Timber buildings, including cross laminated timber (CLT), are gaining market shares globally, mainly due to anticipated environmental benefits, but a new technical solution also raises new questions. Durability is critical to obtain real sustainable constructions built for the future. There are field studies concerning hygrothermal conditions of timber structures, however, there is a lack of documented experiences combining hygrothermal conditions, mould growth potential and weather protection during construction using CLT. The use of full weather protection is being debated in the building industry as well as in the research community, due to lack of knowledge of the combined effects. How does weather protection during the construction affect hygrothermal conditions and risk of mould growth in a CLT structure? A case study using a weather protected six-storey CLT building was performed. The hygrothermal conditions – indoors and outdoors – were monitored during construction and samples from CLT were analysed with respect to mould. The results were analysed together with simulations of mould growth using actual hygrothermal conditions. Theoretical conclusions show the weather protection gives significantly improved conditions resulting in lower potential of mould growth compared to outdoor conditions. The results also show lessons to be learned concerning planning of the construction site.