol/g and CO2/N2 adsorption selectivity of 41 at 273 K and 0.1 MPa. Additionally, the resulting catalyst HCP-TBZ(16:1) achieves an excellent catalytic performance with 96 % yield and 99 % selectivity without metal, halogen, cocatalyst and solvent additions (120 °C, 1.0 MPa CO2, 5 h). Moreover, the HCP-TBZ(16:1) also exhibits a satisfactory catalytic activity under the mild conditions (70 °C, 1.0 MPa CO2), and can effectively catalyze the cyclic carbonate preparation from the dilute CO2 (15 %CO2/85 %N2). The comparable catalytic activity and the determined structural stability, reusability and universality make the prepared imidazole-based HCPs a potential heterogeneous catalyst candidate for the CO2 cycloaddition. This study will provide some guidance for developing metal-free and halogen-free CO2 adsorption and conversion platforms.

Experimental and theoretical investigation of phenylpyridine-based hypercrosslinked polymers for atmospheric CO2 adsorption and fixation under solvent-/metal-free conditions

Several phenylpyridine- and phenyl-based hypercrosslinked polymers (HCPs) were prepared via a one-step Friedel-Crafts polymerization and used as catalysts for the cycloaddition reaction between atmospheric CO2 and epoxides to produce cyclic carbonates. The structural characteristics and catalytic activity of different HCP catalysts were compared, while the recycling performance and universality to various substituted epoxides were investigated. The as-prepared catalysts exhibited regular pore structure and high specific surface area (1133 m2/g). Under the synergistic effect of tetrabutylammonium iodide (TBAI), the optimized TPA-HCP-Py efficiently converted atmospheric CO2 into cyclic carbonates with good to excellent product yields. Furthermore, the TPA-HCP-Py catalyst was easy to recover, and no significant changes were observed after reusing for five times, which demonstrated its excellent recycling performance. The interactions between different active sites and reactants in the TPA-HCP-Py/TBAI catalytic system were investigated by DFT calculation, revealing the catalytic reaction mechanism and providing valuable guidance for developing new multifunctional catalysts.

Efficient and ultrafast adsorption of aromatic amino acids by hyper-crosslinked porous cyclodextrin polymers with high adsorption capacity

The adsorption separation technology is of key significance in the purification of aromatic amino acids (AAAs) and the production of their derivatives. However, defects are always present in existing adsorbents for AAAs with slow adsorption rates, low adsorption capacity, and poor regeneration performance. Therefore, there is an urgent need to develop more efficient adsorbents for AAAs to improve separation and purification efficiency and productivity. In this study, partially benzylated cyclodextrin-based hyper-crosslinked porous polymers (PBCD-B-D) were prepared, among which the one with β-cyclodextrin as monomer (PBβ-CD-B-D) exhibited an extremely rapid adsorption process, a high adsorption capacity for AAAs, and a good selectivity toward AAAs over other amino acids. Specifically, the adsorption of AAAs reached equilibrium within one minute, while the equilibrium adsorption capacities of PBβ-CD-B-D for Trp and Phe were up to 524.58 mg·g−1 (almost the highest till now) and 189.48 mg·g−1, respectively. The pseudo-second-order kinetic model and the Freundlich model were better suited for describing the adsorption process. The comprehensive analysis of experimental results suggested that host–guest cooperation and π-π interactions may be the two dominant factors affecting the adsorption of AAAs on PBβ-CD-B-D. In addition, PBβ-CD-B-D exhibited good reusability, with the adsorption capacity remaining at 83.67 % after 4 adsorption–desorption cycles. Due to its low cost, good reusability, and excellent adsorption performance, PBβ-CD-B-D has great potential for application in the adsorptive removal and recovery of AAAs.

Preparation of ionic porous polymers for extraction of four phenolic endocrine disrupting chemicals from fish and water samples

In this paper, series of ionic polymers were synthesized by crosslinking alkyl quaternary ammonium salts with 1,4-bis(chloromethyl)benzene. Among them, hyper-crosslinked polymer fabricated with dodecyl dimethyl benzyl ammonium chloride (HCP-DD) as monomer delivered superior adsorption performance for endocrine disrupting chemicals (EDCs). The adsorption mechanism mainly includes π-π stacking, hydrophobic and electrostatic interaction. With HCP-DD as solid phase extraction sorbent, a high performance liquid chromatography-diode array detection method was developed for the detection of four phenolic EDCs in water and fish samples. The detection limits of the method were 0.005–0.02 ng mL−1 for water samples and 3–30 ng g−1 for fish samples. The recoveries of EDCs in water samples and fish samples were 80–119% and 81.3–117% (relative standard deviations <4.4%), respectively. The study not only provides a route for preparation ionic porous polymers, but also highlights the applications of ionic polymers as efficient adsorbent to enrich organic pollutants.

