ABSTRACTAim and objectivesTo evaluate and compare the dentinal microcrack formation after obturation using CPoint and gutta percha as root canal filling materials.Materials and methodsForty orthodontically extracted single-rooted premolars were selected. The teeth were decoronated and were then divided into four groups (n = 10). In group I, samples were left unprepared and unfilled (negative control), in group II, samples were prepared and left unobturated (positive control), in group III, samples were prepared and obturation was done with Cpoint (F3) and endosequence bioceramic sealer, and in group IV, samples were prepared and obturation was done with Protaper gutta percha (F3) and endosequence bioceramic sealer. Then, the samples were kept for 1 week at 37°C and 100% humidity. All roots were then sectioned at 2 mm from the apex. Additional cross sections at a 4 mm level were made in groups III and IV. Then, the sections were observed under a scanning electron microscope and the presence of dentinal microcracks was checked.ResultsThere was statistically nonsignificant difference for a mean number of microcracks in the samples after obturation with CPoint and gutta percha.ConclusionCPoint can be used as an alternative to gutta percha as it provides better seal because of its lateral hygroscopic expansion without causing significant damage to the dentinal microstructure.Clinical significanceIn spite of gutta percha being the gold standard in obturating material, still the desired hermetic seal could not be achieved. To achieve this attainable goal, a new material CPoint had been introduced, which has the ability to undergo hygroscopic expansion within the root canal.How to cite this articleSomani R, Jaidka S, Singh DJ, et al. Hermetic Seal in Obturation: An Achievable Goal with Recently Introduced Cpoint. Int J Clin Pediatr Dent 2019;12(5):410–413.