Epidemics of a wide variety of infectious diseases were constantly recorded in Russia. Asian cholera occupied a special place among epidemic diseases. In 1892, cholera was imported into the Russian Empire through the Black Sea ports, which reached the territory of the Kuban region by the summer of the same year. In 1892, about 300 thousand people died of cholera in Russia. They still did not know how to treat this terrible disease, did not know its mechanism of spread, as well as the peculiarities of its course. The article, prepared on the basis of an analysis of documentary data from the Archive Department of the administration of the municipal formation of the city of Novorossiysk and the archival Department of the Administration of the municipal formation of the Mostovsky district, examines the cholera epidemic that swept the territories of the Kuban region in 1892 and 1910. The authors characterize the main factors that contributed to the rapid spread of infection and assess the measures that were taken to combat the disease: the implementation of anti-cholera measures organized by the authorities was greatly hampered by the lack of education, prejudices and superstitions of the vast majority of the population; representatives of the nonresident population not only did not comply with basic standards of personal hygiene, but also expressed distrust, and sometimes and hostility towards doctors. Using archival data, the authors investigate the impact of infectious diseases on the demographic indicators of these settlements.