Palladium catalyst immobilized on functionalized hyper–cross-linked polymers with 8-hydroxyquinoline as monomer for Suzuki–Miyaura coupling reactions

Palladium catalyst immobilized on functionalized hyper–cross-linked polymers with 8-hydroxyquinoline as monomer for Suzuki–Miyaura coupling reactions

Hypercrosslinked polymers with hierarchical pores synthesized using biphenyl crosslinker for carbon dioxide capture

Microporous hypercrosslinked polymers have an upright capacity to develop into prime materials in energy and environmental applications in the near future. The chemical tunability, structural robustness and high surface area are some of the critical factors that lead to their application in the gas adsorption area. Three novel hypercrosslinked porous polymers viz. PABMC, PFBMC and PPzBMC were synthesized via the Friedel-Crafts alkylation process using 4,4′-bis(chloromethyl)biphenyl as the external cross-linker and anhydrous FeCl3 as the catalyst. The polymers obtained are found to be microporous with very high surface areas of 983 m2/g, 1002 m2/g, and 1265 m2/g, respectively, for PABMC, PFBMC and PPzBMC. The polymers PABMC, PFBMC and PPzBMC exhibited appreciable carbon dioxide uptake of 10.18 wt%, 12.02 wt% and 14.18 wt%, respectively, at 273 K. The results reveal a practical approach to synthesizing low-cost heteroatom-rich hypercrosslinked organic polymers with hierarchical pores for gas adsorption and storage applications.

Mechanically Robust, Durable, and Multifunctional Hyper-Crosslinked Elastomer Based on Metal-Organic-Cluster Crosslinker: The Role of Topological Structure.

Polymer materials formed by conventional metal-ligand bonds have very low branch functionality, the crosslinker of such polymer usually consists of 2-4 polymer chains and a single metal ion. Thus, these materials are weak, soft, humidity-sensitive, and unable to withstand their shape under long-term service. In this work, a new hyperbranched metal-organic cluster (MOC) crosslinker containing up to 16 vinyl groups is prepared by a straightforward coordination reaction. Compared with the current typical synthesis of metal-organic cages (MOCs) or metal-organic-polyhedra (MOP) crosslinkers with complex operations and low yield, the preparation of the MOC is simple and gram-scale. Thus, MOC can serve as a high-connectivity crosslinker to construct hyper-crosslinked polymer networks. The as-prepared elastomer exhibits mechanical robustness, creep-resistance, and humidity-stability. Besides, the elastomer possesses self-healing and recyclability at mild condition as well as fluorescence stability. These impressive comprehensive properties are proven to originate from the hyper-crosslinked topological structure and microphase-separated morphology. The MOC-driven hyper-crosslinked elastomers provide a new solution for the construction of mechanically robust, durable, and multifunctional polymers.

Construction of self-healing multifunctional hyper-crosslinked hyperbranched polymer @ metal–organic polyhedra (HHMOP) membranes

The preparation of hybrid membranes composed of polymer matrix and porous materials is a hot topic. Herein, a highly reversible hyper-crosslinked hyperbranched polymer @ metal–organic polyhedra (HHMOP) membrane was designed and synthesized using hyperbranched polyamide amine (HPMA), UiO-66-NH2, diethylenetriamine, and terephthalaldehyde through a multi-component Schiff-base condensation reaction of aldehyde and amine groups. The structures of HHMOP membranes were characterized by FTIR, XRD, and SEM. The mechanical properties, thermal properties, reversible self-healing properties, and biological activity of the membranes were studied. Introducing HPMA as hyper-crosslinking monomer and UiO-66-NH2 as porous comonomers into the network resulted in HHMOPs membranes with multiple functionalities: flexibility, humidity sensitivity, self-healing capacity, antibacterial capacity and better mechanical properties than the original polyimine films. The tensional intensity and breaking elongation of HHMOP membrane has been remarkably ameliorated, with the maximum tensile strength reached 54.64 MPa. The membranes showed humidity-sensitive mechanical properties and excellent self-healing performance, with 91.35 % strength revovered after 24-hours at room temperature and a relative humidity of 60 %, indicating that HPMA has a significant impact on the humidity responsiveness and self-healing performance of HHMOP membranes. The HHMOP membrane also demonstrated good antibacterial activity against common food lethal bacteria like the gram-positive Staphylococcus aureus and gram-negative Escherichia coli. This work will greatly enrich the devise and preparation of versatile membranes and broaden the use of MOFs.

Implantation of guanidine chemical adsorption sites in hyper-crosslinked polymers for effective adsorption and conversion of H2S

The efficient and selective separation of H2S is of critical scientific importance in the desulphurization of natural gas. In this work, we demonstrate a novel approach for incorporating guanidine chemical adsorption sites into hyper-crosslinked polymers (HCPs) for the first time. As expected, these HCPs exhibited excellent H2S adsorption capacity of up to 7.66 mmol·g−1 and high separation selectivity values of 133 for H2S/CO2 (0.15/0.85) and 977 for H2S/CH4 (0.15/0.85) at 25 °C and 1 bar. These HCPs maintained their structural stability after adsorbing H2S and successfully catalyzed the conversion of H2S to thiols with an approximate yield of 99 % under mild conditions. The results obtained from X-ray photoelectron spectroscopy (XPS), nuclear magnetic resonance (NMR), In-situ FTIR spectrometer (FTIR), and density functional theory (DFT) calculations validated that the HCPs achieved good selective trapping and catalytic conversion of H2S through chemisorption interaction and activation. This study provides valuable insights into the development of porous materials for efficient removal and conversion of H2S, while also highlights the potential of HCPs in gas separation and conversion.

Photothermal Conversion Porous Organic Polymers: Design, Synthesis, and Applications.

Solar energy is a primary form of renewable energy, and photothermal conversion is a direct conversion process with tunable conversion efficiency. Among various kinds of photothermal conversion materials, porous organic polymers (POP) are widely investigated owing to their controllable molecular design, tailored porous structures, good absorption of solar light, and low thermal conductivity. A variety of POP, such as conjugated microporous polymers (CMP), covalent organic frameworks (COF), hyper-crosslinked porous polymers (HCP), polymers of intrinsic microporosity (PIM), porous ionic polymers (PIP), are developed and applied in photothermal conversion applications of seawater desalination, latent energy storage, and biomedical fields. In this review, a comprehensive overview of the recent advances in POP for photothermal conversion is provided. The micro molecular structure characteristics and macro morphology of POP are designed for applications such as seawater desalination, latent heat energy storage, phototherapy and photodynamic therapy, and drug delivery. Besides, a probe into the underlying mechanism of structural design for constructing POP with excellent photothermal conversion performance is methodicalized. Finally, the remaining challenges and prospective opportunities for the future development of POP for solar energy-driven photothermal conversion applications are elucidated.

Facile synthesis of magnetic hyper-crosslinked porous polymer for efficient extraction and sensitive determination of nitroimidazole antibiotics

Antibiotics are a class of emerging organic pollutants that pose serious risk to human health and the environment. Nitroimidazoles (NDZs), as a group of important antibiotics, are widely used in livestock and poultry. However, their toxicity has caused world-wide public attention. Based on the idea of turning trash into treasure, in this study, a novel magnetic hyper-crosslinked polymer (M−HCP) was facilely synthesized via Friedel-Crafts reaction by crosslinking wasted polystyrene foam with 1,4-bis(chloromethyl)benzene in the presence of Fe3O4. The prepared M−HCP was characterized by scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, Brunauer-Emmett-Teller surface area and porosity measurements. The M−HCP showed a high adsorption ability for NDZs including ronidazole, secnidazole, dimetridazole and ornidazole. By coupling M−HCP based magnetic solid-phase extraction with high performance liquid-phase chromatography-ultraviolet detector, a sensitive method was developed for the determination of four NDZs in environmental water. Under optimal conditions, a good linearity was obtained in the range of 0.04–100 ng∙mL−1 with the correlation coefficients above 0.9993. Low limits of detection were achieved between 0.01 and 0.03 ng∙mL−1. The developed method was successfully applied to simultaneously determine four NDZs in environmental water, with recoveries from 94.0 % to 105 % and relative standard deviations below 4.8 %, demonstrating that the method has a good sensitivity and accuracy for the determination of NDZs in environmental water. This work not only provides a good alternative for effective detection of trace NDZs, but also has great significance in environment protection and sustainable development by conversing wastes into higher-value-added materials.